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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Review Open Access

Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review)

  • Authors:
    • Jingyu Wang
    • Yuan Li
    • Meiman Ding
    • Honghe Zhang
    • Xiaoming Xu
    • Jinlong Tang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Hospital of Jiaxing, Zhejiang, P.R. China, Department of Pediatrics, The Affiliated Children's Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China, The Criminal Investigation Detachment of Jiaxing Public Security Bureau, Hangzhou, Zhejiang, P.R. China, Department of Pathology, Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 345-355
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    Published online on: December 19, 2016
       https://doi.org/10.3892/ijo.2016.3811
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Abstract

miRNAs (microRNAs) have been validated to play fateful roles in the occurrence and development of cancers by post-transcriptionally targeting 3'-untranslated regions of the downstream gene mRNAs to repress mRNA expression. Mounting investigations forcefully document that not only does miR‑22 biologically impinge on the processes of senescence, energy supply, angiogenesis, EMT (epithelial-mesenchymal transition), proliferation, migration, invasion, metastasis and apoptosis, but also it genetically or epigenetically exerts dual (inhibitory/promoting cancer) effects in various cancers via CNAs (copy number alterations), SNPs (single nucleotide polymorphisms), methylation, acetylation and even more momentously hydroxymethylation. Additionally, miR‑22 expression may fluctuate with cancer progression in the body fluids of cancer patients and miR‑22 could amplify its inhibitory or promoting effects through partaking in positive or negative feedback loops and interplaying with many other related miRNAs in the cascade of events, making it possible for miR‑22 to be a promising and complementary or even independent cancer biomarker in some cancers and engendering profound influences on the early diagnosis, therapeutics, supervising curative effects and prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Li Y, Ding M, Zhang H, Xu X and Tang J: Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review). Int J Oncol 50: 345-355, 2017.
APA
Wang, J., Li, Y., Ding, M., Zhang, H., Xu, X., & Tang, J. (2017). Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review). International Journal of Oncology, 50, 345-355. https://doi.org/10.3892/ijo.2016.3811
MLA
Wang, J., Li, Y., Ding, M., Zhang, H., Xu, X., Tang, J."Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review)". International Journal of Oncology 50.2 (2017): 345-355.
Chicago
Wang, J., Li, Y., Ding, M., Zhang, H., Xu, X., Tang, J."Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review)". International Journal of Oncology 50, no. 2 (2017): 345-355. https://doi.org/10.3892/ijo.2016.3811
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Li Y, Ding M, Zhang H, Xu X and Tang J: Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review). Int J Oncol 50: 345-355, 2017.
APA
Wang, J., Li, Y., Ding, M., Zhang, H., Xu, X., & Tang, J. (2017). Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review). International Journal of Oncology, 50, 345-355. https://doi.org/10.3892/ijo.2016.3811
MLA
Wang, J., Li, Y., Ding, M., Zhang, H., Xu, X., Tang, J."Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review)". International Journal of Oncology 50.2 (2017): 345-355.
Chicago
Wang, J., Li, Y., Ding, M., Zhang, H., Xu, X., Tang, J."Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review)". International Journal of Oncology 50, no. 2 (2017): 345-355. https://doi.org/10.3892/ijo.2016.3811
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