Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines

  • Authors:
    • Eliana Guerriero
    • Angela Sorice
    • Francesca Capone
    • Gabriella Storti
    • Giovanni Colonna
    • Gennaro Ciliberto
    • Susan Costantini
  • View Affiliations

  • Published online on: January 2, 2017     https://doi.org/10.3892/ijo.2017.3835
  • Pages: 468-476
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Abstract

Breast cancer is one of the most frequently diagnosed forms of cancer and different treatments are used to block its progression. However, it still represents a very common cause of death in women. Doxorubicin (Dox) is reported as an effective agent in breast cancer treatment nonetheless it induces many side‑effects. For this reason, many laboratories are engaged in understanding how it is possible to decrease the drug concentration, considering that one of the possible solutions is to use drug synergy, combining it with natural substances. Recently we showed that a phenolic extract from flaxseed (FS) oil, named PEFSO, induced on MCF‑7 cell line an increase of apoptosis with related modification of G0/G1 phase cell cycle, and the activation of signaling and pro‑oxidant pathways. In this study we present data on the combined effect of Dox and PEFSO on two different breast cancer cell lines to define the conditions to use lower doses of this chemotherapeutic agent. We report the data relating to the ability of this mixture to induce cytotoxicity and apoptosis, cell cycle modification, mitochondrial membrane depolarization and activation of extrinsic and/or intrinsic apoptotic pathway.
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February-2017
Volume 50 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Guerriero E, Sorice A, Capone F, Storti G, Colonna G, Ciliberto G and Costantini S: Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. Int J Oncol 50: 468-476, 2017
APA
Guerriero, E., Sorice, A., Capone, F., Storti, G., Colonna, G., Ciliberto, G., & Costantini, S. (2017). Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. International Journal of Oncology, 50, 468-476. https://doi.org/10.3892/ijo.2017.3835
MLA
Guerriero, E., Sorice, A., Capone, F., Storti, G., Colonna, G., Ciliberto, G., Costantini, S."Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines". International Journal of Oncology 50.2 (2017): 468-476.
Chicago
Guerriero, E., Sorice, A., Capone, F., Storti, G., Colonna, G., Ciliberto, G., Costantini, S."Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines". International Journal of Oncology 50, no. 2 (2017): 468-476. https://doi.org/10.3892/ijo.2017.3835