|
1
|
Bjelakovic G, Nikolova D, Simonetti RG and
Gluud C: Antioxidant supplements for preventing gastrointestinal
cancers. Cochrane Database Syst Rev. 3:CD0041832008.
|
|
2
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng
H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China,
2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial-mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Gonzalez DM and Medici D: Signaling
mechanisms of the epithelial-mesenchymal transition. Sci Signal.
7:re82014. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kalluri R and Weinberg RA: The basics of
epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Zheng X, Carstens JL, Kim J, Scheible M,
Kaye J, Sugimoto H, Wu CC, LeBleu VS and Kalluri R:
Epithelial-to-mesenchymal transition is dispensable for metastasis
but induces chemoresistance in pancreatic cancer. Nature.
527:525–530. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan
A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The
epithelial-mesenchymal transition generates cells with properties
of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Yu H and Jove R: The STATs of cancer--new
molecular targets come of age. Nat Rev Cancer. 4:97–105. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Kanda N, Seno H, Konda Y, Marusawa H,
Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y,
et al: STAT3 is constitutively activated and supports cell survival
in association with survivin expression in gastric cancer cells.
Oncogene. 23:4921–4929. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Corvinus FM, Orth C, Moriggl R, Tsareva
SA, Wagner S, Pfitzner EB, Baus D, Kaufmann R, Huber LA, Zatloukal
K, et al: Persistent STAT3 activation in colon cancer is associated
with enhanced cell proliferation and tumor growth. Neoplasia.
7:545–555. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Scholz A, Heinze S, Detjen KM, Peters M,
Welzel M, Hauff P, Schirner M, Wiedenmann B and Rosewicz S:
Activated signal transducer and activator of transcription 3
(STAT3) supports the malignant phenotype of human pancreatic
cancer. Gastroenterology. 125:891–905. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Yang SF, Wang SN, Wu CF, Yeh YT, Chai CY,
Chunag SC, Sheen MC and Lee KT: Altered p-STAT3 (tyr705) expression
is associated with histological grading and intratumour microvessel
density in hepatocellular carcinoma. J Clin Pathol. 60:642–648.
2007. View Article : Google Scholar
|
|
14
|
De Craene B and Berx G: Regulatory
networks defining EMT during cancer initiation and progression. Nat
Rev Cancer. 13:97–110. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Pignatelli M, Ansari TW, Gunter P, Liu D,
Hirano S, Takeichi M, Klöppel G and Lemoine NR: Loss of membranous
E-cadherin expression in pancreatic cancer: Correlation with lymph
node metastasis, high grade, and advanced stage. J Pathol.
174:243–248. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Lee SJ, Choi SY, Kim WJ, Ji M, Lee TG, Son
BR, Yoon SM, Sung R, Lee EJ, Youn SJ, et al: Combined aberrant
expression of E-cadherin and S100A4, but not β-catenin is
associated with disease-free survival and overall survival in
colorectal cancer patients. Diagn Pathol. 8:992013. View Article : Google Scholar
|
|
17
|
Cano A, Pérez-Moreno MA, Rodrigo I,
Locascio A, Blanco MJ, del Barrio MG, Portillo F and Nieto MA: The
transcription factor snail controls epithelial-mesenchymal
transitions by repressing E-cadherin expression. Nat Cell Biol.
2:76–83. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Lamouille S, Xu J and Derynck R: Molecular
mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell
Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Rhim AD, Mirek ET, Aiello NM, Maitra A,
Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK,
Vonderheide RH, et al: EMT and dissemination precede pancreatic
tumor formation. Cell. 148:349–361. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhong Z, Wen Z and Darnell JE Jr: Stat3: A
STAT family member activated by tyrosine phosphorylation in
response to epidermal growth factor and interleukin-6. Science.
264:95–98. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Turkson J: STAT proteins as novel targets
for cancer drug discovery. Expert Opin Ther Targets. 8:409–422.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Yu H, Lee H, Herrmann A, Buettner R and
Jove R: Revisiting STAT3 signalling in cancer: New and unexpected
biological functions. Nat Rev Cancer. 14:736–746. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Choi JH, Ahn MJ, Park CK, Han HX, Kwon SJ,
Lee YY and Kim IS: Phospho-Stat3 expression and correlation with
VEGF, p53, and Bcl-2 in gastric carcinoma using tissue microarray.
APMIS. 114:619–625. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wake MS and Watson CJ: STAT3 the oncogene
- still eluding therapy? FEBS J. 282:2600–2611. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Corcoran RB, Contino G, Deshpande V,
Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA
and Bardeesy N: STAT3 plays a critical role in KRAS-induced
pancreatic tumorigenesis. Cancer Res. 71:5020–5029. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Rebouissou S, Amessou M, Couchy G, Poussin
K, Imbeaud S, Pilati C, Izard T, Balabaud C, Bioulac-Sage P and
Zucman-Rossi J: Frequent in-frame somatic deletions activate gp130
in inflammatory hepatocellular tumours. Nature. 457:200–204. 2009.
View Article : Google Scholar :
|
|
27
|
Putoczki TL, Thiem S, Loving A, Busuttil
RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards
KM, et al: Interleukin-11 is the dominant IL-6 family cytokine
during gastrointestinal tumorigenesis and can be targeted
therapeutically. Cancer Cell. 24:257–271. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Bromberg JF, Wrzeszczynska MH, Devgan G,
Zhao Y, Pestell RG, Albanese C and Darnell JE Jr: Stat3 as an
oncogene. Cell. 98:295–303. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Yu H, Pardoll D and Jove R: STATs in
cancer inflammation and immunity: A leading role for STAT3. Nat Rev
Cancer. 9:798–809. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fukuda A, Wang SC, Morris JP IV, Folias
AE, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, et
al: Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma
initiation and progression. Cancer Cell. 19:441–455. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Lesina M, Kurkowski MU, Ludes K, Rose-John
S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S,
et al: Stat3/Socs3 activation by IL-6 transsignaling promotes
progression of pancreatic intraepithelial neoplasia and development
of pancreatic cancer. Cancer Cell. 19:456–469. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
McAllister F, Bailey JM, Alsina J, Nirschl
CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H,
et al: Oncogenic Kras activates a hematopoietic-to-epithelial IL-17
signaling axis in preinvasive pancreatic neoplasia. Cancer Cell.
25:621–637. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Loncle C, Bonjoch L, Folch-Puy E,
Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus
P, Lomberk G, et al: IL17 functions through the novel
REG3b-JAK2-STAT3 inflammatory pathway to promote the transition
from chronic pancreatitis to pancreatic Cancer. Cancer Res.
75:4852–4862. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Liang J, Nagahashi M, Kim EY, Harikumar
KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, et
al: Sphingosine-1-phosphate links persistent STAT3 activation,
chronic intestinal inflammation, and development of
colitis-associated cancer. Cancer Cell. 23:107–120. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Grivennikov S, Karin E, Terzic J, Mucida
D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H,
Eckmann L, et al: IL-6 and Stat3 are required for survival of
intestinal epithelial cells and development of colitis-associated
cancer. Cancer Cell. 15:103–113. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Ernst M, Najdovska M, Grail D,
Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS,
Hughes NR, et al: STAT3 and STAT1 mediate IL-11-dependent and
inflammation-associated gastric tumorigenesis in gp130 receptor
mutant mice. J Clin Invest. 118:1727–1738. 2008.PubMed/NCBI
|
|
37
|
Niu G, Wright KL, Huang M, Song L, Haura
E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, et al:
Constitutive Stat3 activity upregulates VEGF expression and tumor
angiogenesis. Oncogene. 21:2000–2008. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao
AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, et al: Stat3
activation regulates the expression of vascular endothelial growth
factor and human pancreatic cancer angiogenesis and metastasis.
Oncogene. 22:319–329. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Li WC, Ye SL, Sun RX, Liu YK, Tang ZY, Kim
Y, Karras JG and Zhang H: Inhibition of growth and metastasis of
human hepatocellular carcinoma by antisense oligonucleotide
targeting signal transducer and activator of transcription 3. Clin
Cancer Res. 12:7140–7148. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Huang C, Jiang T, Zhu L, Liu J, Cao J,
Huang KJ and Qiu ZJ: STAT3-targeting RNA interference inhibits
pancreatic cancer angiogenesis in vitro and in vivo. Int J Oncol.
38:1637–1644. 2011.PubMed/NCBI
|
|
41
|
Huang C, Huang R, Chang W, Jiang T, Huang
K, Cao J, Sun X and Qiu Z: The expression and clinical significance
of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Neoplasma.
59:52–61. 2012. View Article : Google Scholar
|
|
42
|
Xu Q, Briggs J, Park S, Niu G, Kortylewski
M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, et al:
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by
multiple oncogenic growth signaling pathways. Oncogene.
24:5552–5560. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Kujawski M, Kortylewski M, Lee H, Herrmann
A, Kay H and Yu H: Stat3 mediates myeloid cell-dependent tumor
angiogenesis in mice. J Clin Invest. 118:3367–3377. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Li HD, Huang C, Huang KJ, Wu WD, Jiang T,
Cao J, Feng ZZ and Qiu ZJ: STAT3 knockdown reduces pancreatic
cancer invasiveness and matrix metalloproteinase-7 expression in
nude mice. PLoS One. 6:e259412011. View Article : Google Scholar
|
|
45
|
Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F,
Sawaya R and Huang S: Stat3 activation regulates the expression of
matrix metalloproteinase-2 and tumor invasion and metastasis.
Oncogene. 23:3550–3560. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Huang C, Cao J, Huang KJ, Zhang F, Jiang
T, Zhu L and Qiu ZJ: Inhibition of STAT3 activity with AG490
decreases the invasion of human pancreatic cancer cells in vitro.
Cancer Sci. 97:1417–1423. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Qiu Z, Huang C, Sun J, Qiu W, Zhang J, Li
H, Jiang T, Huang K and Cao J: RNA interference-mediated signal
transducers and activators of transcription 3 gene silencing
inhibits invasion and metastasis of human pancreatic cancer cells.
Cancer Sci. 98:1099–1106. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Yang G, Huang C, Cao J, Huang KJ, Jiang T
and Qiu ZJ: Lentivirus-mediated shRNA interference targeting STAT3
inhibits human pancreatic cancer cell invasion. World J
Gastroenterol. 15:3757–3766. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Tsareva SA, Moriggl R, Corvinus FM,
Wiederanders B, Schütz A, Kovacic B and Friedrich K: Signal
transducer and activator of transcription 3 activation promotes
invasive growth of colon carcinomas through matrix
metalloproteinase induction. Neoplasia. 9:279–291. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Xie TX, Huang FJ, Aldape KD, Kang SH, Liu
M, Gershenwald JE, Xie K, Sawaya R and Huang S: Activation of stat3
in human melanoma promotes brain metastasis. Cancer Res.
66:3188–3196. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Jones LM, Broz ML, Ranger JJ, Ozcelik J,
Ahn R, Zuo D, Ursini-Siegel J, Hallett MT, Krummel M and Muller WJ:
Stat3 establishes an immunosuppressive microenvironment during the
early stages of breast carcinogenesis to promote tumor growth and
metastasis. Cancer Res. 76:1416–1428. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Yu H, Kortylewski M and Pardoll D:
Crosstalk between cancer and immune cells: Role of STAT3 in the
tumour microenvironment. Nat Rev Immunol. 7:41–51. 2007. View Article : Google Scholar
|
|
53
|
Deng J, Liu Y, Lee H, Herrmann A, Zhang W,
Zhang C, Shen S, Priceman SJ, Kujawski M, Pal SK, et al:
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at
future metastatic sites. Cancer Cell. 21:642–654. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Lin L, Liu A, Peng Z, Lin HJ, Li PK, Li C
and Lin J: STAT3 is necessary for proliferation and survival in
colon cancer-initiating cells. Cancer Res. 71:7226–7237. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Su YJ, Lai HM, Chang YW, Chen GY and Lee
JL: Direct reprogramming of stem cell properties in colon cancer
cells by CD44. EMBO J. 30:3186–3199. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Lee TK, Castilho A, Cheung VC, Tang KH, Ma
S and Ng IO: CD24(+) liver tumor-initiating cells drive
self-renewal and tumor initiation through STAT3-mediated NANOG
regulation. Cell Stem Cell. 9:50–63. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Won C, Kim BH, Yi EH, Choi KJ, Kim EK,
Jeong JM, Lee JH, Jang JJ, Yoon JH, Jeong WI, et al: Signal
transducer and activator of transcription 3-mediated CD133
upregulation contributes to promotion of hepatocellular carcinoma.
Hepatology. 62:1160–1173. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Niwa H, Ogawa K, Shimosato D and Adachi K:
A parallel circuit of LIF signalling pathways maintains
pluripotency of mouse ES cells. Nature. 460:118–122. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Marotta LL, Almendro V, Marusyk A,
Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ,
Choudhury SA, Maruyama R, et al: The JAK2/STAT3 signaling pathway
is required for growth of CD44+CD24− stem
cell-like breast cancer cells in human tumors. J Clin Invest.
121:2723–2735. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Schroeder A, Herrmann A, Cherryholmes G,
Kowolik C, Buettner R, Pal S, Yu H, Müller-Newen G and Jove R: Loss
of androgen receptor expression promotes a stem-like cell phenotype
in prostate cancer through STAT3 signaling. Cancer Res.
74:1227–1237. 2014. View Article : Google Scholar
|
|
61
|
Panni RZ, Sanford DE, Belt BA, Mitchem JB,
Worley LA, Goetz BD, Mukherjee P, Wang-Gillam A, Link DC, Denardo
DG, et al: Tumor-induced STAT3 activation in monocytic
myeloid-derived suppressor cells enhances stemness and mesenchymal
properties in human pancreatic cancer. Cancer Immunol Immunother.
63:513–528. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Wan S, Zhao E, Kryczek I, Vatan L,
Sadovskaya A, Ludema G, Simeone DM, Zou W and Welling TH:
Tumor-associated macrophages produce interleukin 6 and signal via
STAT3 to promote expansion of human hepatocellular carcinoma stem
cells. Gastroenterology. 147:1393–1404. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Kryczek I, Lin Y, Nagarsheth N, Peng D,
Zhao L, Zhao E, Vatan L, Szeliga W, Dou Y, Owens S, et al:
IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3
transcription factor activation and induction of the
methyltransferase DOT1L. Immunity. 40:772–784. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Sano S, Itami S, Takeda K, Tarutani M,
Yamaguchi Y, Miura H, Yoshikawa K, Akira S and Takeda J:
Keratinocyte-specific ablation of Stat3 exhibits impaired skin
remodeling, but does not affect skin morphogenesis. EMBO J.
18:4657–4668. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Yamashita S, Miyagi C, Fukada T, Kagara N,
Che YS and Hirano T: Zinc transporter LIVI controls
epithelial-mesenchymal transition in zebrafish gastrula organizer.
Nature. 429:298–302. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Huang C, Yang G, Jiang T, Zhu G, Li H and
Qiu Z: The effects and mechanisms of blockage of STAT3 signaling
pathway on IL-6 inducing EMT in human pancreatic cancer cells in
vitro. Neoplasma. 58:396–405. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Huang C, Yang G, Jiang T, Huang K, Cao J
and Qiu Z: Effects of IL-6 and AG490 on regulation of Stat3
signaling pathway and invasion of human pancreatic cancer cells in
vitro. J Exp Clin Cancer Res. 29:512010. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Liu H, Ren G, Wang T, Chen Y, Gong C, Bai
Y, Wang B, Qi H, Shen J, Zhu L, et al: Aberrantly expressed Fra-1
by IL-6/STAT3 transactivation promotes colorectal cancer
aggressiveness through epithelial-mesenchymal transition.
Carcinogenesis. 36:459–468. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E,
Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, et al: Protein
kinase Cα is a central signaling node and therapeutic target for
breast cancer stem cells. Cancer Cell. 24:347–364. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Wang Y, Shi J, Chai K, Ying X and Zhou BP:
The Role of Snail in EMT and Tumorigenesis. Curr Cancer Drug
Targets. 13:963–972. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Ota I, Li XY, Hu Y and Weiss SJ: Induction
of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration
program in cancer cells by Snail1. Proc Natl Acad Sci USA.
106:20318–20323. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Kudo-Saito C, Shirako H, Takeuchi T and
Kawakami Y: Cancer metastasis is accelerated through
immunosuppression during Snail-induced EMT of cancer cells. Cancer
Cell. 15:195–206. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Hotz B, Arndt M, Dullat S, Bhargava S,
Buhr HJ and Hotz HG: Epithelial to mesenchymal transition:
Expression of the regulators snail, slug, and twist in pancreatic
cancer. Clin Cancer Res. 13:4769–4776. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Shin NR, Jeong EH, Choi CI, Moon HJ, Kwon
CH, Chu IS, Kim GH, Jeon TY, Kim DH, Lee JH, et al: Overexpression
of Snail is associated with lymph node metastasis and poor
prognosis in patients with gastric cancer. BMC Cancer. 12:5212012.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Kim YH, Kim G, Kwon CI, Kim JW, Park PW
and Hahm KB: TWIST1 and SNAI1 as markers of poor prognosis in human
colorectal cancer are associated with the expression of ALDH1 and
TGF-β1. Oncol Rep. 31:1380–1388. 2014.PubMed/NCBI
|
|
76
|
Yang MH, Chen CL, Chau GY, Chiou SH, Su
CW, Chou TY, Peng WL and Wu JC: Comprehensive analysis of the
independent effect of twist and snail in promoting metastasis of
hepatocellular carcinoma. Hepatology. 50:1464–1474. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
77
|
von Burstin J, Eser S, Paul MC, Seidler B,
Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, et
al: E-cadherin regulates metastasis of pancreatic cancer in vivo
and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.
Gastroenterology. 137:361–371. 371.e1–5. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Herranz N, Pasini D, Díaz VM, Francí C,
Gutierrez A, Dave N, Escrivà M, Hernandez-Muñoz I, Di Croce L,
Helin K, et al: Polycomb complex 2 is required for E-cadherin
repression by the Snail1 transcription factor. Mol Cell Biol.
28:4772–4781. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Chen J, Xu H, Zou X, Wang J, Zhu Y, Chen
H, Shen B, Deng X, Zhou A, Chin YE, et al: Snail recruits Ring1B to
mediate transcriptional repression and cell migration in pancreatic
cancer cells. Cancer Res. 74:4353–4363. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Vincent T, Neve EP, Johnson JR, Kukalev A,
Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL,
et al: A SNAIL1-SMAD3/4 transcriptional repressor complex promotes
TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol.
11:943–950. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Sahlgren C, Gustafsson MV, Jin S,
Poellinger L and Lendahl U: Notch signaling mediates
hypoxia-induced tumor cell migration and invasion. Proc Natl Acad
Sci USA. 105:6392–6397. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim
NH, Cha SY, Ryu JK, Choi YJ, Kim J, et al: A Wnt-Axin2-GSK3β
cascade regulates Snail1 activity in breast cancer cells. Nat Cell
Biol. 8:1398–1406. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM
and Zhou BP: Stabilization of snail by NF-kappaB is required for
inflammation-induced cell migration and invasion. Cancer Cell.
15:416–428. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Unno J, Satoh K, Hirota M, Kanno A, Hamada
S, Ito H, Masamune A, Tsukamoto N, Motoi F, Egawa S, et al: LIV-1
enhances the aggressive phenotype through the induction of
epithelial to mesenchymal transition in human pancreatic carcinoma
cells. Int J Oncol. 35:813–821. 2009.PubMed/NCBI
|
|
85
|
Shen R, Xie F, Shen H, liu Q, Zheng T, Kou
X, Wang D and Yang J: Negative correlation of LIV-1 and E-cadherin
expression in hepatocellular carcinoma cells. PLoS One.
8:e565422013. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Hogstrand C, Kille P, Ackland ML, Hiscox S
and Taylor KM: A mechanism for epithelial-mesenchymal transition
and anoikis resistance in breast cancer triggered by zinc channel
ZIP6 and STAT3 (signal transducer and activator of transcription
3). Biochem J. 455:229–237. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Yadav A, Kumar B, Datta J, Teknos TN and
Kumar P: IL-6 promotes head and neck tumor metastasis by inducing
epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling
pathway. Mol Cancer Res. 9:1658–1667. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Saitoh M, Endo K, Furuya S, Minami M,
Fukasawa A, Imamura T and Miyazawa K: STAT3 integrates cooperative
Ras and TGF-β signals that induce Snail expression. Oncogene.
35:1049–1057. 2016. View Article : Google Scholar
|
|
89
|
Lee DC, Kang YK, Kim WH, Jang YJ, Kim DJ,
Park IY, Sohn BH, Sohn HA, Lee HG, Lim JS, et al: Functional and
clinical evidence for NDRG2 as a candidate suppressor of liver
cancer metastasis. Cancer Res. 68:4210–4220. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Kim MJ, Lim J, Yang Y, Lee MS and Lim JS:
N-myc downstream-regulated gene 2 (NDRG2) suppresses the
epithelial-mesenchymal transition (EMT) in breast cancer cells via
STAT3/Snail signaling. Cancer Lett. 354:33–42. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Wang J, Yin D, Xie C, Zheng T, Liang Y,
Hong X, Lu Z, Song X, Song R, Yang H, et al: The iron chelator
Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc
downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.
Oncotarget. 5:8478–8491. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Yin X, Zhang BH, Zheng SS, Gao DM, Qiu SJ,
Wu WZ and Ren ZG: Coexpression of gene Oct4 and Nanog initiates
stem cell characteristics in hepatocellular carcinoma and promotes
epithelial-mesenchymal transition through activation of Stat3/Snail
signaling. J Hematol Oncol. 8:232015. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Yao C, Su L, Shan J, Zhu C, Liu L, Liu C,
Xu Y, Yang Z, Bian X, Shao J, et al: IGF/STAT3/NANOG/Slug signaling
axis simultaneously controls epithelial-mesenchymal transition and
stemness maintenance in colorectal cancer. Stem Cells. 34:820–831.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Jung HY, Fattet L and Yang J: Molecular
pathways: Linking tumor microenvironment to epithelial-mesenchymal
transition in metastasis. Clin Cancer Res. 21:962–968. 2015.
View Article : Google Scholar
|
|
95
|
Fu XT, Dai Z, Song K, Zhang ZJ, Zhou ZJ,
Zhou SL, Zhao YM, Xiao YS, Sun QM, Ding ZB, et al:
Macrophage-secreted IL-8 induces epithelial-mesenchymal transition
in hepatocellular carcinoma cells by activating the
JAK2/STAT3/Snail pathway. Int J Oncol. 46:587–596. 2015.
|
|
96
|
Hamada S, Masamune A, Yoshida N, Takikawa
T and Shimosegawa T: IL-6/STAT3 plays a regulatory role in the
interaction between pancreatic stellate cells and cancer cells. Dig
Dis Sci. 61:1561–1571. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Kikuta K, Masamune A, Watanabe T, Ariga H,
Itoh H, Hamada S, Satoh K, Egawa S, Unno M and Shimosegawa T:
Pancreatic stellate cells promote epithelial-mesenchymal transition
in pancreatic cancer cells. Biochem Biophys Res Commun.
403:380–384. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Yang J, Mani SA, Donaher JL, Ramaswamy S,
Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A and
Weinberg RA: Twist, a master regulator of morphogenesis, plays an
essential role in tumor metastasis. Cell. 117:927–939. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Sasaki K, Natsugoe S, Ishigami S,
Matsumoto M, Okumura H, Setoyama T, Uchikado Y, Kita Y, Tamotsu K,
Sakamoto A, et al: Significance of Twist expression and its
association with E-cadherin in esophageal squamous cell carcinoma.
J Exp Clin Cancer Res. 28:1582009. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Feng MY, Wang K, Song HT, Yu HW, Qin Y,
Shi QT and Geng JS: Metastasis-induction and apoptosis-protection
by TWIST in gastric cancer cells. Clin Exp Metastasis.
26:1013–1023. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Satoh K, Hamada S, Kimura K, Kanno A,
Hirota M, Umino J, Fujibuchi W, Masamune A, Tanaka N, Miura K, et
al: Upregulation of MSX2 enhances the malignant phenotype and is
associated with twist 1 expression in human pancreatic cancer
cells. Am J Pathol. 172:926–939. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Tsai JH, Donaher JL, Murphy DA, Chau S and
Yang J: Spatiotemporal regulation of epithelial-mesenchymal
transition is essential for squamous cell carcinoma metastasis.
Cancer Cell. 22:725–736. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Yang MH, Wu MZ, Chiou SH, Chen PM, Chang
SY, Liu CJ, Teng SC and Wu KJ: Direct regulation of TWIST by HIF-1α
promotes metastasis. Nat Cell Biol. 10:295–305. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Hong J, Zhou J, Fu J, He T, Qin J, Wang L,
Liao L and Xu J: Phosphorylation of serine 68 of Twist1 by MAPKs
stabilizes Twist1 protein and promotes breast cancer cell
invasiveness. Cancer Res. 71:3980–3990. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Xue G, Restuccia DF, Lan Q, Hynx D,
Dirnhofer S, Hess D, Rüegg C and Hemmings BA: Akt/PKB-mediated
phosphorylation of Twist1 promotes tumor metastasis via mediating
cross-talk between PI3K/Akt and TGF-β signaling axes. Cancer
Discov. 2:248–259. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Fu J, Qin L, He T, Qin J, Hong J, Wong J,
Liao L and Xu J: The TWIST/Mi2/NuRD protein complex and its
essential role in cancer metastasis. Cell Res. 21:275–289. 2011.
View Article : Google Scholar
|
|
107
|
Yang MH, Hsu DS, Wang HW, Wang HJ, Lan HY,
Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, et al: Bmi1 is
essential in Twist1-induced epithelial-mesenchymal transition. Nat
Cell Biol. 12:982–992. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Cheng GZ, Zhang WZ, Sun M, Wang Q, Coppola
D, Mansour M, Xu LM, Costanzo C, Cheng JQ and Wang LH: Twist is
transcrip-tionally induced by activation of STAT3 and mediates
STAT3 oncogenic function. J Biol Chem. 283:14665–14673. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Sullivan NJ, Sasser AK, Axel AE, Vesuna F,
Raman V, Ramirez N, Oberyszyn TM and Hall BM: Interleukin-6 induces
an epithelial-mesenchymal transition phenotype in human breast
cancer cells. Oncogene. 28:2940–2947. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Zhang C, Guo F, Xu G, Ma J and Shao F:
STAT3 cooperates with Twist to mediate epithelial-mesenchymal
transition in human hepatocellular carcinoma cells. Oncol Rep.
33:1872–1882. 2015.PubMed/NCBI
|
|
111
|
Cho KH, Choi MJ, Jeong KJ, Kim JJ, Hwang
MH, Shin SC, Park CG and Lee HY: A ROS/STAT3/HIF-1α signaling
cascade mediates EGF-induced TWIST1 expression and prostate cancer
cell invasion. Prostate. 74:528–536. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei
Y, Abbruzzese JL, Hortobagyi GN and Hung MC: Epidermal growth
factor receptor cooperates with signal transducer and activator of
transcription 3 to induce epithelial-mesenchymal transition in
cancer cells via upregulation of TWIST gene expression. Cancer Res.
67:9066–9076. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Zhang P, Sun Y and Ma L: ZEB1: At the
crossroads of epithelial-mesenchymal transition, metastasis and
therapy resistance. Cell Cycle. 14:481–487. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Shi Y, Sawada J, Sui G, Affar B, Whetstine
JR, Lan F, Ogawa H, Luke MP, Nakatani Y and Shi Y: Coordinated
histone modifications mediated by a CtBP co-repressor complex.
Nature. 422:735–738. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Sánchez-Tilló E, Lázaro A, Torrent R,
Cuatrecasas M, Vaquero EC, Castells A, Engel P and Postigo A: ZEB1
represses E-cadherin and induces an EMT by recruiting the SWI/SNF
chromatin-remodeling protein BRG1. Oncogene. 29:3490–3500. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Aghdassi A, Sendler M, Guenther A, Mayerle
J, Behn CO, Heidecke CD, Friess H, Büchler M, Evert M, Lerch MM, et
al: Recruitment of histone deacetylases HDAC1 and HDAC2 by the
transcriptional repressor ZEB1 downregulates E-cadherin expression
in pancreatic cancer. Gut. 61:439–448. 2012. View Article : Google Scholar
|
|
117
|
Dave N, Guaita-Esteruelas S, Gutarra S,
Frias À, Beltran M, Peiró S and de Herreros AG: Functional
cooperation between Snail1 and twist in the regulation of ZEB1
expression during epithelial to mesenchymal transition. J Biol
Chem. 286:12024–12032. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Gregory PA, Bert AG, Paterson EL, Barry
SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y and Goodall GJ:
The miR-200 family and miR-205 regulate epithelial to mesenchymal
transition by targeting ZEB1 and SIP1. Nat Cell Biol. 10:593–601.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Burk U, Schubert J, Wellner U, Schmalhofer
O, Vincan E, Spaderna S and Brabletz T: A reciprocal repression
between ZEB1 and members of the miR-200 family promotes EMT and
invasion in cancer cells. EMBO Rep. 9:582–589. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Wellner U, Schubert J, Burk UC,
Schmalhofer O, Zhu F, Sonntag A, Waldvogel B, Vannier C, Darling D,
zur Hausen A, et al: The EMT-activator ZEB1 promotes tumorigenicity
by repressing stemness-inhibiting microRNAs. Nat Cell Biol.
11:1487–1495. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Xiong H, Hong J, Du W, Lin YW, Ren LL,
Wang YC, Su WY, Wang JL, Cui Y, Wang ZH, et al: Roles of STAT3 and
ZEB1 proteins in E-cadherin downregulation and human colorectal
cancer epithelial-mesenchymal transition. J Biol Chem.
287:5819–5832. 2012. View Article : Google Scholar
|
|
122
|
Avtanski DB, Nagalingam A, Bonner MY,
Arbiser JL, Saxena NK and Sharma D: Honokiol inhibits
epithelial-mesenchymal transition in breast cancer cells by
targeting signal transducer and activator of transcription
3/Zeb1/E-cadherin axis. Mol Oncol. 8:565–580. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Bak Y, Kwon T, Bak IS, Hong J, Yu DY and
Yoon DY: IL-32θ inhibits stemness and epithelial-mesenchymal
transition of cancer stem cells via the STAT3 pathway in colon
cancer. Oncotarget. 7:7307–7317. 2016.PubMed/NCBI
|
|
124
|
Tsai CY, Wang CS, Tsai MM, Chi HC, Cheng
WL, Tseng YH, Chen CY, Lin CD, Wu JI, Wang LH, et al:
Interleukin-32 increases human gastric cancer cell invasion
associated with tumor progression and metastasis. Clin Cancer Res.
20:2276–2288. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Cao Q, Li YY, He WF, Zhang ZZ, Zhou Q, Liu
X, Shen Y and Huang TT: Interplay between microRNAs and the STAT3
signaling pathway in human cancers. Physiol Genomics. 45:1206–1214.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Siemens H, Jackstadt R, Hünten S, Kaller
M, Menssen A, Götz U and Hermeking H: miR-34 and SNAIL form a
double-negative feedback loop to regulate epithelial-mesenchymal
transitions. Cell Cycle. 10:4256–4271. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Chang CJ, Chao CH, Xia W, Yang JY, Xiong
Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, et al: p53 regulates
epithelial-mesenchymal transition and stem cell properties through
modulating miRNAs. Nat Cell Biol. 13:317–323. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Kim NH, Kim HS, Li XY, Lee I, Choi HS,
Kang SE, Cha SY, Ryu JK, Yoon D, Fearon ER, et al: A p53/miRNA-34
axis regulates Snail1-dependent cancer cell epithelial-mesenchymal
transition. J Cell Biol. 195:417–433. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Rokavec M, Öner MG, Li H, Jackstadt R,
Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, et
al: IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated
colorectal cancer invasion and metastasis. J Clin Invest.
124:1853–1867. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Guo L, Chen C, Shi M, Wang F, Chen X, Diao
D, Hu M, Yu M, Qian L and Guo N: Stat3-coordinated
Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain
oncostatin M-driven epithelial-mesenchymal transition. Oncogene.
32:5272–5282. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Patel K, Kollory A, Takashima A, Sarkar S,
Faller DV and Ghosh SK: MicroRNA let-7 downregulates STAT3
phos-phorylation in pancreatic cancer cells by increasing SOCS3
expression. Cancer Lett. 347:54–64. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Sugimura K, Miyata H, Tanaka K, Hamano R,
Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Mori
M, et al: Let-7 expression is a significant determinant of response
to chemotherapy through the regulation of IL-6/STAT3 pathway in
esophageal squamous cell carcinoma. Clin Cancer Res. 18:5144–5153.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Li Y, VandenBoom TG II, Kong D, Wang Z,
Ali S, Philip PA and Sarkar FH: Upregulation of miR-200 and let-7
by natural agents leads to the reversal of
epithelial-to-mesenchymal transition in gemcitabine-resistant
pancreatic cancer cells. Cancer Res. 69:6704–6712. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Nagao Y, Hisaoka M, Matsuyama A, Kanemitsu
S, Hamada T, Fukuyama T, Nakano R, Uchiyama A, Kawamoto M,
Yamaguchi K, et al: Association of microRNA-21 expression with its
targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma. Mod
Pathol. 25:112–121. 2012. View Article : Google Scholar
|
|
135
|
Selaru FM, Olaru AV, Kan T, David S, Cheng
Y, Mori Y, Yang J, Paun B, Jin Z, Agarwal R, et al: MicroRNA-21 is
overexpressed in human cholangiocarcinoma and regulates programmed
cell death 4 and tissue inhibitor of metalloproteinase 3.
Hepatology. 49:1595–1601. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Löffler D, Brocke-Heidrich K, Pfeifer G,
Stocsits C, Hackermüller J, Kretzschmar AK, Burger R, Gramatzki M,
Blumert C, Bauer K, et al: Interleukin-6 dependent survival of
multiple myeloma cells involves the Stat3-mediated induction of
microRNA-21 through a highly conserved enhancer. Blood.
110:1330–1333. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Yue X, Zhao Y, Zhang C, Li J, Liu Z, Liu J
and Hu W: Leukemia inhibitory factor promotes EMT through
STAT3-dependent miR-21 induction. Oncotarget. 7:3777–3790.
2016.
|
|
138
|
Luo F, Xu Y, Ling M, Zhao Y, Xu W, Liang
X, Jiang R, Wang B, Bian Q and Liu Q: Arsenite evokes IL-6
secretion, autocrine regulation of STAT3 signaling, and miR-21
expression, processes involved in the EMT and malignant
transformation of human bronchial epithelial cells. Toxicol Appl
Pharmacol. 273:27–34. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Gironella M, Seux M, Xie MJ, Cano C,
Tomasini R, Gommeaux J, Garcia S, Nowak J, Yeung ML, Jeang KT, et
al: Tumor protein 53-induced nuclear protein 1 expression is
repressed by miR-155, and its restoration inhibits pancreatic tumor
development. Proc Natl Acad Sci USA. 104:16170–16175. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Huang C, Li H, Wu W, Jiang T and Qiu Z:
Regulation of miR-155 affects pancreatic cancer cell invasiveness
and migration by modulating the STAT3 signaling pathway through
SOCS1. Oncol Rep. 30:1223–1230. 2013.PubMed/NCBI
|
|
141
|
Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu
H, Liu MF and Wang ED: MicroRNA-155 functions as an OncomiR in
breast cancer by targeting the suppressor of cytokine signaling 1
gene. Cancer Res. 70:3119–3127. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ,
Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA
activated by TGF-β promotes the invasion-metastasis cascade in
hepato-cellular carcinoma. Cancer Cell. 25:666–681. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Wu J, Zhang J, Shen B, Yin K, Xu J, Gao W
and Zhang L: Long noncoding RNA lncTCF7, induced by IL-6/STAT3
transactivation, promotes hepatocellular carcinoma aggressiveness
through epithelial-mesenchymal transition. J Exp Clin Cancer Res.
34:1162015. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Qu S, Yang X, Li X, Wang J, Gao Y, Shang
R, Sun W, Dou K and Li H: Circular RNA: A new star of noncoding
RNAs. Cancer Lett. 365:141–148. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Hansen TB, Jensen TI, Clausen BH, Bramsen
JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function
as efficient microRNA sponges. Nature. 495:384–388. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Zhao X, Dou W, He L, Liang S, Tie J, Liu
C, Li T, Lu Y, Mo P, Shi Y, et al: MicroRNA-7 functions as an
anti-metastatic microRNA in gastric cancer by targeting
insulin-like growth factor-1 receptor. Oncogene. 32:1363–1372.
2013. View Article : Google Scholar
|
|
147
|
Zhang N, Li X, Wu CW, Dong Y, Cai M, Mok
MT, Wang H, Chen J, Ng SS, Chen M, et al: microRNA-7 is a novel
inhibitor of YY1 contributing to colorectal tumorigenesis.
Oncogene. 32:5078–5088. 2013. View Article : Google Scholar
|
|
148
|
Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y,
Yang S, Zeng Z, Liao W, Ding YQ, et al: Emerging roles of
circRNA_001569 targeting miR-145 in the proliferation and invasion
of colorectal cancer. Oncotarget. 7:26680–26691. 2016.PubMed/NCBI
|
|
149
|
Massagué J: TGFbeta in cancer. Cell.
134:215–230. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Zhao S, Venkatasubbarao K, Lazor JW,
Sperry J, Jin C, Cao L and Freeman JW: Inhibition of STAT3 Tyr705
phosphorylation by Smad4 suppresses transforming growth factor
beta-mediated invasion and metastasis in pancreatic cancer cells.
Cancer Res. 68:4221–4228. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Liu RY, Zeng Y, Lei Z, Wang L, Yang H, Liu
Z, Zhao J and Zhang HT: JAK/STAT3 signaling is required for
TGF-β-induced epithelial-mesenchymal transition in lung cancer
cells. Int J Oncol. 44:1643–1651. 2014.PubMed/NCBI
|
|
152
|
Espinoza I and Miele L: Deadly crosstalk:
Notch signaling at the intersection of EMT and cancer stem cells.
Cancer Lett. 341:41–45. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Wang Z, Li Y, Kong D, Banerjee S, Ahmad A,
Azmi AS, Ali S, Abbruzzese JL, Gallick GE and Sarkar FH:
Acquisition of epithelial-mesenchymal transition phenotype of
gemcitabine-resistant pancreatic cancer cells is linked with
activation of the notch signaling pathway. Cancer Res.
69:2400–2407. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Palagani V, Bozko P, El Khatib M, Belahmer
H, Giese N, Sipos B, Malek NP and Plentz RR: Combined inhibition of
Notch and JAK/STAT is superior to monotherapies and impairs
pancreatic cancer progression. Carcinogenesis. 35:859–866. 2014.
View Article : Google Scholar
|
|
155
|
Hsu KW, Hsieh RH, Huang KH, Fen-Yau Li A,
Chi CW, Wang TY, Tseng MJ, Wu KJ and Yeh TS: Activation of the
Notch1/STAT3/Twist signaling axis promotes gastric cancer
progression. Carcinogenesis. 33:1459–1467. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
156
|
Kamakura S, Oishi K, Yoshimatsu T,
Nakafuku M, Masuyama N and Gotoh Y: Hes binding to STAT3 mediates
crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol.
6:547–554. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Jin S, Mutvei AP, Chivukula IV, Andersson
ER, Ramsköld D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling
P, et al: Non-canonical Notch signaling activates IL-6/JAK/STAT
signaling in breast tumor cells and is controlled by p53 and
IKKα/IKKβ. Oncogene. 32:4892–4902. 2013. View Article : Google Scholar
|
|
158
|
Yang Z, Guo L, Liu D, Sun L, Chen H, Deng
Q, Liu Y, Yu M, Ma Y, Guo N, et al: Acquisition of resistance to
trastuzumab in gastric cancer cells is associated with activation
of IL-6/STAT3/Jagged-1/Notch positive feedback loop. Oncotarget.
6:5072–5087. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Kawada M, Seno H, Uenoyama Y, Sawabu T,
Kanda N, Fukui H, Shimahara Y and Chiba T: Signal transducers and
activators of transcription 3 activation is involved in nuclear
accumulation of beta-catenin in colorectal cancer. Cancer Res.
66:2913–2917. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
160
|
Pramanik KC, Fofaria NM, Gupta P, Ranjan
A, Kim SH and Srivastava SK: Inhibition of β-catenin signaling
suppresses pancreatic tumor growth by disrupting nuclear
β-catenin/TCF-1 complex: Critical role of STAT-3. Oncotarget.
6:11561–11574. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Yan S, Zhou C, Zhang W, Zhang G, Zhao X,
Yang S, Wang Y, Lu N, Zhu H and Xu N: beta-Catenin/TCF pathway
upregulates STAT3 expression in human esophageal squamous cell
carcinoma. Cancer Lett. 271:85–97. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
162
|
Gujral TS, Chan M, Peshkin L, Sorger PK,
Kirschner MW and MacBeath G: A noncanonical Frizzled2 pathway
regulates epithelial-mesenchymal transition and metastasis. Cell.
159:844–856. 2014. View Article : Google Scholar : PubMed/NCBI
|
