Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS

  • Authors:
    • Moussa Ide Nasser
    • Muqaddas Masood
    • Wei Wei
    • Xiaochun Li
    • Yifa Zhou
    • Bao Liu
    • Jiang Li
    • Xiaomeng Li
  • View Affiliations

  • Published online on: January 25, 2017     https://doi.org/10.3892/ijo.2017.3862
  • Pages: 911-919
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Abstract

Medicinal plants are affluent sources of several effectual natural drugs. Among them cordycepin which is extracted from Cordyceps militaris is a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated the efficacy of cordycepin in the context of human gastric cancer SGC‑7901 and searched for the cell death procedure. Cordycepin incorporates mitochondrial-mediated apoptosis in SGC‑7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP). In addition, phosphorylation of PI3K/Akt and DNA damage by cordycepin induced the production of reactive oxygen species (ROS), and mediates SGC‑7901 cell cycle cessation at S phase. Collectively, this study suggests that cordycepin might be effective as a modern chemotherapy drug for gastric cancer.
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March-2017
Volume 50 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nasser MI, Masood M, Wei W, Li X, Zhou Y, Liu B, Li J and Li X: Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS. Int J Oncol 50: 911-919, 2017.
APA
Nasser, M.I., Masood, M., Wei, W., Li, X., Zhou, Y., Liu, B. ... Li, X. (2017). Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS. International Journal of Oncology, 50, 911-919. https://doi.org/10.3892/ijo.2017.3862
MLA
Nasser, M. I., Masood, M., Wei, W., Li, X., Zhou, Y., Liu, B., Li, J., Li, X."Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS". International Journal of Oncology 50.3 (2017): 911-919.
Chicago
Nasser, M. I., Masood, M., Wei, W., Li, X., Zhou, Y., Liu, B., Li, J., Li, X."Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS". International Journal of Oncology 50, no. 3 (2017): 911-919. https://doi.org/10.3892/ijo.2017.3862