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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April-2017 Volume 50 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells

  • Authors:
    • Lian Hui
    • Jingru Zhang
    • Xiaoxu Ding
    • Xing Guo
    • Xuejun Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 1439-1447
    |
    Published online on: February 15, 2017
       https://doi.org/10.3892/ijo.2017.3877
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Abstract

Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports. Sox2 is essential for the chemoresistance of Hep-2 cells cultured in soft stiffness. Our results demonstrated that Sox2 promotes chemoresistance of Hep-2 cells in soft stiffness via upregulating the expression of ABCG2. Our findings will provide a new platform for the future design of anticancer drugs based on the biophysical properties of the tumor site.
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Copy and paste a formatted citation
Spandidos Publications style
Hui L, Zhang J, Ding X, Guo X and Jiang X: Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells. Int J Oncol 50: 1439-1447, 2017.
APA
Hui, L., Zhang, J., Ding, X., Guo, X., & Jiang, X. (2017). Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells. International Journal of Oncology, 50, 1439-1447. https://doi.org/10.3892/ijo.2017.3877
MLA
Hui, L., Zhang, J., Ding, X., Guo, X., Jiang, X."Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells". International Journal of Oncology 50.4 (2017): 1439-1447.
Chicago
Hui, L., Zhang, J., Ding, X., Guo, X., Jiang, X."Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells". International Journal of Oncology 50, no. 4 (2017): 1439-1447. https://doi.org/10.3892/ijo.2017.3877
Copy and paste a formatted citation
x
Spandidos Publications style
Hui L, Zhang J, Ding X, Guo X and Jiang X: Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells. Int J Oncol 50: 1439-1447, 2017.
APA
Hui, L., Zhang, J., Ding, X., Guo, X., & Jiang, X. (2017). Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells. International Journal of Oncology, 50, 1439-1447. https://doi.org/10.3892/ijo.2017.3877
MLA
Hui, L., Zhang, J., Ding, X., Guo, X., Jiang, X."Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells". International Journal of Oncology 50.4 (2017): 1439-1447.
Chicago
Hui, L., Zhang, J., Ding, X., Guo, X., Jiang, X."Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells". International Journal of Oncology 50, no. 4 (2017): 1439-1447. https://doi.org/10.3892/ijo.2017.3877
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