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Article

Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells

Corrigendum in: /10.3892/ijo.2023.5533
  • Authors:
    • Zhiqi Liu
    • Jie Liu
    • Li Zhao
    • Hao Geng
    • Jiaxing Ma
    • Zhiqiang Zhang
    • Dexin Yu
    • Caiyun Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China
  • Pages: 1321-1329
    |
    Published online on: February 21, 2017
       https://doi.org/10.3892/ijo.2017.3887
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Abstract

Overexposure to benzidine has been manifested as an important cause of bladder cancer. However, the molecular mechanism of benzidine-induced malignancy is still insufficiently interpreted. Epithelial-mesenchymal transition (EMT) is a crucial pathophysiological process in embryonic development as well as initiation and development of epithelium-originated malignant tumors. The role of extracellular regulated protein kinase 5 (ERK5) in benzidine-meditated bladder cancer development has not been explored. In the present study, we explored the role of ERK5/AP-1 pathway in benzidine-induced EMT in human normal urothelial cells and the intervention effect of curcumin on bezidine-induced EMT. We found that benzidine-induced EMT in SV-40 immortalized human urothelial cells (SV-HUC-1) at low concentrations. We detected that ERK5/AP-1 pathway was notably activated. Specific ERK5 inhibitor, XMD8-92 was applied to determine the role of ERK5 in benzidine-induced EMT. Results indicated that XMD8-92 reversed the EMT process. Furthermore, curcumin effectively attenuated benzidine-induced urocystic EMT by suppressing ERK5/AP-1 pathway. In conclusion, the present study revealed the positive role of ERK5/AP-1 in benzidine-provoked urocystic EMT and the curcumin promising use in bladder cancer prevention and intervention via ERK5/AP-1 pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Liu J, Zhao L, Geng H, Ma J, Zhang Z, Yu D and Zhong C: Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533. Int J Oncol 50: 1321-1329, 2017.
APA
Liu, Z., Liu, J., Zhao, L., Geng, H., Ma, J., Zhang, Z. ... Zhong, C. (2017). Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533. International Journal of Oncology, 50, 1321-1329. https://doi.org/10.3892/ijo.2017.3887
MLA
Liu, Z., Liu, J., Zhao, L., Geng, H., Ma, J., Zhang, Z., Yu, D., Zhong, C."Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533". International Journal of Oncology 50.4 (2017): 1321-1329.
Chicago
Liu, Z., Liu, J., Zhao, L., Geng, H., Ma, J., Zhang, Z., Yu, D., Zhong, C."Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533". International Journal of Oncology 50, no. 4 (2017): 1321-1329. https://doi.org/10.3892/ijo.2017.3887
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Liu J, Zhao L, Geng H, Ma J, Zhang Z, Yu D and Zhong C: Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533. Int J Oncol 50: 1321-1329, 2017.
APA
Liu, Z., Liu, J., Zhao, L., Geng, H., Ma, J., Zhang, Z. ... Zhong, C. (2017). Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533. International Journal of Oncology, 50, 1321-1329. https://doi.org/10.3892/ijo.2017.3887
MLA
Liu, Z., Liu, J., Zhao, L., Geng, H., Ma, J., Zhang, Z., Yu, D., Zhong, C."Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533". International Journal of Oncology 50.4 (2017): 1321-1329.
Chicago
Liu, Z., Liu, J., Zhao, L., Geng, H., Ma, J., Zhang, Z., Yu, D., Zhong, C."Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells Corrigendum in /10.3892/ijo.2023.5533". International Journal of Oncology 50, no. 4 (2017): 1321-1329. https://doi.org/10.3892/ijo.2017.3887
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