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Article

High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma

  • Authors:
    • Shigemasa Suzuki
    • Takehiko Yokobori
    • Bolag Altan
    • Keigo Hara
    • Daigo Ozawa
    • Naritaka Tanaka
    • Makoto Sakai
    • Akihiko Sano
    • Makoto Sohda
    • Halin Bao
    • Minoru Fukuchi
    • Tatsuya Miyazaki
    • Kyoichi Kaira
    • Takayuki Asao
    • Hiroyuki Kuwano
  • View Affiliations / Copyright

    Affiliations: Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan, Department of Oncology Clinical Development, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan, Big Data Center for Integrative Analysis, Gunma University Initiative for Advance Research (GIAR), Gunma, Japan
  • Pages: 1184-1190
    |
    Published online on: March 7, 2017
       https://doi.org/10.3892/ijo.2017.3899
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Abstract

Stathmin 1 (STMN1) is a major cytosolic phosphoprotein regulating microtubule dynamics, thereby playing an important role in cancer progression and resistance to microtubule-binding anticancer agents. We assessed the prognostic significance of STMN1 expression and STMN1-associated resistance to docetaxel and radiation in esophageal squamous cell carcinoma (ESCC) patients. STMN1 expression was evaluated by immunohistochemistry in 172 surgical specimens. The association of STMN1 expression with chemoradiation resistance using docetaxel was examined by comparing expression in 15 biopsy specimens obtained before neoadjuvant therapy to histological grades of post-therapy surgically resected tumors. We also evaluated the effects of STMN1 on sensitivity to docetaxel and radiation in ESCC cell lines. High STMN1 immunoexpression was significantly associated with tumor depth, lymph node metastasis, lymphatic invasion and venous invasion. Survival rates were significantly lower in ESCC patients with high STMN1 expression than in those with low STMN1 expression. Multivariable analysis showed that high STMN1 expression was an independent factor for poor survival. High STMN1 expression was also associated with poor response to neoadjuvant chemoradiotherapy using docetaxel. Knockdown of STMN1 expression enhanced ESCC cell line sensitivity to docetaxel and radiation. STMN1 appears critical for ESCC invasiveness and predicts an unfavorable prognosis in ESCC.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med. 349:2241–2252. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Gebski V, Burmeister B, Smithers BM, Foo K, Zalcberg J and Simes J; Australasian Gastro-Intestinal Trials group: Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: A meta-analysis. Lancet Oncol. 8:226–234. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Mariette C, Piessen G and Triboulet JP: Therapeutic strategies in oesophageal carcinoma: Role of surgery and other modalities. Lancet Oncol. 8:545–553. 2007. View Article : Google Scholar : PubMed/NCBI

5 

van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, et al CROSS group: Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 366:2074–2084. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Rubin CI and Atweh GF: The role of stathmin in the regulation of the cell cycle. J Cell Biochem. 93:242–250. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Alli E, Yang JM, Ford JM and Hait WN: Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cells. Mol Pharmacol. 71:1233–1240. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Golouh R, Cufer T, Sadikov A, Nussdorfer P, Usher PA, Brünner N, Schmitt M, Lesche R, Maier S, Timmermans M, et al: The prognostic value of Stathmin-1, S100B2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study. Breast Cancer Res Treat. 110:317–326. 2008. View Article : Google Scholar

9 

Ghosh R, Gu G, Tillman E, Yuan J, Wang Y, Fazli L, Rennie PS and Kasper S: Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression. Prostate. 67:1038–1052. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Xi W, Rui W, Fang L, Ke D, Ping G and Hui-Zhong Z: Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients. J Cancer Res Clin Oncol. 135:837–846. 2009. View Article : Google Scholar

11 

Kim JY, Harvard C, You L, Xu Z, Kuchenbecker K, Baehner R and Jablons D: Stathmin is overexpressed in malignant mesothelioma. Anticancer Res. 27:39–44. 2007.PubMed/NCBI

12 

Jeon TY, Han ME, Lee YW, Lee YS, Kim GH, Song GA, Hur GY, Kim JY, Kim HJ, Yoon S, et al: Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cells. Br J Cancer. 102:710–718. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Kang W, Tong JH, Chan AW, Lung RW, Chau SL, Wong QW, Wong N, Yu J, Cheng AS and To KF: Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer. PloS One. 7:e339192012. View Article : Google Scholar : PubMed/NCBI

14 

Hsieh SY, Huang SF, Yu MC, Yeh TS, Chen TC, Lin YJ, Chang CJ, Sung CM, Lee YL and Hsu CY: Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinog. 49:476–487. 2010.PubMed/NCBI

15 

Trovik J, Wik E, Stefansson IM, Marcickiewicz J, Tingulstad S, Staff AC, Njolstad TS; MoMaTec Study Group; Vandenput I and Amant F: Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. Clin Cancer Res. 17:3368–3377. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Zheng P, Liu YX, Chen L, Liu XH, Xiao ZQ, Zhao L, Li GQ, Zhou J, Ding YQ and Li JM: Stathmin, a new target of PRl-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer. J Proteome Res. 9:4897–4905. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Lin WC, Chen SC, Hu FC, Chueh SC, Pu YS, Yu HJ and Huang KH: Expression of stathmin in localized upper urinary tract urothelial carcinoma: Correlations with prognosis. Urology. 74:1264–1269. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Akhtar J, Wang Z, Yu C, Li CS, Shi YL and Liu HJ: STMN-1 is a potential marker of lymph node metastasis in distal esophageal adenocarcinomas and silencing its expression can reverse malignant phenotype of tumor cells. BMC Cancer. 14:282014. View Article : Google Scholar : PubMed/NCBI

19 

Wang R, Dong K, Lin F, Wang X, Gao P, Wei SH, Cheng SY and Zhang HZ: Inhibiting proliferation and enhancing chemosensitivity to taxanes in osteosarcoma cells by RNA interference-mediated downregulation of stathmin expression. Mol Med. 13:567–575. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Feng W, Xiaoyan X, Xuan Y, Xiangke L, Zichang Y, Ran Z, Liuxing W and Qingxia F: Silencing stathmin-modulating efficiency of chemotherapy for esophageal squamous cell cancer with paclitaxel. Cancer Gene Ther. 22:115–121. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Thallinger CM, Raderer M and Hejna M: Esophageal cancer: A critical evaluation of systemic second-line therapy. J Clin Oncol. 29:4709–4714. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Pasini F, De Manzoni G, Pedrazzani C, Grandinetti A, Durante E, Gabbani M, Tomezzoli A, Griso C, Guglielmi A, Pelosi G, et al: High pathological response rate in locally advanced esophageal cancer after neoadjuvant combined modality therapy: Dose finding of a weekly chemotherapy schedule with protracted venous infusion of 5-fluorouracil and dose escalation of cisplatin, docetaxel and concurrent radiotherapy. Ann Oncol. 16:1133–1139. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Okumura H, Uchikado Y, Setoyama T, Matsumoto M, Owaki T, Ishigami S and Natsugoe S: Biomarkers for predicting the response of esophageal squamous cell carcinoma to neoadjuvant chemoradiation therapy. Surg Today. 44:421–428. 2014. View Article : Google Scholar

24 

Zhang X, Ji J, Yang Y, Zhang J and Shen L: Stathmin1 increases radioresistance by enhancing autophagy in non-small-cell lung cancer cells. Onco Targets Ther. 9:2565–2574. 2016.PubMed/NCBI

25 

Sobin LH and Wittekind CW: TNM Classification of Malignant Tumours. 6th edition. John Wiley & Sons; Hoboken, NJ: 2002

26 

Fukuchi M, Fukai Y, Sohda M, Miyazaki T, Nakajima M, Inose T, Tanaka N, Tsukada K, Kato H and Kuwano H: Expression of the prolyl isomerase Pin1 is a useful indicator of sensitivity to chemoradiotherapy in advanced esophageal squamous cell carcinoma. Oncol Rep. 21:853–859. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Suzuki S, Miyazaki T, Tanaka N, Sakai M, Sano A, Inose T, Sohda M, Nakajima M, Kato H and Kuwano H: Prognostic significance of CD151 expression in esophageal squamous cell carcinoma with aggressive cell proliferation and invasiveness. Ann Surg Oncol. 18:888–893. 2011. View Article : Google Scholar

28 

Singer S, Ehemann V, Brauckhoff A, Keith M, Vreden S, Schirmacher P and Breuhahn K: Protumorigenic overexpression of stathmin/op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis. Hepatology. 46:759–768. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Japanese Society for Esophageal Diseases: Guidelines for the Clinical and Pathological Studies on Carcinoma of the Esophagus. 10th edition. Kanehara; 2007

30 

Watanabe A, Suzuki H, Yokobori T, Altan B, Kubo N, Araki K, Wada S, Mochida Y, Sasaki S, Kashiwabara K, et al: Forkhead box protein C2 contributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis. Cancer Sci. 104:1427–1432. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Belletti B, Nicoloso MS, Schiappacassi M, Berton S, Lovat F, Wolf K, Canzonieri V, D'andrea S, Zucchetto A, Friedl P, et al: Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell. 19:2003–2013. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Li N, Jiang P, Du W, Wu Z, Li C, Qiao M, Yang X and Wu M: Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. Proc Natl Acad Sci USA. 108:12851–12856. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Yokobori T, Suzuki S, Tanaka N, Inose T, Sohda M, Sano A, Sakai M, Nakajima M, Miyazaki T, Kato H, et al: MiR-150 is associated with poor prognosis in esophageal squamous cell carcinoma via targeting the EMT inducer ZEB1. Cancer Sci. 104:48–54. 2013. View Article : Google Scholar

34 

Salvesen HB, Carter SL, Mannelqvist M, Dutt A, Getz G, Stefansson IM, Raeder MB, Sos ML, Engelsen IB, Trovik J, et al: Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proc Natl Acad Sci USA. 106:4834–4839. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Kim BM and Hong Y, Lee S, Liu P, Lim JH, Lee YH, Lee TH, Chang KT and Hong Y: Therapeutic implications for overcoming radiation resistance in cancer therapy. Int J Mol Sci. 16:26880–26913. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Vaupel P, Thews O and Hoeckel M: Treatment resistance of solid tumors: Role of hypoxia and anemia. Med Oncol. 18:243–259. 2001. View Article : Google Scholar

37 

Yoshie M, Miyajima E, Kyo S and Tamura K: Stathmin, a micro-tubule regulatory protein, is associated with hypoxia-inducible factor-1alpha levels in human endometrial and endothelial cells. Endocrinology. 150:2413–2418. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Suzuki S, Yokobori T, Altan B, Hara K, Ozawa D, Tanaka N, Sakai M, Sano A, Sohda M, Bao H, Bao H, et al: High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma. Int J Oncol 50: 1184-1190, 2017.
APA
Suzuki, S., Yokobori, T., Altan, B., Hara, K., Ozawa, D., Tanaka, N. ... Kuwano, H. (2017). High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma. International Journal of Oncology, 50, 1184-1190. https://doi.org/10.3892/ijo.2017.3899
MLA
Suzuki, S., Yokobori, T., Altan, B., Hara, K., Ozawa, D., Tanaka, N., Sakai, M., Sano, A., Sohda, M., Bao, H., Fukuchi, M., Miyazaki, T., Kaira, K., Asao, T., Kuwano, H."High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma". International Journal of Oncology 50.4 (2017): 1184-1190.
Chicago
Suzuki, S., Yokobori, T., Altan, B., Hara, K., Ozawa, D., Tanaka, N., Sakai, M., Sano, A., Sohda, M., Bao, H., Fukuchi, M., Miyazaki, T., Kaira, K., Asao, T., Kuwano, H."High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma". International Journal of Oncology 50, no. 4 (2017): 1184-1190. https://doi.org/10.3892/ijo.2017.3899
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki S, Yokobori T, Altan B, Hara K, Ozawa D, Tanaka N, Sakai M, Sano A, Sohda M, Bao H, Bao H, et al: High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma. Int J Oncol 50: 1184-1190, 2017.
APA
Suzuki, S., Yokobori, T., Altan, B., Hara, K., Ozawa, D., Tanaka, N. ... Kuwano, H. (2017). High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma. International Journal of Oncology, 50, 1184-1190. https://doi.org/10.3892/ijo.2017.3899
MLA
Suzuki, S., Yokobori, T., Altan, B., Hara, K., Ozawa, D., Tanaka, N., Sakai, M., Sano, A., Sohda, M., Bao, H., Fukuchi, M., Miyazaki, T., Kaira, K., Asao, T., Kuwano, H."High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma". International Journal of Oncology 50.4 (2017): 1184-1190.
Chicago
Suzuki, S., Yokobori, T., Altan, B., Hara, K., Ozawa, D., Tanaka, N., Sakai, M., Sano, A., Sohda, M., Bao, H., Fukuchi, M., Miyazaki, T., Kaira, K., Asao, T., Kuwano, H."High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma". International Journal of Oncology 50, no. 4 (2017): 1184-1190. https://doi.org/10.3892/ijo.2017.3899
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