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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April-2017 Volume 50 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma

  • Authors:
    • Wenlin Yang
    • Ji-Gang Wang
    • Jiawen Xu
    • Danmei Zhou
    • Kehan Ren
    • Chenjian Hou
    • Linlin Chen
    • Xiuping Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China, Department of Pathology, Shangdong Provincial Hospital Affiliated to Shangdong University, Jinan, Shandong 250021, P.R. China, Department of Pathology, The Fifth Hospital of Shanghai, Fudan University, Shanghai 200240, P.R. China
  • Pages: 1233-1240
    |
    Published online on: March 8, 2017
       https://doi.org/10.3892/ijo.2017.3903
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Abstract

Hepatocellular carcinoma-related protein 1 (HCRP1), also known as human vacuolar protein sorting 37 homologue A (hVps37A), has not been detected or is significantly downregulated in hepatocellular carcinoma (HCC) tissues. However, information on the regulatory mechanisms of HCRP1 in HCC remains unclear. Here we found that the downregulation of HCRP1 in HepG2 cells (with low invasion capacity) significantly enhanced migration and invasion, whereas HCRP1 upregulation in SMMC-7721 cells (with high invasion capacity) generated the opposite result. Interestingly, the morphology of HepG2 cells significantly changed from an epithelial to mesenchymal phenotype after HCRP1 knockdown. Moreover, we observed a decrease in the expression of epithelial cell markers E-cadherin and β-catenin, and an increase in the expression of mesenchymal cell markers N-cadherin and vimentin. We also observed that the downregulation of HCRP1 induced epithelial-mesenchymal transition (EMT) through the transforming growth factor-β pathway. Together, our findings define a novel function for HCRP1 from the perspective of EMT, which is closely associated with the migration and invasion of HCC cells.
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Copy and paste a formatted citation
Spandidos Publications style
Yang W, Wang J, Xu J, Zhou D, Ren K, Hou C, Chen L and Liu X: HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma. Int J Oncol 50: 1233-1240, 2017.
APA
Yang, W., Wang, J., Xu, J., Zhou, D., Ren, K., Hou, C. ... Liu, X. (2017). HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma. International Journal of Oncology, 50, 1233-1240. https://doi.org/10.3892/ijo.2017.3903
MLA
Yang, W., Wang, J., Xu, J., Zhou, D., Ren, K., Hou, C., Chen, L., Liu, X."HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma". International Journal of Oncology 50.4 (2017): 1233-1240.
Chicago
Yang, W., Wang, J., Xu, J., Zhou, D., Ren, K., Hou, C., Chen, L., Liu, X."HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma". International Journal of Oncology 50, no. 4 (2017): 1233-1240. https://doi.org/10.3892/ijo.2017.3903
Copy and paste a formatted citation
x
Spandidos Publications style
Yang W, Wang J, Xu J, Zhou D, Ren K, Hou C, Chen L and Liu X: HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma. Int J Oncol 50: 1233-1240, 2017.
APA
Yang, W., Wang, J., Xu, J., Zhou, D., Ren, K., Hou, C. ... Liu, X. (2017). HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma. International Journal of Oncology, 50, 1233-1240. https://doi.org/10.3892/ijo.2017.3903
MLA
Yang, W., Wang, J., Xu, J., Zhou, D., Ren, K., Hou, C., Chen, L., Liu, X."HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma". International Journal of Oncology 50.4 (2017): 1233-1240.
Chicago
Yang, W., Wang, J., Xu, J., Zhou, D., Ren, K., Hou, C., Chen, L., Liu, X."HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma". International Journal of Oncology 50, no. 4 (2017): 1233-1240. https://doi.org/10.3892/ijo.2017.3903
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