|
1
|
Helman LJ and Meltzer P: Mechanisms of
sarcoma development. Nat Rev Cancer. 3:685–694. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Mirabello L, Troisi RJ and Savage SA:
Osteosarcoma incidence and survival rates from 1973 to 2004: Data
from the Surveillance, Epidemiology, and End Results Program.
Cancer. 115:1531–1543. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Whelan JS, Bielack SS, Marina N, Smeland
S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T,
Böhling T, et al EURAMOS collaborators: EURAMOS-1, an international
randomised study for osteosarcoma: Results from pre-randomisation
treatment. Ann Oncol. 26:407–414. 2015. View Article : Google Scholar :
|
|
4
|
Wang LL: Biology of osteogenic sarcoma.
Cancer J. 11:294–305. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Isakoff MS, Bielack SS, Meltzer P and
Gorlick R: Osteosarcoma: Current treatment and a collaborative
pathway to success. J Clin Oncol. 33:3029–3035. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Dai X, Ma W, He X and Jha RK: Review of
therapeutic strategies for osteosarcoma, chondrosarcoma, and
Ewing's sarcoma. Med Sci Monit. 17:RA177–RA190. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Thomas D and Kansara M: Epigenetic
modifications in osteogenic differentiation and transformation. J
Cell Biochem. 98:757–769. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Haydon RC, Luu HH and He TC: Osteosarcoma
and osteoblastic differentiation: A new perspective on oncogenesis.
Clin Orthop Relat Res. 454:237–246. 2007. View Article : Google Scholar
|
|
9
|
Tang N, Song WX, Luo J, Haydon RC and He
TC: Osteosarcoma development and stem cell differentiation. Clin
Orthop Relat Res. 466:2114–2130. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Luo X, Chen J, Song WX, Tang N, Luo J,
Deng ZL, Sharff KA, He G, Bi Y, He BC, et al: Osteogenic BMPs
promote tumor growth of human osteosarcomas that harbor
differentiation defects. Lab Invest. 88:1264–1277. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang J, Zhang H, Zhang W, Huang E, Wang N,
Wu N, Wen S, Chen X, Liao Z, Deng F, et al: Bone morphogenetic
protein-9 effectively induces osteo/odontoblastic differentiation
of the reversibly immortalized stem cells of dental apical papilla.
Stem Cells Dev. 23:1405–1416. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Li Y, Wagner ER, Yan Z, Wang Z, Luther G,
Jiang W, Ye J, Wei Q, Wang J, Zhao L, et al: The calcium-binding
protein S100A6 accelerates human osteosarcoma growth by promoting
cell proliferation and inhibiting osteogenic differentiation. Cell
Physiol Biochem. 37:2375–2392. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Yang R, Piperdi S, Zhang Y, Zhu Z,
Neophytou N, Hoang BH, Mason G, Geller D, Dorfman H, Meyers PA, et
al: Transcriptional profiling identifies the signaling axes of IGF
and transforming growth factor-β as involved in the pathogenesis of
osteosarcoma. Clin Orthop Relat Res. 474:178–189. 2016. View Article : Google Scholar
|
|
14
|
Sánchez-Duffhues G, Hiepen C, Knaus P and
Ten Dijke P: Bone morphogenetic protein signaling in bone
homeostasis. Bone. 80:43–59. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Chen D, Zhao M, Harris SE and Mi Z: Signal
transduction and biological functions of bone morphogenetic
proteins. Front Biosci. 9:349–358. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Duan L, Ye L, Wu R, Wang H, Li X, Li H,
Yuan S, Zha H, Sun H, Zhang Y, et al: Inactivation of the
phosphatidylinositol 3-kinase/Akt pathway is involved in
BMP9-mediated tumor-suppressive effects in gastric cancer cells. J
Cell Biochem. 116:1080–1089. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Xiang L, Liang C, Zhen-Yong K, Liang-Jun Y
and Zhong-Liang D: BMP9-induced osteogenetic differentiation and
bone formation of muscle-derived stem cells. J Biomed Biotechnol.
2012:6109522012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Wang JH, Liu YZ, Yin LJ, Chen L, Huang J,
Liu Y, Zhang RX, Zhou LY, Yang QJ, Luo JY, et al: BMP9 and COX-2
form an important regulatory loop in BMP9-induced osteogenic
differentiation of mesenchymal stem cells. Bone. 57:311–321. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Yuan SX, Wang DX, Wu QX, Ren CM, Li Y,
Chen QZ, Zeng YH, Shao Y, Yang JQ, Bai Y, et al: BMP9/p38 MAPK is
essential for the antiproliferative effect of resveratrol on human
colon cancer. Oncol Rep. 35:939–947. 2016.
|
|
20
|
Holtzhausen A, Golzio C, How T, Lee YH,
Schiemann WP, Katsanis N and Blobe GC: Novel bone morphogenetic
protein signaling through Smad2 and Smad3 to regulate cancer
progression and development. FASEB J. 28:1248–1267. 2014.
View Article : Google Scholar :
|
|
21
|
Herrera B, van Dinther M, Ten Dijke P and
Inman GJ: Autocrine bone morphogenetic protein-9 signals through
activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian
cancer cell proliferation. Cancer Res. 69:9254–9262. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Herrera B, García-Álvaro M, Cruz S, Walsh
P, Fernández M, Roncero C, Fabregat I, Sánchez A and Inman GJ: BMP9
isa proliferative and survival factor for human hepatocellular
carcinoma cells. PloS One. 8:e695352013. View Article : Google Scholar
|
|
23
|
Wu LZ, Chaudhary SC, Atigadda VR, Belyaeva
OV, Harville SR, Elmets CA, Muccio DD, Athar M, Kedishvili NY and
Retinoid X: Receptor agonists upregulate genes Responsible for the
biosynthesis of all-trans-retinoic acid in human epidermis. PLoS
One. 11:e015355620162016.
|
|
24
|
Dilworth FJ and Chambon P: Nuclear
receptors coordinate the activities of chromatin remodeling
complexes and coactivators to facilitate initiation of
transcription. Oncogene. 20:3047–3054. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Atashrazm F, Lowenthal RM, Dickinson JL,
Holloway AF and Woods GM: Fucoidan enhances the therapeutic
potential of arsenic trioxide and all-trans retinoic acid in acute
promyelocytic leukemia, in vitro and in vivo. Oncotarget.
7:46028–46041. 2016.PubMed/NCBI
|
|
26
|
Silvis AM, McCormick ML, Spitz DR and
Kiningham KK: Redox balance influences differentiation status of
neuroblastoma in the presence of all-trans retinoic acid. Redox
Biol. 7:88–96. 2016. View Article : Google Scholar :
|
|
27
|
Yan Y, Li Z, Xu X, Chen C, Wei W, Fan M,
Chen X, Li JJ, Wang Y and Huang J: All-trans retinoic acids induce
differentiation and sensitize a radioresistant breast cancer cells
to chemotherapy. BMC Complement Altern Med. 16:113–123. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Amann PM, Czaja K, Bazhin AV, Rühl R,
Skazik C, Heise R, Marquardt Y, Eichmüller SB, Merk HF and Baron
JM: Knockdown of lecithin retinol acyltransferase increases
all-trans retinoic acid levels and restores retinoid sensitivity in
malignant melanoma cells. Exp Dermatol. 23:832–837. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Yang QJ, Zhou LY, Mu YQ, Zhou QX, Luo JY,
Cheng L, Deng ZL, He TC, Haydon RC and He BC: All-trans retinoic
acid inhibits tumor growth of human osteosarcoma by activating Smad
signaling-induced osteogenic differentiation. Int J Oncol.
41:153–160. 2012.PubMed/NCBI
|
|
30
|
Zhang L, Zhou Q, Zhang N, Li W, Ying M,
Ding W, Yang B and He Q: E2F1 impairs all-trans retinoic
acid-induced osteogenic differentiation of osteosarcoma via
promoting ubiquitination-mediated degradation of RARα. Cell Cycle.
13:1277–1287. 2014. View Article : Google Scholar :
|
|
31
|
Luo P, Yang X, Ying M, Chaudhry P, Wang A,
Shimada H, May WA, Adams GB, Mock D, Triche TJ, et al:
Retinoid-suppressed phosphorylation of RARalpha mediates the
differentiation pathway of osteosarcoma cells. Oncogene.
29:2772–2783. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Ying M, Zhang L, Zhou Q, Shao X, Cao J,
Zhang N, Li W, Zhu H, Yang B and He Q: The E3 ubiquitin protein
ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic
differentiation of osteosarcoma cells by modulating the degradation
of RARα. Oncogene. 35:4358–4367. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Liu Y, Liu Y, Zhang R, Wang X, Huang F,
Yan Z, Nie M, Huang J, Wang Y, Wang Y, et al: All-trans retinoic
acid modulates bone morphogenic protein 9-induced osteogenesis and
adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin
signaling pathways. Int J Biochem Cell Biol. 47:47–56. 2014.
View Article : Google Scholar
|
|
34
|
Tang N, Song WX, Luo J, Luo X, Chen J,
Sharff KA, Bi Y, He BC, Huang JY, Zhu GH, et al: BMP-9-induced
osteogenic differentiation of mesenchymal progenitors requires
functional canonical Wnt/beta-catenin signalling. J Cell Mol Med.
13B:2448–2464. 2009. View Article : Google Scholar
|
|
35
|
He BC, Chen L, Zuo GW, Zhang W, Bi Y,
Huang J, Wang Y, Jiang W, Luo Q, Shi Q, et al: Synergistic
antitumor effect of the activated PPARgamma and retinoid receptors
on human osteosarcoma. Clin Cancer Res. 16:2235–2245. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Meng ZJ, Wu N, Liu Y, Shu KJ, Zou X, Zhang
RX, Pi CJ, He BC, Ke ZY, Chen L, et al: Evodiamine inhibits the
proliferation of human osteosarcoma cells by blocking PI3K/Akt
signaling. Oncol Rep. 34:1388–1396. 2015.PubMed/NCBI
|
|
37
|
Strzalka W and Ziemienowicz A:
Proliferating cell nuclear antigen (PCNA): A key factor in DNA
replication and cell cycle regulation. Ann Bot. 107:1127–1140.
2011. View Article : Google Scholar :
|
|
38
|
Huang J, Yuan SX, Wang DX, Wu QX, Wang X,
Pi CJ, Zou X, Chen L, Ying LJ, Wu K, et al: The role of COX-2 in
mediating the effect of PTEN on BMP9 induced osteogenic
differentiation in mouse embryonic fibroblasts. Biomaterials.
35:9649–9659. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Herrera B, Dooley S and Breitkopf-Heinlein
K: Potential roles of bone morphogenetic protein (BMP)-9 in human
liver diseases. Int J Mol Sci. 15:5199–5220. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Li R, Zhang W, Cui J, Shui W, Yin L, Wang
Y, Zhang H, Wang N, Wu N, Nan G, et al: Targeting BMP9-promoted
human osteosarcoma growth by inactivation of notch signaling. Curr
Cancer Drug Targets. 14:274–285. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Lv Z, Wang C, Yuan T, Liu Y, Song T, Liu
Y, Chen C, Yang M, Tang Z, Shi Q, et al: Bone morphogenetic protein
9 regulates tumor growth of osteosarcoma cells through the
Wnt/β-catenin pathway. Oncol Rep. 31:989–994. 2014.
|
|
42
|
Kranenburg O, Scharnhorst V, Van der Eb AJ
and Zantema A: Inhibition of cyclin-dependent kinase activity
triggers neuronal differentiation of mouse neuroblastoma cells. J
Cell Biol. 131:227–234. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Adachi M, Roussel MF, Havenith K and Sherr
CJ: Features of macrophage differentiation induced by p19INK4d, a
specific inhibitor of cyclin D-dependent kinases. Blood.
90:126–137. 1997.PubMed/NCBI
|
|
44
|
Matushansky I, Radparvar F and Skoultchi
AI: Reprogramming leukemic cells to terminal differentiation by
inhibiting specific cyclin-dependent kinases in G1. Proc Natl Acad
Sci USA. 97:14317–14322. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Rosenbauer F and Tenen DG: Transcription
factors in myeloid development: Balancing differentiation with
transformation. Nat Rev Immunol. 7:105–117. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Ruijtenberg S and van den Heuvel S:
Coordinating cell proliferation and differentiation: Antagonism
between cell cycle regulators and cell type-specific gene
expression. Cell Cycle. 15:196–212. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhang W, Deng ZL, Chen L, Zuo GW, Luo Q,
Shi Q, Zhang BQ, Wagner ER, Rastegar F, Kim SH, et al: Retinoic
acids potentiate BMP9-induced osteogenic differentiation of
mesenchymal progenitor cells. PLoS One. 5:e119172010. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Zhao Y, Song T, Wang W, Wang J, He J, Wu
N, Tang M, He B and Luo J: P38 and ERK1/2 MAPKs act in opposition
to regulate BMP9-induced osteogenic differentiation of mesenchymal
progenitor cells. PLoS One. 7:e433832012. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Cuadrado A and Nebreda AR: Mechanisms and
functions of p38 MAPK signalling. Biochem J. 429:403–417. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Cheng HL, Lin CW, Yang JS, Hsieh MJ, Yang
SF and Lu KH: Zoledronate blocks geranylgeranylation not
farnesylation to suppress human osteosarcoma U2OS cells metastasis
by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways.
Oncotarget. 7:9742–9758. 2016.PubMed/NCBI
|
|
52
|
Lv T, Wu Y, Mu C, Liu G, Yan M, Xu X, Wu
H, Du J, Yu J and Mu J: Insulin-like growth factor 1 promotes the
proliferation and committed differentiation of human dental pulp
stem cells through MAPK pathways. Arch Oral Biol. 72:116–123. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Liu J, Wang B, Huang P, Wang H, Xu K, Wang
X, Xu L and Guo Z: Microcystin-LR promotes cell proliferation in
the mice liver by activating Akt and p38/ERK/JNK cascades.
Chemosphere. 163:14–21. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Xu DJ, Zhao YZ, Wang J, He JW, Weng YG and
Luo JY: Smads, p38 and ERK1/2 are involved in BMP9-induced
osteogenic differentiation of C3H10T1/2 mesenchymal stem cells. BMB
Rep. 45:247–252. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Ye G, Li C, Xiang X, Chen C, Zhang R, Yang
X, Yu X, Wang J, Wang L, Shi Q, et al: Bone morphogenetic protein-9
induces PDLSCs osteogenic differentiation through the ERK and p38
signal pathways. Int J Med Sci. 11:1065–1072. 2014. View Article : Google Scholar : PubMed/NCBI
|
