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Article Open Access

miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway

Retraction in: /10.3892/ijo.2023.5557
  • Authors:
    • Ming He
    • Guangbin Wang
    • Linlin Jiang
    • Chuang Qiu
    • Bin Li
    • Jiashi Wang
    • Yonghui Fu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China, Department of Electrotheropy, Shenyang Medical College Affiliated Central Hospital, Shenyang, Liaoning, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1590-1600
    |
    Published online on: March 22, 2017
       https://doi.org/10.3892/ijo.2017.3928
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Abstract

Osteosarcoma is one of the most highly malignant types of cancer in adolescents and young adults with a high mortality rate. Despite advances in surgery, radiation therapy and chemotherapy, the prognosis for patients with osteosarcoma has not significantly improved over the past several decades. It is necessary to find new indicators of prognosis and therapeutic targets of osteosarcoma. Through the analysis of 40 osteosarcoma tissues, we found that the expression of miR‑486 was low and the expression of PKC‑δ was high in osteosarcoma. Median survival of patients with low expression of miR-486 (30 months) was shorter than the patients with higher expression of miR‑486 (40 months). We further found that miR-486 can inhibit the targeting of PKC‑δ signaling pathways, and this inhibition can inhibit the growth and invasion of osteosarcoma cells. After transfection of miR‑486 for 24 h, the proliferation of osteosarcoma cells was inhibited by ~20%, and the migration was inhibited by ~15%. In the present investigation, we demonstrated that miR‑486 is negatively associated with the expression of PKC-δ and could regulate the development of osteosarcoma. miR-486 may be a potential target for the treatment of osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
He M, Wang G, Jiang L, Qiu C, Li B, Wang J and Fu Y: miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557. Int J Oncol 50: 1590-1600, 2017.
APA
He, M., Wang, G., Jiang, L., Qiu, C., Li, B., Wang, J., & Fu, Y. (2017). miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557. International Journal of Oncology, 50, 1590-1600. https://doi.org/10.3892/ijo.2017.3928
MLA
He, M., Wang, G., Jiang, L., Qiu, C., Li, B., Wang, J., Fu, Y."miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557". International Journal of Oncology 50.5 (2017): 1590-1600.
Chicago
He, M., Wang, G., Jiang, L., Qiu, C., Li, B., Wang, J., Fu, Y."miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557". International Journal of Oncology 50, no. 5 (2017): 1590-1600. https://doi.org/10.3892/ijo.2017.3928
Copy and paste a formatted citation
x
Spandidos Publications style
He M, Wang G, Jiang L, Qiu C, Li B, Wang J and Fu Y: miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557. Int J Oncol 50: 1590-1600, 2017.
APA
He, M., Wang, G., Jiang, L., Qiu, C., Li, B., Wang, J., & Fu, Y. (2017). miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557. International Journal of Oncology, 50, 1590-1600. https://doi.org/10.3892/ijo.2017.3928
MLA
He, M., Wang, G., Jiang, L., Qiu, C., Li, B., Wang, J., Fu, Y."miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557". International Journal of Oncology 50.5 (2017): 1590-1600.
Chicago
He, M., Wang, G., Jiang, L., Qiu, C., Li, B., Wang, J., Fu, Y."miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway Retraction in /10.3892/ijo.2023.5557". International Journal of Oncology 50, no. 5 (2017): 1590-1600. https://doi.org/10.3892/ijo.2017.3928
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