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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May-2017 Volume 50 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1

  • Authors:
    • Jie Xi
    • Jing Feng
    • Qian Li
    • Xia Li
    • Saitian Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Cangzhou Central Hospital, Cangzhou, Heibei 061001, P.R. China
  • Pages: 1663-1670
    |
    Published online on: March 24, 2017
       https://doi.org/10.3892/ijo.2017.3933
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Abstract

Breast cancer, one of the common cancers of women, is the leading cause of death among women below the age of 50 years in western countries. Long non-coding RNAs (lncRNAs) have been shown to be involved in diverse biological processes, both physical and pathological. However, to date, only a few lncRNAs have been functionally identified in breast cancer, and the overall pathophysiological contributions of lncRNAs to breast cancer remain largely unknown. In the present study, we identified a novel lncRNA termed lncFOXO1 through microarray screening. lncFOXO1 is significantly decreased in breast cancer tissues and cell lines and downregulation of lncFOXO1 expression associates with poorer overall survival. Functional assays demonstrated its suppressive role in breast cancer in vivo and in vitro. Mechanistically, lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 transcription. Moreover, we found that lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 promoter.
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Copy and paste a formatted citation
Spandidos Publications style
Xi J, Feng J, Li Q, Li X and Zeng S: The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. Int J Oncol 50: 1663-1670, 2017.
APA
Xi, J., Feng, J., Li, Q., Li, X., & Zeng, S. (2017). The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. International Journal of Oncology, 50, 1663-1670. https://doi.org/10.3892/ijo.2017.3933
MLA
Xi, J., Feng, J., Li, Q., Li, X., Zeng, S."The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1". International Journal of Oncology 50.5 (2017): 1663-1670.
Chicago
Xi, J., Feng, J., Li, Q., Li, X., Zeng, S."The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1". International Journal of Oncology 50, no. 5 (2017): 1663-1670. https://doi.org/10.3892/ijo.2017.3933
Copy and paste a formatted citation
x
Spandidos Publications style
Xi J, Feng J, Li Q, Li X and Zeng S: The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. Int J Oncol 50: 1663-1670, 2017.
APA
Xi, J., Feng, J., Li, Q., Li, X., & Zeng, S. (2017). The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. International Journal of Oncology, 50, 1663-1670. https://doi.org/10.3892/ijo.2017.3933
MLA
Xi, J., Feng, J., Li, Q., Li, X., Zeng, S."The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1". International Journal of Oncology 50.5 (2017): 1663-1670.
Chicago
Xi, J., Feng, J., Li, Q., Li, X., Zeng, S."The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1". International Journal of Oncology 50, no. 5 (2017): 1663-1670. https://doi.org/10.3892/ijo.2017.3933
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