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International Journal of Oncology
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Article

Multiple therapeutic peptide vaccines for patients with advanced gastric cancer

  • Authors:
    • Yoshiyuki Fujiwara
    • Kaoru Okada
    • Takeshi Omori
    • Keijiro Sugimura
    • Hiroshi Miyata
    • Masayuki Ohue
    • Shogo Kobayashi
    • Hidenori Takahashi
    • Hiroyuki Nakano
    • Chie Mochizuki
    • Katsuji Shimizu
    • Masahiko Yano
    • Yusuke Nakamura
    • Masaki Mori
    • Yuichiro Doki
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan, Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan, Department of Pharmacy, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan, Center for Personalized Therapeutics, The University of Chicago, Chicago, IL 60637, USA, Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
  • Pages: 1655-1662
    |
    Published online on: April 6, 2017
       https://doi.org/10.3892/ijo.2017.3955
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Abstract

We performed a clinical trial using HLA-A24-binding peptide vaccines containing a combination of novel cancer-testis antigens and anti-angiogenic peptides for advanced gastric cancer (GC). Thirty-five GC patients who had shown resistance to the standard therapy were enrolled in this clinical trial using vaccinations with a mixture of multiple peptides derived from DEPDC1, URLC10, FoxM1, Kif20A and VEGFR1. The safety, the overall survival (OS), and the immunological responses based on an ELISPOT assay were determined to assess differences in patients who were HLA-A24-positive [24(+)] and HLA-A24-negative [24(-)]. No severe adverse effects were observed except for severe skin reactions in 4 patients. The differences in OS were not significant between patients who were 24(+) and 24(-). In the 24(+) group, patients who showed T cell responses specific to antigen peptides had a tendency towards better survival than those who showed no response, especially to the DEPDC1 peptide. The patients with local skin reactions had significantly better OS than the others. Peptide vaccine therapy was found to be safe and is expected to induce specific T cell responses in patients with advanced GC. The survival benefit of peptide vaccine monotherapy may not have been shown and further trials are needed to confirm these results.
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Copy and paste a formatted citation
Spandidos Publications style
Fujiwara Y, Okada K, Omori T, Sugimura K, Miyata H, Ohue M, Kobayashi S, Takahashi H, Nakano H, Mochizuki C, Mochizuki C, et al: Multiple therapeutic peptide vaccines for patients with advanced gastric cancer. Int J Oncol 50: 1655-1662, 2017.
APA
Fujiwara, Y., Okada, K., Omori, T., Sugimura, K., Miyata, H., Ohue, M. ... Doki, Y. (2017). Multiple therapeutic peptide vaccines for patients with advanced gastric cancer. International Journal of Oncology, 50, 1655-1662. https://doi.org/10.3892/ijo.2017.3955
MLA
Fujiwara, Y., Okada, K., Omori, T., Sugimura, K., Miyata, H., Ohue, M., Kobayashi, S., Takahashi, H., Nakano, H., Mochizuki, C., Shimizu, K., Yano, M., Nakamura, Y., Mori, M., Doki, Y."Multiple therapeutic peptide vaccines for patients with advanced gastric cancer". International Journal of Oncology 50.5 (2017): 1655-1662.
Chicago
Fujiwara, Y., Okada, K., Omori, T., Sugimura, K., Miyata, H., Ohue, M., Kobayashi, S., Takahashi, H., Nakano, H., Mochizuki, C., Shimizu, K., Yano, M., Nakamura, Y., Mori, M., Doki, Y."Multiple therapeutic peptide vaccines for patients with advanced gastric cancer". International Journal of Oncology 50, no. 5 (2017): 1655-1662. https://doi.org/10.3892/ijo.2017.3955
Copy and paste a formatted citation
x
Spandidos Publications style
Fujiwara Y, Okada K, Omori T, Sugimura K, Miyata H, Ohue M, Kobayashi S, Takahashi H, Nakano H, Mochizuki C, Mochizuki C, et al: Multiple therapeutic peptide vaccines for patients with advanced gastric cancer. Int J Oncol 50: 1655-1662, 2017.
APA
Fujiwara, Y., Okada, K., Omori, T., Sugimura, K., Miyata, H., Ohue, M. ... Doki, Y. (2017). Multiple therapeutic peptide vaccines for patients with advanced gastric cancer. International Journal of Oncology, 50, 1655-1662. https://doi.org/10.3892/ijo.2017.3955
MLA
Fujiwara, Y., Okada, K., Omori, T., Sugimura, K., Miyata, H., Ohue, M., Kobayashi, S., Takahashi, H., Nakano, H., Mochizuki, C., Shimizu, K., Yano, M., Nakamura, Y., Mori, M., Doki, Y."Multiple therapeutic peptide vaccines for patients with advanced gastric cancer". International Journal of Oncology 50.5 (2017): 1655-1662.
Chicago
Fujiwara, Y., Okada, K., Omori, T., Sugimura, K., Miyata, H., Ohue, M., Kobayashi, S., Takahashi, H., Nakano, H., Mochizuki, C., Shimizu, K., Yano, M., Nakamura, Y., Mori, M., Doki, Y."Multiple therapeutic peptide vaccines for patients with advanced gastric cancer". International Journal of Oncology 50, no. 5 (2017): 1655-1662. https://doi.org/10.3892/ijo.2017.3955
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