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Article

5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest

  • Authors:
    • Daiying Zuo
    • Lili Pang
    • Jiwei Shen
    • Qi Guan
    • Zhaoshi Bai
    • Huijuan Zhang
    • Yao Li
    • Guodong Lu
    • Weige Zhang
    • Yingliang Wu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China, Department of Clinical Pharmacy, The Sixth People's Hospital of Chengdu, Chengdu, Sichuan 610051, P.R. China, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China
  • Pages: 2069-2078
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    Published online on: April 18, 2017
       https://doi.org/10.3892/ijo.2017.3963
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Abstract

In the current study, we synthesized a series of new compounds targeting tubulin and tested their anti-proliferative activities. Among these new synthetic com­pounds, 5-(furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f) exhibited significant anti-proliferative activity against different human cancer cell lines including human gastric adenocarcinoma SGC-7901, human non-small cell lung cancer A549, and human fibrosarcoma HT-1080. As a result, 6f was selected to further test the sensitivity to different cancer cell lines including human cervical cancer cell line HeLa, human breast cancer cell line MCF-7, non-small cell lung cancer cell line A549, human liver carcinoma cell line HepG-2, human oral squamous cell carcinoma cell lines KB, SGC-7901 and HT-1080. Among these cell lines, HT-1080 and HeLa are the most sensitive. Therefore, HT-1080 was selected to further explore the properties of anti-proliferative activity and the underlying mechanisms. Our data proved that 6f exhibited strong anti-proliferative effects against HT-1080 cells in a time- and dose-dependent manner. We showed that the growth inhibitory effect of 6f in HT-1080 cells was related with microtubule depolymerisation. Molecular docking studies revealed that 6f interacted and bound efficiently with the colchicine-binding site of tubulin. In addition, 6f treatment induced G2/M cell cycle arrest dose-dependently and subsequently induced cell apoptosis. Western blot study indicated that upregulation of cyclin B1 and p-cdc2 was related with G2/M arrest. 6f-induced cell apoptosis was associated with both mitochondrial and death receptor pathway. In conclusion, our data showed that 6f, among the newly synthetic compounds, exhibited highest anti-proliferative activity by disrupting the microtubule polymerisation, causing G2/M arrest and subsequently inducing cell apoptosis in HT-1080 cells. Hence, 6f is a promising microtubule depolymerising agent for the treatment of various cancers especially human fibrosarcoma.
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1 

Lombardi R, Jovine E, Zanini N, Salone MC, Gambarotti M, Righi A, Balladelli A, Colangeli M and Rocca M: A case of lung metastasis in myxoinflammatory fibroblastic sarcoma: Analytical review of one hundred and thirty eight cases. Int Orthop. 37:2429–2436. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Amos LA: What tubulin drugs tell us about microtubule structure and dynamics. Semin Cell Dev Biol. 22:916–926. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Perez EA: Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Mol Cancer Ther. 8:2086–2095. 2009. View Article : Google Scholar : PubMed/NCBI

4 

de Forges H, Bouissou A and Perez F: Interplay between microtubule dynamics and intracellular organization. Int J Biochem Cell Biol. 44:266–274. 2012. View Article : Google Scholar

5 

Dumontet C and Jordan MA: Microtubule-binding agents: A dynamic field of cancer therapeutics. Nat Rev Drug Discov. 9:790–803. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Kim SN, Kim NH, Park YS, Kim H, Lee S, Wang Q and Kim YK: 7-Diethylamino-3(2′-benzoxazolyl)-coumarin is a novel microtubule inhibitor with antimitotic activity in multidrug resistant cancer cells. Biochem Pharmacol. 77:1773–1779. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Chang LC, Yu YL, Hsieh MT, Wang SH, Chou RH, Huang WC, Lin HY, Hung HY, Huang LJ and Kuo SC: A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics. Am J Cancer Res. 6:747–763. 2016.PubMed/NCBI

8 

Velasco-Velázquez MA, Agramonte-Hevia J, Barrera D, Jiménez-Orozco A, García-Mondragón MJ, Mendoza-Patiño N, Landa A and Mandoki J: 4-Hydroxycoumarin disorganizes the actin cytoskeleton in B16-F10 melanoma cells but not in B82 fibroblasts, decreasing their adhesion to extracellular matrix proteins and motility. Cancer Lett. 198:179–186. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Gismondi A, Nanni V, Reina G, Orlanducci S, Terranova ML and Canini A: Nanodiamonds coupled with 5,7-dimethoxycoumarin, a plant bioactive metabolite, interfere with the mitotic process in B16F10 cells altering the actin organization. Int J Nanomed. 11:557–574. 2016. View Article : Google Scholar

10 

Kavallaris M, Annereau JP and Barret JM: Potential mechanisms of resistance to microtubule inhibitors. Semin Oncol. 35(Suppl 3): S22–S27. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Pettit GR, Singh SB, Hamel E, Lin CM, Alberts DS and Garcia-Kendall D: Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia. 45:209–211. 1989. View Article : Google Scholar : PubMed/NCBI

12 

Aziz G, Odlo K, Hansen TV, Paulsen RE and Mathisen GH: Combretastatin A-4 and structurally related triazole analogues induce caspase-3 and reactive oxygen species-dependent cell death in PC12 cells. Eur J Pharmacol. 703:25–32. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Xu Q, Qi H, Sun M, Zuo D, Jiang X, Wen Z, Wang Z, Wu Y and Zhang W: Synthesis and biological evaluation of 3-alkyl-1,5-diaryl-1h-pyrazoles as rigid analogues of combretastatin a-4 with potent antiproliferative activity. PLoS One. 10:e01287102015. View Article : Google Scholar : PubMed/NCBI

14 

Mahal K, Biersack B, Caysa H, Schobert R and Mueller T: Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation. Invest New Drugs. 33:541–554. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Zuo D, Guo D, Jiang X, Guan Q, Qi H, Xu J, Li Z, Yang F, Zhang W and Wu Y: 3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells. Chem Biol interact. 227:7–17. 2015. View Article : Google Scholar

16 

Wen Z, Li X, Zuo D, Lang B, Wu Y, Jiang M, Ma H, Bao K, Wu Y and Zhang W: Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues. Sci Rep. 6:239862016. View Article : Google Scholar : PubMed/NCBI

17 

Duan YT, Man RJ, Tang DJ, Yao YF, Tao XX, Yu C, Liang XY, Makawana JA, Zou MJ, Wang ZC, et al: Design, synthesis and antitumor activity of novel link-bridge and b-ring modified combretastatin a-4 (ca-4) analogues as potent antitubulin agents. Sci Rep. 6:253872016. View Article : Google Scholar : PubMed/NCBI

18 

Wang Z, Qi H, Shen Q, Lu G, Li M, Bao K, Wu Y and Zhang W: 4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin. Eur J Med Chem. 122:520–529. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Qiao F, Zuo D, Shen X, Qi H, Wang H, Zhang W and Wu Y: DAT-230, a novel microtubule inhibitor, exhibits potent antitumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080. Cancer Chemother Pharmacol. 70:259–270. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Eisenlöffel C, Schmöle AC, Pews-Davtyan A, Brennführer A, Kuznetsov SA, Hübner R, Frech S, Schult C, Junghanss C, Beller M, et al: Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells. Biochem Pharmacol. 85:763–771. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Yu G, Chen X, Chen S, Ye W, Hou K and Liang M: Arsenic trioxide reduces chemo-resistance to 5-fluorouracil and cisplatin in HBx-HepG2 cells via complex mechanisms. Cancer Cell int. 15:1162015. View Article : Google Scholar : PubMed/NCBI

22 

Islam MN and Iskander MN: Microtubulin binding sites as target for developing anticancer agents. Mini Rev Med Chem. 4:1077–1104. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Huang Z, Xu Y and Peng W: Colchicine induces apoptosis in HT-29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. Mol Med Rep. 12:5939–5944. 2015.PubMed/NCBI

24 

Chiu WH, Luo SJ, Chen CL, Cheng JH, Hsieh CY, Wang CY, Huang WC, Su WC and Lin CF: Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochem Pharmacol. 83:1159–1171. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Ganansia-Leymarie V, Bischoff P, Bergerat JP and Holl V: Signal transduction pathways of taxanes-induced apoptosis. Curr Med Chem Anticancer Agents. 3:291–306. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Hsieh CC, Kuo YH, Kuo CC, Chen LT, Cheung CH, Chao TY, Lin CH, Pan WY, Chang CY, Chien SC, et al: Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells. Biochem Pharmacol. 79:1261–1271. 2010. View Article : Google Scholar

27 

Chen CH, Liao CH, Chang YL, Guh JH, Pan SL and Teng CM: Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett. 315:1–11. 2012. View Article : Google Scholar

28 

Vermeulen K, Van Bockstaele DR and Berneman ZN: The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36:131–149. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Zhu H, Zhang J, Xue N, Hu Y, Yang B and He Q: Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells. Invest New Drugs. 28:493–501. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Tao L, Fu R, Wang X, Yao J, Zhou Y, Dai Q, Li Z, Lu N and Wang W: LL-202, a newly synthesized flavonoid, inhibits tumor growth via inducing G(2)/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo. Toxicol Lett. 228:1–12. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B and Bao JK: Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 45:487–498. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Mollinedo F and Gajate C: Microtubules, microtubule-interfering agents and apoptosis. Apoptosis. 8:413–450. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Jeung HC, Che XF, Haraguchi M, Furukawa T, Zheng CL, Sumizawa T, Rha SY, Roh JK and Akiyama S: Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents. Biochem Pharmacol. 70:13–21. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Zhou L, Cai X, Han X, Xu N and Chang DC: CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents. Cell Biol Int. 38:737–746. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Khan KH, Blanco-Codesido M and Molife LR: Cancer therapeutics: Targeting the apoptotic pathway. Crit Rev Oncol Hematol. 90:200–219. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Ola MS, Nawaz M and Ahsan H: Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem. 351:41–58. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Parrish AB, Freel CD and Kornbluth S: Cellular mechanisms controlling caspase activation and function. Cold Spring Harb Perspect Biol. 5:52013. View Article : Google Scholar

39 

Golks A, Brenner D, Fritsch C, Krammer PH and Lavrik IN: c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem. 280:14507–14513. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G and Vandenabeele P: Toxic proteins released from mitochondria in cell death. Oncogene. 23:2861–2874. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Wang CC, Liu HE, Lee YL, Huang YW, Chen YJ, Liou JP and Huang HM: Mpt0b169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and mcl-1 downregulation. Tumour Biol. 37:6065–6072. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zuo D, Pang L, Shen J, Guan Q, Bai Z, Zhang H, Li Y, Lu G, Zhang W, Wu Y, Wu Y, et al: 5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest. Int J Oncol 50: 2069-2078, 2017.
APA
Zuo, D., Pang, L., Shen, J., Guan, Q., Bai, Z., Zhang, H. ... Wu, Y. (2017). 5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest. International Journal of Oncology, 50, 2069-2078. https://doi.org/10.3892/ijo.2017.3963
MLA
Zuo, D., Pang, L., Shen, J., Guan, Q., Bai, Z., Zhang, H., Li, Y., Lu, G., Zhang, W., Wu, Y."5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest". International Journal of Oncology 50.6 (2017): 2069-2078.
Chicago
Zuo, D., Pang, L., Shen, J., Guan, Q., Bai, Z., Zhang, H., Li, Y., Lu, G., Zhang, W., Wu, Y."5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest". International Journal of Oncology 50, no. 6 (2017): 2069-2078. https://doi.org/10.3892/ijo.2017.3963
Copy and paste a formatted citation
x
Spandidos Publications style
Zuo D, Pang L, Shen J, Guan Q, Bai Z, Zhang H, Li Y, Lu G, Zhang W, Wu Y, Wu Y, et al: 5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest. Int J Oncol 50: 2069-2078, 2017.
APA
Zuo, D., Pang, L., Shen, J., Guan, Q., Bai, Z., Zhang, H. ... Wu, Y. (2017). 5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest. International Journal of Oncology, 50, 2069-2078. https://doi.org/10.3892/ijo.2017.3963
MLA
Zuo, D., Pang, L., Shen, J., Guan, Q., Bai, Z., Zhang, H., Li, Y., Lu, G., Zhang, W., Wu, Y."5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest". International Journal of Oncology 50.6 (2017): 2069-2078.
Chicago
Zuo, D., Pang, L., Shen, J., Guan, Q., Bai, Z., Zhang, H., Li, Y., Lu, G., Zhang, W., Wu, Y."5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest". International Journal of Oncology 50, no. 6 (2017): 2069-2078. https://doi.org/10.3892/ijo.2017.3963
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