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Article

Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction

  • Authors:
    • Bin Shi
    • Li-Fang Wang
    • Wen-Shu Meng
    • Liang Chen
    • Zi-Li Meng
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Suqian People's Hospital, Xuzhou Medical University, Suqian, Jiangsu 223800, P.R. China, Department of Respiration, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
  • Pages: 2123-2135
    |
    Published online on: April 20, 2017
       https://doi.org/10.3892/ijo.2017.3970
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Abstract

Carnosic acid is a phenolic diterpene with anti-inflammation, anticancer, anti-bacterial, anti-diabetic, as well as neuroprotective properties, which is generated by many species from Lamiaceae family. Fisetin (3,3',4',7-tetrahydroxyflavone), a naturally flavonoid is abundantly produced in different vegetables and fruits. Fisetin has been reported to have various positive biological effects, including anti-proliferative, anticancer, anti-oxidative and neuroprotective effects. Lung cancer is reported as the most common neoplasm in human world-wide. In the present study, the possible benefits of carnosic acid combined with fisetin on lung cancer in vitro and in vivo was explored. Carnosic acid and fisetin combination led to apoptosis in lung cancer cells. Caspase-3 signaling pathway was promoted in carnosic acid and fisetin co-treatment, which was accompanied by anti-apoptotic proteins of Bcl-2 and Bcl-xl decreasing and pro-apoptotic signals of Bax and Bad increasing. The death receptor (DR) of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) was enhanced in carnosic acid and fisetin combined treatment. Furthermore, the mouse xenograft model in vivo suggested that carnosic acid and fisetin combined treatment inhibited lung cancer growth in comparison to the carnosic acid or fisetin monotherapy. This study supplies a novel therapy to induce apoptosis to inhibit lung cancer through caspase-3 activation.
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Copy and paste a formatted citation
Spandidos Publications style
Shi B, Wang L, Meng W, Chen L and Meng Z: Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction. Int J Oncol 50: 2123-2135, 2017.
APA
Shi, B., Wang, L., Meng, W., Chen, L., & Meng, Z. (2017). Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction. International Journal of Oncology, 50, 2123-2135. https://doi.org/10.3892/ijo.2017.3970
MLA
Shi, B., Wang, L., Meng, W., Chen, L., Meng, Z."Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction". International Journal of Oncology 50.6 (2017): 2123-2135.
Chicago
Shi, B., Wang, L., Meng, W., Chen, L., Meng, Z."Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction". International Journal of Oncology 50, no. 6 (2017): 2123-2135. https://doi.org/10.3892/ijo.2017.3970
Copy and paste a formatted citation
x
Spandidos Publications style
Shi B, Wang L, Meng W, Chen L and Meng Z: Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction. Int J Oncol 50: 2123-2135, 2017.
APA
Shi, B., Wang, L., Meng, W., Chen, L., & Meng, Z. (2017). Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction. International Journal of Oncology, 50, 2123-2135. https://doi.org/10.3892/ijo.2017.3970
MLA
Shi, B., Wang, L., Meng, W., Chen, L., Meng, Z."Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction". International Journal of Oncology 50.6 (2017): 2123-2135.
Chicago
Shi, B., Wang, L., Meng, W., Chen, L., Meng, Z."Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction". International Journal of Oncology 50, no. 6 (2017): 2123-2135. https://doi.org/10.3892/ijo.2017.3970
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