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Article

Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901

  • Authors:
    • Kun Zhuang
    • Lingxia Zhang
    • Xin Zhang
    • Hailing Tang
    • Jun Zhang
    • Yuan Yan
    • Kun Han
    • Hanqing Guo
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Xi'an Central Hospital, Xi'an, Shaanxi 710003, P.R. China, Division of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
  • Pages: 2091-2100
    |
    Published online on: May 4, 2017
       https://doi.org/10.3892/ijo.2017.3983
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Abstract

Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy-based gastric carcinoma (GC) treatments, hence, biologically based therapies are urgently needed. Gastrin (GAS), a key gastrointestinal (GI) hormone, was found to be involved in tumor formation, progression, and metastasis. In this study, quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemical staining analysis revealed a high level of expression of GAS in drug-insensitive GC tissues (P<0.01) and similar results were revealed in GC cell lines SGC7901 and its multidrug-resistant variants SGC7901/VCR and SGC7901/ADR. We constructed a eukaryotic expression vector pCDNA3.1(+)/GAS for GAS overexpression and recombinant lentiviral vectors for specific siRNA (siGAS). Transfection of pCDNA3.1(+)/GAS increased (P<0.05) while transfection of siGAS (P<0.05) and co-treated with paclitaxel (TAX) and vincristine (VCR) combination (TAX-VCR) decreased (P<0.01) the cell viability of SGC7901, SGC7901/VCR and SGC7901/ADR. Apoptosis rates of SGC7901/VCR and SGC7901/ADR were reduced by pCDNA3.1(+)/GAS and increased by siGAS (P<0.05). The apoptosis rates of SGC7901/VCR, SGC7901/ADR and SGC7901 were all upregulated (P<0.01) when cells were co-treated with a combination of siGAS and TAX-VCR. Additionally, siGAS significantly downregulated the expression of Bcl-2 and multidrug-resistant associate protein (MRP1) and P-glycoprotein (Pgp) (P<0.05) in SGC7901/VCR and SGC7901/ADR cells. Moreover, GAS overexpression in SGC7901 cells significantly inhibited p27Kip1 expression but increased phosphorylation levels of p27Kip1 on Thr (187) and Ser (10) sites (P<0.05), as well as increasing nuclear accumulation of S-phase kinase-associated protein 2 (Skp2) and cytoplasmic accumulation of the Kip1 ubiquitination-promoting complex (KPC) (P<0.05). Silencing of Skp2 blocked the promoting effects of pCDNA3.1(+)/GAS on viability, the expression of MRP1 and Pgp and the inhibitory effects of pCDNA3.1(+)/GAS on apoptosis. In conclusion, we suggest that GAS contributes to the emergence of MDR of SGC7901 cells via the degradation of p27Kip1.
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1 

Glavinas H, Krajcsi P, Cserepes J and Sarkadi B: The role of ABC transporters in drug resistance, metabolism and toxicity. Curr Drug Deliv. 1:27–42. 2004. View Article : Google Scholar

2 

Varma MV, Ashokraj Y, Dey CS and Panchagnula R: P-glycoprotein inhibitors and their screening: A perspective from bioavailability enhancement. Pharmacol Res. 48:347–359. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Marie JP, Zittoun R and Sikic BI: Multidrug resistance (mdr1) gene expression in adult acute leukemias: Correlations with treatment outcome and in vitro drug sensitivity. Blood. 78:586–592. 1991.PubMed/NCBI

4 

Huang Z, Zhang S, Shen Y, Liu W, Long J and Zhou S: Influence of MDR1 methylation on the curative effect of interventional embolism chemotherapy for cervical cancer. Ther Clin Risk Manag. 12:217–223. 2016.PubMed/NCBI

5 

Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P and Massagué J: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 78:59–66. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Zhao Y, Li Q, Wu X and Chen P: Upregulation of p27Kip1 by demethylation sensitizes cisplatin-resistant human ovarian cancer SKOV3 cells. Mol Med Rep. 14:1659–1666. 2016.PubMed/NCBI

7 

Yang Y, Chen Y, Saha MN, Chen J, Evans K, Qiu L, Reece D, Chen GA and Chang H: Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myeloma. Leukemia. 29:715–726. 2015. View Article : Google Scholar

8 

Sun L, Liu L, Liu X, Wang Y, Li M, Yao L, Yang J, Ji G, Guo C, Pan Y, et al: Gastric cancer cell adhesion to laminin enhances acquired chemotherapeutic drug resistance mediated by MGr1-Ag/37LRP. Oncol Rep. 32:105–114. 2014.PubMed/NCBI

9 

Fei M, Hang Q, Hou S and Ruan C: Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells. Int J Hematol. 98:446–455. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Carrano AC, Eytan E, Hershko A and Pagano M: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1:193–199. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Masumoto K and Kitagawa M: E3 ubiquitin ligases as molecular targets in human oral cancers. Curr Cancer Drug Targets. 16:130–135. 2016. View Article : Google Scholar

12 

Yan LH, Wang XT, Yang J, Kong FB, Lian C, Wei WY, Luo W, Xie YB and Xiao Q: Reversal of multidrug resistance in gastric cancer cells by E2F-1 downregulation in vitro and in vivo. J Cell Biochem. 115:34–41. 2014. View Article : Google Scholar

13 

Hnit SS, Xie C, Yao M, Holst J, Bensoussan A, De Souza P, Li Z and Dong Q: p27(Kip1) signaling: Transcriptional and post-translational regulation. Int J Biochem Cell Biol. 68:9–14. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Friis-Hansen L, Sundler F, Li Y, Gillespie PJ, Saunders TL, Greenson JK, Owyang C, Rehfeld JF and Samuelson LC: Impaired gastric acid secretion in gastrin-deficient mice. Am J Physiol. 274:G561–G568. 1998.PubMed/NCBI

15 

Rehfeld JF, Hansen CP and Johnsen AH: Post-poly(Glu) cleavage and degradation modified by O-sulfated tyrosine: A novel post-translational processing mechanism. EMBO J. 14:389–396. 1995.PubMed/NCBI

16 

Goetze JP, Eiland S, Svendsen LB, Vainer B, Hannibal J and Rehfeld JF: Characterization of gastrins and their receptor in solid human gastric adenocarcinomas. Scand J Gastroenterol. 48:688–695. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Merali Z, McIntosh J and Anisman H: Role of bombesin-related peptides in the control of food intake. Neuropeptides. 33:376–386. 1999. View Article : Google Scholar

18 

Han YM, Park JM, Kangwan N, Jeong M, Lee S, Cho JY, Ko WJ and Hahm KB: Role of proton pump inhibitors in preventing hypergastrinemia-associated carcinogenesis and in antagonizing the trophic effect of gastrin. J Physiol Pharmacol. 66:159–167. 2015.PubMed/NCBI

19 

Lloyd KA, Moore AR, Parsons BN, O'Hara A, Boyce M, Dockray GJ, Varro A and Pritchard DM: Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1. Oncotarget. 7:45462–45478. 2016.PubMed/NCBI

20 

Niu YL, Li YJ, Wang JB, Lu YY, Liu ZX, Feng SS, Hu JG and Zhai HH: CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells. World J Gastroenterol. 22:3992–4001. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Zhuang K, Yan Y, Zhang X, Zhang J, Zhang L and Han K: Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway. Oncol Rep. 36:1369–1376. 2016.PubMed/NCBI

22 

Varro A, Kenny S, Hemers E, McCaig C, Przemeck S, Wang TC, Bodger K and Pritchard DM: Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling. Am J Physiol Gastrointest Liver Physiol. 292:G1133–G1140. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Kumar JD, Steele I, Moore AR, Murugesan SV, Rakonczay Z, Venglovecz V, Pritchard DM, Dimaline R, Tiszlavicz L, Varro A, et al: Gastrin stimulates MMP-1 expression in gastric epithelial cells: Putative role in gastric epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 309:G78–G86. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Singh P, Owlia A, Varro A, Dai B, Rajaraman S and Wood T: Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res. 56:4111–4115. 1996.PubMed/NCBI

25 

Hayashi N, Kayo T, Sugano K and Takeuchi T: Production of bioactive gastrin from the non-endocrine cell lines CHO and COS-7. FEBS Lett. 337:27–32. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Supriatno HK, Harada K, Hoque MO, Bando T, Yoshida H and Sato M: Overexpression of p27(Kip1) induces growth arrest and apoptosis in an oral cancer cell line. Oral Oncol. 38:730–736. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Yin Y, Grabowska AM, Clarke PA, Whelband E, Robinson K, Argent RH, Tobias A, Kumari R, Atherton JC and Watson SA: Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: Links to soluble HB-EGF, gastrin and matrix metalloproteinase-7. Gut. 59:1037–1045. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Sumimoto H, Yamagata S, Shimizu A, Miyoshi H, Mizuguchi H, Hayakawa T, Miyagishi M, Taira K and Kawakami Y: Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference. Gene Ther. 12:95–100. 2005. View Article : Google Scholar

29 

Hristova NR, Tagscherer KE, Fassl A, Kopitz J and Roth W: Notch1-dependent regulation of p27 determines cell fate in colorectal cancer. Int J Oncol. 43:1967–1975. 2013.PubMed/NCBI

30 

Del Vecchio CA, Feng Y, Sokol ES, Tillman EJ, Sanduja S, Reinhardt F and Gupta PB: De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling. PLoS Biol. 12:e10019452014. View Article : Google Scholar : PubMed/NCBI

31 

Conway RM, Madigan MC, Billson FA and Penfold PL: Vincristine- and cisplatin-induced apoptosis in human retinoblastoma. Potentiation by sodium butyrate. Eur J Cancer. 34:1741–1748. 1998. View Article : Google Scholar

32 

Gutkind JS: The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem. 273:1839–1842. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Stendahl M, Nilsson S, Wigerup C, Jirström K, Jönsson PE, Stål O and Landberg G: p27Kip1 is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patients. Int J Cancer. 127:2851–2858. 2010. View Article : Google Scholar

34 

Tsvetkov LM, Yeh KH, Lee SJ, Sun H and Zhang H: p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol. 9:661–664. 1999. View Article : Google Scholar : PubMed/NCBI

35 

Marshall KM, Laval M, Estacio O, Hudson DF, Kalitsis P, Shulkes A, Baldwin GS and Patel O: Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo. Metallomics. 7:1390–1398. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Reed JC, Miyashita T, Takayama S, Wang HG, Sato T, Krajewski S, Aimé-Sempé C, Bodrug S, Kitada S and Hanada M: BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem. 60:23–32. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Mao JD, Wu P, Xia XH, Hu JQ, Huang WB and Xu GQ: Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma. World J Gastroenterol. 11:721–725. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Gandhi L, Camidge DR, Ribeiro de Oliveira M, Bonomi P, Gandara D, Khaira D, Hann CL, McKeegan EM, Litvinovich E, Hemken PM, et al: Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J Clin Oncol. 29:909–916. 2011. View Article : Google Scholar : PubMed/NCBI

39 

De Milito A and Fais S: Proton pump inhibitors may reduce tumour resistance. Expert Opin Pharmacother. 6:1049–1054. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Rintoul RC and Sethi T: Extracellular matrix regulation of drug resistance in small-cell lung cancer. Clin Sci (Lond). 102:417–424. 2002. View Article : Google Scholar

41 

Hara T, Kamura T, Kotoshiba S, Takahashi H, Fujiwara K, Onoyama I, Shirakawa M, Mizushima N and Nakayama KI: Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Mol Cell Biol. 25:9292–9303. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, et al: Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19:2069–2081. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T and Nakayama KI: Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell. 6:661–672. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhuang K, Zhang L, Zhang X, Tang H, Zhang J, Yan Y, Han K and Guo H: Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901. Int J Oncol 50: 2091-2100, 2017.
APA
Zhuang, K., Zhang, L., Zhang, X., Tang, H., Zhang, J., Yan, Y. ... Guo, H. (2017). Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901. International Journal of Oncology, 50, 2091-2100. https://doi.org/10.3892/ijo.2017.3983
MLA
Zhuang, K., Zhang, L., Zhang, X., Tang, H., Zhang, J., Yan, Y., Han, K., Guo, H."Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901". International Journal of Oncology 50.6 (2017): 2091-2100.
Chicago
Zhuang, K., Zhang, L., Zhang, X., Tang, H., Zhang, J., Yan, Y., Han, K., Guo, H."Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901". International Journal of Oncology 50, no. 6 (2017): 2091-2100. https://doi.org/10.3892/ijo.2017.3983
Copy and paste a formatted citation
x
Spandidos Publications style
Zhuang K, Zhang L, Zhang X, Tang H, Zhang J, Yan Y, Han K and Guo H: Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901. Int J Oncol 50: 2091-2100, 2017.
APA
Zhuang, K., Zhang, L., Zhang, X., Tang, H., Zhang, J., Yan, Y. ... Guo, H. (2017). Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901. International Journal of Oncology, 50, 2091-2100. https://doi.org/10.3892/ijo.2017.3983
MLA
Zhuang, K., Zhang, L., Zhang, X., Tang, H., Zhang, J., Yan, Y., Han, K., Guo, H."Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901". International Journal of Oncology 50.6 (2017): 2091-2100.
Chicago
Zhuang, K., Zhang, L., Zhang, X., Tang, H., Zhang, J., Yan, Y., Han, K., Guo, H."Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901". International Journal of Oncology 50, no. 6 (2017): 2091-2100. https://doi.org/10.3892/ijo.2017.3983
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