Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
November-2017 Volume 51 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 51 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model

  • Authors:
    • Gloria M. Calaf
    • Debasish Roy
  • View Affiliations / Copyright

    Affiliations: Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Chile, Department of Natural Sciences, Hostos College, The City University of New York, Bronx, NY, USA
  • Pages: 1590-1600
    |
    Published online on: September 14, 2017
       https://doi.org/10.3892/ijo.2017.4125
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer remains the second most common disease worldwide. Radiotherapy, alone or in combination with chemotherapy, is widely used after surgery as a treatment for cancer with proven therapeutic efficacy manifested by reduced incidence of loco-regional and distant recurrences. However, clinical evidence indicates that relapses occurring after radiotherapy are associated with increased metastatic potential and poor prognosis in the breast. Among the anticarcinogenic and antiproliferative agents, curcumin is a well-known major dietary natural yellow pigment derived from the rhizome of the herb Curcuma longa (Zingiberaceae). The aim of the present study was to analyze the differential expression of metastatic genes in radiation- and estrogen-induced breast cancer cell model and the effect of curcumin on such metastatic genes in breast carcinogenesis. Expression levels of TGF-α and TGFβ1 genes were upregulated in MCF-10F and downregulated in Tumor2 cell lines treated with curcumin. Expression levels of other genes such as caspase 9 and collagen 4 A2 were upregulated in both MCF-10F and Tumor2-treated cell lines. Integrin α5 and cathepsin B and D decreased its expression in Tumor2, whereas E-Cadherin, c-myc and CD44 expressions were only increased in MCF-10F. It can be concluded that metastatic genes can be affected by curcumin in cancer progression and such substance can be used in breast cancer patients with advanced disease without side-effects commonly observed with therapeutic drugs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D and Bray F: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer. 49:1374–1403. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Bartelink H, Horiot JC, Poortmans P, Struikmans H, Van den Bogaert W, Barillot I, Fourquet A, Borger J, Jager J, Hoogenraad W, et al European Organization for Research and Treatment of Cancer Radiotherapy and Breast Cancer Groups: Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med. 345:1378–1387. 2001. View Article : Google Scholar

3 

Early Breast Cancer Trialists' Collaborative Group (EBCTCG); Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J, et al: Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10,801 women in 17 randomized trials. Lancet. 378:1707–1716. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Le Scodan R, Stevens D, Brain E, Floiras JL, Cohen-Solal C, De La Lande B, Tubiana-Hulin M, Yacoub S, Gutierrez M, Ali D, et al: Breast cancer with synchronous metastases: Survival impact of exclusive locoregional radiotherapy. J Clin Oncol. 27:1375–1381. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Mattsson A, Rudén BI, Hall P, Wilking N and Rutqvist LE: Radiation-induced breast cancer: Long-term follow-up of radiation therapy for benign breast disease. J Natl Cancer Inst. 85:1679–1685. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Goldstein NS, Kestin L and Vicini F: Factors associated with ipsilateral breast failure and distant metastases in patients with invasive breast carcinoma treated with breast-conserving therapy. A clinicopathologic study of 607 neoplasms from 583 patients. Am J Clin Pathol. 120:500–527. 2003. View Article : Google Scholar : PubMed/NCBI

7 

O'Brien CJ, Smith JW, Soong SJ, Urist MM and Maddox WA: Neck dissection with and without radiotherapy: Prognostic factors, patterns of recurrence, and survival. Am J Surg. 152:456–463. 1986. View Article : Google Scholar : PubMed/NCBI

8 

Vikram B, Strong EW, Shah JP and Spiro R: Second malignant neoplasms in patients successfully treated with multimodality treatment for advanced head and neck cancer. Head Neck Surg. 6:734–737. 1984. View Article : Google Scholar : PubMed/NCBI

9 

Barcellos-Hoff MH and Ravani SA: Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 60:1254–1260. 2000.PubMed/NCBI

10 

Lemay R, Archambault M, Tremblay L, Bujold R, Lepage M and Paquette B: Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells. Int J Radiat Biol. 87:472–482. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Bouchard G, Bouvette G, Therriault H, Bujold R, Saucier C and Paquette B: Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. Br J Cancer. 109:1829–1838. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Kozłowski J, Kozłowska A and Kocki J: Breast cancer metastasis - insight into selected molecular mechanisms of the phenomenon. Postepy Hig Med Dosw Online. 69:447–451. 2015. View Article : Google Scholar

15 

Smid M, Wang Y, Zhang Y, Sieuwerts AM, Yu J, Klijn JG, Foekens JA and Martens JW: Subtypes of breast cancer show preferential site of relapse. Cancer Res. 68:3108–3114. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Weigelt B, Glas AM, Wessels LF, Witteveen AT, Peterse JL and van't Veer LJ: Gene expression profiles of primary breast tumors maintained in distant metastases. Proc Natl Acad Sci USA. 100:15901–15905. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Klein CA: Gene expression signatures, cancer cell evolution and metastatic progression. Cell Cycle. 3:29–31. 2004. View Article : Google Scholar

18 

Sato F, Saji S and Toi M: Genomic tumor evolution of breast cancer. Breast Cancer. 23:4–11. 2016. View Article : Google Scholar

19 

Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 23:363–398. 2003.PubMed/NCBI

20 

Korutla L and Kumar R: Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim Biophys Acta. 1224:597–600. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Surh YJ, Han SS, Keum YS, Seo HJ and Lee SS: Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1. Biofactors. 12:107–112. 2000. View Article : Google Scholar

22 

Shiri S, Alizadeh AM, Baradaran B, Farhanghi B, Shanehbandi D, Khodayari S, Khodayari H and Tavassoli A: Dendrosomal curcumin suppresses metastatic breast cancer in mice by changing m1/m2 macrophage balance in the tumor microenvironment. Asian Pac J Cancer Prev. 16:3917–3922. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Farhangi B, Alizadeh AM, Khodayari H, Khodayari S, Dehghan MJ, Khori V, Heidarzadeh A, Khaniki M, Sadeghiezadeh M and Najafi F: Protective effects of dendrosomal curcumin on an animal metastatic breast tumor. Eur J Pharmacol. 758:188–196. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Zong H, Wang F, Fan QX and Wang LX: Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways. Mol Biol Rep. 39:4803–4808. 2012. View Article : Google Scholar

25 

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE and Price JE: Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 11:7490–7498. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S and Aggarwal BB: Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol. 69:195–206. 2006.

27 

Shishodia S, Amin HM, Lai R and Aggarwal BB: Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 70:700–713. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Siwak DR, Shishodia S, Aggarwal BB and Kurzrock R: Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer. 104:879–890. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Ramachandran C and You W: Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast Cancer Res Treat. 54:269–278. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Zhou QM, Chen QL, Du J, Wang XF, Lu YY, Zhang H and Su SB: Synergistic effect of combinatorial treatment with curcumin and mitomycin C on the induction of apoptosis of breast cancer cells: A cDNA microarray analysis. Int J Mol Sci. 15:16284–16301. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Calaf GM and Hei TK: Establishment of a radiation- and estrogen-induced breast cancer model. Carcinogenesis. 4:769–776. 2000. View Article : Google Scholar

32 

Roy D, Calaf G and Hei TK: Profiling of differentially expressed genes induced by high linear energy transfer radiation in breast epithelial cells. Mol Carcinog. 31:192–203. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Calaf G and Hei TK: Oncoprotein expression in human breast epithelial cells transformed by high-LET radiation. Int J Radiat Biol. 77:31–40. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Calaf GM and Roy D: Gene and protein expressions induced by 17β-estradiol and parathion in cultured breast epithelial cells. Mol Med. 13:255–265. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Calaf GM, Roy D and Hei TK: Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation. Histochem Cell Biol. 124:261–274. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Calaf GM, Alvarado ME and Hei TK: Beta catenin is associated with breast cancer progression in vitro. Int J Oncol. 26:913–921. 2005.PubMed/NCBI

37 

Sambrook J, Fritsch EF and Maniatis T: Molecular Cloning: A Laboratory Manual. 3rd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor; NY: 1989

38 

Liu WM, Mei R, Di X, Ryder TB, Hubbell E, Dee S, Webster TA, Harrington CA, Ho MH, Baid J, et al: Analysis of high density expression microarrays with signed-rank call algorithms. Bioinformatics. 18:1593–1599. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Sartorius CA, Hanna CT, Gril B, Cruz H, Serkova NJ, Huber KM, Kabos P, Schedin TB, Borges VF, Steeg PS, et al: Estrogen promotes the brain metastatic colonization of triple negative breast cancer cells via an astrocyte-mediated paracrine mechanism. Oncogene. 10:1038–1053. 2015.

40 

Wright LE, Frye JB, Lukefahr AL, Timmermann BN, Mohammad KS, Guise TA and Funk JL: Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis. J Nat Prod. 76:316–321. 2013. View Article : Google Scholar

41 

Ferreira LC, Arbab AS, Jardim-Perassi BV, Borin TF, Varma NR, Iskander AS, Shankar A, Ali MM and Zuccari DA: Effect of curcumin on pro-angiogenic factors in the xenograft model of breast cancer. Anticancer Agents Med Chem. 15:1285–1296. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Wang W, Sukamtoh E, Xiao H and Zhang G: Curcumin inhibits lymphangiogenesis in vitro and in vivo. Mol Nutr Food Res. 59:2345–2354. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Mohankumar K, Pajaniradje S, Sridharan S, Singh VK, Ronsard L, Banerjea AC, Benson CS, Coumar MS and Rajagopalan R: Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin - an in vitro and in silico approach. Chem Biol Interact. 210:51–63. 2014. View Article : Google Scholar

44 

Thaloor D, Singh AK, Sidhu GS, Prasad PV, Kleinman HK and Maheshwari RK: Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell Growth Differ. 9:305–312. 1998.PubMed/NCBI

45 

Mitra A, Chakrabarti J, Banerji A, Chatterjee A and Das BR: Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. J Environ Pathol Toxicol Oncol. 25:679–690. 2006. View Article : Google Scholar

46 

Prud'homme GJ: Cancer stem cells and novel targets for antitumor strategies. Review. Curr Pharm Des. 18:2838–2849. 2012. View Article : Google Scholar

47 

Sun T, Jiang D, Zhang L, Su Q, Mao W and Jiang C: Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients. Oncol Lett. 11:575–583. 2016.PubMed/NCBI

48 

Ruan H, Hao S, Young P and Zhang H: Targeting cathepsin B for cancer therapies. Horiz Cancer Res. 56:23–40. 2015.PubMed/NCBI

49 

Chen CC, Sureshbabul M, Chen HW, Lin YS, Lee JY, Hong QS, Yang YC and Yu SL: Curcumin suppresses metastasis via Sp-1, FAK inhibition, and E-Cadherin upregulation in colorectal cancer. Evid Based Complement Alternat Med. 2013:5416952013.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Calaf GM and Roy D: Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model. Int J Oncol 51: 1590-1600, 2017.
APA
Calaf, G.M., & Roy, D. (2017). Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model. International Journal of Oncology, 51, 1590-1600. https://doi.org/10.3892/ijo.2017.4125
MLA
Calaf, G. M., Roy, D."Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model". International Journal of Oncology 51.5 (2017): 1590-1600.
Chicago
Calaf, G. M., Roy, D."Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model". International Journal of Oncology 51, no. 5 (2017): 1590-1600. https://doi.org/10.3892/ijo.2017.4125
Copy and paste a formatted citation
x
Spandidos Publications style
Calaf GM and Roy D: Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model. Int J Oncol 51: 1590-1600, 2017.
APA
Calaf, G.M., & Roy, D. (2017). Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model. International Journal of Oncology, 51, 1590-1600. https://doi.org/10.3892/ijo.2017.4125
MLA
Calaf, G. M., Roy, D."Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model". International Journal of Oncology 51.5 (2017): 1590-1600.
Chicago
Calaf, G. M., Roy, D."Metastatic genes targeted by an antioxidant in an established radiation- and estrogen-breast cancer model". International Journal of Oncology 51, no. 5 (2017): 1590-1600. https://doi.org/10.3892/ijo.2017.4125
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team