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Evidence of lateral transmission of aggressive features between different types of breast cancer cells

  • Authors:
    • Nancy Adriana Espinoza-Sánchez
    • Eduardo Vadillo
    • Juan Carlos Balandrán
    • Alberto Monroy-García
    • Rosana Pelayo
    • Ezequiel M. Fuentes-Pananá
  • View Affiliations / Copyright

    Affiliations: PhD Program in Biomedical Science, Medicine Faculty, National Autonomous University of Mexico, University City, Mexico City 04510, Mexico, Department of Molecular Biomedicine, Centre for Investigation and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Mexico City 07360, Mexico, Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Mexico City 06720, Mexico, Virology and Cancer Research Unit, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico
    Copyright: © Espinoza-Sánchez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1482-1496
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    Published online on: September 19, 2017
       https://doi.org/10.3892/ijo.2017.4128
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Abstract

Breast cancer (BrC) is a major public health problem worldwide. The intra-tumoral heterogeneity and tumor cell plasticity importantly contribute to disease progression and treatment failure. However, the dynamic interactions between different tumor clones, as well as their contribution to tumor aggressiveness are still poorly understood. In this study, we provide evidence of a lateral transmission of aggressive features between aggressive and non-aggressive tumor cells, consisting of gain of expression of cancer stem cell markers, increased expression of CXCL12 receptors CXCR4 and CXCR7 and increased invasiveness in response to CXCL12, which correlated with high levels of secretion of pro-inflammatory mediators G-CSF, GM-CSF, MCP-1, IL-8 and metalloproteinases 1 and 2 by the aggressive cells. Noteworthy, we found no evidence of a TGF-β participation in the inducible-invasive phenotype. Altogether, our results provide evidence of communication between tumor cells with different potentials for aggressiveness, which could influence intra-tumoral population dynamics promoting the emergence of clones with novel functions. Understanding these interactions will provide better targets for diagnosis, prognosis and therapeutic strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Espinoza-Sánchez NA, Vadillo E, Balandrán JC, Monroy-García A, Pelayo R and Fuentes-Pananá EM: Evidence of lateral transmission of aggressive features between different types of breast cancer cells. Int J Oncol 51: 1482-1496, 2017.
APA
Espinoza-Sánchez, N.A., Vadillo, E., Balandrán, J.C., Monroy-García, A., Pelayo, R., & Fuentes-Pananá, E.M. (2017). Evidence of lateral transmission of aggressive features between different types of breast cancer cells. International Journal of Oncology, 51, 1482-1496. https://doi.org/10.3892/ijo.2017.4128
MLA
Espinoza-Sánchez, N. A., Vadillo, E., Balandrán, J. C., Monroy-García, A., Pelayo, R., Fuentes-Pananá, E. M."Evidence of lateral transmission of aggressive features between different types of breast cancer cells". International Journal of Oncology 51.5 (2017): 1482-1496.
Chicago
Espinoza-Sánchez, N. A., Vadillo, E., Balandrán, J. C., Monroy-García, A., Pelayo, R., Fuentes-Pananá, E. M."Evidence of lateral transmission of aggressive features between different types of breast cancer cells". International Journal of Oncology 51, no. 5 (2017): 1482-1496. https://doi.org/10.3892/ijo.2017.4128
Copy and paste a formatted citation
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Spandidos Publications style
Espinoza-Sánchez NA, Vadillo E, Balandrán JC, Monroy-García A, Pelayo R and Fuentes-Pananá EM: Evidence of lateral transmission of aggressive features between different types of breast cancer cells. Int J Oncol 51: 1482-1496, 2017.
APA
Espinoza-Sánchez, N.A., Vadillo, E., Balandrán, J.C., Monroy-García, A., Pelayo, R., & Fuentes-Pananá, E.M. (2017). Evidence of lateral transmission of aggressive features between different types of breast cancer cells. International Journal of Oncology, 51, 1482-1496. https://doi.org/10.3892/ijo.2017.4128
MLA
Espinoza-Sánchez, N. A., Vadillo, E., Balandrán, J. C., Monroy-García, A., Pelayo, R., Fuentes-Pananá, E. M."Evidence of lateral transmission of aggressive features between different types of breast cancer cells". International Journal of Oncology 51.5 (2017): 1482-1496.
Chicago
Espinoza-Sánchez, N. A., Vadillo, E., Balandrán, J. C., Monroy-García, A., Pelayo, R., Fuentes-Pananá, E. M."Evidence of lateral transmission of aggressive features between different types of breast cancer cells". International Journal of Oncology 51, no. 5 (2017): 1482-1496. https://doi.org/10.3892/ijo.2017.4128
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