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International Journal of Oncology
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Article

miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas

  • Authors:
    • Zuozhou Xie
    • Weiqiang Chen
    • Yinghua Chen
    • Xiang Wang
    • Wenyong Gao
    • Yi Liu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Medicine, No. 2 People's Hospital of Kunming, Kunming, Yunnan 650204, P.R. China
  • Pages: 1574-1582
    |
    Published online on: September 22, 2017
       https://doi.org/10.3892/ijo.2017.4133
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Abstract

Altered microRNA expression has been found to be a common feature of several cancers, including lung carcinomas. However, the possible roles of miR-768-3p in the pathological changes of lung carcinomas are still unknown. The aim of the present study was to investigate the expression and possible effects of miR-768-3p in human non-small cell lung carcinomas (NSCLC). Eighty-three NSCLC patients attending the clinic of Kunming Hospital were invited to participate in the study. Their tumor samples were obtained for qRT-PCR analysis. Human NSCLC cell lines, A549 and HCC4006, were employed and transfected with either miR-768-3p mimics or miR-768-3p antagomir. Following transfection, the in vitro and in vivo proliferation, apoptosis fractions, migration and invasion of NSCLC cells were evaluated. The data revealed that: i) upregulated miR-768-3p in tumors were associated with the clinicopathological features of NSCLC patients; ii) inhibiting miR-768-3p function by miR-768-3p antagomir induced distinctly apoptosis and Fas/FasL expressional alteration of NSCLC cells; iii) miR-768-3p antagomir transduction also decreased the viability, migration and invasion, as well as MMP-2 and MMP-9 activities in A549 and HCC4006 cells; and iv) miR-768-3p antagomir transfection also inhibited the growth and proliferation of NSCLC xenografts in nude mice. The present results suggested that abnormal elevated miR-768-3p in NSCLC tumors and cell lines played important roles in NSCLC carcinogenic progression, and the targeting of miR-768-3p might be a potential therapeutic strategy for the treatment of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Xie Z, Chen W, Chen Y, Wang X, Gao W and Liu Y: miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas. Int J Oncol 51: 1574-1582, 2017.
APA
Xie, Z., Chen, W., Chen, Y., Wang, X., Gao, W., & Liu, Y. (2017). miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas. International Journal of Oncology, 51, 1574-1582. https://doi.org/10.3892/ijo.2017.4133
MLA
Xie, Z., Chen, W., Chen, Y., Wang, X., Gao, W., Liu, Y."miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas". International Journal of Oncology 51.5 (2017): 1574-1582.
Chicago
Xie, Z., Chen, W., Chen, Y., Wang, X., Gao, W., Liu, Y."miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas". International Journal of Oncology 51, no. 5 (2017): 1574-1582. https://doi.org/10.3892/ijo.2017.4133
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Z, Chen W, Chen Y, Wang X, Gao W and Liu Y: miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas. Int J Oncol 51: 1574-1582, 2017.
APA
Xie, Z., Chen, W., Chen, Y., Wang, X., Gao, W., & Liu, Y. (2017). miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas. International Journal of Oncology, 51, 1574-1582. https://doi.org/10.3892/ijo.2017.4133
MLA
Xie, Z., Chen, W., Chen, Y., Wang, X., Gao, W., Liu, Y."miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas". International Journal of Oncology 51.5 (2017): 1574-1582.
Chicago
Xie, Z., Chen, W., Chen, Y., Wang, X., Gao, W., Liu, Y."miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas". International Journal of Oncology 51, no. 5 (2017): 1574-1582. https://doi.org/10.3892/ijo.2017.4133
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