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The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer

  • Authors:
    • Shan Liao
    • Songshu Xiao
    • Hongxiang Chen
    • Manying Zhang
    • Zhifang Chen
    • Yuehua Long
    • Lu Gao
    • Junyu He
    • Yanshan Ge
    • Wei Yi
    • Minghua Wu
    • Guiyuan Li
    • Yanhong Zhou
  • View Affiliations / Copyright

    Affiliations: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, P.R. China, Department of Gynecology and Obstetrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China, The Gynecology Department, People's Hospital of Xinjiang, Urumchi, Xinjiang, P.R. China, The Gynecology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1497-1507
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    Published online on: September 27, 2017
       https://doi.org/10.3892/ijo.2017.4137
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Abstract

Cervical cancer is one of the most common malignant tumors in women all over the world. However, the exact etiology of cervical cancer remains unclear. The receptor for activated protein kinase C (RACK1) is reported to be involved in tumorigenesis and tumor progression. Besides, the prognostic value of RACK1 in several kinds of tumors has been identified. However, there are limited studies on the functional role of RACK1 in cervical cancer. In this study, we tested the expression level of RACK1 by immunohistochemistry and western blot technologies and find that it is upregulated in cervical cancer. Colony formation and CCK8 assays indicate that RACK1 promotes cell proliferation in CaSki cervical cancer cells. While the silence of RACK1 decreases the cell proliferation in CCK8 analysis. β-galactosidase staining suggests that RACK1 decreases cell senescence in cervical cancer cells. Invasion and migration assay show that RACK1 promotes the invasion and migration of cervical cancer cells. Also, when RACK1 was silenced, it exerts the opposite result. Furthermore, the mRNA expression levels of MMP‑3, MMP‑9 and MMP‑10 were upregulated in RACK1‑overexpressed CaSki cells by qPCR analysis. RACK1 also induces S phase accumulation in cell cycle analysis and suppresses cell apoptosis in cervical cancer cells. Flow cytometry analysis of mitochondria functions suggests that RACK1 increases the mitochondrial membrane potential (Δψm) levels to prevent mitochondrial apoptosis in cervical cancer cells. To explore the possible mechanism of RACK1, we tested and found that RACK1 upregulates the expression of NF-κB, cyclin D1 and CDK4 and downregulates the expression of p53, p38, p21 and STAT1 in cervical cancer cells. These results suggest that RACK1 promotes cell growth and invasion and inhibits the senescence and apoptosis in cervical cancer cells probably by affecting the p53 pathway.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Yugawa T and Kiyono T: Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: Novel functions of E6 and E7 oncoproteins. Rev Med Virol. 19:97–113. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Latsuzbaia A, Tapp J, Nguyen T, Fischer M, Arbyn M, Weyers S and Mossong J: Analytical performance evaluation of Anyplex II HPV28 and Euroarray HPV for genotyping of cervical samples. Diagn Microbiol Infect Dis. 85:318–322. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Tang A, Dadaglio G, Oberkampf M, Di Carlo S, Peduto L, Laubreton D, Desrues B, Sun CM, Montagutelli X and Leclerc C: B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer. Int J Cancer. 139:1358–1371. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Chatzistamatiou K, Moysiadis T, Moschaki V, Panteleris N and Agorastos T: Comparison of cytology, HPV DNA testing and HPV 16/18 genotyping alone or combined targeting to the more balanced methodology for cervical cancer screening. Gynecol Oncol. 142:120–127. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Scotto L, Narayan G, Nandula SV, Subramaniyam S, Kaufmann AM, Wright JD, Pothuri B, Mansukhani M, Schneider A, Arias-Pulido H, et al: Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha. Mol Cancer. 7:582008. View Article : Google Scholar : PubMed/NCBI

7 

Dowen SE, Neutze DM, Pett MR, Cottage A, Stern P, Coleman N and Stanley MA: Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes. Oncogene. 22:2531–2540. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Ron D and Mochly-Rosen D: Agonists and antagonists of protein kinase C function, derived from its binding proteins. J Biol Chem. 269:21395–21398. 1994.PubMed/NCBI

9 

McCahill A, Warwicker J, Bolger GB, Houslay MD and Yarwood SJ: The RACK1 scaffold protein: A dynamic cog in cell response mechanisms. Mol Pharmacol. 62:1261–1273. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Peng R, Jiang B, Ma J, Ma Z, Wan X, Liu H, Chen Z, Cheng Q and Chen R: Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity. Oncol Rep. 30:2195–2202. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wu J, Meng J, Du Y, Huang Y, Jin Y, Zhang J, Wang B, Zhang Y, Sun M and Tang J: RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway. Biomed Pharmacother. 67:313–319. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Shi S, Deng YZ, Zhao JS, Ji XD, Shi J, Feng YX, Li G, Li JJ, Zhu D, Koeffler HP, et al: RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem. 287:7845–7858. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Yong-Zheng X, Wan-Li M, Ji-Ming M and Xue-Qun R: Receptor for activated protein kinase C 1 suppresses gastric tumor progression through nuclear factor-κB pathway. Indian J Cancer. 52(Suppl 3): E172–E175. 2015. View Article : Google Scholar

14 

Chen L, Min L, Wang X, Zhao J, Chen H, Qin J, Chen W, Shen Z, Tang Z, Gan Q, et al: Loss of RACK1 promotes metastasis of gastric cancer by inducing a miR-302c/IL8 signaling loop. Cancer Res. 75:3832–3841. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Li X, Xiao Y, Fan S, Xiao M, Wang X, Chen X, Li C, Zong G, Zhou G and Wan C: RACK1 overexpression associates with pancreatic ductal adenocarcinoma growth and poor prognosis. Exp Mol Pathol. 101:176–186. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Peng H, Gong PG, Li JB, Cai LM, Yang L, Liu YY, Yao KT and Li X: The important role of the receptor for activated C kinase 1 (RACK1) in nasopharyngeal carcinoma progression. J Transl Med. 14:1312016. View Article : Google Scholar : PubMed/NCBI

17 

Hu F, Tao Z, Wang M, Li G, Zhang Y, Zhong H, Xiao H, Xie X and Ju M: RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma. Tumour Biol. 34:3893–3899. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Lu F, Zhang C, Wu WJ and Wu YM: RACK1 downregulation suppresses migration and proliferation of neuroblastoma cell lines. Oncol Rep. 27:1646–1652. 2012.PubMed/NCBI

19 

Ruan Y, Sun L, Hao Y, Wang L, Xu J, Zhang W, Xie J, Guo L, Zhou L, Yun X, et al: Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma. J Clin Invest. 122:2554–2566. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Gao X, Xue A, Fang Y, Shu P, Ling J, Hou Y, Shen K, Qin J, Sun Y and Qin X: RACK1 overexpression is linked to acquired imatinib resistance in gastrointestinal stromal tumor. Oncotarget. 7:14300–14309. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Wang Z, Zhang B, Jiang L, Zeng X, Chen Y, Feng X, Guo Y and Chen Q: RACK1, an excellent predictor for poor clinical outcome in oral squamous carcinoma, similar to Ki67. Eur J Cancer. 45:490–496. 2009. View Article : Google Scholar

22 

Li JJ and Xie D: RACK1, a versatile hub in cancer. Oncogene. 34:1890–1898. 2015. View Article : Google Scholar

23 

Zhong X, Li M, Nie B, Wu F, Zhang L, Wang E and Han Y: Overexpressions of RACK1 and CD147 associated with poor prognosis in stage T1 pulmonary adenocarcinoma. Ann Surg Oncol. 20:1044–1052. 2013. View Article : Google Scholar

24 

Nagashio R, Sato Y, Matsumoto T, Kageyama T, Satoh Y, Shinichiro R, Masuda N, Goshima N, Jiang SX and Okayasu I: Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas. Lung Cancer. 69:54–59. 2010. View Article : Google Scholar

25 

Guo Y, Wang W, Wang J, Feng J, Wang Q, Jin J, Lv M, Li X, Li Y, Ma Y, et al: Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity. Hepatology. 57:140–151. 2013. View Article : Google Scholar

26 

Deng YZ, Yao F, Li JJ, Mao ZF, Hu PT, Long LY, Li G, Ji XD, Shi S, Guan DX, et al: RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Gastroenterology. 142:812–823.e15. 2012. View Article : Google Scholar

27 

Mamidipudi V, Dhillon NK, Parman T, Miller LD, Lee KC and Cartwright CA: RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints. Oncogene. 26:2914–2924. 2007. View Article : Google Scholar

28 

Liao S, Xiao S, Zhu G, Zheng D, He J, Pei Z, Li G and Zhou Y: CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. Oncol Rep. 32:2703–2709. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Hara A and Okayasu I: Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: Correlation with angiogenesis and prognostic significance. Acta Neuropathol. 108:43–48. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Lin Y, Cui M, Teng H, Wang F, Yu W and Xu T: Silencing the receptor of activated C-kinase 1 (RACK1) suppresses tumorigenicity in epithelial ovarian cancer in vitro and in vivo. Int J Oncol. 44:1252–1258. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Shen F, Yan C, Liu M, Feng Y and Chen Y: RACK1 promotes prostate cancer cell proliferation, invasion and metastasis. Mol Med Rep. 8:999–1004. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Li J, Guo Y, Feng X, Wang Z, Wang Y, Deng P, Zhang D, Wang R, Xie L, Xu X, et al: Receptor for activated C kinase 1 (RACK1): A regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol. 138:563–571. 2012. View Article : Google Scholar

33 

Dave JM, Kang H, Abbey CA, Maxwell SA and Bayless KJ: Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). J Biol Chem. 288:30720–30733. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Gandin V, Senft D, Topisirovic I and Ronai ZA: RACK1 function in cell motility and protein synthesis. Genes Cancer. 4:369–377. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Liu B, Wang C, Chen P, Wang L and Cheng Y: RACK1 promotes radiation resistance in esophageal cancer via regulating AKT pathway and Bcl-2 expression. Biochem Biophys Res Commun. 491:622–628. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Fei L, Ma Y, Zhang M, Liu X, Luo Y, Wang C, Zhang H, Zhang W and Han Y: RACK1 promotes lung cancer cell growth via an MCM7/RACK1/Akt signaling complex. Oncotarget. 8:40501–40513. 2017.PubMed/NCBI

37 

Zhou C, Chen T, Xie Z, Qin Y, Ou Y, Zhang J, Li S, Chen R and Zhong N: RACK1 forms a complex with FGFR1 and PKM2 and stimulates the growth and migration of squamous lung cancer cells. Mol Carcinog. Apr 18–2017.Epub ahead of print. View Article : Google Scholar

38 

Wang Q, Zhou S, Wang JY, Cao J, Zhang X, Wang J, Han K, Cheng Q, Qiu G, Zhao Y, et al: RACK1 antagonizes TNF-α-induced cell death by promoting p38 activation. Sci Rep. 5:142982015. View Article : Google Scholar

39 

Diaz-Moralli S, Tarrado-Castellarnau M, Miranda A and Cascante M: Targeting cell cycle regulation in cancer therapy. Pharmacol Ther. 138:255–271. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Williams GH and Stoeber K: The cell cycle and cancer. J Pathol. 226:352–364. 2012. View Article : Google Scholar

41 

Aarts M, Linardopoulos S and Turner NC: Tumour selective targeting of cell cycle kinases for cancer treatment. Curr Opin Pharmacol. 13:529–535. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Vermeulen K, Van Bockstaele DR and Berneman ZN: The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36:131–149. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Schafer KA: The cell cycle: A review. Vet Pathol. 35:461–478. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Waga S, Li R and Stillman B: p53-induced p21 controls DNA replication. Leukemia. 11(Suppl 3): 321–323. 1997.PubMed/NCBI

45 

Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L and Swindell E: Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell. 6:387–400. 1995. View Article : Google Scholar : PubMed/NCBI

46 

Besson A, Dowdy SF and Roberts JM: CDK inhibitors: Cell cycle regulators and beyond. Dev Cell. 14:159–169. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Li D, Dai C, Yang X, Wang F, Yu X and Xiao X: Tang S. Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1 pathway. Food Chem Toxicol. 108:148–160. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Kim HS and Lee MS: STAT1 as a key modulator of cell death. Cell Signal. 19:454–465. 2007. View Article : Google Scholar

49 

Zhang Y, Zhang Y, Yun H, Lai R and Su M: Correlation of STAT1 with apoptosis and cell-cycle markers in esophageal squamous cell carcinoma. PLoS One. 9:e1139282014. View Article : Google Scholar : PubMed/NCBI

50 

Townsend PA, Scarabelli TM, Davidson SM, Knight RA, Latchman DS and Stephanou A: STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem. 279:5811–5820. 2004. View Article : Google Scholar

51 

Aggarwal BB: Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB. Ann Rheum Dis. 59(Suppl 1): i6–i16. 2000. View Article : Google Scholar : PubMed/NCBI

52 

Kerr JF, Wyllie AH and Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:239–257. 1972. View Article : Google Scholar : PubMed/NCBI

53 

Perkins ND: The diverse and complex roles of NF-κB subunits in cancer. Nat Rev Cancer. 12:121–132. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liao S, Xiao S, Chen H, Zhang M, Chen Z, Long Y, Gao L, He J, Ge Y, Yi W, Yi W, et al: The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. Int J Oncol 51: 1497-1507, 2017.
APA
Liao, S., Xiao, S., Chen, H., Zhang, M., Chen, Z., Long, Y. ... Zhou, Y. (2017). The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. International Journal of Oncology, 51, 1497-1507. https://doi.org/10.3892/ijo.2017.4137
MLA
Liao, S., Xiao, S., Chen, H., Zhang, M., Chen, Z., Long, Y., Gao, L., He, J., Ge, Y., Yi, W., Wu, M., Li, G., Zhou, Y."The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer". International Journal of Oncology 51.5 (2017): 1497-1507.
Chicago
Liao, S., Xiao, S., Chen, H., Zhang, M., Chen, Z., Long, Y., Gao, L., He, J., Ge, Y., Yi, W., Wu, M., Li, G., Zhou, Y."The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer". International Journal of Oncology 51, no. 5 (2017): 1497-1507. https://doi.org/10.3892/ijo.2017.4137
Copy and paste a formatted citation
x
Spandidos Publications style
Liao S, Xiao S, Chen H, Zhang M, Chen Z, Long Y, Gao L, He J, Ge Y, Yi W, Yi W, et al: The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. Int J Oncol 51: 1497-1507, 2017.
APA
Liao, S., Xiao, S., Chen, H., Zhang, M., Chen, Z., Long, Y. ... Zhou, Y. (2017). The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. International Journal of Oncology, 51, 1497-1507. https://doi.org/10.3892/ijo.2017.4137
MLA
Liao, S., Xiao, S., Chen, H., Zhang, M., Chen, Z., Long, Y., Gao, L., He, J., Ge, Y., Yi, W., Wu, M., Li, G., Zhou, Y."The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer". International Journal of Oncology 51.5 (2017): 1497-1507.
Chicago
Liao, S., Xiao, S., Chen, H., Zhang, M., Chen, Z., Long, Y., Gao, L., He, J., Ge, Y., Yi, W., Wu, M., Li, G., Zhou, Y."The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer". International Journal of Oncology 51, no. 5 (2017): 1497-1507. https://doi.org/10.3892/ijo.2017.4137
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