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Article

Annexin A2 and cancer: A systematic review

  • Authors:
    • Maria V. Christensen
    • Claus K. Høgdall
    • Kirsten M. Jochumsen
    • Estrid V.S. Høgdall
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Molecular Unit, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark, Department of Gynaecology, Juliane Maria Centre (JMC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, Department of Gynaecology and Obstetrics, Odense University Hospital, Odense, Denmark
  • Pages: 5-18
    |
    Published online on: November 8, 2017
       https://doi.org/10.3892/ijo.2017.4197
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Abstract

Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma, prostate cancer and urothelial carcinoma were evaluated. Annexin A2 expression correlates with resistance to treatment, binding to the bone marrow, histological grade and type, TNM-stage and shortened overall survival. The regulation of Annexin A2 is of interest due to its potential as target for a more individualized cancer management.
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Copy and paste a formatted citation
Spandidos Publications style
Christensen MV, Høgdall CK, Jochumsen KM and Høgdall EV: Annexin A2 and cancer: A systematic review. Int J Oncol 52: 5-18, 2018.
APA
Christensen, M.V., Høgdall, C.K., Jochumsen, K.M., & Høgdall, E.V. (2018). Annexin A2 and cancer: A systematic review. International Journal of Oncology, 52, 5-18. https://doi.org/10.3892/ijo.2017.4197
MLA
Christensen, M. V., Høgdall, C. K., Jochumsen, K. M., Høgdall, E. V."Annexin A2 and cancer: A systematic review". International Journal of Oncology 52.1 (2018): 5-18.
Chicago
Christensen, M. V., Høgdall, C. K., Jochumsen, K. M., Høgdall, E. V."Annexin A2 and cancer: A systematic review". International Journal of Oncology 52, no. 1 (2018): 5-18. https://doi.org/10.3892/ijo.2017.4197
Copy and paste a formatted citation
x
Spandidos Publications style
Christensen MV, Høgdall CK, Jochumsen KM and Høgdall EV: Annexin A2 and cancer: A systematic review. Int J Oncol 52: 5-18, 2018.
APA
Christensen, M.V., Høgdall, C.K., Jochumsen, K.M., & Høgdall, E.V. (2018). Annexin A2 and cancer: A systematic review. International Journal of Oncology, 52, 5-18. https://doi.org/10.3892/ijo.2017.4197
MLA
Christensen, M. V., Høgdall, C. K., Jochumsen, K. M., Høgdall, E. V."Annexin A2 and cancer: A systematic review". International Journal of Oncology 52.1 (2018): 5-18.
Chicago
Christensen, M. V., Høgdall, C. K., Jochumsen, K. M., Høgdall, E. V."Annexin A2 and cancer: A systematic review". International Journal of Oncology 52, no. 1 (2018): 5-18. https://doi.org/10.3892/ijo.2017.4197
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