Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
February-2018 Volume 52 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 52 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation

  • Authors:
    • Yusuke Baba
    • Zenpei Shigemi
    • Naoko Hara
    • Misato Moriguchi
    • Marina Ikeda
    • Tadashi Watanabe
    • Masahiro Fujimuro
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan
  • Pages: 505-517
    |
    Published online on: December 1, 2017
       https://doi.org/10.3892/ijo.2017.4215
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of primary effusion lymphoma (PEL) and Kaposi's sarcoma. PEL is a type of non-Hodgkin's B-cell lymphoma, affecting immunosuppressed individuals, such as post-transplant or AIDS patients. However, since PEL is resistant to chemotherapeutic regimens, new effective treatment strategies are required. Arctigenin, a natural lignan compound found in the plant Arctium lappa, has been widely investigated as a potential anticancer agent in the clinical setting. In the present study, we examined the cytotoxic effects of arctigenin by cell viability assay and found that arctigenin markedly inhibited the proliferation of PEL cells compared with KSHV-uninfected B-lymphoma cells under conditions of glucose deprivation. Arctigenin decreased cellular ATP levels, disrupted mitochondrial membrane potential and triggered caspase-9-mediated apoptosis in the glucose-deprived PEL cells. In addition, western blot analysis using phospho-specific antibodies were used to evaluate activity changes in the signaling pathways of interest. As a result, arctigenin suppressed the activation of the extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38 MAPK) signaling pathways by inhibiting ERK and p38 MAPK phosphorylation in the glucose-deprived PEL cells. We confirmed that an inhibitor of ERK (U0126) or p38 MAPK (SB202190 and SB203580) suppressed the proliferation of the BC3 PEL cells compared with the KSHV-negative DG75 cells. Moreover, RT-PCR and luciferase reporter assay revealed that arctigenin and p38 MAPK inhibition by SB202190 or SB203580 downregulated the transcriptional expression of unfolded protein response (UPR)‑related molecules, including GRP78 and ATF6α under conditions of glucose deprivation. Finally, we confirmed that arctigenin did not affect KSHV replication in PEL cells, suggesting that arctigenin treatment for PEL does not contribute to the risk of de novo KSHV production. These data thus indicate that arctigenin may serve as a lead compound for the development of novel and effective drugs for the treatment of PEL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Russo JJ, Bohenzky RA, Chien MC, Chen J, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, et al: Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA. 93:14862–14867. 1996. View Article : Google Scholar : PubMed/NCBI

2 

Nador RG, Cesarman E, Chadburn A, Dawson DB, Ansari MQ, Sald J and Knowles DM: Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood. 88:645–656. 1996.PubMed/NCBI

3 

Antar A, El Hajj H, Jabbour M, Khalifeh I, El-Merhi F, Mahfouz R and Bazarbachi A: Primary effusion lymphoma in an elderly patient effectively treated by lenalidomide: Case report and review of literature. Blood Cancer J. 4:e1902014. View Article : Google Scholar : PubMed/NCBI

4 

Boulanger E, Gérard L, Gabarre J, Molina JM, Rapp C, Abino JF, Cadranel J, Chevret S and Oksenhendler E: Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS. J Clin Oncol. 23:4372–4380. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Carbone A and Gloghini A: KSHV/HHV8-associated lymphomas. Br J Haematol. 140:13–24. 2008.

6 

Okada S, Goto H and Yotsumoto M: Current status of treatment for primary effusion lymphoma. Intractable Rare Dis Res. 3:65–74. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Damania B and Cesarman E: Kaposi's sarcoma-associated herpesvirus. Fields Virology. Knipe DM and Howley PM: 2. 6th edition. Lippincott Williams & Wilkins; Philadelphia: pp. 2080–2128. 2013

8 

Schulz TF and Cesarman E: Kaposi Sarcoma-associated Herpesvirus: Mechanisms of oncogenesis. Curr Opin Virol. 14:116–128. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Fujimuro M, Wu FY, ApRhys C, Kajumbula H, Young DB, Hayward GS and Hayward SD: A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat Med. 9:300–306. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Ashizawa A, Higashi C, Masuda K, Ohga R, Taira T and Fujimuro M: The Ubiquitin system and Kaposi's sarcoma-associated herpesvirus. Front Microbiol. 3:662012. View Article : Google Scholar : PubMed/NCBI

11 

Sun R, Lin SF, Gradoville L, Yuan Y, Zhu F and Miller G: A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci USA. 95:10866–10871. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Shigemi Z, Furukawa Y, Hosokawa K, Minami S, Matsuhiro J, Nakata S, Watanabe T, Kagawa H, Nakagawa K, Takeda H, et al: Diallyl trisulfide induces apoptosis by suppressing NF-κB signaling through destabilization of TRAF6 in primary effusion lymphoma. Int J Oncol. 48:293–304. 2016. View Article : Google Scholar

13 

Watanabe T, Nakamura S, Ono T, Ui S, Yagi S, Kagawa H, Watanabe H, Ohe T, Mashino T and Fujimuro M: Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochem Biophys Res Commun. 451:93–100. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Wakao K, Watanabe T, Takadama T, Ui S, Shigemi Z, Kagawa H, Higashi C, Ohga R, Taira T and Fujimuro M: Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells. Biochem Biophys Res Commun. 444:135–140. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Shigemi Z, Baba Y, Hara N, Matsuhiro J, Kagawa H, Watanabe T and Fujimuro M: Effects of ER stress on unfolded protein responses, cell survival, and viral replication in primary effusion lymphoma. Biochem Biophys Res Commun. 469:565–572. 2016. View Article : Google Scholar

16 

Shigemi Z, Manabe K, Hara N, Baba Y, Hosokawa K, Kagawa H, Watanabe T and Fujimuro M: Methylseleninic acid and sodium selenite induce severe ER stress and subsequent apoptosis through UPR activation in PEL cells. Chem Biol Interact. 266:28–37. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Bastos JK, Carvalho JC, de Souza GH, Pedrazzi AH and Sarti SJ: Anti-inflammatory activity of cubebin, a lignan from the leaves of Zanthoxyllum naranjillo Griseb. J Ethnopharmacol. 75:279–282. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Swarup V, Ghosh J, Mishra MK and Basu A: Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan. J Antimicrob Chemother. 61:679–688. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Hayashi K, Narutaki K, Nagaoka Y, Hayashi T and Uesato S: Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 33:1199–1205. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Jang YP, Kim SR, Choi YH, Kim J, Kim SG, Markelonis GJ, Oh TH and Kim YC: Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J Neurosci Res. 68:233–240. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD and Leng Y: Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia. 55:1469–1481. 2012. View Article : Google Scholar

22 

Yao X, Zhu F, Zhao Z, Liu C, Luo L and Yin Z: Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway. J Cell Biochem. 112:2837–2849. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Jiang X, Zeng L, Huang J, Zhou H and Liu Y: Arctigenin, a natural lignan compound, induces apoptotic death of hepatocellular carcinoma cells via suppression of PI3-K/Akt signaling. J Biochem Mol Toxicol. 29:458–464. 2015. View Article : Google Scholar

24 

Maxwell T, Chun SY, Lee KS, Kim S and Nam KS: The anti-metastatic effects of the phytoestrogen arctigenin on human breast cancer cell lines regardless of the status of ER expression. Int J Oncol. 50:727–735. 2017. View Article : Google Scholar

25 

Li QC, Liang Y, Tian Y and Hu GR: Arctigenin induces apoptosis in colon cancer cells through ROS/p38MAPK pathway. J BUON. 21:87–94. 2016.PubMed/NCBI

26 

Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM and Hsu YL: Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. Free Radic Biol Med. 67:159–170. 2014. View Article : Google Scholar

27 

Zhang M, Cai S, Zuo B, Gong W, Tang Z, Zhou D, Weng M, Qin Y, Wang S, Liu J, et al: Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway. Tumour Biol. 39:10104283176983592017.PubMed/NCBI

28 

Kim JY, Hwang JH, Cha MR, Yoon MY, Son ES, Tomida A, Ko B, Song SW, Shin-ya K, Hwang YI, et al: Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol. 224:33–40. 2010.PubMed/NCBI

29 

Sun S, Wang X, Wang C, Nawaz A, Wei W, Li J, Wang L and Yu DH: Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Med. 77:141–145. 2011. View Article : Google Scholar

30 

Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, Krähenbühl S and Uteng M: Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicol In Vitro. 40:55–65. 2017. View Article : Google Scholar

31 

Jeong JB, Hong SC, Jeong HJ and Koo JS: Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells. Int Immunopharmacol. 11:1573–1577. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Kudou N, Taniguchi A, Sugimoto K, Matsuya Y, Kawasaki M, Toyooka N, Miyoshi C, Awale S, Dibwe DF, Esumi H, et al: Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy. Eur J Med Chem. 60:76–88. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Huang K, Li LA, Meng YG, You YQ, Fu XY and Song L: Arctigenin promotes apoptosis in ovarian cancer cells via the iNOS/NO/STAT3/survivin signalling. Basic Clin Pharmacol Toxicol. 115:507–511. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, Kadota S and Esumi H: Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res. 66:1751–1757. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Ikeda M, Sato A, Mochizuki N, Toyosaki K, Miyoshi C, Fujioka R, Mitsunaga S, Ohno I, Hashimoto Y, Takahashi H, et al: Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine. Cancer Sci. 107:1818–1824. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Gu Y, Qi C, Sun X, Ma X, Zhang H, Hu L, Yuan J and Yu Q: Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. Biochem Pharmacol. 84:468–476. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Chen C and Okayama H: High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol. 7:2745–2752. 1987. View Article : Google Scholar : PubMed/NCBI

38 

Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S and Yoshida K: Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress. Cell Stress Chaperones. 18:11–23. 2013. View Article : Google Scholar :

39 

Xie J, Pan H, Yoo S and Gao SJ: Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. J Virol. 79:15027–15037. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Sharma-Walia N, Patel K, Chandran K, Marginean A, Bottero V, Kerur N and Paul AG: COX-2/GE2: Molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP. Oncogenesis. 1:e52012. View Article : Google Scholar

41 

Sharma-Walia N, Krishnan HH, Naranatt PP, Zeng L, Smith MS and Chandran B: ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection. J Virol. 79:10308–10329. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Pan H, Xie J, Ye F and Gao SJ: Modulation of Kaposi's sarcoma-associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infection. J Virol. 80:5371–5382. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Gade P, Manjegowda SB, Nallar SC, Maachani UB, Cross AS and Kalvakolanu DV: Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1. Mol Cell Biol. 34:4033–4048. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K and Takahashi R: The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem. 286:7947–7957. 2011. View Article : Google Scholar

45 

Wang M and Kaufman RJ: Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature. 529:326–335. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Sovolyova N, Healy S, Samali A and Logue SE: Stressed to death - mechanisms of ER stress-induced cell death. Biol Chem. 395:1–13. 2014. View Article : Google Scholar

47 

Li X, Feng J and Sun R: Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells. J Virol. 85:715–724. 2011. View Article : Google Scholar :

48 

Leung HJ, Duran EM, Kurtoglu M, Andreansky S, Lampidis TJ and Mesri EA: Activation of the unfolded protein response by 2-deoxy-D-glucose inhibits Kaposi's sarcoma-associated herpesvirus replication and gene expression. Antimicrob Agents Chemother. 56:5794–5803. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Liao G, Cai J, Yue C and Qing X: Extracavitary/solid variant of primary effusion lymphoma presenting as a gastric mass. Exp Mol Pathol. 99:445–448. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Katz H, Rose C, Rivera NT and Bray N: HIV-associated primary effusion lymphoma presenting as a paracardial mass. BMJ Case Rep. 2015.bcr20142087182015. View Article : Google Scholar : PubMed/NCBI

51 

Gu Y, Sun XX, Ye JM, He L, Yan SS, Zhang HH, Hu LH, Yuan JY and Yu Q: Arctigenin alleviates ER stress via activating AMPK. Acta Pharmacol Sin. 33:941–952. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Ichijo H: From receptors to stress-activated MAP kinases. Oncogene. 18:6087–6093. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Cho MK, Jang YP, Kim YC and Kim SG: Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: The role in TNF-alpha inhibition. Int Immunopharmacol. 4:1419–1429. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Lee JY, Cho BJ, Park TW, Park BE, Kim SJ, Sim SS and Kim CJ: Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κB and mitogen-activated protein kinase in RAW264.7 cells. Biol Pharm Bull. 33:1847–1853. 2010. View Article : Google Scholar

55 

Li X, Chen S, Feng J, Deng H and Sun R: Myc is required for the maintenance of Kaposi's sarcoma-associated herpesvirus latency. J Virol. 84:8945–8948. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind JS, Asch AS, Cesarman E, Gershengorn MC and Mesri EA: G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 391:86–89. 1998. View Article : Google Scholar : PubMed/NCBI

57 

Sadagopan S, Sharma-Walia N, Veettil MV, Raghu H, Sivakumar R, Bottero V and Chandran B: Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression. J Virol. 81:3949–3968. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Ye F, Zhou F, Bedolla RG, Jones T, Lei X, Kang T, Guadalupe M and Gao SJ: Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathog. 7:e10020542011. View Article : Google Scholar : PubMed/NCBI

59 

Naranatt PP, Akula SM, Zien CA, Krishnan HH and Chandran B: Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: Implications for infectivity. J Virol. 77:1524–1539. 2003. View Article : Google Scholar :

60 

Ranganathan AC, Zhang L, Adam AP and Aguirre-Ghiso JA: Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res. 66:1702–1711. 2006. View Article : Google Scholar : PubMed/NCBI

61 

He B, Luo B, Chen Q and Zhang L: Cigarette smoke extract induces the expression of GRP78 in A549 cells via the p38/MAPK pathway. Mol Med Rep. 8:1683–1688. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Baba Y, Shigemi Z, Hara N, Moriguchi M, Ikeda M, Watanabe T and Fujimuro M: Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation. Int J Oncol 52: 505-517, 2018.
APA
Baba, Y., Shigemi, Z., Hara, N., Moriguchi, M., Ikeda, M., Watanabe, T., & Fujimuro, M. (2018). Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation. International Journal of Oncology, 52, 505-517. https://doi.org/10.3892/ijo.2017.4215
MLA
Baba, Y., Shigemi, Z., Hara, N., Moriguchi, M., Ikeda, M., Watanabe, T., Fujimuro, M."Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation". International Journal of Oncology 52.2 (2018): 505-517.
Chicago
Baba, Y., Shigemi, Z., Hara, N., Moriguchi, M., Ikeda, M., Watanabe, T., Fujimuro, M."Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation". International Journal of Oncology 52, no. 2 (2018): 505-517. https://doi.org/10.3892/ijo.2017.4215
Copy and paste a formatted citation
x
Spandidos Publications style
Baba Y, Shigemi Z, Hara N, Moriguchi M, Ikeda M, Watanabe T and Fujimuro M: Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation. Int J Oncol 52: 505-517, 2018.
APA
Baba, Y., Shigemi, Z., Hara, N., Moriguchi, M., Ikeda, M., Watanabe, T., & Fujimuro, M. (2018). Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation. International Journal of Oncology, 52, 505-517. https://doi.org/10.3892/ijo.2017.4215
MLA
Baba, Y., Shigemi, Z., Hara, N., Moriguchi, M., Ikeda, M., Watanabe, T., Fujimuro, M."Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation". International Journal of Oncology 52.2 (2018): 505-517.
Chicago
Baba, Y., Shigemi, Z., Hara, N., Moriguchi, M., Ikeda, M., Watanabe, T., Fujimuro, M."Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation". International Journal of Oncology 52, no. 2 (2018): 505-517. https://doi.org/10.3892/ijo.2017.4215
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team