Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
February-2018 Volume 52 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 52 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model

  • Authors:
    • Osamu Kusuoka
    • Rina Fujiwara-Tani
    • Chie Nakashima
    • Kiyomu Fujii
    • Hitoshi Ohmori
    • Takuya Mori
    • Shingo Kishi
    • Yoshihiro Miyagawa
    • Kei Goto
    • Isao Kawahara
    • Hiroki Kuniyasu
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan
    Copyright: © Kusuoka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 413-423
    |
    Published online on: December 18, 2017
       https://doi.org/10.3892/ijo.2017.4229
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The effect of intermittent calorie restriction (ICR) on cancer is controversial. In this study, we examined the effects of ICR and food content in syngeneic BALB/c mice injected with CT26 mouse colon cancer cells. Mice were subjected to 24-h fasting once a week for 4 weeks, and then provided with a control, high-calorie, or trans fatty acid-rich diet. While ICR resulted in increases in tumor weights, metastasis and in the number of cancer stem cells (CSCs) in the tumors or blood of mice fed the control and high-fat diets, it had no effect on body weight after 4 weeks. In particular, we detected increases in the numbers of CSCs in the tumor or blood on the day after starvation, when food overconsumption was detected. Conversely, continuous calorie restriction had no effect on tumor weight, metastasis, or the number of CSCs in tumors or blood. In the post-starvation period, energy metabolism in the tumor was altered from oxidative phosphorylation to glycolysis/lactate fermentation, with the acquisition of the epithelial-mesenchymal transition (EMT) phenotype. Hyperglycemia at the post-starvation period induced the expression of insulin-like growth factor-1, hypoxia-induced factor-1α and Nanog, as well as the phosphorylation of Stat3. Taken together, these findings suggest that ICR induces an increase in the number of CSCs and enhances EMT by promoting the Warburg/Crabtree effect following post-fasting food overconsumption.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Lee C and Longo V: Dietary restriction with and without caloric restriction for healthy aging. F1000Res. 5:52016.

2 

Allott EH and Hursting SD: Obesity and cancer: Mechanistic insights from transdisciplinary studies. Endocr Relat Cancer. 22:R365–R386. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Barnosky AR, Hoddy KK, Unterman TG and Varady KA: Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: A review of human findings. Transl Res. 164:302–311. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Varady KA: Intermittent versus daily calorie restriction: Which diet regimen is more effective for weight loss? Obes Rev. 12:e593–e601. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Johnstone A: Fasting for weight loss: An effective strategy or latest dieting trend? Int J Obes. 39:727–733. 2015. View Article : Google Scholar

6 

Lv M, Zhu X, Wang H, Wang F and Guan W: Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: A systematic review and meta-analysis. PLoS One. 9:e1151472014. View Article : Google Scholar : PubMed/NCBI

7 

Thompson HJ and McTiernan A: Weight cycling and cancer: Weighing the evidence of intermittent caloric restriction and cancer risk. Cancer Prev Res (Phila). 4:1736–1742. 2011. View Article : Google Scholar

8 

Calder PC: Functional roles of fatty acids and their effects on human health. JPEN J Parenter Enteral Nutr. 39(Suppl 1): 18S–32S. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Rose DP: Dietary fatty acids and cancer. Am J Clin Nutr. 66(Suppl 4): 998S–1003S. 1997.PubMed/NCBI

10 

Kuniyasu H, Ohmori H and Fujii K: Significance of trans fatty acids in colorectal cancer. Current Research in Cancer. 9. Sunitha M: Research Media; Kerala, India: pp. 21–29. 2015

11 

Food and Drug Administration: Final Determination Regarding Partially Hydrogenated Oils. 2015

12 

Cascio G, Schiera G and Di Liegro I: Dietary fatty acids in metabolic syndrome, diabetes and cardiovascular diseases. Curr Diabetes Rev. 8:2–17. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Mozaffarian D, Aro A and Willett WC: Health effects of trans-fatty acids: Experimental and observational evidence. Eur J Clin Nutr. 63(Suppl 2): S5–S21. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Zong WX, Rabinowitz JD and White E: Mitochondria and Cancer. Mol Cell. 61:667–676. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Warburg O: On respiratory impairment in cancer cells. Science. 124:269–270. 1956.PubMed/NCBI

16 

Kellenberger LD, Bruin JE, Greenaway J, Campbell NE, Moorehead RA, Holloway AC and Petrik J: The role of dysregulated glucose metabolism in epithelial ovarian cancer. J Oncol. 2010:5143102010. View Article : Google Scholar : PubMed/NCBI

17 

Dell' Antone P: Energy metabolism in cancer cells: How to explain the Warburg and Crabtree effects? Med Hypotheses. 79:388–392. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Kuwada M, Chihara Y, Luo Y, Li X, Nishiguchi Y, Fujiwara R, Sasaki T, Fujii K, Ohmori H, Fujimoto K, et al: Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer. Cancer Lett. 369:212–221. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

20 

Kuniyasu H, Yano S, Sasaki T, Sasahira T, Sone S and Ohmori H: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. Am J Pathol. 166:751–760. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Kuniyasu H, Oue N, Wakikawa A, Shigeishi H, Matsutani N, Kuraoka K, Ito R, Yokozaki H and Yasui W: Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer. J Pathol. 196:163–170. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T and Kuniyasu H: Elaidic acid, a trans-fatty acid, enhances the metastasis of colorectal cancer cells. Pathobiology. 84:144–151. 2017. View Article : Google Scholar

23 

Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H and Kuniyasu H: Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Int J Oncol. 50:85–92. 2017. View Article : Google Scholar

24 

Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, et al: Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 15:848–860. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Zarrinpar A, Chaix A and Panda S: Daily eating patterns and their impact on health and disease. Trends Endocrinol Metab. 27:69–83. 2016. View Article : Google Scholar :

26 

Crabtree HG: Observations on the carbohydrate metabolism of tumours. Biochem J. 23:536–545. 1929. View Article : Google Scholar : PubMed/NCBI

27 

Wang Y, Zhu YD, Gui Q, Wang XD and Zhu YX: Glucagon-induced angiogenesis and tumor growth through the HIF-1-VEGF-dependent pathway in hyperglycemic nude mice. Genet Mol Res. 13:7173–7183. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X, Shi H, Dang CV and Le AD: EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect. Oncotarget. 8:9557–9571. 2017.

29 

Lee C and Longo VD: Fasting vs dietary restriction in cellular protection and cancer treatment: From model organisms to patients. Oncogene. 30:3305–3316. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Guimarães TA, Farias LC, Santos ES, de Carvalho Fraga CA, Orsini LA, de Freitas Teles L, Feltenberger JD, de Jesus SF, de Souza MG, Santos SH, et al: Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma. Oncotarget. 7:55057–55068. 2016. View Article : Google Scholar

31 

Klement RJ and Champ CE: Calories, carbohydrates, and cancer therapy with radiation: Exploiting the five R's through dietary manipulation. Cancer Metastasis Rev. 33:217–229. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Shaw RJ: Glucose metabolism and cancer. Curr Opin Cell Biol. 18:598–608. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Garcia-Heredia JM and Carnero A: Decoding Warburg's hypothesis: Tumor-related mutations in the mitochondrial respiratory chain. Oncotarget. 6:41582–41599. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhong Y, Li X, Yu D, Li X, Li Y, Long Y, Yuan Y, Ji Z, Zhang M, Wen JG, et al: Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro. Oncotarget. 6:37758–37769. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Yin X, Zhang BH, Zheng SS, Gao DM, Qiu SJ, Wu WZ and Ren ZG: Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3-Snail signaling. J Hematol Oncol. 8:232015. View Article : Google Scholar

36 

Liu S, Sun J, Cai B, Xi X, Yang L, Zhang Z, Feng Y and Sun Y: NANOG regulates epithelial-mesenchymal transition and chemoresistance through activation of the STAT3 pathway in epithelial ovarian cancer. Tumour Biol. 37:9671–9680. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Ganguly R and Pierce GN: Trans fat involvement in cardiovascular disease. Mol Nutr Food Res. 56:1090–1096. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Prentice AM: Overeating: The health risks. Obes Res. 9(Suppl 4): 234S–238S. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Costa N, Cruz R, Graça P, Breda J and Casal S: Trans fatty acids in the Portuguese food market. Food Control. 64:128–134. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Chausse B, Solon C, Caldeira da Silva CC, Masselli Dos Reis IG, Manchado-Gobatto FB, Gobatto CA, Velloso LA and Kowaltowski AJ: Intermittent fasting induces hypothalamic modifications resulting in low feeding efficiency, low body mass and overeating. Endocrinology. 155:2456–2466. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Lauzurica N, García-García L, Pinto S, Fuentes JA and Delgado M: Changes in NPY and POMC, but not serotonin transporter, following a restricted feeding/repletion protocol in rats. Brain Res. 1313:103–112. 2010. View Article : Google Scholar

42 

Corwin RL: The face of uncertainty eats. Curr Drug Abuse Rev. 4:174–181. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Zhao J, Huang X, Xu Z, Dai J, He H, Zhu Y and Wang H: LDHA promotes tumor metastasis by facilitating epithelial mesenchymal transition in renal cell carcinoma. Mol Med Rep. 16:8335–8344. 2017.PubMed/NCBI

44 

Morandi A, Taddei ML, Chiarugi P and Giannoni E: Targeting the metabolic reprogramming that controls epithelial-to-mesenchymal transition in aggressive tumors. Front Oncol. 7:402017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kawahara I, et al: Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model. Int J Oncol 52: 413-423, 2018.
APA
Kusuoka, O., Fujiwara-Tani, R., Nakashima, C., Fujii, K., Ohmori, H., Mori, T. ... Kuniyasu, H. (2018). Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model. International Journal of Oncology, 52, 413-423. https://doi.org/10.3892/ijo.2017.4229
MLA
Kusuoka, O., Fujiwara-Tani, R., Nakashima, C., Fujii, K., Ohmori, H., Mori, T., Kishi, S., Miyagawa, Y., Goto, K., Kawahara, I., Kuniyasu, H."Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model". International Journal of Oncology 52.2 (2018): 413-423.
Chicago
Kusuoka, O., Fujiwara-Tani, R., Nakashima, C., Fujii, K., Ohmori, H., Mori, T., Kishi, S., Miyagawa, Y., Goto, K., Kawahara, I., Kuniyasu, H."Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model". International Journal of Oncology 52, no. 2 (2018): 413-423. https://doi.org/10.3892/ijo.2017.4229
Copy and paste a formatted citation
x
Spandidos Publications style
Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kawahara I, et al: Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model. Int J Oncol 52: 413-423, 2018.
APA
Kusuoka, O., Fujiwara-Tani, R., Nakashima, C., Fujii, K., Ohmori, H., Mori, T. ... Kuniyasu, H. (2018). Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model. International Journal of Oncology, 52, 413-423. https://doi.org/10.3892/ijo.2017.4229
MLA
Kusuoka, O., Fujiwara-Tani, R., Nakashima, C., Fujii, K., Ohmori, H., Mori, T., Kishi, S., Miyagawa, Y., Goto, K., Kawahara, I., Kuniyasu, H."Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model". International Journal of Oncology 52.2 (2018): 413-423.
Chicago
Kusuoka, O., Fujiwara-Tani, R., Nakashima, C., Fujii, K., Ohmori, H., Mori, T., Kishi, S., Miyagawa, Y., Goto, K., Kawahara, I., Kuniyasu, H."Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model". International Journal of Oncology 52, no. 2 (2018): 413-423. https://doi.org/10.3892/ijo.2017.4229
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team