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Article

Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis

  • Authors:
    • Hong-Jun Fei
    • Song-Chang Chen
    • Jun-Yu Zhang
    • Shu-Yuan Li
    • Lan-Lan Zhang
    • Yi-Yao Chen
    • Chun-Xin Chang
    • Chen-Ming Xu
  • View Affiliations / Copyright

    Affiliations: Department of Reproductive Genetics, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P.R. China
  • Pages: 955-966
    |
    Published online on: January 11, 2018
       https://doi.org/10.3892/ijo.2018.4243
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Abstract

The incidence of gastric cancer (GC) is extremely high in East Asia. GC is also one of the most common and lethal forms of cancer from a global perspective. However, to date, we have not been able to determine one or several genes as biomarkers in the diagnosis of GC and have also been unable to identify the genes which are important in the therapy of GC. In this study, we analyzed all genome-wide expression profiling arrays uploaded onto the Gene Expression Omnibus (GEO) database to filtrate the differentially expressed genes (DEGs) between normal stomach tissues and GC tissues. GSE13911, GSE19826 and GSE79973 were based on the GPL570 platform, and GSE29272 was based on the GPL96 platform. We screened out the DEGs from the two platforms and by selecting the intersection of these two platforms, we identified the common DEGs in the sequencing data from different laboratories. Finally, we obtained 3 upregulated and 34 downregulated DEGs in GC from 384 samples. As the number of downregulated DEGs was greater than that of the upregulated DEGs, functional analysis and pathway enrichment analysis were performed on the downregulated DEGs. Through our analysis, we identified the most significant genes associated with GC, such as secreted phosphoprotein 1 (SPP1), sulfatase 1 (SULF1), thrombospondin 2 (THBS2), ATPase H+/K+ transporting beta subunit (ATP4B), gastric intrinsic factor (GIF) and gastrokine 1 (GKN1). The prognostic power of these genes was corroborated in the Oncomine database and by Kaplan-Meier plotter (KM-plotter) analysis. Moreover, gastric acid secretion, collecting duct acid secretion, nitrogen metabolism and drug metabolism were significantly related to GC. Thus, these genes and pathways may be potential targets for improving the diagnosis and clinical effects in patients with GC.
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1 

Lordick F and Terashima M: Gastric cancer adjuvant therapy. Best Pract Res Clin Gastroenterol. 30:581–591. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Yoon H and Kim N: Diagnosis and management of high risk group for gastric cancer. Gut Liver. 9:5–17. 2015. View Article : Google Scholar :

3 

Gong EJ and Kim DH: Endoscopic ultrasonography in the diagnosis of gastric subepithelial lesions. Clin Endosc. 49:425–433. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Xue H, Ge HY, Miao LY, Wang SM, Zhao B, Wang JR and Cui LG: Differential diagnosis of gastric cancer and gastritis: The role of contrast-enhanced ultrasound (CEUS). Abdom Radiol (NY). 42:802–809. 2017. View Article : Google Scholar

5 

Bass AJ, Thorsson V, Shmulevich I, Reynolds SM, Miller M, Bernard B, Hinoue T, Laird PW, Curtis C, Shen H, et al Cancer Genome Atlas Research Network: Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 513:202–209. 2014. View Article : Google Scholar :

6 

Badgwell B: Multimodality therapy of localized gastric adenocarcinoma. J Natl Compr Canc Netw. 14:1321–1327. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Ghadyalpatil NS, Supriya C, Prachi P, Ashwin D and Avanish S: Gastrointestinal cancers in India: Treatment perspective. South Asian J Cancer. 5:126–136. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Pasechnikov V, Chukov S, Fedorov E, Kikuste I and Leja M: Gastric cancer: Prevention, screening and early diagnosis. World J Gastroenterol. 20:13842–13862. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Lazăr DC, Tăban S, Cornianu M, Faur A and Goldiş A: New advances in targeted gastric cancer treatment. World J Gastroenterol. 22:6776–6799. 2016. View Article : Google Scholar

10 

Riquelme I, Saavedra K, Espinoza JA, Weber H, García P, Nervi B, Garrido M, Corvalán AH, Roa JC and Bizama C: Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. Oncotarget. 6:24750–24779. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Kothari N and Almhanna K: Current status of novel agents in advanced gastroesophageal adenocarcinoma. J Gastrointest Oncol. 6:60–74. 2015.PubMed/NCBI

12 

Zhang J, Huang JY, Chen YN, Yuan F, Zhang H, Yan FH, Wang MJ, Wang G, Su M, Lu G, et al: Erratum: Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma. Sci Rep. 5:153092015. View Article : Google Scholar : PubMed/NCBI

13 

Hudler P: Challenges of deciphering gastric cancer heterogeneity. World J Gastroenterol. 21:10510–10527. 2015. View Article : Google Scholar : PubMed/NCBI

14 

DeRisi JL, Iyer VR and Brown PO: Exploring the metabolic and genetic control of gene expression on a genomic scale. Science. 278:680–686. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, et al: Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring. Science. 286:531–537. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets - update. Nucleic Acids Res. 41:D991–D995. 2013. View Article : Google Scholar

17 

Ogata H, Goto S, Sato K, Fujibuchi W, Bono H and Kanehisa M: KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 27:29–34. 1999. View Article : Google Scholar

18 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Gyorffy B, Lánczky A and Szállási Z: Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer. 19:197–208. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Györffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q and Szallasi Z: An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 123:725–731. 2010. View Article : Google Scholar

22 

Correa P: A human model of gastric carcinogenesis. Cancer Res. 48:3554–3560. 1988.PubMed/NCBI

23 

Holbrook JD, Parker JS, Gallagher KT, Halsey WS, Hughes AM, Weigman VJ, Lebowitz PF and Kumar R: Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine. J Transl Med. 9:1192011. View Article : Google Scholar : PubMed/NCBI

24 

Lim B, Kim JH, Kim M and Kim SY: Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer. World J Gastroenterol. 22:1190–1201. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Pfeifer SP: From next-generation resequencing reads to a high-quality variant data set. Hered Edinb. 118:111–124. 2017. View Article : Google Scholar

26 

Raja UM, Gopal G and Rajkumar T: Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker. Asian Pac J Cancer Prev. 13:5563–5568. 2012. View Article : Google Scholar

27 

Yang M, Jiang N, Cao QW, Ma MQ and Sun Q: The E3 ligase UBR5 regulates gastric cancer cell growth by destabilizing the tumor suppressor GKN1. Biochem Biophys Res Commun. 478:1624–1629. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Yoon JH, Choi WS, Kim O, Choi BJ, Nam SW, Lee JY and Park WS: Gastrokine 1 inhibits gastric cancer cell migration and invasion by downregulating RhoA expression. Gastric Cancer. 20:274–285. 2017. View Article : Google Scholar

29 

Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY and Park WS: Gastrokine 1 inhibits gastrin-induced cell proliferation. Gastric Cancer. 19:381–391. 2016. View Article : Google Scholar

30 

Xing R, Cui JT, Xia N and Lu YY: GKN1 inhibits cell invasion in gastric cancer by inactivating the NF-kappaB pathway. Discov Med. 19:65–71. 2015.PubMed/NCBI

31 

Wu W, Juan WC, Liang CR, Yeoh KG, So J and Chung MC: S100A9, GIF and AAT as potential combinatorial biomarkers in gastric cancer diagnosis and prognosis. Proteomics Clin Appl. 6:152–162. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Kong Y, Zheng Y, Jia Y, Li P and Wang Y: Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer. Oncol Rep. 36:1852–1860. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Wang D, Yu X and Wang X: High/positive expression of 5-fluorouracil metabolic enzymes predicts better response to S-1 in patients with gastric cancer: A meta-analysis. Int J Biol Markers. 31:e101–e109. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Hunt RH, Camilleri M, Crowe SE, El-Omar EM, Fox JG, Kuipers EJ, Malfertheiner P, McColl KE, Pritchard DM, Rugge M, et al: The stomach in health and disease. Gut. 64:1650–1668. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Di Mario F and Goni E: Gastric acid secretion: Changes during a century. Best Pract Res Clin Gastroenterol. 28:953–965. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Martinsen TC, Bergh K and Waldum HL: Gastric juice: A barrier against infectious diseases. Basic Clin Pharmacol Toxicol. 96:94–102. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Modlin IM, Sachs G, Wright N and Kidd M: Edkins and a century of acid suppression. Digestion. 72:129–145. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Wagner CA and Geibel JP: Acid-base transport in the collecting duct. J Nephrol. 15(Suppl 5): S112–S127. 2002.PubMed/NCBI

39 

Alper SL: Genetic diseases of acid-base transporters. Annu Rev Physiol. 64:899–923. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Li JH, Han L, Du TP and Guo MJ: The effect of low-nitrogen and low-calorie parenteral nutrition combined with enteral nutrition on inflammatory cytokines and immune functions in patients with gastric cancer: A double blind placebo trial. Eur Rev Med Pharmacol Sci. 19:1345–1350. 2015.PubMed/NCBI

41 

Ishizuka M, Oyama Y, Abe A, Tago K, Tanaka G and Kubota K: Prognostic nutritional index is associated with survival after total gastrectomy for patients with gastric cancer. Anticancer Res. 34:4223–4229. 2014.PubMed/NCBI

42 

Tegels JJ, De Maat MF, Hulsewé KW, Hoofwijk AG and Stoot JH: Improving the outcomes in gastric cancer surgery. World J Gastroenterol. 20:13692–13704. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Sun K, Chen S, Xu J, Li G and He Y: The prognostic significance of the prognostic nutritional index in cancer: A systematic review and meta-analysis. J Cancer Res Clin Oncol. 140:1537–1549. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Kang C, Song JJ, Lee J and Kim MY: Epigenetics: An emerging player in gastric cancer. World J Gastroenterol. 20:6433–6447. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fei H, Chen S, Zhang J, Li S, Zhang L, Chen Y, Chang C and Xu C: Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis. Int J Oncol 52: 955-966, 2018.
APA
Fei, H., Chen, S., Zhang, J., Li, S., Zhang, L., Chen, Y. ... Xu, C. (2018). Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis. International Journal of Oncology, 52, 955-966. https://doi.org/10.3892/ijo.2018.4243
MLA
Fei, H., Chen, S., Zhang, J., Li, S., Zhang, L., Chen, Y., Chang, C., Xu, C."Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis". International Journal of Oncology 52.3 (2018): 955-966.
Chicago
Fei, H., Chen, S., Zhang, J., Li, S., Zhang, L., Chen, Y., Chang, C., Xu, C."Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis". International Journal of Oncology 52, no. 3 (2018): 955-966. https://doi.org/10.3892/ijo.2018.4243
Copy and paste a formatted citation
x
Spandidos Publications style
Fei H, Chen S, Zhang J, Li S, Zhang L, Chen Y, Chang C and Xu C: Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis. Int J Oncol 52: 955-966, 2018.
APA
Fei, H., Chen, S., Zhang, J., Li, S., Zhang, L., Chen, Y. ... Xu, C. (2018). Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis. International Journal of Oncology, 52, 955-966. https://doi.org/10.3892/ijo.2018.4243
MLA
Fei, H., Chen, S., Zhang, J., Li, S., Zhang, L., Chen, Y., Chang, C., Xu, C."Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis". International Journal of Oncology 52.3 (2018): 955-966.
Chicago
Fei, H., Chen, S., Zhang, J., Li, S., Zhang, L., Chen, Y., Chang, C., Xu, C."Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis". International Journal of Oncology 52, no. 3 (2018): 955-966. https://doi.org/10.3892/ijo.2018.4243
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