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miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway

  • Authors:
    • Manman Xu
    • Juan Xiao
    • Ming Chen
    • Linjing Yuan
    • Jundong Li
    • Hongwei Shen
    • Shuzhong Yao
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510700, P.R. China, Department of Cancer Prevention, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Gynecology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 815-827
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    Published online on: January 24, 2018
       https://doi.org/10.3892/ijo.2018.4252
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Abstract

Chemotherapeutic resistance remains a critical clinical issue is responsible for treatment failure in patients with ovarian cancer. Evidence of the involvement of miRNAs in chemoresistance in ovarian cancer has been recently emerging. However, the underlying molecular links between chemoresistance and miRNAs remain largely unknown. In this study, we report that miR‑149‑5p expression is markedly elevated in chemoresistant ovarian cancer tissues compared with the chemosensitive ovarian cancer tissues. Furthermore, the silencing of miR‑149‑5p enhanced the chemosensitivity of ovarian cancer cells to cisplatin in vitro and in vivo. Conversely, the upregulation of miR‑149‑5p aggravated chemoresistance in ovarian cancer cells. Our results further revealed that miR‑149‑5p directly targeted the core kinase components of the Hippo signaling pathway, STE20-like kinase (MST)1 and protein salvador homolog 1 (SAV1), resulting in the inactivation of TEA domain (TEAD) transcription. On the whole, our findings reveal a novel mechanism of of action miR‑149‑5p in inducing chemotherapeutic resistance in ovarian cancer, indicating that miR‑149‑5p may serve as a chemotherapeutic response indicator and a potential therapeutic target in ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Xu M, Xiao J, Chen M, Yuan L, Li J, Shen H and Yao S: miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. Int J Oncol 52: 815-827, 2018.
APA
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., & Yao, S. (2018). miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. International Journal of Oncology, 52, 815-827. https://doi.org/10.3892/ijo.2018.4252
MLA
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., Yao, S."miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway". International Journal of Oncology 52.3 (2018): 815-827.
Chicago
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., Yao, S."miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway". International Journal of Oncology 52, no. 3 (2018): 815-827. https://doi.org/10.3892/ijo.2018.4252
Copy and paste a formatted citation
x
Spandidos Publications style
Xu M, Xiao J, Chen M, Yuan L, Li J, Shen H and Yao S: miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. Int J Oncol 52: 815-827, 2018.
APA
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., & Yao, S. (2018). miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. International Journal of Oncology, 52, 815-827. https://doi.org/10.3892/ijo.2018.4252
MLA
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., Yao, S."miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway". International Journal of Oncology 52.3 (2018): 815-827.
Chicago
Xu, M., Xiao, J., Chen, M., Yuan, L., Li, J., Shen, H., Yao, S."miR‑149‑5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway". International Journal of Oncology 52, no. 3 (2018): 815-827. https://doi.org/10.3892/ijo.2018.4252
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