Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
April-2018 Volume 52 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 52 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1

  • Authors:
    • Jin Liu
    • Mingpeng Li
    • Xiancheng Liu
    • Fan Liu
    • Jianwei Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 1295-1304
    |
    Published online on: February 14, 2018
       https://doi.org/10.3892/ijo.2018.4275
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteosarcoma has become one of the most common primary malignant tumors affecting children and adolescents. Although increasing evidence has indicated that microRNAs (miRNAs or miRs) play important roles in the development of osteosarcoma, the expression of miR‑27a‑3p and its effects on osteosarcoma are not yet fully understood. In the present study, our data demonstrated that the expression of miR‑27a‑3p in osteosarcoma cell lines was significantly higher than that in the normal human osteoblastic cell line, hFOB 1.19 cell (P<0.01). In order to explore the role of miR‑27a‑3p in the development and progression of osteosarcoma, the expression of miR‑27a‑3p was inhibited by transfection of the MG-63 cells with miR‑27a‑3p inhibitor. The results revealed that the cell proliferative ability significantly decreased (P<0.01), the number of apoptotic cells significantly increased (P<0.01) and the number of cells passing through the Transwell membrane was significantly reduced in the group transfected with the miR‑27a‑3p inhibitor (P<0.01). At the same time, the expression of E-cadherin and α-catenin was significantly upregulated (P<0.01), while the expression of vimentin was significantly downregulated in the group transfected with the miR‑27a‑3p inhibitor (P<0.01). Our results also revealed that the mRNA expression of ten-eleven translocation 1 (TET1) in the osteosarcoma cells was significantly downregulated compared with that in the hFOB 1.19 cells (P<0.01). Luciferase reporter system analysis indicated that miR‑27a‑3p recognized the TET1 3'-UTR. The protein expression of TET1 significantly increased in the group transfected with the miR‑27a‑3p inhibitor. The results from CCK-8 assay, flow cytometric assay and Transwell invasion analysis revealed that TET1 knockdown inhibited the biological effects induced by the downregulation of miR‑27a‑3p. Taken together, the findings of this study indicate that miR‑27a‑3p is upregulated, while TET1 is downregulated in human osteosarcoma cells. miR‑27a‑3p inhibition suppresses the proliferation and invasion of osteosarcoma cells, and promotes cell apoptosis via the negative regulation of TET1. miR‑27a‑3p/TET1 may thus be a potential target for the treatment of osteosarcoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Bilbao-Aldaiturriaga N, Askaiturrieta Z, Granado-Tajada I, Goričar K, Dolžan V, Garcia-Miguel P, Garcia de Andoin N, Martin-Guerrero I and Garcia-Orad A; For The Slovenian Osteosarcoma Study Group: A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility. Pediatr Res. 80:472–479. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Anderson PM, Bielack SS, Gorlick RG, Skubitz K, Daw NC, Herzog CE, Monge OR, Lassaletta A, Boldrini E, Pápai Z, et al: A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma. Pediatr Blood Cancer. 63:1761–1770. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Nikitovic D, Kavasi RM, Berdiaki A, Papachristou DJ, Tsiaoussis J, Spandidos DA, Tsatsakis AM and Tzanakakis GN: Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review). Oncol Rep. 36:1787–1792. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Liao LQ, Yan HH, Mai JH, Liu WW, Li H, Guo ZM, Zeng ZY and Liu XK: Radiation-induced osteosarcoma of the maxilla and mandible after radiotherapy for nasopharyngeal carcinoma. Chin J Cancer. 35:892016. View Article : Google Scholar : PubMed/NCBI

5 

Bami M, Mavrogenis AF, Angelini A, Milonaki M, Mitsiokapa E, Stamoulis D and Soucacos PN: Bone morphogenetic protein signaling in musculoskeletal cancer. J Cancer Res Clin Oncol. 142:2061–2072. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Angelini A, Mavrogenis AF, Trovarelli G, Ferrari S, Picci P and Ruggieri P: Telangiectatic osteosarcoma: A review of 87 cases. J Cancer Res Clin Oncol. 142:2197–2207. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Wang Z, Li B, Ren Y and Ye Z: T-cell-based immunotherapy for osteosarcoma: Challenges and opportunities. Front Immunol. 7:3532016. View Article : Google Scholar : PubMed/NCBI

8 

Osasan S, Zhang M, Shen F, Paul PJ, Persad S and Sergi C: Osteogenic sarcoma: A 21st century review. Anticancer Res. 36:4391–4398. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Nataraj V, Rastogi S, Khan SA, Sharma MC, Agarwala S, Vishnubhatla S and Bakhshi S: Prognosticating metastatic osteosarcoma treated with uniform chemotherapy protocol without high dose methotrexate and delayed metastasectomy: A single center experience of 102 patients. Clin Transl Oncol. 18:937–944. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hu K, Dai HB and Qiu ZL: mTOR signaling in osteosarcoma: Oncogenesis and therapeutic aspects (Review). Oncol Rep. 36:1219–1225. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Lee JA, Jeon DG, Cho WH, Song WS, Yoon HS, Park HJ, Park BK, Choi HS, Ahn HS, Lee JW, et al: Higher gemcitabine dose was associated with better outcome of osteosarcoma patients receiving gemcitabine-docetaxel chemotherapy. Pediatr Blood Cancer. 63:1552–1556. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Kebudi R, Ozger H, Kızılocak H, Bay SB and Bilgiç B: Osteosarcoma after hematopoietic stem cell transplantation in children and adolescents: Case report and review of the literature. Pediatr Blood Cancer. 63:1664–1666. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Adamopoulos C, Gargalionis AN, Piperi C and Papavassiliou AG: Recent advances in mechanobiology of osteosarcoma. J Cell Biochem. 118:232–236. 2017. View Article : Google Scholar

14 

Li CJ, Liu XZ, Zhang L, Chen LB, Shi X, Wu SJ and Zhao JN: Advances in bone-targeted drug delivery systems for neoadjuvant chemotherapy for osteosarcoma. Orthop Surg. 8:105–110. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Abarrategi A, Tornin J, Martinez-Cruzado L, Hamilton A, Martinez-Campos E, Rodrigo JP, González MV, Baldini N, Garcia-Castro J and Rodriguez R: Osteosarcoma: Cells-of-origin, cancer stem cells, and targeted therapies. Stem Cells Int. 2016:36317642016. View Article : Google Scholar : PubMed/NCBI

16 

Wang SD, Li HY, Li BH, Xie T, Zhu T, Sun LL, Ren HY and Ye ZM: The role of CTLA-4 and PD-1 in anti-tumor immune response and their potential efficacy against osteosarcoma. Int Immunopharmacol. 38:81–89. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Ding L, Congwei L, Bei Q, Tao Y, Ruiguo W, Heze Y, Bo D and Zhihong L: mTOR: An attractive therapeutic target for osteosarcoma? Oncotarget. 7:50805–50813. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Ravindra VM, Eli IM, Schmidt MH and Brockmeyer DL: Primary osseous tumors of the pediatric spinal column: Review of pathology and surgical decision making. Neurosurg Focus. 41:E32016. View Article : Google Scholar : PubMed/NCBI

19 

Hurley C, McCarville MB, Shulkin BL, Mao S, Wu J, Navid F, Daw NC, Pappo AS and Bishop MW: Comparison of (18) F-FDG-PET-CT and bone scintigraphy for evaluation of osseous metastases in newly diagnosed and recurrent osteosarcoma. Pediatr Blood Cancer. 63:1381–1386. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Kulcheski FR, Christoff AP and Margis R: Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 238:42–51. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Stope MB, Koensgen D, Weimer J, Paditz M, Burchardt M, Bauerschlag D and Mustea A: The future therapy of endometrial cancer: microRNA's functionality, capability, and putative clinical application. Arch Gynecol Obstet. 294:889–895. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Fang Q, Xu T, Wu C, Zhou S and Sun H: Biotargets in neural regeneration. Biotarget. 1:62017. View Article : Google Scholar

23 

Wang DD, Chen X, Yu DD, Yang SJ, Shen HY, Sha HH, Zhong SL, Zhao JH and Tang JH: miR-197: A novel biomarker for cancers. Gene. 591:313–319. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Yang C, Zheng SD, Wu HJ and Chen SJ: Regulatory mechanisms of the molecular pathways in fibrosis induced by microRNAs. Chin Med J (Engl). 129:2365–2372. 2016. View Article : Google Scholar

25 

Lee K and Ferguson LR: MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer. World J Gastroenterol. 22:7389–7401. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Matin F, Jeet V, Clements JA, Yousef GM and Batra J: MicroRNA theranostics in prostate cancer precision medicine. Clin Chem. 62:1318–1333. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Rajasekaran S, Pattarayan D, Rajaguru P, Sudhakar Gandhi PS and Thimmulappa RK: MicroRNA regulation of acute lung injury and acute respiratory distress syndrome. J Cell Physiol. 231:2097–2106. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Connelly CM, Moon MH and Schneekloth JS Jr: The emerging role of RNA as a therapeutic target for small molecules. Cell Chem Biol. 23:1077–1090. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Li Y, Li J, Sun X, Chen J, Sun X, Zheng J and Chen R: MicroRNA-27a functions as a tumor suppressor in renal cell carcinoma by targeting epidermal growth factor receptor. Oncol Lett. 11:4217–4223. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Chen S, Sun YY, Zhang ZX, Li YH, Xu ZM and Fu WN: Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway. Oncotarget. 8:14708–14718. 2017.PubMed/NCBI

31 

Jiang H, Zhang G, Wu JH and Jiang CP: Diverse roles of miR-29 in cancer (review). Oncol Rep. 31:1509–1516. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Kollinerova S, Vassanelli S and Modriansky M: The role of miR-29 family members in malignant hematopoiesis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 158:489–501. 2014.PubMed/NCBI

33 

Pan W, Wang H, Jianwei R and Ye Z: MicroRNA-27a promotes proliferation, migration and invasion by targeting MAP2K4 in human osteosarcoma cells. Cell Physiol Biochem. 33:402–412. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Zhou L, Liang X, Zhang L, Yang L, Nagao N, Wu H, Liu C, Lin S, Cai G and Liu J: miR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2. Oncotarget. 7:51943–51954. 2016.PubMed/NCBI

35 

Hu D and Shilatifard A: Epigenetics of hematopoiesis and hematological malignancies. Genes Dev. 30:2021–2041. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, et al: Oncogenic EGFR represses the TET1 DNA demethylase to induce silencing of tumor suppressors in cancer cells. Cell Reports. 16:457–471. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Li L, Li C, Mao H, Du Z, Chan WY, Murray P, Luo B, Chan AT, Mok TS, Chan FK, et al: Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Sci Rep. 6:265912016. View Article : Google Scholar : PubMed/NCBI

38 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

39 

Zhou K, Liu M and Cao Y: New insight into microRNA functions in cancer: Oncogene-microRNA-tumor suppressor gene network. Front Mol Biosci. 4:462017. View Article : Google Scholar : PubMed/NCBI

40 

Kaur S, Lotsari-Salomaa JE, Seppänen-Kaijansinkko R and Peltomäki P: MicroRNA methylation in colorectal cancer. Adv Exp Med Biol. 937:109–122. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Tang W, Zhu J, Su S, Wu W, Liu Q, Su F and Yu F: miR-27 as a prognostic marker for breast cancer progression and patient survival. PLoS One. 7:e517022012. View Article : Google Scholar : PubMed/NCBI

42 

Tanaka K, Miyata H, Sugimura K, Fukuda S, Kanemura T, Yamashita K, Miyazaki Y, Takahashi T, Kurokawa Y, Yamasaki M, et al: miR-27 is associated with chemoresistance in esophageal cancer through transformation of normal fibroblasts to cancer-associated fibroblasts. Carcinogenesis. 36:894–903. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Colangelo T, Polcaro G, Ziccardi P, Pucci B, Muccillo L, Galgani M, Fucci A, Milone MR, Budillon A, Santopaolo M, et al: Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer. Cell Death Dis. 7:e21202016. View Article : Google Scholar : PubMed/NCBI

44 

Zhou S, Huang Q, Zheng S, Lin K, You J and Zhang X: miR-27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK-SMAC/DIABLO-XIAP axis. Tumour Biol. 37:6837–6845. 2016. View Article : Google Scholar

45 

Mirabello L, Koster R, Moriarity BS, Spector LG, Meltzer PS, Gary J, Machiela MJ, Pankratz N, Panagiotou OA, Largaespada D, et al: A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma. Cancer Discov. 5:920–931. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Lv YF, Dai H, Yan GN, Meng G, Zhang X and Guo QN: Downregulation of tumor suppressing STF cDNA 3 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by the Wnt/GSK-3β/β-catenin/Snail signaling pathway. Cancer Lett. 373:164–173. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Wu Y and Jiang M: The revolution of lung cancer treatment: From vaccines, to immune checkpoint inhibitors, to chimeric antigen receptor T therapy. Biotarget. 1:72017. View Article : Google Scholar

48 

Sun L and Fang J: Epigenetic regulation of epithelial-mesenchymal transition. Cell Mol Life Sci. 73:4493–4515. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Tufekci KU, Oner MG, Genc S and Genc K: MicroRNAs and multiple sclerosis. Autoimmune Dis. 2011:8074262010.PubMed/NCBI

50 

Lu HG, Zhan W, Yan L, Qin RY, Yan YP, Yang ZJ, Liu GC, Li GQ, Wang HF, Li XL, et al: TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion. Mol Med Rep. 10:2595–2600. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Li M, Liu X, Liu F and Zhu J: miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1. Int J Oncol 52: 1295-1304, 2018.
APA
Liu, J., Li, M., Liu, X., Liu, F., & Zhu, J. (2018). miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1. International Journal of Oncology, 52, 1295-1304. https://doi.org/10.3892/ijo.2018.4275
MLA
Liu, J., Li, M., Liu, X., Liu, F., Zhu, J."miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1". International Journal of Oncology 52.4 (2018): 1295-1304.
Chicago
Liu, J., Li, M., Liu, X., Liu, F., Zhu, J."miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1". International Journal of Oncology 52, no. 4 (2018): 1295-1304. https://doi.org/10.3892/ijo.2018.4275
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Li M, Liu X, Liu F and Zhu J: miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1. Int J Oncol 52: 1295-1304, 2018.
APA
Liu, J., Li, M., Liu, X., Liu, F., & Zhu, J. (2018). miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1. International Journal of Oncology, 52, 1295-1304. https://doi.org/10.3892/ijo.2018.4275
MLA
Liu, J., Li, M., Liu, X., Liu, F., Zhu, J."miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1". International Journal of Oncology 52.4 (2018): 1295-1304.
Chicago
Liu, J., Li, M., Liu, X., Liu, F., Zhu, J."miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1". International Journal of Oncology 52, no. 4 (2018): 1295-1304. https://doi.org/10.3892/ijo.2018.4275
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team