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Article

miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling

  • Authors:
    • You-Jie Li
    • Yun-Xiao Sun
    • Rui-Min Hao
    • Pin Wu
    • Li-Jun Zhang
    • Xu Ma
    • Ying Ma
    • Ping-Yu Wang
    • Ning Xie
    • Shu-Yang Xie
    • Wei Chen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Pediatrics, The Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong 264003, P.R. China, Department of Chest Surgery, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China
  • Pages: 1328-1338
    |
    Published online on: February 14, 2018
       https://doi.org/10.3892/ijo.2018.4276
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Abstract

MicroRNAs (miRNAs or miRs) have recently become a popular focus of cancer research due to their ability to act as oncogenes or tumor suppressors. In the present study, miR‑33a‑5p expression was identified to be downregulated in lung adenocarcinoma samples compared with normal, which suggested that miR‑33a‑5p may serve as a tumor suppressor gene. Transfection with miR‑33a‑5p mimics inhibited the proliferation and migration of A549 and LTEP‑a‑2 cells and increased cellular apoptosis. A luciferase reporter assay confirmed that miR‑33a‑5p targets the 3'‑untranslated region of the mechanistic target of rapamycin (mTOR) gene. mTOR expression was decreased in A549 and LTEP‑a‑2 cells treated with miR‑33a‑5p mimics, as well as the expression of its downstream effectors phosphorylated (p)‑p70 ribosomal protein S6 kinase (p70S6K) and p‑eukaryotic translation initiation factor 4E binding protein 1 (4EBP1). Following treatment with celastrol, miR‑33a‑5p expression was upregulated, and miR‑33a‑5p could enhance cellular sensitivity to celastrol. Western blot analysis revealed that the expression of mTOR, p‑p70S6K and p‑4EBP1 decreased following celastrol treatment. These results suggested that mTOR was involved in the mechanism by which miR‑33a‑5p enhanced the sensitivity of lung adenocarcinoma cells to celastrol. Furthermore, LTEP‑a‑2 cells were xenografted subcutaneously into nude mice, to examine the effect of celastrol and miR‑33a‑5p on the growth of LTEP‑a‑2 cells in vivo. The results demonstrated that tumor growth in the celastrol‑treated or miR‑33a‑5p‑treated group was attenuated compared with the control group. Notably, tumor growth in the combination treatment group was almost arrested after 2 weeks. In addition, celastrol upregulated the expression of miR‑33a‑5p, and high expression of miR‑33a‑5p inhibited mTOR and its downstream effectors. In summary, miR‑33a‑5p inhibited the proliferation of lung adenocarcinoma cells, enhanced the antitumor effect of celastrol, and improved sensitivity to celastrol by targeting mTOR in lung adenocarcinoma in vitro and in vivo.
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View References

1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, et al: Non-small cell lung cancer, version 1. J Natl Compr Canc Netw. 12:1738–1761. 2015. View Article : Google Scholar

3 

Tan CS, Gilligan D and Pacey S: Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer. Lancet Oncol. 16:e447–e459. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Zhang C, Zhang Y, Ding W, Lin Y, Huang Z and Luo Q: MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1. Protein Cell. 6:881–889. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Pu M, Li C, Qi X, Chen J, Wang Y, Gao L, Miao L and Ren J: MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth. PLoS Genet. 13:e10068962017. View Article : Google Scholar : PubMed/NCBI

6 

Guo X, Zhu Y and Hong X, Zhang M, Qiu X, Wang Z, Qi Z and Hong X: miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer. Cell Death Dis. 8:e29582017. View Article : Google Scholar : PubMed/NCBI

7 

Azmi AS, Li Y, Muqbil I, Aboukameel A, Senapedis W, Baloglu E, Landesman Y, Shacham S, Kauffman MG, Philip PA, et al: Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration. Oncotarget. 8:82144–82155. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Liu Z, Sun F, Hong Y, Liu Y, Fen M, Yin K, Ge X, Wang F, Chen X and Guan W: MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells. Mol Cancer. 16:1332017. View Article : Google Scholar : PubMed/NCBI

9 

Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE and Näär AM: MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 328:1566–1569. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Mao M, Lei H, Liu Q, Chen Y, Zhao L, Li Q, Luo S, Zuo Z, He Q, Huang W, et al: Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages. PLoS One. 9:e1097222014. View Article : Google Scholar : PubMed/NCBI

11 

Yang L, Yang J, Li J, Shen X, Le Y, Zhou C, Wang S, Zhang S, Xu D and Gong Z: MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer. Sci Rep. 5:136772015. View Article : Google Scholar : PubMed/NCBI

12 

Xu Y, Xia F, Ma L, Shan J, Shen J, Yang Z, Liu J, Cui Y, Bian X, Bie P, et al: MicroRNA-122 sensitizes HCC cancer cells to adri-amycin and vincristinethrough modulating expression of MDR and inducing cell cycle arrest. Cancer Lett. 310:160–169. 2011.PubMed/NCBI

13 

Zhu X, Li Y, Xie C, Yin X, Liu Y, Cao Y, Fang Y, Lin X, Xu Y, Xu W, et al: miR-145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6. Int J Cancer. 135:1286–1296. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Wang R, Gu X, Dai W, Ye J, Lu F, Chai Y, Fan G, Gonzalez FJ, Duan G and Qi Y: A lipidomics investigation into the intervention of celastrol in experimental colitis. Mol Biosyst. 12:1436–1444. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Yang L, Li Y, Ren J, Zhu C, Fu J, Lin D and Qiu Y: Celastrol attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2. Int J Mol Sci. 15:13637–13648. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Gu L, Bai W, Li S, Zhang Y, Han Y, Gu Y, Meng G, Xie L, Wang J, Xiao Y, et al: Celastrol prevents atherosclerosis via inhibiting LOX-1 and oxidative stress. PLoS One. 8:e654772013. View Article : Google Scholar : PubMed/NCBI

17 

Chang W, He W, Li PP, Song SS, Yuan PF, Lu JT and Wei W: Protective effects of celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. Eur J Pharmacol. 784:173–180. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Shao L, Zhou Z, Cai Y, Castro P, Dakhov O, Shi P, Bai Y, Ji H, Shen W and Wang J: Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer. PLoS One. 8:e583912013. View Article : Google Scholar

19 

Yang HS, Kim JY, Lee JH, Lee BW, Park KH, Shim KH, Lee MK and Seo KI: Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells. Food Chem Toxicol. 49:527–532. 2011. View Article : Google Scholar

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) methods. Methods. 25:402–408. 2001. View Article : Google Scholar

21 

Zhang X, Chen S and Wang Y: Honokiol up-regulates prostacyclin synthease protein expression and inhibits endothelial cell apoptosis. Eur J Pharmacol. 554:1–7. 2007. View Article : Google Scholar

22 

Labak CM, Wang PY, Arora R, Guda MR, Asuthkar S, Tsung AJ and Velpula KK: Glucose transport: Meeting the metabolic demands of cancer, and applications in glioblastoma treatment. Am J Cancer Res. 6:1599–1608. 2016.PubMed/NCBI

23 

Jiang R, Zhang C, Liu G, Gu R and Wu H: MicroRNA-101 inhibits proliferation, migration and invasion in osteosarcoma cells by targeting ROCK1. Am J Cancer Res. 7:88–97. 2017.PubMed/NCBI

24 

Baranwal and Alahari SK: miRNA control of tumor cell invasion and metastasis. Int J Cancer. 126:1283–1290. 2010.

25 

Li H, Chen H, Wang H, Dong Y, Yin M, Zhang L and Wei J: MicroRNA-374a promotes hepatocellular carcinoma cell proliferation by targeting mitogen-inducible gene-6 (MIG-6). Oncol Res. Jul 21–2017.Epub ahead of print. View Article : Google Scholar

26 

Wang X, Bu J, Liu X, Wang W, Mai W, Lv B, Zou J, Mo X, Li X, Wang J, et al: miR-133b suppresses metastasis by targeting HOXA9 in human colorectal cancer. Oncotarget. 8:63935–63948. 2017.PubMed/NCBI

27 

Lu Y, Qin T, Li J, Wang L, Zhang Q, Jiang Z and Mao J: MicroRNA-140-5p inhibits invasion and angiogenesis through targeting VEGF-A in breast cancer. Cancer Gene Ther. 24:386–392. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Wang Y, Zhou X, Shan B, Han J, Wang F, Fan X, Lv Y, Chang L and Liu W: Downregulation of microRNA-33a promotes cyclin-dependent kinase 6, cyclin D1 and PIM1 expression and gastric cancer cell proliferation. Mol Med Rep. 12:6491–6500. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Chang W, Zhang L, Xian Y and Yu Z: MicroRNA-33a promotes cell proliferation and inhibits apoptosis by targeting PPARα in human hepatocellular carcinoma. Exp Ther Med. 13:2507–2514. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Wei F, Ma C, Zhou T, Dong X, Luo Q, Geng L, Ding L, Zhang Y, Zhang L, Li N, et al: Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p. Mol Cancer. 16:1322017. View Article : Google Scholar : PubMed/NCBI

31 

Li JA, Wang YD, Wang K, Wang ZL, Jia DY, Yang BY and Xiong CB: Downregulation of miR-214-3p may contribute to pathogenesis of ulcerative colitis via targeting STAT6. BioMed Res Int. 2017:85249722017.PubMed/NCBI

32 

Perl A: mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging. Ann NY Acad Sci. 1346:33–44. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, Majchrzak B, Sonenberg N, Hay N, Fish EN and Platanias LC: Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem. 278:27772–27780. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Mi C, Ma J, Wang KS, Zuo HX, Wang Z, Li MY, Piao LX, Xu GH, Li X, Quan ZS, et al: Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways. J Ethnopharmacol. 203:27–38. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Karatas OF, Wang J, Shao L, Ozen M, Zhang Y, Creighton CJ and Ittmann M: miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer. Oncotarget. 8:60243–60256. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Tian F, Wei H, Tian H, Qiu Y and Xu J: miR-33a is downregulated in melanoma cells and modulates cell proliferation by targeting PCTAIRE1. Oncol Lett. 11:2741–2746. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Kuo PL, Liao SH, Hung JY, Huang MS and Hsu YL: MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein. Biochim Biophys Acta. 1830:3756–3766. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Guo J, Mei Y, Li K, Huang X and Yang H: Downregulation of miR-17-92a cluster promotes autophagy induction in response to celastrol treatment in prostate cancer cells. Biochem Biophys Res Commun. 478:804–810. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Li H, Li Y, Liu D, Sun H and Liu J: miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells. Cell Physiol Biochem. 32:448–458. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Lu W, Hu Y, Ma Q, Zhou L, Jiang L, Li Z, Zhao S, Xu Y, Shi W, Li S, et al: miR-223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1. Oncotarget. 7:62364–62376. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Chen LG, Xia YJ and Cui Y: Upregulation of miR-101 enhances the cytotoxic effect of anticancer drugs through inhibition of colon cancer cell proliferation. Oncol Rep. 38:100–108. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Asukai K, Kawamoto K, Eguchi H, Konno M, Asai A, Iwagami Y, Yamada D, Asaoka T, Noda T, Wada H, et al: Micro-RNA-130a-3p regulates gemcitabine resistance via PPARG in cholangiocarcinoma. Ann Surg Oncol. 24:2344–2352. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Sun Y, Hao R, Wu P, Zhang L, Ma X, Ma Y, Wang P, Xie N, Xie S, Xie S, et al: miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling. Int J Oncol 52: 1328-1338, 2018.
APA
Li, Y., Sun, Y., Hao, R., Wu, P., Zhang, L., Ma, X. ... Chen, W. (2018). miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling. International Journal of Oncology, 52, 1328-1338. https://doi.org/10.3892/ijo.2018.4276
MLA
Li, Y., Sun, Y., Hao, R., Wu, P., Zhang, L., Ma, X., Ma, Y., Wang, P., Xie, N., Xie, S., Chen, W."miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling". International Journal of Oncology 52.4 (2018): 1328-1338.
Chicago
Li, Y., Sun, Y., Hao, R., Wu, P., Zhang, L., Ma, X., Ma, Y., Wang, P., Xie, N., Xie, S., Chen, W."miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling". International Journal of Oncology 52, no. 4 (2018): 1328-1338. https://doi.org/10.3892/ijo.2018.4276
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Sun Y, Hao R, Wu P, Zhang L, Ma X, Ma Y, Wang P, Xie N, Xie S, Xie S, et al: miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling. Int J Oncol 52: 1328-1338, 2018.
APA
Li, Y., Sun, Y., Hao, R., Wu, P., Zhang, L., Ma, X. ... Chen, W. (2018). miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling. International Journal of Oncology, 52, 1328-1338. https://doi.org/10.3892/ijo.2018.4276
MLA
Li, Y., Sun, Y., Hao, R., Wu, P., Zhang, L., Ma, X., Ma, Y., Wang, P., Xie, N., Xie, S., Chen, W."miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling". International Journal of Oncology 52.4 (2018): 1328-1338.
Chicago
Li, Y., Sun, Y., Hao, R., Wu, P., Zhang, L., Ma, X., Ma, Y., Wang, P., Xie, N., Xie, S., Chen, W."miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling". International Journal of Oncology 52, no. 4 (2018): 1328-1338. https://doi.org/10.3892/ijo.2018.4276
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