Downregulation of SOX3 leads to the inhibition of the proliferation, migration and invasion of osteosarcoma cells

  • Authors:
    • Yanjie Guo
    • Jimin Yin
    • Mingjie Tang
    • Xingang Yu
  • View Affiliations

  • Published online on: February 20, 2018     https://doi.org/10.3892/ijo.2018.4278
  • Pages: 1277-1284
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Sex determining region Y-box protein 3 (SOX3) is involved in embryonic development and tumorigenesis. However, the expression and precise role of SOX3 in osteosarcoma remain unclear. In this study, we reported that SOX3 expression was upregulated in osteosarcoma tissues compared with non-cancerous bone cyst tissues. To elucidate the cellular and molecular function of SOX3, we examined the consequences of SOX3 knockdown in osteosarcoma cells. We found that the downregulation of SOX3 inhibited the proliferation, migration and invasion of osteosarcoma cells. SOX3 downregulation also increased the cell population in the G1 phase and induced cell apoptosis. SOX3 knockdown-mediated cell cycle arrest and cell apoptosis were associated with decreased levels of Cdc25A, cyclin D1, proliferating cell nuclear antigen (PCNA) and Bcl-2, as well as an increased Bax expression. We also found that the downregulation of SOX3 decreased the expression of Snail, Twist and matrix metalloproteinase-9 (MMP-9), and increased E-cadherin expression, resulting in the inhibition of cell migration and invasion. Taken together, our data indicate that SOX3 may serve as an oncogene in osteosarcoma, and SOX3 downregulation may prove to be a novel approach for the inhibition of osteosarcoma progression.
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 52 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Yin J, Tang M and Yu X: Downregulation of SOX3 leads to the inhibition of the proliferation, migration and invasion of osteosarcoma cells. Int J Oncol 52: 1277-1284, 2018
APA
Guo, Y., Yin, J., Tang, M., & Yu, X. (2018). Downregulation of SOX3 leads to the inhibition of the proliferation, migration and invasion of osteosarcoma cells. International Journal of Oncology, 52, 1277-1284. https://doi.org/10.3892/ijo.2018.4278
MLA
Guo, Y., Yin, J., Tang, M., Yu, X."Downregulation of SOX3 leads to the inhibition of the proliferation, migration and invasion of osteosarcoma cells". International Journal of Oncology 52.4 (2018): 1277-1284.
Chicago
Guo, Y., Yin, J., Tang, M., Yu, X."Downregulation of SOX3 leads to the inhibition of the proliferation, migration and invasion of osteosarcoma cells". International Journal of Oncology 52, no. 4 (2018): 1277-1284. https://doi.org/10.3892/ijo.2018.4278