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Article

Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells

  • Authors:
    • Pei Jou Chua
    • Jia Pei Lim
    • Tian Tian Guo
    • Puja Khanna
    • Qidong Hu
    • Boon Huat Bay
    • Gyeong Hun Baeg
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore
  • Pages: 2579-2589
    |
    Published online on: September 11, 2018
       https://doi.org/10.3892/ijo.2018.4557
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Abstract

Y-box binding protein-1 (YB-1) facilitates cancer chemoresistance through the upregulation of ATP-binding cassette (ABC) transporters associated with multidrug resistance, which is one of the primary obstacles in cancer treatment. Since aberrant Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling is also implicated in chemoresistance in numerous human malignancies, the interaction between YB-1 and JAK/STAT signaling was explored underlying the chemoresistance of NUGC3 gastric cancer cells. It was demonstrated that YB-1 translocated into the nuclei of NUGC3 cells exposed to doxorubicin hydrochloride, suggesting its important role in chemoresistance. Consistently, knockdown of YB-1 significantly decreased the chemoresistance of cells to doxorubicin hydrochloride and epirubicin hydrochloride, as evidenced by a decrease in cell viability. Notably, JAK inhibitor AG490 treatment further decreased the cell viability caused by YB-1 inhibition and doxorubicin hydrochloride. It was also observed that YB-1 transcriptionally regulated the ABCC3 transporter, whereas STAT3 modulated ABCC2 transporter levels. These findings suggest that YB-1 and STAT3 act together to facilitate chemoresistance via modulating the expression of different ABC transporters in NUGC3 cells. Notably, siYB-1 did not exhibit any significant effect on STAT3 expression. Similarly, siSTAT3 failed to alter YB-1 expression, suggesting that the two may not regulate each other in a mutual manner. However, double knockdown of YB-1 and STAT3 led to a synergistic inhibition of cell invasion in NUGC3 cells. Nonetheless, the combined treatment of YB-1 antagonists with STAT3 inhibitors may serve as an effective therapy in gastric cancer.
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1 

Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Didier DK, Schiffenbauer J, Woulfe SL, Zacheis M and Schwartz BD: Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. Proc Natl Acad Sci USA. 85:7322–7326. 1988. View Article : Google Scholar : PubMed/NCBI

3 

Eliseeva IA, Kim ER, Guryanov SG, Ovchinnikov LP and Lyabin DN: Y-box-binding protein 1 (YB-1) and its functions. Biochemistry (Mosc). 76:1402–1433. 2011. View Article : Google Scholar

4 

Bargou RC, Jürchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dörken B, et al: Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 3:447–450. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Janz M, Harbeck N, Dettmar P, Berger U, Schmidt A, Jürchott K, Schmitt M and Royer HD: Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1. Int J Cancer. 97:278–282. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Mo D, Fang H, Niu K, Liu J, Wu M, Li S, Zhu T, Aleskandarany MA, Arora A, Lobo DN, et al: Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway. Cancer Res. 76:3057–3066. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Khanna P, Chua PJ, Bay BH and Baeg GH: The JAK/STAT signaling cascade in gastric carcinoma (Review). Int J Oncol. 47:1617–1626. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kiu H and Nicholson SE: Biology and significance of the JAK/STAT signalling pathways. Growth Factors. 30:88–106. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Darnell JE Jr, Kerr IM and Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1415–1421. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Catlett-Falcone R, Dalton WS and Jove R: STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. Curr Opin Oncol. 11:490–496. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Wang Z, Si X, Xu A, Meng X, Gao S, Qi Y, Zhu L, Li T, Li W and Dong L: Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications. PLoS One. 8:e757882013. View Article : Google Scholar : PubMed/NCBI

12 

Giraud AS, Menheniott TR and Judd LM: Targeting STAT3 in gastric cancer. Expert Opin Ther Targets. 16:889–901. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kim DY, Cha ST, Ahn DH, Kang HY, Kwon CI, Ko KH, Hwang SG, Park PW, Rim KS and Hong SP: STAT3 expression in gastric cancer indicates a poor prognosis. J Gastroenterol Hepatol. 24:646–651. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Deng JY, Sun D, Liu XY, Pan Y and Liang H: STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer. World J Gastroenterol. 16:5380–5387. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Kanda N, Seno H, Konda Y, Marusawa H, Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y, et al: STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. 23:4921–4929. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Huang S, Chen M, Shen Y, Shen W, Guo H, Gao Q and Zou X: Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells. Cancer Lett. 315:198–205. 2012. View Article : Google Scholar

17 

Lim JP, Shyamasundar S, Gunaratne J, Scully OJ, Matsumoto K and Bay BH: YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro. BMC Cancer. 17:2012017. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

19 

Tay WL, Yip GW, Tan PH, Matsumoto K, Yeo R, Ng TP, Kumar SD, Tsujimoto M and Bay BH: Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer. Mod Pathol. 22:282–290. 2009. View Article : Google Scholar

20 

Kosnopfel C, Sinnberg T and Schittek B: Y-box binding protein 1 - a prognostic marker and target in tumour therapy. Eur J Cell Biol. 93:61–70. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Huang J, Tan PH, Li KB, Matsumoto K, Tsujimoto M and Bay BH: Y-box binding protein, YB-1, as a marker of tumor aggressiveness and response to adjuvant chemotherapy in breast cancer. Int J Oncol. 26:607–613. 2005.PubMed/NCBI

22 

Stephanou A, Brar BK, Knight RA and Latchman DS: Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters. Cell Death Differ. 7:329–330. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Nascimento AS, Peres LL, Fari AVS, Milani R, Silva RA, da Costa Fernandes CJ, Peppelenbosch MP, Ferreira-Halder CV and Zambuzzi WF: Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer. Oncotarget. 8:114756–114768. 2017. View Article : Google Scholar

24 

Becker TM, Boyd SC, Mijatov B, Gowrishankar K, Snoyman S, Pupo GM, Scolyer RA, Mann GJ, Kefford RF, Zhang XD, et al: Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene. 33:1158–1166. 2014. View Article : Google Scholar

25 

Saneja A, Khare V, Alam N, Dubey RD and Gupta PN: Advances in P-glycoprotein-based approaches for delivering anticancer drugs: Pharmacokinetic perspective and clinical relevance. Expert Opin Drug Deliv. 11:121–138. 2014. View Article : Google Scholar

26 

Noguchi K, Katayama K, Mitsuhashi J and Sugimoto Y: Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy. Adv Drug Deliv Rev. 61:26–33. 2009. View Article : Google Scholar

27 

Zhang W, Meng Y, Liu N, Wen X-F and Yang T: Insights into chemo-resistance of prostate cancer. Int J Biol Sci. 11:1160–1170. 2015. View Article : Google Scholar :

28 

Zhang G, Wang Z, Qian F, Zhao C and Sun C: Silencing of the ABCC4 gene by RNA interference reverses multidrug resistance in human gastric cancer. Oncol Rep. 33:1147–1154. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Guo T, Yu Y, Yip GW, Baeg GH, Thike AA, Lim TK, Tan PH, Matsumoto K and Bay BH: Y-box binding protein 1 is correlated with lymph node metastasis in intestinal-type gastric cancer. Histopathology. 66:491–499. 2015. View Article : Google Scholar

30 

Oda Y, Sakamoto A, Shinohara N, Ohga T, Uchiumi T, Kohno K, Tsuneyoshi M, Kuwano M and Iwamoto Y: Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. Clin Cancer Res. 4:2273–2277. 1998.PubMed/NCBI

31 

Koike K, Uchiumi T, Ohga T, Toh S, Wada M, Kohno K and Kuwano M: Nuclear translocation of the Y-box binding protein by ultraviolet irradiation. FEBS Lett. 417:390–394. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Schittek B, Psenner K, Sauer B, Meier F, Iftner T and Garbe C: The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance. Int J Cancer. 120:2110–2118. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Yahata H, Kobayashi H, Kamura T, Amada S, Hirakawa T, Kohno K, Kuwano M and Nakano H: Increased nuclear localization of transcription factor YB-1 in acquired cisplatin-resistant ovarian cancer. J Cancer Res Clin Oncol. 128:621–626. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Jackson CB and Giraud AS: STAT3 as a prognostic marker in human gastric cancer. J Gastroenterol Hepatol. 24:505–507. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Yu H, Lee H, Herrmann A, Buettner R and Jove R: Revisiting STAT3 signalling in cancer: New and unexpected biological functions. Nat Rev Cancer. 14:736–746. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Joo MK, Park JJ and Chun HJ: Recent updates of precision therapy for gastric cancer: Towards optimal tailored management. World J Gastroenterol. 22:4638–4650. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R and Huang S: Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res. 11:1386–1393. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Fujii T, Seki N, Namoto-Matsubayashi R, Takahashi H, Inoue Y, Toh U, Kage M and Shirouzu K: YB-1 prevents apoptosis via the mTOR/STAT3 pathway in HER-2-overexpressing breast cancer cells. Future Oncol. 5:153–156. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Deng J, Liang H, Zhang R, Sun D, Pan Y, Liu Y, Zhang L and Hao X: STAT3 is associated with lymph node metastasis in gastric cancer. Tumour Biol. 34:2791–2800. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Guo TT, Yu YN, Yip GW, Matsumoto K and Bay BH: Silencing the YB-1 gene inhibits cell migration in gastric cancer in vitro. Anat Rec (Hoboken). 296:891–898. 2013. View Article : Google Scholar

41 

Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, et al: Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Res. 68:8661–8666. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chua P, Lim J, Guo T, Khanna P, Hu Q, Bay B and Baeg G: Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells. Int J Oncol 53: 2579-2589, 2018.
APA
Chua, P., Lim, J., Guo, T., Khanna, P., Hu, Q., Bay, B., & Baeg, G. (2018). Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells. International Journal of Oncology, 53, 2579-2589. https://doi.org/10.3892/ijo.2018.4557
MLA
Chua, P., Lim, J., Guo, T., Khanna, P., Hu, Q., Bay, B., Baeg, G."Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells". International Journal of Oncology 53.6 (2018): 2579-2589.
Chicago
Chua, P., Lim, J., Guo, T., Khanna, P., Hu, Q., Bay, B., Baeg, G."Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells". International Journal of Oncology 53, no. 6 (2018): 2579-2589. https://doi.org/10.3892/ijo.2018.4557
Copy and paste a formatted citation
x
Spandidos Publications style
Chua P, Lim J, Guo T, Khanna P, Hu Q, Bay B and Baeg G: Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells. Int J Oncol 53: 2579-2589, 2018.
APA
Chua, P., Lim, J., Guo, T., Khanna, P., Hu, Q., Bay, B., & Baeg, G. (2018). Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells. International Journal of Oncology, 53, 2579-2589. https://doi.org/10.3892/ijo.2018.4557
MLA
Chua, P., Lim, J., Guo, T., Khanna, P., Hu, Q., Bay, B., Baeg, G."Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells". International Journal of Oncology 53.6 (2018): 2579-2589.
Chicago
Chua, P., Lim, J., Guo, T., Khanna, P., Hu, Q., Bay, B., Baeg, G."Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells". International Journal of Oncology 53, no. 6 (2018): 2579-2589. https://doi.org/10.3892/ijo.2018.4557
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