Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
August-2019 Volume 55 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 55 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission

  • Authors:
    • Pantong Li
    • Yu Liu
    • Wuyi Liu
    • Guobing Li
    • Qin Tang
    • Qian Zhang
    • Faning Leng
    • Fangfang Sheng
    • Changpeng Hu
    • Wenjing Lai
    • Yali Liu
    • Min Zhou
    • Jingbin Huang
    • Huyue Zhou
    • Rong Zhang
    • Yu Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The University-Town Hospital of Chongqing Medical University, Chongqing 401331, P.R. China, Department of Pharmacy, Xinqiao Hospital, Army Medical University, Chongqing, 400037, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 415-424
    |
    Published online on: June 6, 2019
       https://doi.org/10.3892/ijo.2019.4821
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

IR‑783, a near‑infrared heptamethine cyanine dye, has been reported to possess cancer targeting and anticancer effects; Ηowever, the molecular mechanism by which IR‑783 exhibits anti‑breast cancer activity is unclear. In the present study, the inhibitory effects of IR‑783 on the proliferation and migration of breast cancer cells were investigated. Our results revealed that IR‑783 inhibited MDA‑MB‑231 and MCF‑7 cell proliferation in a dose‑ and time‑dependent manner by inducing cell cycle arrest at the G0/G1 phase. In addition, a Transwell assay demonstrated that IR‑783 treatment suppressed the migratory ability of MDA‑MB‑231 and MCF‑7 cells. Furthermore, IR‑783 treatment decreased the expression levels of matrix metalloproteinase (MMP)‑2 and MMP‑9 in MDA‑MB‑231 cells. Furthermore, IR‑783 induced MDA‑MB‑231 and MCF‑7 cell mitochondrial fission, and also decreased the levels of ATP. This was accompanied with a decrease in polymerized filamentous actin, which is the fundamental component of filopodia at the cell surface. Collectively, the results of the present study demonstrated that IR‑783 inhibited the proliferation and migration of MDA‑MB‑231 and MCF‑7 cells by inducing mitochondrial fission and subsequently decreasing ATP levels, resulting in cell cycle arrest and filopodia formation suppression. These findings suggest that IR‑783 may be developed into an effective novel drug for treating breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Dai X, Li T, Bai Z, Yang Y, Liu X, Zhan J and Shi B: Breast cancer intrinsic subtype classification, clinical use and future trends. Am J Cancer Res. 5:2929–2943. 2015.PubMed/NCBI

2 

Wang B, Xing Z, Wang F, Yuan X and Zhang Y: Fangchinoline inhibits migration and causes apoptosis of human breast cancer MDA-MB-231 cells. Oncol Lett. 14:5307–5312. 2017.PubMed/NCBI

3 

He MY, Rancoule C, Rehailia-Blanchard A, Espenel S, Trone JC, Bernichon E, Guillaume E, Vallard A and Magné N: Radiotherapy in triple-negative breast cancer: Current situation and upcoming strategies. Crit Rev Oncol Hematol. 131:96–101. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Mathe A, Wong-Brown M, Morten B, Forbes JF, Braye SG, Avery-Kiejda KA and Scott RJ: Novel genes associated with lymph node metastasis in triple negative breast cancer. Sci Rep. 5:158322015. View Article : Google Scholar : PubMed/NCBI

5 

Jones JE, Busi SB, Mitchem JB, Amos-Landgraf JM and Lewis MR: Evaluation of a tumor-targeting, near-infrared fluorescent peptide for early detection and endoscopic resection of polyps in a rat model of colorectal cancer. Mol Imaging. 17:15360121187900652018. View Article : Google Scholar : PubMed/NCBI

6 

Nagaya T, Okuyama S, Ogata F, Maruoka Y, Choyke PL and Kobayashi H: Endoscopic near infrared photoimmunotherapy using a fiber optic diffuser for peritoneal dissemination of gastric cancer. Cancer Sci. 109:1902–1908. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Yang X, Shao C, Wang R, Chu CY, Hu P, Master V, Osunkoya AO, Kim HL, Zhau HE and Chung LWK: Optical imaging of kidney cancer with novel near infrared heptamethine carbocyanine fluorescent dyes. J Urol. 189:702–710. 2013. View Article : Google Scholar

8 

Holt D, Okusanya O, Judy R, Venegas O, Jiang J, DeJesus E, Eruslanov E, Quatromoni J, Bhojnagarwala P, Deshpande C, et al: Intraoperative near-infrared imaging can distinguish cancer from normal tissue but not inflammation. PLoS One. 9:e1033422014. View Article : Google Scholar : PubMed/NCBI

9 

Deng G, Li S, Sun Z, Li W, Zhou L, Zhang J, Gong P and Cai L: Near-infrared fluorescence imaging in the largely unexplored window of 900-1,000 nm. Theranostics. 8:4116–4128. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Wu JB, Shi C, Chu GC, Xu Q, Zhang Y, Li Q, Yu JS, Zhau HE and Chung LW: Near-infrared fluorescence heptamethine carbo-cyanine dyes mediate imaging and targeted drug delivery for human brain tumor. Biomaterials. 67:1–10. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Shao C, Liao CP, Hu P, Chu CY, Zhang L, Bui MH, Ng CS, Josephson DY, Knudsen B, Tighiouart M, et al: Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer. PLoS One. 9:e889672014. View Article : Google Scholar : PubMed/NCBI

12 

Cohen S and Margel S; S. C S M: Engineering of near IR fluorescent albumin nanoparticles for in vivo detection of colon cancer. J Nanobiotechnology. 10:362012. View Article : Google Scholar : PubMed/NCBI

13 

Zhang J, Liu Z, Lian P, Qian J, Li X, Wang L, Fu W, Chen L, Wei X and Li C: Selective imaging and cancer cell death via pH switchable nearinfrared fluorescence and photothermal effects. Chem Sci. 7:5995–6005. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Thomas RG and Jeong YY: NIRF heptamethine cyanine dye nanocomplexes for multi modal theranosis of tumors. Chonnam Med J. 53:83–94. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Tang Q, Liu W, Zhang Q, Huang J, Hu C, Liu Y, Wang Q, Zhou M, Lai W, Sheng F, et al: Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells. J Cell Mol Med. 22:4474–4485. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Hou L, Yang X, Ren J, Wang Y, Zhang H, Feng Q, Shi Y, Shan X, Yuan Y and Zhang Z: A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging. Int J Nanomedicine. 11:607–624. 2016.PubMed/NCBI

17 

Tokarz P and Blasiak J: Role of mitochondria in carcinogenesis. Acta Biochim Pol. 61:671–678. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Eirin A, Lerman A and Lerman LO: Mitochondria: A pathogenic paradigm in hypertensive renal disease. Hypertension. 65:264–270. 2015. View Article : Google Scholar :

19 

Ruan S, Zhang Z, Tian X, Huang D, Liu W, Yang B, Shen M and Tao F: Compound fuling granule suppresses ovarian cancer development and progression by disrupting mitochondrial function, galactose and fatty acid metabolism. J Cancer. 9:3382–3393. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Scott I and Youle RJ: Mitochondrial fission and fusion. Essays Biochem. 47:85–98. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Han XJ, Yang ZJ, Jiang LP, Wei YF, Liao MF, Qian Y, Li Y, Huang X, Wang JB, Xin HB, et al: Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 46:691–700. 2015. View Article : Google Scholar

22 

Matsuishi YI, Kato H, Masuda K, Yamaza H, Hirofuji Y, Sato H, Wada H, Kiyoshima T and Nonaka K: Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 1. Biochem Biophys Res Commun. 495:1655–1660. 2018. View Article : Google Scholar

23 

Archer SL: Mitochondrial dynamics - mitochondrial fission and fusion in human diseases. N Engl J Med. 369:2236–2251. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Westermann B: Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol. 11:872–884. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Eatemadi A, Aiyelabegan HT, Negahdari B, Mazlomi MA, Daraee H, Daraee N, Eatemadi R and Sadroddiny E: Role of protease and protease inhibitors in cancer pathogenesis and treatment. Biomed Pharmacother. 86:221–231. 2017. View Article : Google Scholar

26 

Han S, Huang J, Liu B, Xing B, Bordeleau F, Reinhart-King CA, Li W, Zhang JJ and Huang XY: Improving fascin inhibitors to block tumor cell migration and metastasis. Mol Oncol. 10:966–980. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Shibue T, Brooks MW, Inan MF, Reinhardt F and Weinberg RA: The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov. 2:706–721. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Atilgan E, Wirtz D and Sun SX: Mechanics and dynamics of actin-driven thin membrane protrusions. Biophys J. 90:65–76. 2006. View Article : Google Scholar

29 

Ke R, Xu Q, Li C, Luo L and Huang D: Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism. Cell Biol Int. 42:384–392. 2018. View Article : Google Scholar

30 

Wang X, Li Y, Qian Y, Cao Y, Shriwas P, Zhang H and Chen X: Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase. Oncotarget. 8:87860–87877. 2017.PubMed/NCBI

31 

Yang X, Shi C, Tong R, Qian W, Zhau HE, Wang R, Zhu G, Cheng J, Yang VW, Cheng T, et al: Near IR heptamethine cyanine dye-mediated cancer imaging. Clin Cancer Res. 16:2833–2844. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Yuan J, Yi X, Yan F, Wang F, Qin W, Wu G, Yang X, Shao C and Chung LW: Near infrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyes. Mol Med Rep. 11:821–828. 2015. View Article : Google Scholar

33 

Papaccio F, Paino F, Regad T, Papaccio G, Desiderio V and Tirino V: Concise Review: Cancer cells, cancer stem cells, and mesenchymal stem cells: Influence in cancer development. Stem Cells Transl Med. 6:2115–2125. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Sun L, Huang Y, Wei Q, Tong X, Cai R, Nalepa G and Ye X: Cyclin E-CDK2 protein phosphorylates plant homeodomain finger protein 8 (PHF8) and regulates its function in the cell cycle. J Biol Chem. 290:4075–4085. 2015. View Article : Google Scholar :

35 

Zhang R, Wei YH, Zhao CY, Song HY, Shen N, Cui X, Gao X, Qi ZT, Zhong M and Shen W: EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway. Int J Ophthalmol. 11:18–24. 2018.

36 

Gupta GP and Massagué J: Cancer metastasis: Building a framework. Cell. 127:679–695. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Benson CS, Babu SD, Radhakrishna S, Selvamurugan N and Ravi Sankar B: Expression of matrix metalloproteinases in human breast cancer tissues. Dis Markers. 34:395–405. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Mendes O, Kim HT and Stoica G: Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Clin Exp Metastasis. 22:237–246. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Flamini MI, Fu X-D, Sanchez AM, Giretti MS, Garibaldi S, Goglia L, Pisaneschi S, Tosi V, Genazzani AR and Simoncini T: Effects of raloxifene on breast cancer cell migration and invasion through the actin cytoskeleton. J Cell Mol Med. 13:2396–2407. 2009. View Article : Google Scholar

40 

Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X, et al: The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling. Cancer Lett. 355:288–296. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Ozawa S, Ueda S, Imamura H, Mori K, Asanuma K, Yanagita M and Nakagawa T: Glycolysis, but not Mitochondria, responsible for intracellular ATP distribution in cortical area of podocytes. Sci Rep. 5:185752015. View Article : Google Scholar : PubMed/NCBI

42 

Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ III and Lotze MT: High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab. 13:701–711. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Newell C, Shutt TE, Ahn Y, Hittel DS, Khan A, Rho JM and Shearer J: Tissue specific impacts of a ketogenic diet on mitochondrial dynamics in the BTBRT+tf/j mouse. Front Physiol. 7:6542016. View Article : Google Scholar

44 

Kar R, Mishra N, Singha PK, Venkatachalam MA and Saikumar P: Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. Biochem Biophys Res Commun. 399:548–554. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li P, Liu Y, Liu W, Li G, Tang Q, Zhang Q, Leng F, Sheng F, Hu C, Lai W, Lai W, et al: IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission. Int J Oncol 55: 415-424, 2019.
APA
Li, P., Liu, Y., Liu, W., Li, G., Tang, Q., Zhang, Q. ... Zhao, Y. (2019). IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission. International Journal of Oncology, 55, 415-424. https://doi.org/10.3892/ijo.2019.4821
MLA
Li, P., Liu, Y., Liu, W., Li, G., Tang, Q., Zhang, Q., Leng, F., Sheng, F., Hu, C., Lai, W., Liu, Y., Zhou, M., Huang, J., Zhou, H., Zhang, R., Zhao, Y."IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission". International Journal of Oncology 55.2 (2019): 415-424.
Chicago
Li, P., Liu, Y., Liu, W., Li, G., Tang, Q., Zhang, Q., Leng, F., Sheng, F., Hu, C., Lai, W., Liu, Y., Zhou, M., Huang, J., Zhou, H., Zhang, R., Zhao, Y."IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission". International Journal of Oncology 55, no. 2 (2019): 415-424. https://doi.org/10.3892/ijo.2019.4821
Copy and paste a formatted citation
x
Spandidos Publications style
Li P, Liu Y, Liu W, Li G, Tang Q, Zhang Q, Leng F, Sheng F, Hu C, Lai W, Lai W, et al: IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission. Int J Oncol 55: 415-424, 2019.
APA
Li, P., Liu, Y., Liu, W., Li, G., Tang, Q., Zhang, Q. ... Zhao, Y. (2019). IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission. International Journal of Oncology, 55, 415-424. https://doi.org/10.3892/ijo.2019.4821
MLA
Li, P., Liu, Y., Liu, W., Li, G., Tang, Q., Zhang, Q., Leng, F., Sheng, F., Hu, C., Lai, W., Liu, Y., Zhou, M., Huang, J., Zhou, H., Zhang, R., Zhao, Y."IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission". International Journal of Oncology 55.2 (2019): 415-424.
Chicago
Li, P., Liu, Y., Liu, W., Li, G., Tang, Q., Zhang, Q., Leng, F., Sheng, F., Hu, C., Lai, W., Liu, Y., Zhou, M., Huang, J., Zhou, H., Zhang, R., Zhao, Y."IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission". International Journal of Oncology 55, no. 2 (2019): 415-424. https://doi.org/10.3892/ijo.2019.4821
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team