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Article Open Access

Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer

  • Authors:
    • Yang Liu
    • Shuanshuan Xie
    • Jie Zeng
    • Xiaolian Song
    • Min Tan
    • Dannong He
    • Jie Wang
    • Ping Wang
    • Jun Zhu
    • Changhui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, P.R. China, National Engineering Research Center for Nanotechnology, Shanghai 200241, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 462-472
    |
    Published online on: June 6, 2019
       https://doi.org/10.3892/ijo.2019.4822
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Abstract

Non‑small cell lung cancer (NSCLC) is one of the most fatal cancers worldwide. Adenylyl cyclase‑associated protein 1 (CAP1) belongs to a family of cyclase‑associated proteins that are involved in the development of cancerous tumors. A previous study by our group confirmed the association between CAP1, lung cancer and the metastasis of cancer cells. In the present study, poly(lactic‑polyglycolic acid; PLGA)/CAP1‑small interfering (si)RNA nanoparticles were prepared and delivered into A549 cells. The performance of PLGA/siCAP1‑siRNA nanoparticles for siRNA delivery was measured based on the results of migration assay and animal experiments. The multifunctional nanoparticles were determined to be capable of inhibiting CAP1 expression, which reduced NSCLC metastasis in vitro and in vivo. Therefore, the findings of the current study highlighted the potential use of PLGA/siCAP1‑siRNA nanoparticles for the treatment of NSCLC metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Xie S, Zeng J, Song X, Tan M, He D, Wang J, Wang P, Zhu J, Wang C, Wang C, et al: Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer. Int J Oncol 55: 462-472, 2019.
APA
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D. ... Wang, C. (2019). Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer. International Journal of Oncology, 55, 462-472. https://doi.org/10.3892/ijo.2019.4822
MLA
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D., Wang, J., Wang, P., Zhu, J., Wang, C."Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer". International Journal of Oncology 55.2 (2019): 462-472.
Chicago
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D., Wang, J., Wang, P., Zhu, J., Wang, C."Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer". International Journal of Oncology 55, no. 2 (2019): 462-472. https://doi.org/10.3892/ijo.2019.4822
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Xie S, Zeng J, Song X, Tan M, He D, Wang J, Wang P, Zhu J, Wang C, Wang C, et al: Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer. Int J Oncol 55: 462-472, 2019.
APA
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D. ... Wang, C. (2019). Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer. International Journal of Oncology, 55, 462-472. https://doi.org/10.3892/ijo.2019.4822
MLA
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D., Wang, J., Wang, P., Zhu, J., Wang, C."Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer". International Journal of Oncology 55.2 (2019): 462-472.
Chicago
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D., Wang, J., Wang, P., Zhu, J., Wang, C."Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer". International Journal of Oncology 55, no. 2 (2019): 462-472. https://doi.org/10.3892/ijo.2019.4822
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