|
1
|
Burger M, Catto JW, Dalbagni G, Grossman
HB, Herr H, Karakiewicz P, Kassouf W, Kiemeney LA, La Vecchia C,
Shariat S, et al: Epidemiology and risk factors of urothelial
bladder cancer. Eur Urol. 63:234–241. 2013. View Article : Google Scholar
|
|
2
|
Hashim D and Boffetta P: Occupational and
environmental exposures and cancers in developing countries. Ann
Glob Health. 80:393–411. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Smith ND, Prasad SM, Patel AR, Weiner AB,
Pariser JJ, Razmaria A, Maene C, Schuble T, Pierce B and Steinberg
GD: Bladder Cancer Mortality in the United States: A Geographic and
Temporal Analysis of Socioeconomic and Environmental Factors. J
Urol. 195:290–296. 2016. View Article : Google Scholar
|
|
4
|
Hurst CD and Knowles MA: Bladder cancer:
Multi-omic profiling refines the molecular view. Nat Rev Clin
Oncol. 15:203–204. 2018. View Article : Google Scholar
|
|
5
|
Aine M, Eriksson P, Liedberg F, Höglund M
and Sjödahl G: On molecular classification of bladder cancer: Out
of one, many. Eur Urol. 68:921–923. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Robertson AG, Kim J, Al-Ahmadie H,
Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA,
Akbani R, et al: Comprehensive molecular characterization of
muscle-invasive bladder cancer. Cell. 174:10332018. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Sjödahl G, Eriksson P, Liedberg F and
Höglund M: Molecular classification of urothelial carcinoma: Global
mRNA classification versus tumour-cell phenotype classification. J
Pathol. 242:113–125. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Network TCGAR; Cancer Genome Atlas
Research Network: Comprehensive molecular characterization of
urothelial bladder carcinoma. Nature. 507:315–322. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Harley V and Lefebvre V: Twenty Sox,
twenty years. The International Int J Biochem Cell Biol.
42:376–377. 2010. View Article : Google Scholar
|
|
10
|
Aue G, Du Y, Cleveland SM, Smith SB, Davé
UP, Liu D, Weniger MA, Metais JY, Jenkins NA, Copeland NG, et al:
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid
leukemia. Blood. 118:4674–4681. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Ikushima H, Todo T, Ino Y, Takahashi M,
Saito N, Miyazawa K and Miyazono K: Glioma-initiating cells retain
their tumorigenicity through integration of the Sox axis and Oct4
protein. J Biol Chem. 286:41434–41441. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Sinner D, Kordich JJ, Spence JR, Opoka R,
Rankin S, Lin SC, Jonatan D, Zorn AM and Wells JM: Sox17 and Sox4
differentially regulate beta-catenin/T-cell factor activity and
proliferation of colon carcinoma cells. Mol Cell Biol.
27:7802–7815. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Tanaka S, Kamachi Y, Tanouchi A, Hamada H,
Jing N and Kondoh H: Interplay of SOX and POU factors in regulation
of the Nestin gene in neural primordial cells. Mol Cell Biol.
24:8834–8846. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Dy P, Penzo-Méndez A, Wang H, Pedraza CE,
Macklin WB and Lefebvre V: The three SoxC proteins–Sox4, Sox11 and
Sox12 - exhibit overlapping expression patterns and molecular
properties. Nucleic Acids Res. 36:3101–3117. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Jauch R, Ng CK, Narasimhan K and Kolatkar
PR: The crystal structure of the Sox4 HMG domain-DNA complex
suggests a mechanism for positional interdependence in DNA
recognition. Biochem J. 443:39–47. 2012. View Article : Google Scholar
|
|
16
|
Scharer CD, McCabe CD, Ali-Seyed M, Berger
MF, Bulyk ML and Moreno CS: Genome-wide promoter analysis of the
SOX4 transcriptional network in prostate cancer cells. Cancer Res.
69:709–717. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Pramoonjago P, Baras AS and Moskaluk CA:
Knockdown of Sox4 expression by RNAi induces apoptosis in ACC3
cells. Oncogene. 25:5626–5639. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Jafarnejad SM, Ardekani GS, Ghaffari M,
Martinka M and Li G: Sox4-mediated Dicer expression is critical for
suppression of melanoma cell invasion. Oncogene. 32:2131–2139.
2013. View Article : Google Scholar
|
|
19
|
Bergsland M, Werme M, Malewicz M, Perlmann
T and Muhr J: The establishment of neuronal properties is
controlled by Sox4 and Sox11. Genes Dev. 20:3475–3486. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Shen H, Morrison CD, Zhang J, Underwood W
III, Yang N, Frangou C, Eng K, Head K, Bollag RJ, Kavuri SK, et al:
6p22.3 amplification as a biomarker and potential therapeutic
target of advanced stage bladder cancer. Oncotarget. 4:2124–2134.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wu Q, Hoffmann MJ, Hartmann FH and Schulz
WA: Amplification and overexpression of the ID4 gene at 6p22.3 in
bladder cancer. Mol Cancer. 4:162005. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Vervoort SJ, van Boxtel R and Coffer PJ:
The role of SRY-related HMG box transcription factor 4 (SOX4) in
tumorigenesis and metastasis: Friend or foe? Oncogene.
32:3397–3409. 2013. View Article : Google Scholar
|
|
23
|
Liu P, Ramachandran S, Ali Seyed M,
Scharer CD, Laycock N, Dalton WB, Williams H, Karanam S, Datta MW,
Jaye DL, et al: Sex-determining region Y box 4 is a transforming
oncogene in human prostate cancer cells. Cancer Res. 66:4011–4019.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Pan X, Zhao J, Zhang WN, Li HY, Mu R, Zhou
T, Zhang HY, Gong WL, Yu M, Man JH, et al: Induction of SOX4 by DNA
damage is critical for p53 stabilization and function. Proc Natl
Acad Sci USA. 106:3788–3793. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Hur EH, Hur W, Choi JY, Kim IK, Kim HY,
Yoon SK and Rhim H: Functional identification of the pro-apoptotic
effector domain in human Sox4. Biochem Biophys Res Commun.
325:59–67. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Hur W, Rhim H, Jung CK, Kim JD, Bae SH,
Jang JW, Yang JM, Oh ST, Kim DG, Wang HJ, et al: SOX4
overexpression regulates the p53-mediated apoptosis in
hepatocellular carcinoma: Clinical implication and functional
analysis in vitro. Carcinogenesis. 31:1298–1307. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Ahn SG, Cho GH, Jeong SY, Rhim H, Choi JY
and Kim IK: Identification of cDNAs for Sox-4, an HMG-Box protein,
and a novel human homolog of yeast splicing factor SSF-1
differentially regulated during apoptosis induced by prostaglandin
A2/delta12-PGJ2 in Hep3B cells. Biochem Biophys Res Commun.
260:216–221. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Aaboe M, Birkenkamp-Demtroder K, Wiuf C,
Sørensen FB, Thykjaer T, Sauter G, Jensen KM, Dyrskjøt L and
Ørntoft T: SOX4 expression in bladder carcinoma: Clinical aspects
and in vitro functional characterization. Cancer Res. 66:3434–3442.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Shen H, Blijlevens M, Yang N, Frangou C,
Wilson KE, Xu B, Zhang Y, Zhang L, Morrison CD, Shepherd L, et al:
Sox4 expression confers bladder cancer stem cell properties and
predicts for poor patient outcome. Int J Biol Sci. 11:1363–1375.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Gilbert LA, Horlbeck MA, Adamson B,
Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh
HL, Bassik MC, et al: Genome-Scale CRISPR-mediated control of gene
repression and activation. Cell. 159:647–661. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Jenei V, Sherwood V, Howlin J, Linnskog R,
Säfholm A, Axelsson L and Andersson T: A
t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as
a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc
Natl Acad Sci USA. 106:19473–19478. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Lai YH, Cheng J, Cheng D, Feasel ME, Beste
KD, Peng J, Nusrat A and Moreno CS: SOX4 interacts with plakoglobin
in a Wnt3a-dependent manner in prostate cancer cells. BMC Cell
Biol. 12:502011. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Efron B and Tibshirani R: Empirical bayes
methods and false discovery rates for microarrays. Genet Epidemiol.
23:70–86. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Tusher VG, Tibshirani R and Chu G:
Significance analysis of microarrays applied to the ionizing
radiation response. Proc Natl Acad Sci USA. 98:5116–5121. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Gentleman RC, Carey VJ, Bates DM, Bolstad
B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al:
Bioconductor: Open software development for computational biology
and bioinformatics. Genome Biol. 5:R802004. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Eisen MB, Spellman PT, Brown PO and
Botstein D: Cluster analysis and display of genome-wide expression
patterns. Proc Natl Acad Sci USA. 95:14863–14868. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Saldanha AJ: Java Treeview–extensible
visualization of microarray data. Bioinformatics. 20:3246–3248.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-ΔΔC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar
|
|
39
|
Gao J, Aksoy BA, Dogrusoz U, Dresdner G,
Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al:
Integrative analysis of complex cancer genomics and clinical
profiles using the cBio-Portal. Sci Signal. 6:pl12013. View Article : Google Scholar
|
|
40
|
Cerami E, Gao J, Dogrusoz U, Gross BE,
Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et
al: The cBio cancer genomics portal: An open platform for exploring
multidimensional cancer genomics data. Cancer Discov. 2:401–404.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Rubin MA and Chinnaiyan AM: Bioinformatics
approach leads to the discovery of the TMPRSS2:ETS gene fusion in
prostate cancer. Lab Invest. 86:1099–1102. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Tomlins SA, Laxman B, Dhanasekaran SM,
Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, et
al: Distinct classes of chromosomal rearrangements create oncogenic
ETS gene fusions in prostate cancer. Nature. 448:595–599. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Tomlins SA, Rhodes DR, Perner S,
Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J,
Kuefer R, et al: Recurrent fusion of TMPRSS2 and ETS transcription
factor genes in prostate cancer. Science. 310:644–648. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Qi LS, Larson MH, Gilbert LA, Doudna JA,
Weissman JS, Arkin AP and Lim WA: Repurposing CRISPR as an
RNA-guided platform for sequence-specific control of gene
expression. Cell. 152:1173–1183. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Kearns NA, Genga RMJ, Enuameh MS, Garber
M, Wolfe SA and Maehr R: Cas9 effector-mediated regulation of
transcription and differentiation in human pluripotent stem cells.
Development. 141:219–223. 2014. View Article : Google Scholar :
|
|
46
|
Gilbert LA, Larson MH, Morsut L, Liu Z,
Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH,
Doudna JA, et al: CRISPR-mediated modular RNA-guided regulation of
transcription in eukaryotes. Cell. 154:442–451. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Dai W, Xu X, Li S, Ma J, Shi Q, Guo S, Liu
L, Guo W, Xu P, He Y, et al: SOX4 promotes proliferative signals by
regulating glycolysis through AKT activation in melanoma cells. J
Invest Dermatol. 137:2407–2416. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhao J, Xu J and Zhang R: MicroRNA-539
inhibits colorectal cancer progression by directly targeting SOX4.
Oncol Lett. 16:2693–2700. 2018.PubMed/NCBI
|
|
49
|
Zhang J, Liang Q, Lei Y, Yao M, Li L, Gao
X, Feng J, Zhang Y, Gao H, Liu DX, et al: SOX4 induces
epithelial-mesenchymal transition and contributes to breast cancer
progression. Cancer Res. 72:4597–4608. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Li Y, Chen P, Zu L, Liu B, Wang M and Zhou
Q: MicroRNA-338-3p suppresses metastasis of lung cancer cells by
targeting the EMT regulator Sox4. Am J Cancer Res. 6:127–140.
2016.PubMed/NCBI
|
|
51
|
Zhai L, Ladomersky E, Lenzen A, Nguyen B,
Patel R, Lauing KL, Wu M and Wainwright DA: IDO1 in cancer: A
Gemini of immune checkpoints. Cell Mol Immunol. 15:447–457. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Article CD: Blocking IDO1 helps shrink
bladder, cervical tumors. Cancer Discov. 8:OF32018. View Article : Google Scholar
|
|
53
|
Kremenevskaja N, von Wasielewski R, Rao
AS, Schöfl C, Andersson T and Brabant G: Wnt-5a has tumor
suppressor activity in thyroid carcinoma. Oncogene. 24:2144–2154.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Cao Y, Wang X, Xu C, Gao Z, Zhou H, Wang
Y, Cao R and Liu T and Liu T: 4-HPR impairs bladder cancer cell
migration and invasion by interfering with the Wnt5a/JNK and
Wnt5a/MMP-2 signaling pathways. Oncol Lett. 12:1833–1839. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Shen Z, Zhu D, Liu J, Chen J, Liu Y, Hu C,
Li Z and Li Y: 27-Hydroxycholesterol induces invasion and migration
of breast cancer cells by increasing MMP9 and generating EMT
through activation of STAT-3. Environ Toxicol Pharmacol. 51:1–8.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Marwarha G, Raza S, Hammer K and Ghribi O:
27-hydroxycho-lesterol: A novel player in molecular carcinogenesis
of breast and prostate cancer. Chem Phys Lipids. 207:108–126. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Roy M, Kung HJ and Ghosh PM: Statins and
prostate cancer: role of cholesterol inhibition vs. prevention of
small GTP-binding proteins. Am J Cancer Res. 1:542–561.
2011.PubMed/NCBI
|
|
58
|
Vervoort SJ, Lourenço AR, Tufegdzic
Vidakovic A, Mocholi E, Sandoval JL, Rueda OM, Frederiks C, Pals C,
Peeters JG, Caldas C, et al: SOX4 can redirect TGF-beta-mediated
SMAD3-transcriptional output in a context-dependent manner to
promote tumorigenesis. Nucleic Acids Res. 46:9578–9590. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Nishita M, Enomoto M, Yamagata K and
Minami Y: Cell/tissue-tropic functions of Wnt5a signaling in normal
and cancer cells. Trends Cell Biol. 20:346–354. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Säfholm A, Leandersson K, Dejmek J,
Nielsen CK, Villoutreix BO and Andersson T: A formylated
hexapeptide ligand mimics the ability of Wnt-5a to impair migration
of human breast epithelial cells. J Biol Chem. 281:2740–2749. 2006.
View Article : Google Scholar
|
|
61
|
Dejmek J, Dejmek A, Säfholm A, Sjölander A
and Andersson T: Wnt-5a protein expression in primary dukes B colon
cancers identifies a subgroup of patients with good prognosis.
Cancer Res. 65:9142–9146. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Syed Khaja AS, Helczynski L, Edsjö A,
Ehrnström R, Lindgren A, Ulmert D, Andersson T and Bjartell A:
Elevated level of Wnt5a protein in localized prostate cancer tissue
is associated with better outcome. PLoS One. 6:e265392011.
View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Kato K, Bhattaram P, Penzo-Méndez A, Gadi
A and Lefebvre V: SOXC transcription factors induce cartilage
growth plate formation in mouse embryos by promoting noncanonical
WNT signaling. J Bone Miner Res. 30:1560–1571. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Lee AK, Ahn SG, Yoon JH and Kim SA: Sox4
stimulates β-catenin activity through induction of CK2. Oncol Rep.
25:559–565. 2011.
|
