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Article

Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review)

Corrigendum in: /10.3892/ijo.2019.4935
  • Authors:
    • Xiaofeng Yuan
    • Lianhua Piao
    • Luhui Wang
    • Xu Han
    • Ming Zhuang
    • Zhiwei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China, Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001, P.R. China, Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China
  • Pages: 979-987
    |
    Published online on: September 13, 2019
       https://doi.org/10.3892/ijo.2019.4877
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Abstract

Protein 4.1B/DAL‑1, encoded by erythrocyte membrane protein band 4.1‑like 3 (EPB41L3), belongs to the protein 4.1 superfamily, a group of proteins that share a conserved four.one‑ezrin‑radixin‑moesin (FERM) domain. Protein 4.1B/DAL‑1 serves a crucial role in cytoskeletal organization and a number of processes through multiple interactions with membrane proteins via its FERM, spectrin‑actin‑binding and C‑terminal domains. A number of studies have indicated that a loss of EPB41L3 expression is commonly observed in lung cancer, breast cancer, esophageal squamous cell carcinoma and meningiomas. DNA methylation and a loss of heterozygosity have been reported to contribute to the downregulation of EPB41L3. To date, the biological functions of protein 4.1B/DAL‑1 in carcinogenesis remain unknown. The present review summarizes the current understanding of the role of protein 4.1B/DAL‑1 in cancer and highlights its potential as a cancer diagnostic and prognostic biomarker in cancer therapeutics.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan X, Piao L, Wang L, Han X, Zhuang M and Liu Z: Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935. Int J Oncol 55: 979-987, 2019.
APA
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., & Liu, Z. (2019). Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935. International Journal of Oncology, 55, 979-987. https://doi.org/10.3892/ijo.2019.4877
MLA
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., Liu, Z."Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935". International Journal of Oncology 55.5 (2019): 979-987.
Chicago
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., Liu, Z."Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935". International Journal of Oncology 55, no. 5 (2019): 979-987. https://doi.org/10.3892/ijo.2019.4877
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan X, Piao L, Wang L, Han X, Zhuang M and Liu Z: Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935. Int J Oncol 55: 979-987, 2019.
APA
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., & Liu, Z. (2019). Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935. International Journal of Oncology, 55, 979-987. https://doi.org/10.3892/ijo.2019.4877
MLA
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., Liu, Z."Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935". International Journal of Oncology 55.5 (2019): 979-987.
Chicago
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., Liu, Z."Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935". International Journal of Oncology 55, no. 5 (2019): 979-987. https://doi.org/10.3892/ijo.2019.4877
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