Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review)

Corrigendum in: /10.3892/ijo.2019.4935

  • Authors:
    • Xiaofeng Yuan
    • Lianhua Piao
    • Luhui Wang
    • Xu Han
    • Ming Zhuang
    • Zhiwei Liu
  • View Affiliations

  • Published online on: September 13, 2019     https://doi.org/10.3892/ijo.2019.4877
  • Pages: 979-987
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Abstract

Protein 4.1B/DAL‑1, encoded by erythrocyte membrane protein band 4.1‑like 3 (EPB41L3), belongs to the protein 4.1 superfamily, a group of proteins that share a conserved four.one‑ezrin‑radixin‑moesin (FERM) domain. Protein 4.1B/DAL‑1 serves a crucial role in cytoskeletal organization and a number of processes through multiple interactions with membrane proteins via its FERM, spectrin‑actin‑binding and C‑terminal domains. A number of studies have indicated that a loss of EPB41L3 expression is commonly observed in lung cancer, breast cancer, esophageal squamous cell carcinoma and meningiomas. DNA methylation and a loss of heterozygosity have been reported to contribute to the downregulation of EPB41L3. To date, the biological functions of protein 4.1B/DAL‑1 in carcinogenesis remain unknown. The present review summarizes the current understanding of the role of protein 4.1B/DAL‑1 in cancer and highlights its potential as a cancer diagnostic and prognostic biomarker in cancer therapeutics.
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November-2019
Volume 55 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Yuan X, Piao L, Wang L, Han X, Zhuang M and Liu Z: Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935. Int J Oncol 55: 979-987, 2019
APA
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., & Liu, Z. (2019). Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935. International Journal of Oncology, 55, 979-987. https://doi.org/10.3892/ijo.2019.4877
MLA
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., Liu, Z."Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935". International Journal of Oncology 55.5 (2019): 979-987.
Chicago
Yuan, X., Piao, L., Wang, L., Han, X., Zhuang, M., Liu, Z."Pivotal roles of protein 4.1B/DAL‑1, a FERM‑domain containing protein, in tumor progression (Review) Corrigendum in /10.3892/ijo.2019.4935". International Journal of Oncology 55, no. 5 (2019): 979-987. https://doi.org/10.3892/ijo.2019.4877