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Article Open Access

SIP1 serves a role in HBx‑induced liver cancer growth and metastasis

  • Authors:
    • Yuanyuan Ye
    • Jun Yang
    • Qin Hu
    • Jinju Mao
    • Qianfan Yang
    • Hong Chen
    • Dandan Li
    • Pu Li
    • Liang Duan
    • Bo Wang
    • Juan Chen
    • Weixian Chen
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Key Laboratory of Molecular Biology of Infectious Diseases Designated by The Chinese Ministry of Education, Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1019-1032
    |
    Published online on: September 26, 2019
       https://doi.org/10.3892/ijo.2019.4884
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Abstract

Hepatitis B virus (HBV) has been revealed to be involved in the development of hepatocellular carcinoma. However, the mechanism remains to be fully elucidated. Smad‑interacting protein 1 (SIP1) is a transcriptional repressor, which serves a pivotal role in cell metastasis. In the present study, the role of SIP1 in HBx‑induced hepatocyte EMT and cancer aggressiveness was examined. It was found that HBV X protein (HBx) increased the expression of SIP1 and recruited it to the promoter of E‑cadherin, resulting in depression of the transcription of E‑cadherin. Histone deacetylase 1 was also found to be involved in the repressive complex formation. Furthermore, in an orthotopic tumor transplantation model in vivo, HBx promoted tumor growth and metastasis, whereas the knockdown of SIP1 attenuated the effect of HBx. These results indicate a novel mechanism for the development of HBV‑related liver cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ye Y, Yang J, Hu Q, Mao J, Yang Q, Chen H, Li D, Li P, Duan L, Wang B, Wang B, et al: SIP1 serves a role in HBx‑induced liver cancer growth and metastasis. Int J Oncol 55: 1019-1032, 2019.
APA
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H. ... Chen, W. (2019). SIP1 serves a role in HBx‑induced liver cancer growth and metastasis. International Journal of Oncology, 55, 1019-1032. https://doi.org/10.3892/ijo.2019.4884
MLA
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H., Li, D., Li, P., Duan, L., Wang, B., Chen, J., Chen, W."SIP1 serves a role in HBx‑induced liver cancer growth and metastasis". International Journal of Oncology 55.5 (2019): 1019-1032.
Chicago
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H., Li, D., Li, P., Duan, L., Wang, B., Chen, J., Chen, W."SIP1 serves a role in HBx‑induced liver cancer growth and metastasis". International Journal of Oncology 55, no. 5 (2019): 1019-1032. https://doi.org/10.3892/ijo.2019.4884
Copy and paste a formatted citation
x
Spandidos Publications style
Ye Y, Yang J, Hu Q, Mao J, Yang Q, Chen H, Li D, Li P, Duan L, Wang B, Wang B, et al: SIP1 serves a role in HBx‑induced liver cancer growth and metastasis. Int J Oncol 55: 1019-1032, 2019.
APA
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H. ... Chen, W. (2019). SIP1 serves a role in HBx‑induced liver cancer growth and metastasis. International Journal of Oncology, 55, 1019-1032. https://doi.org/10.3892/ijo.2019.4884
MLA
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H., Li, D., Li, P., Duan, L., Wang, B., Chen, J., Chen, W."SIP1 serves a role in HBx‑induced liver cancer growth and metastasis". International Journal of Oncology 55.5 (2019): 1019-1032.
Chicago
Ye, Y., Yang, J., Hu, Q., Mao, J., Yang, Q., Chen, H., Li, D., Li, P., Duan, L., Wang, B., Chen, J., Chen, W."SIP1 serves a role in HBx‑induced liver cancer growth and metastasis". International Journal of Oncology 55, no. 5 (2019): 1019-1032. https://doi.org/10.3892/ijo.2019.4884
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