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Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma

  • Authors:
    • Yu‑Xin Liao
    • Hai‑Yang Yu
    • Ji‑Yang Lv
    • Yan‑Rong Cai
    • Fei Liu
    • Zhi‑Min He
    • Shi‑Sheng He
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1213-1222
    |
    Published online on: October 18, 2019
       https://doi.org/10.3892/ijo.2019.4902
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Abstract

Osteosarcoma (OS) is the most common primary bone malignancy, mainly affecting children and adolescents. Currently, surgical resection combined with adjuvant chemotherapy has been standardized for OS treatment. Despite great advances in chemotherapy for OS, its clinical prognosis remains far from satisfactory; this is due to chemoresistance, which has become a major obstacle to improving OS treatment. Autophagy, a catabolic process through which cells eliminate and recycle their own damaged proteins and organelles to provide energy, can be activated by chemotherapeutic drugs. Accumulating evidence has indicated that autophagy plays the dual role in the regulation of OS chemoresistance by either promoting drug resistance or increasing drug sensitivity. The aim of the present review was to demonstrate thatautophagy has both a cytoprotective and an autophagic cell death function in OS chemoresistance. In addition, methods to detect autophagy, autophagy inducers and inhibitors, as well as autophagy‑mediated metastasis, immunotherapy and clinical prognosis are also discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Liao YX, Yu HY, Lv JY, Cai YR, Liu F, He ZM and He SS: Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma. Int J Oncol 55: 1213-1222, 2019.
APA
Liao, Y., Yu, H., Lv, J., Cai, Y., Liu, F., He, Z., & He, S. (2019). Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma. International Journal of Oncology, 55, 1213-1222. https://doi.org/10.3892/ijo.2019.4902
MLA
Liao, Y., Yu, H., Lv, J., Cai, Y., Liu, F., He, Z., He, S."Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma". International Journal of Oncology 55.6 (2019): 1213-1222.
Chicago
Liao, Y., Yu, H., Lv, J., Cai, Y., Liu, F., He, Z., He, S."Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma". International Journal of Oncology 55, no. 6 (2019): 1213-1222. https://doi.org/10.3892/ijo.2019.4902
Copy and paste a formatted citation
x
Spandidos Publications style
Liao YX, Yu HY, Lv JY, Cai YR, Liu F, He ZM and He SS: Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma. Int J Oncol 55: 1213-1222, 2019.
APA
Liao, Y., Yu, H., Lv, J., Cai, Y., Liu, F., He, Z., & He, S. (2019). Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma. International Journal of Oncology, 55, 1213-1222. https://doi.org/10.3892/ijo.2019.4902
MLA
Liao, Y., Yu, H., Lv, J., Cai, Y., Liu, F., He, Z., He, S."Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma". International Journal of Oncology 55.6 (2019): 1213-1222.
Chicago
Liao, Y., Yu, H., Lv, J., Cai, Y., Liu, F., He, Z., He, S."Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma". International Journal of Oncology 55, no. 6 (2019): 1213-1222. https://doi.org/10.3892/ijo.2019.4902
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