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Article

Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma

  • Authors:
    • Min Fan
    • Kai Wang
    • Xiaohui Wei
    • Hongwei Yao
    • Zhen Chen
    • Xiaozhou He
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China
  • Pages: 1385-1395
    |
    Published online on: October 21, 2019
       https://doi.org/10.3892/ijo.2019.4903
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Abstract

Eukaryotic initiation factor 3c (eIF3C) is involved in the initiation of protein translation. Aberrant eIF3C expression has been reported in different types of human cancer. The present study aimed to assess the role of eIF3C in the malignant behavior of renal cell carcinoma in vitro and in vivo. eIF3C expression was assessed in 16 pairs of renal cell carcinoma (RCC) and matched distant normal tissues, and in RCC cell lines using immunohistochemistry. Subsequently, eIF3C was depleted using lentiviral short hairpin RNA and cell proliferation, cell cycle distribution and apoptosis of these eIF3C‑depleted cells were examined. Additionally, tumor cell xenograft assays in nude mice, Affymetrix microarrays and ingenuity pathway analyses were performed. eIF3C expression was upregulated in RCC tissues and cell lines. Depletion of eIF3C reduced tumor cell proliferation and arrested them at the G1 stage, thus promoting their apoptosis in vitro. Depletion of eIF3C also inhibited the formation and growth of tumor cell xenografts in nude mice. In addition, depletion of eIF3C altered the expression levels of 994 differentially expressed genes in RCC cells (516 genes were upregulated and 478 genes were downregulated). The expression levels of phosphorylated‑AKT, c‑JUN and NFKB inhibitor α were lower in the shorth hairpin RNA eIF3C‑transfected RCC cells compared with in the control group. In conclusion, the present study demonstrated that upregulated eIF3C expression contributed to the development and progression of RCC. Future studies should further evaluate whether eIF3C could be used as a potential strategy for RCC targeting therapy.
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1 

Birkhäuser FD, Kroeger N and Pantuck AJ: Etiology of renal cell carcinoma: Incidence, demographics, and environmental factors. Renal Cell Carcinoma: Clinical Management. Springer Science; New York, NY: pp. 3–22. 2013, View Article : Google Scholar

2 

Zhou M and He H: Pathology of renal cell carcinoma. Renal Cancer. 43:51–69. 2013.

3 

Gupta K, Miller JD, Li JZ, Russell MW and Charbonneau C: Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review. Cancer Treat Rev. 34:193–205. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Cohen HT and McGovern FJ: Renal-cell carcinoma. N Engl J Med. 353:2477–2490. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Najjar YG and Rini BI: Novel agents in renal carcinoma: A reality check. Ther Adv Med Oncol. 4:183–194. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Rini BI, Campbell SC and Escudier B: Renal cell carcinoma. Lancet. 373:1119–1132. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Rohan SM, Xiao Y, Liang Y, Dudas ME, Al-Ahmadie HA, Fine SW, Gopalan A, Reuter VE, Rosenblum MK, Russo P and Tickoo SK: Clear-cell papillary renal cell carcinoma: Molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. Mod Pathol. 24:1207–1220. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Wu CZ, Zheng JJ, Bai YH, Xia P, Zhang HC and Guo Y: HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma. Onco Targets Ther. 11:4501–4510. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Zhai W, Ma J, Zhu R, Xu C, Zhang J, Chen Y, Chen Z, Gong D, Zheng J, Chen C, et al: MiR-532-5p suppresses renal cancer cell proliferation by disrupting the ETS1-mediated positive feedback loop with the KRAS-NAP1L1/P-ERK axis. Br J Cancer. 119:591–604. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Damayanti NP, Budka JA, Khella HWZ, Ferris MW, Ku SY, Kauffman E, Wood AC, Ahmed K, Chintala VN, Adelaiye-Ogala R, et al: Therapeutic targeting of TFE3/IRS-1/PI3K/mTOR axis in translocation renal cell carcinoma. Clin Cancer Res. 24:5977–5989. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Carlo MI, Mukherjee S, Mandelker D, Vijai J, Kemel Y, Zhang L, Knezevic A, Patil S, Ceyhan-Birsoy O, Huang KC, et al: Prevalence of germline mutations in cancer susceptibility genes in patients with advanced renal cell carcinoma. JAMA Oncol. 4:1228–1235. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Mitchell TJ, Rossi SH, Klatte T and Stewart GD: Genomics and clinical correlates of renal cell carcinoma. World J Urol. 36:1899–1911. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Emmanuel R, Weinstein S, Landesman-Milo D and Peer D: eIF3c: A potential therapeutic target for cancer. Cancer Lett. 336:158–166. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Sonenberg N and Hinnebusch AG: Regulation of translation initiation in eukaryotes: Mechanisms and biological targets. Cell. 136:731–745. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, et al: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc Natl Acad Sci USA. 105:18139–18144. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Hinnebusch AG: eIF3: A versatile scaffold for translation initiation complexes. Trends Biochem Sci. 31:553–562. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Hershey JW: The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 1849:792–800. 2015. View Article : Google Scholar

18 

Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J and Topisirovic I: Targeting the translation machinery in cancer. Nat Rev Drug Discov. 14:261–278. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Rothe M, Ko Y, Albers P and Wernert N: Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas. Am J Pathol. 157:1597–1604. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Scoles DR, Yong WH, Qin Y, Wawrowsky K and Pulst SM: Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c). Hum Mol Genet. 15:1059–1070. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Hao J, Liang C and Jiao B: Eukaryotic translation initiation factor 3, subunit C is overexpressed and promotes cell proliferation in human glioma U-87 MG cells. Oncol Lett. 9:2525–2533. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Hao J, Wang Z, Wang Y, Liang Z, Zhang X, Zhao Z and Jiao B: Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma. Oncol Rep. 33:2954–2962. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Song N, Wang Y, Gu XD, Chen ZY and Shi LB: Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells. J Zhejiang Univ Sci B. 14:451–459. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Li T, Li S, Chen D, Chen B, Yu T, Zhao F, Wang Q, Yao M, Huang S, Chen Z and He X: Transcriptomic analyses of RNA-binding proteins reveal eIF3c promotes cell proliferation in hepatocellular carcinoma. Cancer Sci. 108:877–885. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Lee HY, Chen CK, Ho CM, Lee SS, Chang CY, Chen KJ and Jou YS: eIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma. Oncotarget. 9:13193–13205. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Zhao W, Li X, Wang J, Wang C, Jia Y, Yuan S, Huang Y, Shi Y and Tong Z: Decreasing eukaryotic initiation factor 3C (eIF3C) suppresses proliferation and stimulates apoptosis in breast cancer cell lines through mammalian target of rapamycin (mTOR) pathway. Med Sci Monit. 23:4182–4191. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Hammes LS, Tekmal RR, Naud P, Edelweiss MI, Kirma N, Valente PT, Syrjänen KJ and Cunha-Filho JS: Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Gynecol Oncol. 110:445–451. 2008. View Article : Google Scholar : PubMed/NCBI

28 

ANSI/ATCC ASN-0002-2011: Authentication of Human Cell Lines: Standardization of STR Profiling. ANSI eStandards Store; 2012

29 

Capes-Davis A, Reid YA, Kline MC, Storts DR, Strauss E, Dirks WG, Drexler HG, MacLeod RA, Sykes G, Kohara A, et al: Match criteria for human cell line authentication: Where do we draw the line? Int J Cancer. 132:2510–2519. 2013. View Article : Google Scholar

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

31 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987. View Article : Google Scholar : PubMed/NCBI

32 

Dong Z and Zhang JT: Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer. Crit Rev Oncol Hematol. 59:169–180. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG and Hershey JW: Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. J Biol Chem. 272:27042–27052. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Karásková M, Gunišová S, Herrmannová A, Wagner S, Munzarová V and Valášek L: Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition. J Biol Chem. 287:28420–28434. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Erzberger JP, Stengel F, Pellarin R, Zhang S, Schaefer T, Aylett CHS, Cimermančič P, Boehringer D, Sali A, Aebersold R and Ban N: Molecular architecture of the 40SeIF1eIF3 translation initiation complex. Cell. 158:1123–1135. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Srivastava S, Verschoor A and Frank J: Eukaryotic initiation factor 3 does not prevent association through physical blockage of the ribosomal subunit-subunit interface. J Mol Biol. 226:301–304. 1992. View Article : Google Scholar : PubMed/NCBI

37 

Zang Y, Zhang X, Yan L, Gu G, Li D, Zhang Y, Fang L, Fu S, Ren J and Xu Z: Eukaryotic translation initiation factor 3b is both a promising prognostic biomarker and a potential therapeutic target for patients with clear cell renal cell carcinoma. J Cancer. 8:3049–3061. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Sadato D, Ono T, Gotoh-Saito S, Kajiwara N, Nomura N, Ukaji M, Yang L, Sakimura K, Tajima Y, Oboki K and Shibasaki F: Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation. FEBS Open Bio. 8:1188–1201. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Shen J, Yin JY, Li XP, Liu ZQ, Wang Y, Chen J, Qu J, Xu XJ, McLeod HL, He YJ, et al: The prognostic value of altered eIF3a and its association with p27 in non-small cell lung cancers. PLoS One. 9:e960082014. View Article : Google Scholar : PubMed/NCBI

40 

Xu F, Xu CZ, Gu J, Liu X, Liu R, Huang E, Yuan Y, Zhao G, Jiang J, Xu C, et al: Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway. Oncotarget. 7:43401–43411. 2016.PubMed/NCBI

41 

Zhu Q, Qiao GL, Zeng XC, Li Y, Yan JJ, Duan R and Du ZY: Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in human hepatocellular carcinoma. Oncotarget. 7:49888–49901. 2016.PubMed/NCBI

42 

Qi J, Dong Z, Liu J and Zhang JT: EIF3i promotes colon onco-genesis by regulating COX-2 protein synthesis and β-catenin activation. Oncogene. 33:4156–4163. 2014. View Article : Google Scholar

43 

Golob-Schwarzl N, Schweiger C, Koller C, Krassnig S, Gogg-Kamerer M, Gantenbein N, Toeglhofer AM, Wodlej C, Bergler H, Pertschy B, et al: Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6. Oncotarget. 8:101224–101243. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Chen K, Yang J, Li J, Wang X, Chen Y, Huang S and Chen JL: eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants. Oncotarget. 7:10073–10089. 2016.PubMed/NCBI

45 

Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP and Ron D: Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol. 24:10161–10168. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fan M, Wang K, Wei X, Yao H, Chen Z and He X: Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma. Int J Oncol 55: 1385-1395, 2019.
APA
Fan, M., Wang, K., Wei, X., Yao, H., Chen, Z., & He, X. (2019). Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma. International Journal of Oncology, 55, 1385-1395. https://doi.org/10.3892/ijo.2019.4903
MLA
Fan, M., Wang, K., Wei, X., Yao, H., Chen, Z., He, X."Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma". International Journal of Oncology 55.6 (2019): 1385-1395.
Chicago
Fan, M., Wang, K., Wei, X., Yao, H., Chen, Z., He, X."Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma". International Journal of Oncology 55, no. 6 (2019): 1385-1395. https://doi.org/10.3892/ijo.2019.4903
Copy and paste a formatted citation
x
Spandidos Publications style
Fan M, Wang K, Wei X, Yao H, Chen Z and He X: Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma. Int J Oncol 55: 1385-1395, 2019.
APA
Fan, M., Wang, K., Wei, X., Yao, H., Chen, Z., & He, X. (2019). Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma. International Journal of Oncology, 55, 1385-1395. https://doi.org/10.3892/ijo.2019.4903
MLA
Fan, M., Wang, K., Wei, X., Yao, H., Chen, Z., He, X."Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma". International Journal of Oncology 55.6 (2019): 1385-1395.
Chicago
Fan, M., Wang, K., Wei, X., Yao, H., Chen, Z., He, X."Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma". International Journal of Oncology 55, no. 6 (2019): 1385-1395. https://doi.org/10.3892/ijo.2019.4903
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