|
1
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Parkin DM: The global health burden of
infection-associated cancers in the year 2002. Int J Cancer.
118:3030–3044. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Giannelli G and Antonaci S: Novel concepts
in hepatocellular carcinoma: From molecular research to clinical
practice. J Clin Gastroenterol. 40:842–846. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Han YF, Zhao J, Ma LY, Yin JH, Chang WJ,
Zhang HW and Cao GW: Factors predicting occurrence and prognosis of
hepatitis-B-virus-related hepatocellular carcinoma. World J
Gastroenterol. 17:4258–4270. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Tarocchi M, Polvani S, Marroncini G and
Galli A: Molecular mechanism of hepatitis B virus-induced
hepatocarcinogenesis. World J Gastroenterol. 20:11630–11640. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Costa FF: Non-coding RNAs: Could they be
the answer? Brief Funct Genomics. 10:316–319. 2011. View Article : Google Scholar
|
|
7
|
Jia H, Osak M, Bogu GK, Stanton LW,
Johnson R and Lipovich L: Genome-wide computational identification
and manual annotation of human long noncoding RNA genes. RNA.
16:1478–1487. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Cabili MN, Trapnell C, Goff L, Koziol M,
Tazon-Vega B, Regev A and Rinn JL: Integrative annotation of human
large intergenic noncoding RNAs reveals global properties and
specific subclasses. Genes Dev. 25:1915–1927. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Ponting CP, Oliver PL and Reik W:
Evolution and functions of long noncoding RNAs. Cell. 136:629–641.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Huarte M: The emerging role of lncRNAs in
cancer. Nat Med. 21:1253–1261. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
He Y, Meng XM, Huang C, Wu BM, Zhang L, Lv
XW and Li J: Long noncoding RNAs: Novel insights into hepatocelluar
carcinoma. Cancer Lett. 344:20–27. 2014. View Article : Google Scholar
|
|
12
|
Yang F, Zhang L, Huo XS, Yuan JH, Xu D,
Yuan SX, Zhu N, Zhou WP, Yang GS, Wang YZ, et al: Long noncoding
RNA high expression in hepatocellular carcinoma facilitates tumor
growth through enhancer of zeste homolog 2 in humans. Hepatology.
54:1679–1689. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Hu JJ, Song W, Zhang SD, Shen XH, Qiu XM,
Wu HZ, Gong PH, Lu S, Zhao ZJ, He ML and Fan H: HBx-upregulated
lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting
EZH2 and repressing p27Kip1/CDK2 signaling. Sci Rep. 6:235212016.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Fu WM, Zhu X, Wang WM, Lu YF, Hu BG, Wang
H, Liang WC, Wang SS, Ko CH, Waye MM, et al: Hotair mediates
hepatocarcinogenesis through suppressing miRNA-218 expression and
activating P14 and P16 signaling. J Hepatol. 63:886–895. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Deng X, Zhao XF, Liang XQ, Chen R, Pan YF
and Liang J: Linc00152 promotes cancer progression in hepatitis B
virus-associated hepatocellular carcinoma. Biomed Pharmacother.
90:100–108. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Huang MD, Chen WM, Qi FZ, Xia R, Sun M, Xu
TP, Yin L, Zhang EB, De W and Shu YQ: Long non-coding RNA ANRIL is
upregulated in hepatocellular carcinoma and regulates cell
apoptosis by epigenetic silencing of KLF2. J Hematol Oncol.
8:502015. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zhang H, Diab A, Fan H, Mani SK, Hullinger
R, Merle P and Andrisani O: PLK1 and HOTAIR accelerate proteasomal
degradation of SUZ12 and ZNF198 during Hepatitis B virus-induced
liver carcinogenesis. Cancer Res. 75:2363–2374. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zhang H, Xing Z, Mani SK, Bancel B,
Durantel D, Zoulim F, Tran EJ, Merle P and Andrisani O: RNA
helicase DEAD box protein 5 regulates Polycomb repressive complex
2/Hox transcript antisense intergenic RNA function in hepatitis B
virus infection and hepatocarcinogenesis. Hepatology. 64:1033–1048.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wang KC, Yang YW, Liu B, Sanyal A,
Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A, Flynn RA, Gupta
RA, et al: A long noncoding RNA maintains active chromatin to
coordinate homeotic gene expression. Nature. 472:120–124. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Tsang FH, Au SL, Wei L, Fan DN, Lee JM,
Wong CC, Ng IO and Wong CM: Long non-coding RNA HOTTIP is
frequently up-regulated in hepatocellular carcinoma and is targeted
by tumour suppressive miR-125b. Liver Int. 35:1597–606. 2015.
View Article : Google Scholar
|
|
21
|
Quagliata L, Matter MS, Piscuoglio S,
Arabi L, Ruiz C, Procino A, Kovac M, Moretti F, Makowska Z,
Boldanova T, et al: Long noncoding RNA HOTTIP/HOXA13 expression is
associated with disease progression and predicts outcome in
hepatocellular carcinoma patients. Hepatology. 59:911–923. 2014.
View Article : Google Scholar :
|
|
22
|
Quagliata L, Quintavalle C, Lanzafame M,
Matter MS, Novello C, di Tommaso L, Pressiani T, Rimassa L,
Tornillo L, Roncalli M, et al: High expression of HOXA13 correlates
with poorly differentiated hepatocellular carcinomas and modulates
sorafenib response in in vitro models. Lab Invest. 98:95–105. 2018.
View Article : Google Scholar
|
|
23
|
Ji J, Tang J, Deng L, Xie Y, Jiang R, Li G
and Sun B: LINC00152 promotes proliferation in hepatocellular
carcinoma by targeting EpCAM via the mTOR signaling pathway.
Oncotarget. 6:42813–42824. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Hou Z, Xu X, Fu X, Tao S, Zhou J, Liu S
and Tan D: HBx-related long non-coding RNA MALAT1 promotes cell
metastasis via up-regulating LTBP3 in hepatocellular carcinoma. Am
J Cancer Res. 7:845–856. 2017.PubMed/NCBI
|
|
25
|
Tripathi V, Ellis JD, Shen Z, Song DY, Pan
Q, Watt AT, Freier SM, Bennett CF, Sharma A, Bubulya PA, et al: The
nuclear-retained noncoding RNA MALAT1 regulates alternative
splicing by modulating SR splicing factor phosphorylation. Mol
Cell. 39:925–938. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Miyagawa R, Tano K, Mizuno R, Nakamura Y,
Ijiri K, Rakwal R, Shibato J, Masuo Y, Mayeda A, Hirose T and
Akimitsu N: Identification of cis- and trans-acting factors
involved in the localization of MALAT-1 noncoding RNA to nuclear
speckles. RNA. 18:738–751. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Salmena L, Poliseno L, Tay Y, Kats L and
Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA
language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Thomson DW and Dinger ME: Endogenous
microRNA sponges: Evidence and controversy. Nat Rev Genet.
17:272–283. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Lv J, Fan HX, Zhao XP, Lv P, Fan JY, Zhang
Y, Liu M and Tang H: Long non-coding RNA Unigene56159 promotes
epithelial-mesenchymal transition by acting as a ceRNA of
miR-140-5p in hepatocellular carcinoma cells. Cancer Lett.
382:166–175. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y,
Chen N, Sun F and Fan Q: CREB up-regulates long non-coding RNA,
HULC expression through interaction with microRNA-372 in liver
cancer. Nucleic Acids Res. 38:5366–5383. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang Y, Chen F, Zhao M, Yang Z, Li J,
Zhang S, Zhang W, Ye L and Zhang X: The long noncoding RNA HULC
promotes liver cancer by increasing the expression of the HMGA2
oncogene via sequestration of the microRNA-186. J Biol Chem.
292:15395–15407. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Hu D, Shen D, Zhang M, Jiang N, Sun F,
Yuan S and Wan K: MiR-488 suppresses cell proliferation and
invasion by targeting ADAM9 and lncRNA HULC in hepatocellular
carcinoma. Am J Cancer Res. 7:2070–2080. 2017.PubMed/NCBI
|
|
33
|
Li SP, Xu HX, Yu Y, He JD, Wang Z, Xu YJ,
Wang CY, Zhang HM, Zhang RX, Zhang JJ, et al: LncRNA HULC enhances
epithelial-mesenchymal transition to promote tumorigenesis and
metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1
signaling pathway. Oncotarget. 7:42431–42446. 2016.PubMed/NCBI
|
|
34
|
Xiong H, Ni Z, He J, Jiang S, Li X, He J,
Gong W, Zheng L, Chen S, Li B, et al: LncRNA HULC triggers
autophagy via stabilizing Sirt1 and attenuates the chemosensitivity
of HCC cells. Oncogene. 36:3528–3540. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Lu Z, Xiao Z, Liu F, Cui M, Li W, Yang Z,
Li J, Ye L and Zhang X: Long non-coding RNA HULC promotes tumor
angiogenesis in liver cancer by up-regulating sphingosine kinase 1
(SPHK1). Oncotarget. 7:241–254. 2016.
|
|
36
|
Liang HW, Wang N, Wang Y, Wang F, Fu Z,
Yan X, Zhu H, Diao W, Ding Y, Chen X, et al: Hepatitis B
virus-human chimeric transcript HBx-LINE1 promotes hepatic injury
via sequestering cellular microRNA-122. J Hepatol. 64:278–291.
2016. View Article : Google Scholar
|
|
37
|
Xiao JN, Yan TH, Yu RM, Gao Y, Zeng WL, Lu
SW, Que HX, Liu ZP and Jiang JH: Long non-coding RNA UCA1 regulates
the expression of Snail2 by miR-203 to promote hepatocellular
carcinoma progression. J Cancer Res Clin Oncol. 143:981–990. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Ma J, Li T, Han X and Yuan H: Knockdown of
LncRNA ANRIL suppresses cell proliferation, metastasis, and
invasion via regulating miR-122-5p expression in hepatocellular
carcinoma. J Cancer Res Clin Oncol. 144:205–214. 2018. View Article : Google Scholar
|
|
39
|
Xiong H, Li B, He J, Zeng Y, Zhang Y and
He F: lncRNA HULC promotes the growth of hepatocellular carcinoma
cells via stabilizing COX-2 protein. Biochem Biophys Res Commun.
490:693–699. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Huang JF, Guo YJ, Zhao CX, Yuan SX, Wang
Y, Tang GN, Zhou WP and Sun SH: Hepatitis B virus X protein
(HBx)-related long noncoding RNA (lncRNA) down-regulated expression
by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by
targeting the intermediate filament protein vimentin. Hepatology.
57:1882–1892. 2013. View Article : Google Scholar
|
|
41
|
Zhao Q, Li T, Qi J, Liu J and Qin C: The
miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in
HBV-related hepatocellular carcinoma and promotes tumorigenesis and
tumor progression. PLoS One. 9:e1097822014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Panzitt K, Tschernatsch MM, Guelly C,
Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder
R, Trauner M and Zatloukal K: Characterization of HULC, a novel
gene with striking up-regulation in hepatocellular carcinoma, as
noncoding RNA. Gastroenterology. 132:330–342. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Sonohara F, Inokawa Y, Hayashi M, Yamada
S, Sugimoto H, Fujii T, Kodera Y and Nomoto S: Prognostic value of
long non-coding RNA HULC and MALAT1 following the curative
resection of hepatocellular carcinoma. Sci Rep. 7:161422017.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Du Y, Kong G, You X, Zhang S, Zhang T, Gao
Y, Ye L and Zhang X: Elevation of highly up-regulated in liver
cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell
proliferation via down-regulating p18. J Biol Chem.
287:26302–26311. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Jiang Z and Liu H: Metformin inhibits
tumorigenesis in HBV-induced hepatocellular carcinoma by
suppressing HULC overexpression caused by HBX. J Cell Biochem.
119:4482–4495. 2018. View Article : Google Scholar
|
|
46
|
Rinn JL, Kertesz M, Wang JK, Squazzo SL,
Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E and
Chang HY: Functional demarcation of active and silent chromatin
domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1123.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Zhang J, Zhang P, Wang L, Piao HL and Ma
L: Long non-coding RNA HOTAIR in carcinogenesis and metastasis.
Acta Biochim Biophys Sin (Shanghai). 46:1–5. 2014. View Article : Google Scholar
|
|
48
|
Yang Z, Zhou L, Wu LM, Lai MC, Xie HY,
Zhang F and Zheng SS: Overexpression of long non-coding RNA HOTAIR
predicts tumor recurrence in hepatocellular carcinoma patients
following liver transplantation. Ann Surg Oncol. 18:1243–1250.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Ding C, Cheng S, Yang Z, Lv Z, Xiao H, Du
C, Peng C, Xie H, Zhou L, Wu J and Zheng S: Long non-coding RNA
HOTAIR promotes cell migration and invasion via down-regulation of
RNA binding motif protein 38 in hepatocellular carcinoma cells. Int
J Mol Sci. 15:4060–4076. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Su DN, Wu SP, Chen HT and He JH: HOTAIR, a
long non-coding RNA driver of malignancy whose expression is
activated by FOXC1, negatively regulates miRNA-1 in hepatocellular
carcinoma. Oncol Lett. 12:4061–4067. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Gao JZ, Li J, Du JL and Li XL: Long
non-coding RNA HOTAIR is a marker for hepatocellular carcinoma
progression and tumor recurrence. Oncol Lett. 11:1791–1798. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Yang L, Zhang X, Li H and Liu J: The long
noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and
ATG7 in hepatocellular carcinoma. Mol Biosyst. 12:2605–2612. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Wei S, Fan Q, Yang L, Zhang X, Ma Y, Zong
Z, Hua X, Su D, Sun H, Li H and Liu Z: Promotion of glycolysis by
HOTAIR through GLUT1 upregulation via mTOR signaling. Oncol Rep.
38:1902–1908. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Geng YJ, Xie SL, Li Q, Ma J and Wang GY:
Large intervening non-coding RNA HOTAIR is associated with
hepatocellular carcinoma progression. J Int Med Res. 39:2119–2128.
2011. View Article : Google Scholar
|
|
55
|
Ishibashi M, Kogo R, Shibata K, Sawada G,
Takahashi Y, Kurashige J, Akiyoshi S, Sasaki S, Iwaya T, Sudo T, et
al: Clinical significance of the expression of long non-coding RNA
HOTAIR in primary hepatocellular carcinoma. Oncol Rep. 29:946–950.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Wu Y, Xiong Q, Li S, Yang X and Ge F:
Integrated proteomic and transcriptomic analysis reveals long
noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR)
promotes hepatocellular carcinoma cell proliferation by regulating
opioid growth factor receptor (OGFr). Mol Cell Proteomics.
17:146–159. 2018. View Article : Google Scholar :
|
|
57
|
Fujisaka Y, Iwata T, Tamai K, Nakamura M,
Mochizuki M, Shibuya R, Yamaguchi K, Shimosegawa T and Satoh K:
Long non-coding RNA HOTAIR up-regulates chemokine (C-C motif)
ligand 2 and promotes proliferation of macrophages and
myeloid-derived suppressor cells in hepatocellular carcinoma cell
lines. Oncol Lett. 15:509–514. 2018.PubMed/NCBI
|
|
58
|
Zhou JJ, Cheng D, He XY, Meng Z, Ye HL and
Chen RF: Knockdown of long non-coding RNA HOTAIR sensitizes
hepatocellular carcinoma cell to cisplatin by suppressing the
STAT3/ABCB1 signaling pathway. Oncol Lett. 14:7986–7992.
2017.PubMed/NCBI
|
|
59
|
Ji P, Diederichs S, Wang W, Boing S,
Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, et
al: MALAT-1, a novel noncoding RNA, and thymosin beta4 predict
metastasis and survival in early-stage non-small cell lung cancer.
Oncogene. 22:8031–8041. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Tian X and Xu G: Clinical value of lncRNA
MALAT1 as a prognostic marker in human cancer: Systematic review
and meta-analysis. BMJ Open. 5:e0086532015. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY,
Zhang F, Wu LM, Chen LM and Zheng SS: Long non-coding RNA MALAT-1
over-expression predicts tumor recurrence of hepatocellular
carcinoma after liver transplantation. Med Oncol. 29:1810–1816.
2012. View Article : Google Scholar
|
|
62
|
Yuan P, Cao W, Zang Q, Li G, Guo X and Fan
J: The HIF-2a-MALAT1-miR-216b axis regulates multi-drug resistance
of hepatocellular carcinoma cells via modulating autophagy. Biochem
Biophys Res Commun. 478:1067–1073. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Chen L, Yao H, Wang K and Liu X: Long
non-coding RNA MALAT1 regulates ZEB1 expression by sponging
miR-143-3p and promotes hepatocellular carcinoma progression. J
Cell Biochem. 118:4836–4843. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Li C, Miao R, Liu S, Wan Y, Zhang S, Deng
Y, Bi J, Qu K, Zhang J and Liu C: Down-regulation of miR-146b-5p by
long noncoding RNA MALAT1 in hepatocellular carcinoma promotes
cancer growth and metastasis. Oncotarget. 8:28683–28695.
2017.PubMed/NCBI
|
|
65
|
Huang Z, Huang L, Shen S, Li J, Lu H, Mo
W, Dang Y, Luo D, Chen G and Feng Z: Sp1 cooperates with Sp3 to
upregulate MALAT1 expression in human hepatocellular carcinoma.
Oncol Rep. 34:2403–2412. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
He B, Peng F, Li W and Jiang Y:
Interaction of lncRNA-MALAT1 and miR-124 regulates HBx-induced
cancer stem cell properties in HepG2 through PI3K/Akt signaling. J
Cell Biochem. 120:2908–2918. 2019. View Article : Google Scholar
|
|
67
|
Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW,
Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, et al: Rapid identification
of UCA1 as a very sensitive and specific unique marker for human
bladder carcinoma. Clin Cancer Res. 12:4851–4858. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Xue M, Chen W and Li X: Urothelial cancer
associated 1: A long noncoding RNA with a crucial role in cancer. J
Cancer Res Clin Oncol. 142:1407–1419. 2016. View Article : Google Scholar
|
|
69
|
Wang H, Guan Z, He K, Qian J, Cao J and
Teng L: LncRNA UCA1 in anti-cancer drug resistance. Oncotarget.
8:64638–64650. 2017.PubMed/NCBI
|
|
70
|
Wang F, Ying HQ, He BS, Pan YQ, Deng QW,
Sun HL, Chen J, Liu X and Wang SK: Upregulated lncRNA-UCA1
contributes to progression of hepatocellular carcinoma through
inhibition of miR-216b and activation of FGFR1/ERK signaling
pathway. Oncotarget. 6:7899–7917. 2015.PubMed/NCBI
|
|
71
|
Huang J, Zhou N, Watabe K, Lu Z, Wu F, Xu
M and Mo YY: Long non-coding RNA UCA1 promotes breast tumor growth
by suppression of p27 (Kip1). Cell Death Dis. 5:e10082014.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Zhang Y, Li Z, Zhang Y, Zhong Q, Chen Q
and Zhang L: Molecular mechanism of HEIH and HULC in the
proliferation and invasion of hepatoma cells. Int J Clin Exp Med.
8:12956–12962. 2015.PubMed/NCBI
|
|
73
|
Zhang Q, Matsuura K, Kleiner DE, Zamboni
F, Alter HJ and Farci P: Analysis of long noncoding RNA expression
in hepatocellular carcinoma of different viral etiology. J Transl
Med. 14:3282016. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Yu Y, Yang J, Li Q, Xu B, Lian Y and Miao
L: LINC00152: A pivotal oncogenic long non-coding RNA in human
cancers. Cell Prolif. 50:2017. View Article : Google Scholar
|
|
75
|
Neumann O, Kesselmeier M, Geffers R,
Pellegrino R, Radlwimmer B, Hoffmann K, Ehemann V, Schemmer P,
Schirmacher P, Lorenzo Bermejo J and Longerich T: Methylome
analysis and integrative profiling of human HCCs identify novel
protumorigenic factors. Hepatology. 56:1817–1827. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Lian Y, Cai Z, Gong H, Xue S, Wu D and
Wang K: HOTTIP: A critical oncogenic long non-coding RNA in human
cancers. Mol Biosyst. 12:3247–3253. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Zhang Y, Huang JC, Cai KT, Yu XB, Chen YR,
Pan WY, He ZL, Lv J, Feng ZB and Chen G: Long noncoding RNA HOTTIP
promotes hepatocellular carcinoma tumorigenesis and development: A
comprehensive investigation based on bioinformatics, qRTPCR and
metaanalysis of 393 cases. Int J Oncol. 51:1705–1721. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Ge Y, Yan X, Jin Y, Yang X, Yu X, Zhou L,
Han S, Yuan Q and Yang M: MiRNA-192 [corrected] and miRNA-204
directly suppress lncRNA HOTTIP and Interrupt GLS1-mediated
glutaminolysis in hepatocellular carcinoma. PLoS Genet.
11:e10057262015. View Article : Google Scholar
|
|
79
|
Brechot C, Gozuacik D, Murakami Y and
Paterlini-Brechot P: Molecular bases for the development of
hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Semin Cancer Biol. 10:211–231. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Lau CC, Sun T, Ching AK, He M, Li JW, Wong
AM, Co NN, Chan AW, Li PS, Lung RW, et al: Viral-human chimeric
transcript predisposes risk to liver cancer development and
progression. Cancer Cell. 25:335–349. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Ding SL, Yang ZW, Wang J, Zhang XL, Chen
XM and Lu FM: Integrative analysis of aberrant Wnt signaling in
hepatitis B virus-related hepatocellular carcinoma. World J
Gastroenterol. 21:6317–6328. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Pasmant E, Laurendeau I, Hèron D, Vidaud
M, Vidaud D and Bièche I: Characterization of a germ-line deletion,
including the entire INK4/ARF locus, in a melanoma-neural system
tumor family: Identification of ANRIL, an antisense noncoding RNA
whose expression coclusters with ARF. Cancer Res. 67:3963–3969.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Li Z, Yu X and Shen J: ANRIL: A pivotal
tumor suppressor long non-coding RNA in human cancers. Tumour Biol.
37:5657–5661. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Hua L, Wang CY, Yao KH, Chen JT, Zhang JJ
and Ma WL: High expression of long non-coding RNA ANRIL is
associated with poor prognosis in hepatocellular carcinoma. Int J
Clin Exp Pathol. 8:3076–3082. 2015.PubMed/NCBI
|
|
85
|
Magkoufopoulou C, Claessen SM, Jennen DG,
Kleinjans JC and van Delft JH: Comparison of phenotypic and
transcriptomic effects of false-positive genotoxins, true
genotoxins and non-genotoxins using HepG2 cells. Mutagenesis.
26:593–604. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Huang JL, Ren TY, Cao SW, Zheng SH, Hu XM,
Hu YW, Lin L, Chen J, Zheng L and Wang Q: HBx-related long
non-coding RNA DBH-AS1 promotes cell proliferation and survival by
activating MAPK signaling in hepatocellular carcinoma. Oncotarget.
6:33791–33804. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Lv D, Wang Y, Zhang Y, Cui P and Xu Y:
Downregulated long non-coding RNA DREH promotes cell proliferation
in hepatitis B virus-associated hepatocellular carcinoma. Oncol
Lett. 14:2025–2032. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Niu J, Lin Y, Liu P, Yu Y, Su C and Wang
X: Microarray analysis on the lncRNA expression profile in male
hepatocelluar carcinoma patients with chronic hepatitis B virus
infection. Oncotarget. 7:76169–76180. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Fan H, Zhang Q, Zhao X, Lv P, Liu M and
Tang H: Transcriptomic profiling of long non-coding RNAs in
hepatitis B virus-related hepatocellular carcinoma. Oncotarget.
8:65421–65434. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Luo HL, Chen J, Luo T, Wu FX, Liu JJ, Wang
HF, Chen M, Li LQ and Li H: Downregulation of macrophage-derived
T-UCR uc.306 associates with poor prognosis in hepatocellular
carcinoma. Cell Physiol Biochem. 42:1526–1539. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Gong X, Wei W, Chen L, Xia Z and Yu C:
Comprehensive analysis of long non-coding RNA expression profiles
in hepatitis B virus-related hepatocellular carcinoma. Oncotarget.
7:42422–42430. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Xia J, Inagaki Y, Sawakami T, Song P, Cai
Y, Hasegawa K, Sakamoto Y, Akimitsu N, Tang W and Kokudo N:
Preliminary investigation of five novel long non-coding RNAs in
hepatocel-lular carcinoma cell lines. Biosci Trends. 10:315–319.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Yu S, Li N, Huang Z, Chen R, Yi P, Kang R,
Tang D, Hu X and Fan X: A novel lncRNA, TCONS_00006195, represses
hepatocellular carcinoma progression by inhibiting enzymatic
activity of ENO1. Cell Death Dis. 9:11842018. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Hu Z, Huang P, Yan Y, Zhou Z, Wang J and
Wu G: Hepatitis B virus X protein related lncRNA WEE2-AS1 promotes
hepatocellular carcinoma proliferation and invasion. Biochem
Biophys Res Commun. 508:79–86. 2019. View Article : Google Scholar
|
|
95
|
Huang JF, Wang Y, Liu F, Liu Y, Zhao CX,
Guo YJ and Sun SH: EVI1 promotes cell proliferation in HBx-induced
hepatocarcinogenesis as a critical transcription factor regulating
lncRNAs. Oncotarget. 7:21887–21899. 2016.PubMed/NCBI
|
|
96
|
Yu TT, Xu XM, Hu Y, Deng JJ, Ge W, Han NN
and Zhang MX: Long noncoding RNAs in hepatitis B virus-related
hepatocellular carcinoma. World J Gastroenterol. 21:7208–7217.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Pan YF, Qin T, Feng L and Yu ZJ:
Expression profile of altered long non-coding RNAs in patients with
HBV-associated hepatocellular carcinoma. J Huazhong Univ Sci
Technolog Med Sci. 33:96–101. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Kuang XY, Li N, Fu YM, Li J and Fan XG:
Expression profiles of long non-coding RNAs in human liver cell
line LO2 with stable expression of hepatitis B x gene. Zhonghua Gan
Zang Bing Za Zhi. 24:417–421. 2016.In Chinese. PubMed/NCBI
|
|
99
|
Jin Y, Wu D, Yang W, Weng M, Li Y, Wang X,
Zhang X, Jin X and Wang T: Hepatitis B virus x protein induces
epithelial-mesenchymal transition of hepatocellular carcinoma cells
by regulating long non-coding RNA. Virol J. 14:2382017. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Li H, Zhao X, Li C, Sheng C and Bai Z:
Integrated analysis of lncRNA-associated ceRNA network reveals
potential biomarkers for the prognosis of hepatitis B virus-related
hepato-cellular carcinoma. Cancer Manag Res. 11:877–897. 2019.
View Article : Google Scholar :
|
|
101
|
Gu JX, Zhang X, Miao RC, Xiang XH, Fu YN,
Zhang JY, Liu C and Qu K: Six-long non-coding RNA signature
predicts recurrence-free survival in hepatocellular carcinoma.
World J Gastroenterol. 25:220–232. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Toyoda H, Kumada T, Tada T, Sone Y,
Kaneoka Y and Maeda A: Tumor markers for hepatocellular carcinoma:
Simple and significant predictors of outcome in patients with HCC.
Liver Cancer. 4:126–136. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Zhou L, Liu J and Luo F: Serum tumor
markers for detection of hepatocellular carcinoma. World J
Gastroenterol. 12:1175–1181. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Xie H, Ma H and Zhou D: Plasma HULC as a
promising novel biomarker for the detection of hepatocellular
carcinoma. Biomed Res Int. 2013:1361062013. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Li J, Wang X, Tang J, Jiang R, Zhang W, Ji
J and Sun B: HULC and Linc00152 Act as novel biomarkers in
predicting diagnosis of hepatocellular carcinoma. Cell Physiol
Biochem. 37:687–696. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Konishi H, Ichikawa D, Yamamoto Y, Arita
T, Shoda K, Hiramoto H, Hamada J, Itoh H, Fujita Y, Komatsu S, et
al: Plasma level of metastasis-associated lung adenocarcinoma
transcript 1 is associated with liver damage and predicts
development of hepatocellular carcinoma. Cancer Sci. 107:149–154.
2016. View Article : Google Scholar :
|
|
107
|
Yuan W, Sun Y, Liu L, Zhou B, Wang S and
Gu D: Circulating LncRNAs serve as diagnostic markers for
hepatocellular carcinoma. Cell Physiol Biochem. 44:125–132. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Yu J, Han J, Zhang J, Li G, Liu H, Cui X,
Xu Y, Li T, Liu J and Wang C: The long noncoding RNAs PVT1 and
uc002mbe.2 in sera provide a new supplementary method for
hepatocellular carcinoma diagnosis. Medicine (Baltimore).
95:e44362016. View Article : Google Scholar
|
|
109
|
Lu J, Xie F, Geng L, Shen W, Sui C and
Yang J: Investigation of serum lncRNA-uc003wbd and lncRNA-AF085935
expression profile in patients with hepatocellular carcinoma and
HBV. Tumour Biol. 36:3231–3236. 2015. View Article : Google Scholar
|
|
110
|
Wang K, Guo WX, Li N, Gao CF, Shi J, Tang
YF, Shen F, Wu MC, Liu SR and Cheng SQ: Serum LncRNAs profiles
serve as novel potential biomarkers for the diagnosis of
HBV-positive hepatocellular carcinoma. PLoS One. 10:e01449342015.
View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Freedman ML, Monteiro AN, Gayther SA,
Coetzee GA, Risch A, Plass C, Casey G, De Biasi M, Carlson C,
Duggan D, et al: Principles for the post-GWAS functional
characterization of cancer risk loci. Nat Genet. 43:513–518. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Hindorff LA, Sethupathy P, Junkins HA,
Ramos EM, Mehta JP, Collins FS and Manolio TA: Potential etiologic
and functional implications of genome-wide association loci for
human diseases and traits. Proc Natl Acad Sci USA. 106:9362–9367.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Rao A, Rajkumar T and Mani S: Perspectives
of long non-coding RNAs in cancer. Mol Biol Rep. 44:203–218. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Liu Y, Pan S, Liu L, Zhai X, Liu J, Wen J,
Zhang Y, Chen J, Shen H and Hu Z: A genetic variant in long
non-coding RNA HULC contributes to risk of HBV-related
hepatocellular carcinoma in a Chinese population. PLoS One.
7:e351452012. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Li H, Tang XM, Liu Y, Li W, Chen Q and Pan
Y: Association of functional genetic variants of HOTAIR with
hepatocellular carcinoma (HCC) susceptibility in a Chinese
population. Cell Physiol Biochem. 44:447–454. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Chang L, Li C, Lan T, Wu L, Yuan Y, Liu Q
and Liu Z: Decreased expression of long non-coding RNA GAS5
indicates a poor prognosis and promotes cell proliferation and
invasion in hepatocellular carcinoma by regulating vimentin. Mol
Med Rep. 13:1541–1550. 2016. View Article : Google Scholar :
|
|
117
|
Tu ZQ, Li RJ, Mei JZ and Li XH:
Down-regulation of long non-coding RNA GAS5 is associated with the
prognosis of hepatocellular carcinoma. Int J Clin Exp Pathol.
7:4303–4309. 2014.PubMed/NCBI
|
|
118
|
Tao R, Hu S, Wang S, Zhou X, Zhang Q, Wang
C, Zhao X, Zhou W, Zhang S, Li C, et al: Association between indel
polymorphism in the promoter region of lncRNA GAS5 and the risk of
hepatocellular carcinoma. Carcinogenesis. 36:1136–1143. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Zhu Z, Gao X, He Y, Zhao H, Yu Q, Jiang D,
Zhang P, Ma X, Huang H, Dong D, et al: An insertion/deletion
polymorphism within RERT-lncRNA modulates hepatocellular carcinoma
risk. Cancer Res. 72:6163–6172. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Wan J, Huang M, Zhao H, Wang C, Zhao X,
Jiang X, Bian S, He Y and Gao Y: A novel tetranucleotide repeat
polymorphism within KCNQ1OT1 confers risk for hepatocellular
carcinoma. DNA Cell Biol. 32:628–634. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Lin YY, Yu MW, Lin SM, Lee SD, Chen CL,
Chen DS and Chen PJ: Genome-wide association analysis identifies a
GLUL haplotype for familial hepatitis B virus-related
hepatocellular carcinoma. Cancer. 123:3966–3976. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Goring HH, Curran JE, Johnson MP, Dyer TD,
Charlesworth J, Cole SA, Jowett JB, Abraham LJ, Rainwater DL,
Comuzzie AG, et al: Discovery of expression QTLs using large-scale
transcriptional profiling in human lymphocytes. Nat Genet.
39:1208–1216. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
123
|
Yin J, Wen J, Hang D, Han J, Jiang J, Song
C, Liu Y, Liu J, Liu L, Zhu L, et al: Expression quantitative trait
loci for CARD8 contributes to risk of two infection-related
cancers-hepatocellular carcinoma and cervical cancer. PLoS One.
10:e01323522015. View Article : Google Scholar
|
|
124
|
Wen J, Liu Y, Liu J, Liu L, Song C, Han J,
Zhu L, Wang C, Chen J, Zhai X, et al: Expression quantitative trait
loci in long non-coding RNA ZNRD1-AS1 influence both HBV infection
and hepatocellular carcinoma development. Mol Carcinog.
54:1275–1282. 2015. View Article : Google Scholar
|
|
125
|
Liu Z, Song C, Wen J, Xu L, Liu Y, Zhu J,
Zhu L, Hu Z, Ma H and Liu L: Hepatitis B virus genotypes,
expression quantitative trait loci for ZNRD1-AS1 and their
interactions in hepatocellular carcinoma. Oncotarget.
7:44076–44083. 2016.PubMed/NCBI
|
|
126
|
Song C, Liu Y, Xu L, Wen J, Jiang D, Chen
J, Zhai X, Hu Z, Liu L and Liu J: Hepatitis B virus mutations,
expression quantitative trait loci for PTPN12, and their
interactions in hepatocellular carcinoma. Cancer Med. 5:1687–1693.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Wen J, Song C, Liu J, Chen J, Zhai X and
Hu Z: Expression quantitative trait loci for TNFRSF10 influence
both HBV infection and hepatocellular carcinoma development. J Med
Virol. 88:474–480. 2016. View Article : Google Scholar
|
|
128
|
Ma S, Yang J, Song C, Ge Z, Zhou J, Zhang
G and Hu Z: Expression quantitative trait loci for PAX8 contributes
to the prognosis of hepatocellular carcinoma. PLoS One.
12:e01737002017. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Rion N and Rüegg MA: LncRNA-encoded
peptides: More than translational noise? Cell Res. 27:604–605.
2017. View Article : Google Scholar : PubMed/NCBI
|