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UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway

  • Authors:
    • Mingjing Yuan
    • Fuan Xie
    • Xianyuan Xia
    • Kai Zhong
    • Lanlan Lian
    • Shihui Zhang
    • Li Yuan
    • Jun Ye
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China, Department of Laboratory Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian 361102, P.R. China, School of Life Science, Central South University, Changsha, Hunan 410083, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 139-150
    |
    Published online on: December 2, 2019
       https://doi.org/10.3892/ijo.2019.4931
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Abstract

Unc‑5 Netrin Receptor C (UNC5C) is a netrin‑1 dependence receptor that mediates the induction of apoptosis in the absence of netrin‑1. The present study found that UNC5C is heterogeneously expressed in breast cancer cell lines. By knocking down UNC5C in SK‑BR‑3 and ZR‑75‑30 cells and overexpressing UNC5c in MDA‑MB‑231 cells, it was demonstrated that UNC5C exerts an inhibitory effect on the growth and metastasis of breast cancer cells. The mechanism involved a UNC5C‑knockdown‑induced enhancement of matrix metalloproteinase (MMP)3, MMP7, MMP9 and MMP10 expression via activation of the PI3K/AKT, ERK and p38 MAPK signaling pathways. Notably, UNC5C directly interacted with integrin α6, which is involved in the growth and metastasis of breast cancer cells. Additionally, UNC5C‑knockdown enhanced the phosphorylation of FAK and SRC, which are key kinases in the netrin‑1/Unc5C and netrin‑1/integrin α6/β4 signaling pathways. This suggests that netrin‑1 functions as an integrator for both the netrin‑1/Unc5C and netrin‑1/integrin α6/β4 signaling pathways. UNC5C‑knockdown potentiated netrin‑1/integrin α6/β4 signaling. Given that UNC5C‑knockdown inhibited integrin‑liked protein kinase phosphorylation at Thr‑173, at least in SK‑BR‑3 cells, this may be an inhibitory phosphorylation site rather than activating phosphorylation site for relaying integrin signaling.
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1 

Klagsbrun M and Eichmann A: A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis. Cytokine Growth Factor Rev. 16:535–548. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Dillon AK, Jevince AR, Hinck L, Ackerman SL, Lu X, Tessier-Lavigne M and Kaprielian Z: UNC5C is required for spinal accessory motor neuron development. Mol Cell Neurosci. 35:482–489. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Kim D and Ackerman SL: The UNC5C netrin receptor regulates dorsal guidance of mouse hindbrain axons. J Neurosci. 31:2167–2179. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Chédotal A, Kerjan G and Moreau-Fauvarque C: The brain within the tumor: New roles for axon guidance molecules in cancers. Cell Death Differ. 12:1044–1056. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G and Mehlen P: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA. 100:4173–4178. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Mehlen P and Tauszig-Delamasure S: Dependence receptors and colorectal cancer. Gut. 63:1821–1829. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Coissieux MM, Tomsic J, Castets M, Hampel H, Tuupanen S, Andrieu N, Comeras I, Drouet Y, Lasset C, Liyanarachchi S, et al: Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer. Gastroenterology. 141:2039–2046. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Hibi K, Mizukami H, Shirahata A, Goto T, Sakata M and Sanada Y: Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer. World J Surg. 33:1053–1057. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Lejmi E, Leconte L, Pédron-Mazoyer S, Ropert S, Raoul W, Lavalette S, Bouras I, Feron JG, Maitre-Boube M, Assayag F, et al: Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Proc Natl Acad Sci USA. 105:12491–12496. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, et al: Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Dev Cell. 20:33–46. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M and Stein E: A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell. 97:927–941. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Redig AJ and McAllister SS: Breast cancer as a systemic disease: A view of metastasis. J Intern Med. 274:113–126. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Bernet A, Mazelin L, Coissieux MM, Gadot N, Ackerman SL, Scoazec JY and Mehlen P: Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology. 133:1840–1848. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Fitamant J, Guenebeaud C, Coissieux MM, Guix C, Treilleux I, Scoazec JY, Bachelot T, Bernet A and Mehlen P: Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci USA. 105:4850–4855. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Yuan M, Guo H, Li J, Sui C, Qin Y, Wang J, Khan YH, Ye L, Xie F, Wang H, et al: Slit2 and Robo1 induce opposing effects on metastasis of hepatocellular carcinoma Sk-hep-1 cells. Int J Oncol. 49:305–315. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM and Ganesan S: X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell. 9:121–132. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Diagnosis and Treatment Guidelines For Colorectal Cancer Working Group C: Chinese Society of Clinical Oncology (CSCO) diagnosis and treatment guidelines for breast cancer. 2017.In Chinese.

21 

Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, et al: Decreased expression of STING predicts poor prognosis in patients with gastric cancer. Sci Rep. 7:398582017. View Article : Google Scholar : PubMed/NCBI

22 

Zhang C, Guo H, Li B, Sui C, Zhang Y, Xia X, Qin Y, Ye L, Xie F, Wang H, et al: Effects of Slit3 silencing on the invasive ability of lung carcinoma A549 cells. Oncol Rep. 34:952–960. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

24 

Li S, Quarto N, Senarath-Yapa K, Grey N, Bai X and Longaker MT: Enhanced activation of canonical Wnt signaling confers mesoderm-derived parietal bone with similar osteogenic and skeletal healing capacity to neural crest-derived frontal bone. PLoS One. 10:e01380592015. View Article : Google Scholar : PubMed/NCBI

25 

Mao M, Alavi MV, Labelle-Dumais C, Gould DB and Type IV: Type IV collagens and basement membrane diseases: Cell biology and pathogenic mechanisms. Curr Top Membr. 76:61–116. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Tryggvason K, Höyhtyä M and Pyke C: Type IV collagenases in invasive tumors. Breast Cancer Res Treat. 24:209–218. 1993. View Article : Google Scholar : PubMed/NCBI

27 

Zhou R, Xu L, Ye M, Liao M, Du H and Chen H: Formononetin inhibits migration and invasion of MDA-MB-231 and 4T1 breast cancer cells by suppressing MMP-2 and MMP-9 through PI3K/AKT signaling pathways. Horm Metab Res. 46:753–760. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Kim S, Choi JH, Lim HI, Lee SK, Kim WW, Cho S, Kim JS, Kim JH, Choe JH, Nam SJ, et al: EGF-induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line. Cell Signal. 21:892–898. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Kim ES, Kim MS and Moon A: TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells. Int J Oncol. 25:1375–1382. 2004.PubMed/NCBI

30 

Li W, Liu Z, Zhao C and Zhai L: Binding of MMP-9-degraded fibronectin to β6 integrin promotes invasion via the FAK-Src-related Erk1/2 and PI3K/Akt/Smad-1/5/8 pathways in breast cancer. Oncol Rep. 34:1345–1352. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Rolli M, Fransvea E, Pilch J, Saven A and Felding-Habermann B: Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells. Proc Natl Acad Sci USA. 100:9482–9487. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Chung J, Bachelder RE, Lipscomb EA, Shaw LM and Mercurio AM: Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: A survival mechanism for carcinoma cells. J Cell Biol. 158:165–174. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Yebra M, Montgomery AM, Diaferia GR, Kaido T, Silletti S, Perez B, Just ML, Hildbrand S, Hurford R, Florkiewicz E, et al: Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell. 5:695–707. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Gilcrease MZ, Zhou X, Lu X, Woodward WA, Hall BE and Morrissey PJ: Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer. J Exp Clin Cancer Res. 28:672009. View Article : Google Scholar : PubMed/NCBI

35 

Lee SS, Lee SJ, Lee SH, Ryu JM, Lim HS, Kim JS, Song EJ, Jung YH, Lee HJ, Kim CH, et al: Netrin-1-induced stem cell bioactivity contributes to the regeneration of injured tissues via the lipid raft-dependent integrin α6β4 signaling pathway. Sci Rep. 6:375262016. View Article : Google Scholar

36 

Delcommenne M, Tan C, Gray V, Rue L, Woodgett J and Dedhar S: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA. 95:11211–11216. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Bernet A and Mehlen P: Dependence receptors: When apoptosis controls tumor progression. Bull Cancer. 94:E12–E17. 2007.PubMed/NCBI

38 

Paradisi A, Creveaux M, Gibert B, Devailly G, Redoulez E, Neves D, Cleyssac E, Treilleux I, Klein C, Niederfellner G, et al: Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death. EMBO Mol Med. 5:1821–1834. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Grandin M, Mathot P, Devailly G, Bidet Y, Ghantous A, Favrot C, Gibert B, Gadot N, Puisieux I, Herceg Z, et al: Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference. EMBO Mol Med. 8:863–877. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Lipscomb EA, Simpson KJ, Lyle SR, Ring JE, Dugan AS and Mercurio AM: The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res. 65:10970–10976. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Bhatia V, Mula RV, Weigel NL and Falzon M: Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Mol Cancer Res. 7:1119–1131. 2009. View Article : Google Scholar : PubMed/NCBI

42 

van Kempen LCL and Coussens LM: MMP9 potentiates pulmonary metastasis formation. Cancer Cell. 2:251–252. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Missan DS, Mitchell K, Subbaram S and DiPersio CM: Integrin α3β1 signaling through MEK/ERK determines alternative polyadenylation of the MMP-9 mRNA transcript in immortalized mouse keratinocytes. PLoS One. 10:e01195392015. View Article : Google Scholar

44 

Sil H, Sen T and Chatterjee A: Fibronectin-integrin (alpha5beta1) modulates migration and invasion of murine melanoma cell line B16F10 by involving MMP-9. Oncol Res. 19:335–348. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Lamar JM, Iyer V and DiPersio CM: Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes. J Invest Dermatol. 128:575–586. 2008. View Article : Google Scholar

46 

Son TW, Yun SP, Yong MS, Seo BN, Ryu JM, Youn HY, Oh YM and Han HJ: Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin α6β4-dependent Akt, GSK-3β, and HSF-1 in mesenchymal stem cells. Cell Death Dis. 4:e5632013. View Article : Google Scholar

47 

Lee SJ, Jung YH, Oh SY, Yong MS, Ryu JM and Han HJ: Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCα and FAK/Fyn in promoting mesenchymal stem cell motility. Stem Cells Dev. 23:1870–1882. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Taherian A, Li X, Liu Y and Haas TA: Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer. 11:2932011. View Article : Google Scholar : PubMed/NCBI

49 

Chisholm A and Tessier-Lavigne M: Conservation and divergence of axon guidance mechanisms. Curr Opin Neurobiol. 9:603–615. 1999. View Article : Google Scholar : PubMed/NCBI

50 

Harburger DS and Calderwood DA: Integrin signalling at a glance. J Cell Sci. 122:159–163. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Li W, Aurandt J, Jürgensen C, Rao Y and Guan KL: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. J Cell Sci. 119:47–55. 2006. View Article : Google Scholar

52 

Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, et al: Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci. 7:1213–1221. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Aikawa R, Nagai T, Kudoh S, Zou Y, Tanaka M, Tamura M, Akazawa H, Takano H, Nagai R and Komuro I: Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension. 39:233–238. 2002. View Article : Google Scholar : PubMed/NCBI

54 

Huang D, Khoe M, Befekadu M, Chung S, Takata Y, Ilic D and Bryer-Ash M: Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways. Am J Physiol Cell Physiol. 292:C1339–C1352. 2007. View Article : Google Scholar

55 

Chen HC, Appeddu PA, Isoda H and Guan JL: Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem. 271:26329–26334. 1996. View Article : Google Scholar : PubMed/NCBI

56 

Acconcia F, Barnes CJ, Singh RR, Talukder AH and Kumar R: Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. Proc Natl Acad Sci USA. 104:6782–6787. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP and Dedhar S: Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem. 276:27462–27469. 2001. View Article : Google Scholar : PubMed/NCBI

58 

Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD and Dedhar S: The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase-9 (MMP-9). Oncogene. 19:5444–5452. 2000. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Yuan M, Xie F, Xia X, Zhong K, Lian L, Zhang S, Yuan L and Ye J: UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway. Int J Oncol 56: 139-150, 2020.
APA
Yuan, M., Xie, F., Xia, X., Zhong, K., Lian, L., Zhang, S. ... Ye, J. (2020). UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway. International Journal of Oncology, 56, 139-150. https://doi.org/10.3892/ijo.2019.4931
MLA
Yuan, M., Xie, F., Xia, X., Zhong, K., Lian, L., Zhang, S., Yuan, L., Ye, J."UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway". International Journal of Oncology 56.1 (2020): 139-150.
Chicago
Yuan, M., Xie, F., Xia, X., Zhong, K., Lian, L., Zhang, S., Yuan, L., Ye, J."UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway". International Journal of Oncology 56, no. 1 (2020): 139-150. https://doi.org/10.3892/ijo.2019.4931
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Spandidos Publications style
Yuan M, Xie F, Xia X, Zhong K, Lian L, Zhang S, Yuan L and Ye J: UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway. Int J Oncol 56: 139-150, 2020.
APA
Yuan, M., Xie, F., Xia, X., Zhong, K., Lian, L., Zhang, S. ... Ye, J. (2020). UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway. International Journal of Oncology, 56, 139-150. https://doi.org/10.3892/ijo.2019.4931
MLA
Yuan, M., Xie, F., Xia, X., Zhong, K., Lian, L., Zhang, S., Yuan, L., Ye, J."UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway". International Journal of Oncology 56.1 (2020): 139-150.
Chicago
Yuan, M., Xie, F., Xia, X., Zhong, K., Lian, L., Zhang, S., Yuan, L., Ye, J."UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway". International Journal of Oncology 56, no. 1 (2020): 139-150. https://doi.org/10.3892/ijo.2019.4931
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