Bcl2l10 mediates the proliferation, invasion and migration of ovarian cancer cells

  • Authors:
    • Su‑Yeon Lee
    • Jinie Kwon
    • Ji Hye Woo
    • Kyeoung‑Hwa Kim
    • Kyung‑Ah Lee
  • View Affiliations

  • Published online on: December 23, 2019     https://doi.org/10.3892/ijo.2019.4949
  • Pages: 618-629
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Abstract

Bcl2l10, also known as Diva, Bcl‑b and Boo, is a member of the Bcl2 family of proteins, which are involved in signaling pathways that regulate cell apoptosis and autophagy. Previously, it was demonstrated that Bcl2l10 plays a crucial role in the completion of oocyte meiosis and is a key regulator of Aurora kinase A (Aurka) expression and activity in oocytes. Aurka is overexpressed in several types of solid tumors and has been considered a target of cancer therapy. Based on these previous results, in the present study, the authors aimed to investigate the regulatory role of Bcl2l10 in A2780 and SKOV3 human ovarian cancer cells. The protein expression of Bcl2l10 was examined in human cancer tissues and cell lines, including the ovaries, using a tissue microarray and various human ovarian cancer cell lines. It was found that Bcl2l10 regulated the protein stability and activities of Aurka in ovarian cancer cells. Although apoptosis was not affected, the cell cycle was arrested at the G0/G1 phase by Bcl2l10 knockdown. Of note, cell viability and motility were markedly increased by Bcl2l10 knockdown. On the whole, the findings of this study suggest that Bcl2l10 functions as tumor suppressor gene in ovarian cancer.
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February-2020
Volume 56 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lee SY, Kwon J, Woo J, Kim KH and Lee KA: Bcl2l10 mediates the proliferation, invasion and migration of ovarian cancer cells. Int J Oncol 56: 618-629, 2020
APA
Lee, S., Kwon, J., Woo, J., Kim, K., & Lee, K. (2020). Bcl2l10 mediates the proliferation, invasion and migration of ovarian cancer cells. International Journal of Oncology, 56, 618-629. https://doi.org/10.3892/ijo.2019.4949
MLA
Lee, S., Kwon, J., Woo, J., Kim, K., Lee, K."Bcl2l10 mediates the proliferation, invasion and migration of ovarian cancer cells". International Journal of Oncology 56.2 (2020): 618-629.
Chicago
Lee, S., Kwon, J., Woo, J., Kim, K., Lee, K."Bcl2l10 mediates the proliferation, invasion and migration of ovarian cancer cells". International Journal of Oncology 56, no. 2 (2020): 618-629. https://doi.org/10.3892/ijo.2019.4949