Open Access

New drugs are not enough‑drug repositioning in oncology: An update

  • Authors:
    • Romina Gabriela Armando
    • Diego Luis Mengual Gómez
    • Daniel Eduardo Gomez
  • View Affiliations

  • Published online on: January 20, 2020     https://doi.org/10.3892/ijo.2020.4966
  • Pages: 651-684
  • Copyright: © Armando et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that are already known for use treating other diseases. The advantages of this are that several important drug characteristics are already established (including efficacy, pharmacokinetics, pharmacodynamics and toxicity), making the process of research for a putative drug quicker and less costly. Drug repositioning in oncology has received extensive focus. The present review summarizes the most prominent examples of drug repositioning for the treatment of cancer, taking into consideration their primary use, proposed anticancer mechanisms and current development status.
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March 2020
Volume 56 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Armando, R.G., Mengual Gómez, D.L., & Gomez, D.E. (2020). New drugs are not enough‑drug repositioning in oncology: An update. International Journal of Oncology, 56, 651-684. https://doi.org/10.3892/ijo.2020.4966
MLA
Armando, R. G., Mengual Gómez, D. L., Gomez, D. E."New drugs are not enough‑drug repositioning in oncology: An update". International Journal of Oncology 56.3 (2020): 651-684.
Chicago
Armando, R. G., Mengual Gómez, D. L., Gomez, D. E."New drugs are not enough‑drug repositioning in oncology: An update". International Journal of Oncology 56, no. 3 (2020): 651-684. https://doi.org/10.3892/ijo.2020.4966