Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
April-2020 Volume 56 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2020 Volume 56 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways

  • Authors:
    • Juthathip Poofery
    • Bungorn Sripanidkulchai
    • Ratana Banjerdpongchai
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand, Center for Research and Development of Herbal Health Products, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
  • Pages: 969-985
    |
    Published online on: January 31, 2020
       https://doi.org/10.3892/ijo.2020.4973
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer is the most common type of cancer and is also the second leading cause of cancer‑associated death in women worldwide. Thus, there is an urgent requirement for the development of effective treatments for this disease. Bridelia ovata and Croton oblongifolius are herbs used in Thai traditional medicine that have been used to treat various health problems; B. ovata has traditionally been used as a purgative, an antipyretic, a leukorrhea treatment and as a birth control herb. C. oblongifolius has been used to increase breast milk production, for post‑partum care (where it is used as a hot bath herb), and as a treatment for flat worms and dysmenorrhea. However, there is little research investigating the anticancer properties of these herbs. The present study aimed to investigate the anticancer properties of crude ethyl acetate extracts of B. ovata (BEA) and C. oblongifolius (CEA) in order to explore their underlying mechanisms in breast cancer cell death. The phytoconstituents of the crude extracts of BEA and CEA were studied using gas chromatography‑mass spectrometry (GC‑MS). GC‑MS analysis showed that the primary compound in BEA is friedelan‑3‑one, and kaur‑16‑en‑18‑oic acid in CEA. Cytotoxicity was investigated using an MTT assay, both BEA and CEA showed greater toxicity against MDA‑MB‑231 breast cancer cells compared with their effect on MCF10A normal epithelial mammary cells. BEA and CEA exerted various effects, including inducing apoptotic cell death, reducing mitochondrial transmembrane potential, increasing the levels of intracellular ROS, activating caspases, upregulating pro‑apoptotic and downregulating anti‑apoptotic genes and proteins. BEA and CEA were shown to have anticancer activity against breast cancer cells and induce apoptosis in these cells via a mitochondrial pathway and oxidative stress.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

DeSantis CE, Ma J, Goding Sauer A, Newman LA and Jemal A: Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J Clin. 67:439–448. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Sledge GW, Mamounas EP, Hortobagyi GN, Burstein HJ, Goodwin PJ and Wolff AC: Past, present, and future challenges in breast cancer treatment. J Clin Oncol. 32:1979–1986. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Moiseenko F, Volkov N, Bogdanov A, Dubina M and Moiseyenko V: Resistance mechanisms to drug therapy in breast cancer and other solid tumors: An opinion. F1000Res. 6:2882017. View Article : Google Scholar : PubMed/NCBI

5 

Liu W, Fu X, Yang Z, Li S, Cao Y, Li Q and Luan J: Moderate intermittent negative pressure increases invasiveness of MDA-MB-231 triple negative breast cancer cells. Breast. 38:14–21. 2018. View Article : Google Scholar

6 

Sun L, Legood R, Dos-Santos-Silva I, Gaiha SM and Sadique Z: Global treatment costs of breast cancer by stage: A systematic review. PLoS One. 13:e02079932018. View Article : Google Scholar : PubMed/NCBI

7 

Chotchoungchatchai S, Saralamp P, Jenjittikul T, Pornsiripongse S and Prathanturarug S: Medicinal plants used with thai traditional medicine in modern healthcare services: A case study in Kabchoeng Hospital, Surin Province, Thailand. J Ethnopharmacol. 141:193–205. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Boonyaratavej S, Tantayanontha S, Kitchanachai P, Chaichantipyuth C, Chittawong V and Miles DH: Trans-triacontyl-4-hydroxy-3-methoxycinnamate, a new compound from the thai plant bridelia ovata. J Nat Prod. 55:1761–1763. 1992. View Article : Google Scholar

9 

Thongkorn N: Chemical constituents of the leaves of bridelia ovata decne (unpublished PhD thesis). Chulalongkorn University; 1995

10 

Baig H, Diskul-Na-Ayudthaya P, Weeraphan C, Paricharttanakul M, Svasti J and Srisomsap C: Inhibitory effect of bridelia ovata decne extract on HepG2 cell migration and invasion stimulated by fibroblast-conditioned media. Naresuan Phayao J. 1:6–10. 2015.

11 

Sommit D, Petsom A, Ishikawa T and Roengsumran S: Cytotoxic activity of natural labdanes and their semi-synthetic modified derivatives from Croton oblongifolius. Planta Med. 69:167–170. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Ngamrojnavanich N, Sirimongkon S, Roengsumran S, Petsom A and Kamimura H: Inhibition of Na+,K+-ATPase activity by (-)-ent-Kaur-16-en-19-oic acid and its derivatives. Planta Med. 69:555–556. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Ahmed B, Alam T, Varshney M and Khan SA: Hepatoprotective activity of two plants belonging to the Apiaceae and the euphor-biaceae family. J Ethnopharmacol. 79:313–316. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Salatino A, Salatino MLF and Negri G: Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae). J Braz Chem Soc. 18:11–33. 2007. View Article : Google Scholar

15 

Singh M, Pal M and Sharma RP: Biological activity of the labdane diterpenes. Planta Med. 65:2–8. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Takeshige Y, Kawakami S, Matsunami K, Otsuka H, Lhieochaiphant D and Lhieochaiphant S: Oblongionosides A-F, megastigmane glycosides from the leaves of Croton oblongifolius Roxburgh. Phytochemistry. 80:132–136. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Roengsumran S, Petsom A, Kuptiyanuwat N, Vilaivan T, Ngamrojnavanich N, Chaichantipyuth C and Phuthong S: Cytotoxic labdane diterpenoids from Croton oblongifolius. Phytochemistry. 56:103–107. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Pudhom K and Sommit D: Clerodane diterpenoids and a trisubstituted furan from Croton oblongifolius. Phytochem Lett. 4:147–150. 2011. View Article : Google Scholar

19 

Roengsumran S, Musikul K, Petsom A, Vilaivan T, Sangvanich P, Pornpakakul S, Puthong S, Chaichantipyuth C, Jaiboon N and Chaichit N: Croblongifolin, a new anticancer clerodane from Croton oblongifolius. Planta Med. 68:274–277. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Youngsa-ad W, Ngamrojanavanich N, Mahidol C, Ruchirawat S, Prawat H and Kittakoop P: Diterpenoids from the roots of Croton oblongifolius. Planta Med. 73:1491–1494. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Pudhom K, Vilaivan T, Ngamrojanavanich N, Dechangvipart S, Sommit D, Petsom A and Roengsumran S: Furanocembranoids from the stem bark of Croton oblongifolius. J Nat Prod. 70:659–661. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Roengsumran S, Pornpakakul S, Muangsin N, Sangvanich P, Nhujak T, Singtothong P, Chaichit N, Puthong S and Petsom A: New halimane diterpenoids from Croton oblongifolius. Planta Med. 70:87–89. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Roengsumran S, Achayindee S, Petsom A, Pudhom K, Singtothong P, Surachetapan C and Vilaivan T: Two new cembranoids from Croton oblongifolius. J Nat Prod. 61:652–654. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Roengsumran S, Singtothong P, Pudhom K, Ngamrochanavanich N, Petsom A and Chaichantipyuth C: Neocrotocembranal from Croton oblongifolius. J Nat Prod. 62:1163–1164. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Suwancharoen S, Tommeurd W, Phurat C, Muangsin N and Pornpakakul S: Acanthoic acid. Acta Crystallogr Sect E Struct Rep Online. 66:o15312010. View Article : Google Scholar : PubMed/NCBI

26 

Renehan AG, Booth C and Potten CS: What is apoptosis, and why is it important? BMJ. 322:1536–1538. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Favaloro B, Allocati N, Graziano V, Di Ilio C and De Laurenzi V: Role of apoptosis in disease. Aging (Albany N Y). 4:330–349. 2012.

28 

Fathi N, Rashidi G, Khodadadi A, Shahi S and Sharifi S: STAT3 and apoptosis challenges in cancer. Int J Biol Macromol. 117:993–1001. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Kumar R, Herbert PE and Warrens AN: An introduction to death receptors in apoptosis. Int J Surg. 3:268–277. 2005. View Article : Google Scholar

30 

O'Brien MA and Kirby R: Apoptosis: A review of pro-apoptotic and anti-apoptotic pathways and dysregulation in disease. J Veterinary Emergency Crit Care. 18:572–585. 2008. View Article : Google Scholar

31 

Schneider P and Tschopp J: Apoptosis induced by death receptors. Pharm Acta Helv. 74:281–286. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Chinnaiyan AM: The apoptosome: Heart and soul of the cell death machine. Neoplasia. 1:5–15. 1999. View Article : Google Scholar

33 

Tait SW and Green DR: Mitochondria and cell death: Outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol. 11:621–632. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Cao K and Tait SWG: Apoptosis and cancer: Force awakens, phantom menace, or both? Int Rev Cell Mol Biol. 337:135–152. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Dong N, Liu X, Zhao T, Wang L, Li H, Zhang S, Li X, Bai X, Zhang Y and Yang B: Apoptosis-inducing effects and growth inhibitory of a novel chalcone, in human hepatic cancer cells and lung cancer cells. Biomed Pharmacother. 105:195–203. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, et al: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 10:515–527. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Dai X, Cheng H, Bai Z and Li J: Breast cancer cell line classification and its relevance with breast tumor subtyping. J Cancer. 8:3131–3141. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Chen X and Thibeault S: Effect of DMSO concentration, cell density and needle gauge on the viability of cryopreserved cells in three dimensional hyaluronan hydrogel. Conf Proc IEEE Eng Med Biol Soc. 2013:6228–6231. 2013.PubMed/NCBI

39 

Arega ED: Phytochemical studies of the ethyl acetate extract of the fruit of piper capense. J Pharm Nat Products. 4:148–152. 2018.

40 

Obasi NL, Egbuonu ACC, Ukoha PO and Ejikeme PM: Comparative phytochemical and antimicrobial screening of some solvent extracts of Samanea saman (fabaceae or mimosaceae) pods. Afr J Pure Appl Chem. 4:206–212. 2010.

41 

Tiwari P, Kumar B, Kaur M, Kaur G and Kaur H: Phytochemical screening and extraction: A review. Int Pharm Sci. 1:98–106. 2011.

42 

Banjerdpongchai R, Yingyurn S and Kongtawelert P: Sesamin induces human leukemic cell apoptosis via mitochondrial and endoplasmic reticulum stress pathways. World J Oncol. 1:78–86. 2010.PubMed/NCBI

43 

Wudtiwai B, Sripanidkulchai B, Kongtawelert P and Banjerdpongchai R: Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines. J Hematol Oncol. 4:522011. View Article : Google Scholar : PubMed/NCBI

44 

Khaw-on P and Banjerdpongchai R: Induction of intrinsic and extrinsic apoptosis pathways in the human leukemic MOLT-4 cell line by terpinen-4-ol. Asian Pac J Cancer Prev. 13:3073–3076. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Khaw-On P, Pompimon W and Banjerdpongchai R: Goniothalamin induces necroptosis and anoikis in human invasive breast cancer MDA-MB-231 cells. Int J Mol Sci. 20:E39532019. View Article : Google Scholar : PubMed/NCBI

46 

Dikalov S, Griendling KK and Harrison DG: Measurement of reactive oxygen species in cardiovascular studies. Hypertension. 49:717–727. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, Vasquez-Vivar J and Kalyanaraman B: Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: Potential implications in intracellular fluorescence detection of superoxide. Free Radic Biol Med. 34:1359–1368. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

49 

Mitas M, Mikhitarian K, Walters C, Baron PL, Elliott BM, Brothers TE, Robison JG, Metcalf JS, Palesch YY, Zhang Z, et al: Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel. Int J Cancer. 93:162–171. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Hanf A, Oelze M, Manea A, Li H, Munzel T and Daiber A: The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes. Chem Biol Interact. 313:1088342019. View Article : Google Scholar : PubMed/NCBI

51 

Wudtiwai B, Pitchakarn P and Banjerdpongchai R: Alpha-mangostin, an active compound in Garcinia mangostana, abrogates anoikis-resistance in human hepatocellular carcinoma cells. Toxicol In Vitro. 53:222–232. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Badisa RB, Darling-Reed SF, Joseph P, Cooperwood JS, Latinwo LM and Goodman CB: Selective cytotoxic activities of two novel synthetic drugs on human breast carcinoma MCF-7 cells. Anticancer Res. 29:2993–2996. 2009.PubMed/NCBI

53 

Prayong P, Barusrux S and Weerapreeyakul N: Cytotoxic activity screening of some indigenous Thai plants. Fitoterapia. 79:598–601. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Rivankar S: An overview of doxorubicin formulations in cancer therapy. J Cancer Res Ther. 10:853–858. 2014. View Article : Google Scholar

55 

Kalogeris T, Bao Y and Korthuis RJ: Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs. preconditioning Redox Biol. 2:702–714. 2014. View Article : Google Scholar

56 

Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ II and Ischiropoulos H: Measuring reactive oxygen and nitrogen species with fluorescent probes: Challenges and limitations. Free Radic Biol Med. 52:1–6. 2012. View Article : Google Scholar

57 

Tsujimoto Y: Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria? Genes Cells. 3:697–707. 1998. View Article : Google Scholar

58 

Sousa GFd, Soares DCF, Mussel WdN, Pompeu NFE, Silva GDdF, Vieira Filho SA and Duarte LP: Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against. J Braz Chem Soc. 25:1338–1345. 2014.

59 

Martucciello S, Balestrieri ML, Felice F, Estevam Cdos S, Sant'Ana AE, Pizza C and Piacente S: Effects of triterpene derivatives from Maytenus rigida on VEGF-induced Kaposi's sarcoma cell proliferation. Chem Biol Interact. 183:450–454. 2010. View Article : Google Scholar

60 

Balbinot RB, de Oliveira JAM, Bernardi DI, Melo UZ, Zanqueta EB, Endo EH, Ribeiro FM, Volpato H, Figueiredo MC, Back DF, et al: Structural characterization and biological evaluation of 18-Nor-ent-labdane diterpenoids from grazielia gaudichaudeana. Chem Biodivers. 16:e18006442019. View Article : Google Scholar : PubMed/NCBI

61 

Cavalcanti BC, Ferreira JR, Moura DJ, Rosa RM, Furtado GV, Burbano RR, Silveira ER, Lima MA, Camara CA, Saffi J, et al: Structure-mutagenicity relationship of kaurenoic acid from Xylopia sericeae (Annonaceae). Mutat Res. 701:153–163. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Cavalcanti BC, Bezerra Dp, Magalhaes HI, Moraes MO, Lima MA, Silveira ER, Camara CA, Rao VS, Pessoa C and Costa-Lotufo LV: Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells. J Appl Toxicol. 29:560–568. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Cuca LE, Coy ED, Alarcon MA, Fernandez A and Aristizabal FA: Cytotoxic effect of some natural compounds isolated from Lauraceae plants and synthetic derivatives. Biomedica. 31:335–343. 2011. View Article : Google Scholar

64 

Cardoso PCDS, Rocha CAMD, Leal MF, Bahia MO, Alcantara DDFA, Santos RAD, Gongalves NDS, Ambrosio SR, Cavalcanti BC, Moreira-Nunes CA, et al: Effect of diterpenoid kaurenoic acid on genotoxicity and cell cycle progression in gastric cancer cell lines. Biomed Pharmacother. 89:772–780. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Rocha SMMD, Cardoso PCDS, Bahia MO, Pessoa CDO, Soares PC, Rocha SMD, Burbano RMR and Rocha CAMD: Effect of the kaurenoic acid on genotoxicity and cell cycle progression in cervical cancer cells lines. Toxicol In Vitro. 57:126–131. 2019. View Article : Google Scholar : PubMed/NCBI

66 

Fernandes VC, Pereira SI, Coppede J, Martins JS, Rizo WF, Beleboni RO, Marins M, Pereira PS, Pereira AM and Fachin AL: The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction. Genet Mol Res. 12:1005–1011. 2013. View Article : Google Scholar : PubMed/NCBI

67 

Fernando IPS, Sanjeewa KKA, Ann YS, Ko CI, Lee SH, Lee WW and Jeon YJ: Apoptotic and antiproliferative effects of Stigmast-5-en-3-ol from Dendronephthya gigantea on human leukemia HL-60 and human breast cancer MCF-7 cells. Toxicol In Vitro. 52:297–305. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Jian B, Zhang H, Han C and Liu J: Anti-cancer activities of diterpenoids derived from Euphorbia fischeriana steud. Molecules. 23:E3872018. View Article : Google Scholar : PubMed/NCBI

69 

Petiwala SM and Johnson JJ: Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity. Cancer Lett. 367:93–102. 2015. View Article : Google Scholar : PubMed/NCBI

70 

Suttiarporn P, Chumpolsri W, Mahatheeranont S, Luangkamin S, Teepsawang S and Leardkamolkarn V: Structures of phytosterols and triterpenoids with potential anti-cancer activity in bran of black non-glutinous rice. Nutrients. 7:1672–1687. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Saleem M: Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 285:109–115. 2009. View Article : Google Scholar : PubMed/NCBI

72 

Weerapreeyakul N, Nonpunya A, Barusrux S, Thitimetharoch T and Sripanidkulchai B: Evaluation of the anticancer potential of six herbs against a hepatoma cell line. Chin Med. 7:152012. View Article : Google Scholar : PubMed/NCBI

73 

Sinha K, Das J, Pal PB and Sil PC: Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol. 87:1157–1180. 2013. View Article : Google Scholar : PubMed/NCBI

74 

Cairns RA, Harris IS and Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer. 11:85–95. 2011. View Article : Google Scholar : PubMed/NCBI

75 

Circu ML and Aw TY: Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med. 48:749–762. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Redza-Dutordoir M and Averill-Bates DA: Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta. 1863:2977–2992. 2016. View Article : Google Scholar : PubMed/NCBI

77 

He H, Zang LH, Feng YS, Chen LX, Kang N, Tashiro S, Onodera S, Qiu F and Ikejima T: Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-kB survival pathway in A375-S2 cells. J Ethnopharmacol. 148:544–555. 2013. View Article : Google Scholar : PubMed/NCBI

78 

Yu CC, Ko FY, Yu CS, Lin CC, Huang YP, Yang JS, Lin JP and Chung JG: Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells. Int J Oncol. 41:1050–1060. 2012. View Article : Google Scholar : PubMed/NCBI

79 

Weinberg F, Ramnath N and Nagrath D: Reactive oxygen species in the tumor microenvironment: An overview. Cancers (Basel). 11:E11912019. View Article : Google Scholar

80 

Crompton M: The mitochondrial permeability transition pore and its role in cell death. Biochem J. 341:233–249. 1999. View Article : Google Scholar : PubMed/NCBI

81 

Griffith OW: Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med. 27:922–935. 1999. View Article : Google Scholar : PubMed/NCBI

82 

Komonrit P and Banjerdpongchai R: Effect of Pseuderanthemum palatiferum (Nees) radlk fresh leaf ethanolic extract on human breast cancer MDA-MB-231 regulated cell death. Tumour Biol. 40:10104283188001822018. View Article : Google Scholar : PubMed/NCBI

83 

Kumari S, Badana AK, GMM GS and Malla R: Reactive oxygen species: A key constituent in cancer survival. Biomark Insights. 13:11772719187553912018. View Article : Google Scholar : PubMed/NCBI

84 

Kastenhuber ER and Lowe SW: Putting p53 in context. Cell. 170:1062–1078. 2017. View Article : Google Scholar : PubMed/NCBI

85 

Vousden KH and Lu X: Live or let die: The cell's response to p53. Nat Rev Cancer. 2:594–604. 2002. View Article : Google Scholar : PubMed/NCBI

86 

Lowe SW, Ruley HE, Jacks T and Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:957–967. 1993. View Article : Google Scholar : PubMed/NCBI

87 

Shibue T, Suzuki S, Okamoto H, Yoshida H, Ohba Y, Takaoka A and Taniguchi T: Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. EMBO J. 25:4952–4962. 2006. View Article : Google Scholar : PubMed/NCBI

88 

Shibue T, Takeda K, Oda E, Tanaka H, Murasawa H, Takaoka A, Morishita Y, Akira S, Taniguchi T and Tanaka N: Integral role of Noxa in p53-mediated apoptotic response. Genes Dev. 17:2233–2238. 2003. View Article : Google Scholar : PubMed/NCBI

89 

Zhang LN, Li JY and Xu W: A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia. Cancer Gene Ther. 20:1–7. 2013. View Article : Google Scholar

90 

McIlwain DR, Berger T and Mak TW: Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 5:a0086562013. View Article : Google Scholar : PubMed/NCBI

91 

Saraste A and Pulkki K: Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res. 45:528–537. 2000. View Article : Google Scholar : PubMed/NCBI

92 

Huttemann M, Pecina P, Rainbolt M, Sanderson TH, Kagan VE, Samavati L, Doan JW and Lee I: The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion. 11:369–381. 2011. View Article : Google Scholar : PubMed/NCBI

93 

Salvesen GS: Caspases and apoptosis. Essays Biochem. 38:9–19. 2002. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Poofery J, Sripanidkulchai B and Banjerdpongchai R: Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways. Int J Oncol 56: 969-985, 2020.
APA
Poofery, J., Sripanidkulchai, B., & Banjerdpongchai, R. (2020). Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways. International Journal of Oncology, 56, 969-985. https://doi.org/10.3892/ijo.2020.4973
MLA
Poofery, J., Sripanidkulchai, B., Banjerdpongchai, R."Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways". International Journal of Oncology 56.4 (2020): 969-985.
Chicago
Poofery, J., Sripanidkulchai, B., Banjerdpongchai, R."Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways". International Journal of Oncology 56, no. 4 (2020): 969-985. https://doi.org/10.3892/ijo.2020.4973
Copy and paste a formatted citation
x
Spandidos Publications style
Poofery J, Sripanidkulchai B and Banjerdpongchai R: Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways. Int J Oncol 56: 969-985, 2020.
APA
Poofery, J., Sripanidkulchai, B., & Banjerdpongchai, R. (2020). Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways. International Journal of Oncology, 56, 969-985. https://doi.org/10.3892/ijo.2020.4973
MLA
Poofery, J., Sripanidkulchai, B., Banjerdpongchai, R."Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways". International Journal of Oncology 56.4 (2020): 969-985.
Chicago
Poofery, J., Sripanidkulchai, B., Banjerdpongchai, R."Extracts of Bridelia ovata and Croton oblongifolius induce apoptosis in human MDA‑MB‑231 breast cancer cells via oxidative stress and mitochondrial pathways". International Journal of Oncology 56, no. 4 (2020): 969-985. https://doi.org/10.3892/ijo.2020.4973
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team