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Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling

  • Authors:
    • Bomiao Cui
    • Jiao Chen
    • Min Luo
    • Liwei Wang
    • Hongli Chen
    • Yingzhu Kang
    • Jingnan Wang
    • Xuedong Zhou
    • Yun Feng
    • Ping Zhang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 909-920
    |
    Published online on: February 4, 2020
       https://doi.org/10.3892/ijo.2020.4974
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Abstract

Oral squamous cell carcinoma (OSCC) is capable of constructing a favorable immune escape environment through interactions of cells with cells and of cells with the environment. Programmed death ligand‑1 (PD‑L1) is a well‑recognized inhibitor of anti‑tumor immunity that plays an important role in tumor immune escape. However, the molecular mechanisms regulating PD‑L1 expression are not yet fully understood. In this study, to investigate the role of protein kinase D3 (PKD3) in the regulation of PD‑L1 expression, the expression and correlation of PKD3 and PD‑L1 were first analyzed by the immunostaining of human OSCC tissue sections, cell experiments and TCGA gene expression databases. The expression levels of PKD3 and PD‑L1 were found to be significantly higher in OSCC cells than in normal tissues or cells. In addition, the expression levels of PKD3 and PD‑L1 were found to be significantly positively correlated. Subsequently, it was found that the levsel of PD‑L1 expression decreased following the silencing of PKD3 and that the ability of interferon (IFN)‑γ to induce PD‑L1 expression was also decreased in OSCC. The opposite phenomenon occurred following the overexpression of PKD3. It was also found that the phosphorylation of signal transducer and activator of transcription (STAT)1/STAT3 was reduced by the knockdown of PKD3 in OSCC. Moreover, the expression level of PD‑L1 was decreased after the use of siRNA to knockdown STAT1 or STAT3. On the whole, the findings of this study confirm that PKD3 regulates the expression of PD‑L1 induced by IFN‑γ by regulating the phosphorylation of STAT1/STAT3. These findings broaden the understanding of the biological function of PKD3, suggesting that PKD is a potential therapeutic target for OSCC.
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1 

Sathiyasekar AC, Chandrasekar P, Pakash A, Kumar KUG and Jaishlal MS: Overview of immunology of oral squamous cell carcinoma. J Pharm Bioallied Sci. 8(Suppl 1): S8–S12. 2016.PubMed/NCBI

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Lin YM, Sung WW, Hsieh MJ, Tsai SC, Lai HW, Yang SM, Shen KH, Chen MK, Lee H, Yeh KT and Chen CJ: High PD-L1 expression correlates with metastasis and poor prognosis in oral squamous cell carcinoma. PLoS One. 10:e01426562015. View Article : Google Scholar : PubMed/NCBI

4 

Ferris RL: Immunology and immunotherapy of head and neck cancer. J Clin Oncol. 33:3293–3304. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Lu W, Lu L, Feng Y, Chen J, Li Y, Kong X, Chen S, Li X, Chen Q and Zhang P: Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand-1 surface expression. Oncol Lett. 5:1519–1526. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Ritprajak P and Azuma M: Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. Oral Oncol. 51:221–228. 2015. View Article : Google Scholar

7 

Gao Y, Yang J, Cai Y, Fu S, Zhang N, Fu X and Li L: IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling. Int J Cancer. 143:931–943. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Moon JW, Kong SK, Kim BS, Kim HJ, Lim H, Noh K, Kim Y, Choi JW, Lee JH and Kim YS: IFNγ induces PD-L1 overexpression by JAK2/STAT1/IRF-1 signaling in EBV-positive gastric carcinoma. Sci Rep. 7:178102017. View Article : Google Scholar

9 

Bu L, Yu G, Wu L, Mao L, Deng WW, Liu JF, Kulkarni AB, Zhang WF, Zhang L and Sun ZJ: STAT3 induces immunosuppression by upregulating PD-1/PD-L1 in HNSCC. J Dent Res. 96:1027–1034. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Roy A, Ye J, Deng F and Wang QJ: Protein kinase D signaling in cancer: A friend or foe? Biochim Biophys Acta Rev Cancer. 1868:283–294. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Chen J, Feng Y, Lu L, Wang H, Dai L, Li Y and Zhang P: Interferon-γ-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway. Immunobiology. 217:385–393. 2012. View Article : Google Scholar

12 

LaValle CR, George KM, Sharlow ER, Lazo JS, Wipf P and Wang QJ: Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 1806:183–192. 2010.PubMed/NCBI

13 

Evans IM and Zachary IC: Protein kinase D in vascular biology and angiogenesis. IUBMB Life. 63:258–263. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Zhang T, Braun U and Leitges M: PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle. Cell Cycle. 15:1844–1854. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Durand N, Borges S and Storz P: Protein kinase D enzymes as regulators of EMT and cancer cell invasion. J Clin Med. 5:E202016. View Article : Google Scholar : PubMed/NCBI

16 

Baker J, Falconer AM, Wilkinson DJ, Europe-Finner GN, Litherland GJ and Rowan AD: Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. PLoS One. 13:pp. e01958642018, View Article : Google Scholar : PubMed/NCBI

17 

Rozengurt E, Rey O and Waldron RT: Protein kinase D signaling. J Biol Chem. 280:pp. 13205–13208. 2005, View Article : Google Scholar : PubMed/NCBI

18 

Chen J, Deng F, Singh SV and Wang QJ: Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCε/PKD3 pathway downstream of Akt and ERK 1/2. Cancer Res. 68:3844–3853. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Zou Z, Zeng F, Xu W, et al: PKD2 and PKD3 Promote Prostate Cancer Cell Invasion by Modulating NF-κB- And HDAC1-mediated Expression and Activation of uPA. J Cell Sci. 125:4800–4811. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhang J, Wang CM, Zhang P, Wang X, Chen J, Yang J, Lu W, Zhou W, Yuan W and Feng Y: Expression of programmed death 1 ligand 1 on periodontal tissue cells as a possible protective feedback mechanism against periodontal tissue destruction. Mol Med Rep. 13:2423–2430. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Lin W, Choe WH, Hiasa Y, Kamegaya Y, Blackard JT, Schmidt EV and Chung RT: Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Gastroenterology. 128:1034–1041. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Konnikova L, Kotecki M, Kruger MM and Cochran BH: Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer. 3:232003. View Article : Google Scholar : PubMed/NCBI

23 

Qiu W and Steinberg SF: Phos-tag SDS-PAGE resolves agonist-and isoform-specific activation patterns for PKD2 and PKD3 in cardiomyocytes and cardiac fibroblasts. J Mol Cell Cardiol. 99:14–22. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Lin C, Cao W, Ren Z, Tang Y, Zhang C, Yang R, Chen Y, Liu Z, Peng C, Wang L, et al: GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC. Oncoimmunology. 6:e13538602017. View Article : Google Scholar : PubMed/NCBI

25 

Concha-Benavente F, Srivastava RM, Trivedi S, Lei Y, Chandran U, Seethala RR, Freeman GJ and Ferris RL: Identification of the cell-intrinsic and-extrinsic pathways downstream of EGFR and IFNγ that induce PD-L1 expression in head and neck cancer. Cancer Res. 76:1031–1043. 2016. View Article : Google Scholar

26 

Mann J, Hoesli R, Michmerhuizen N, Devenport SN, Ludwig ML, Vandenberg TR, Matovina C, Jawad N, Mierzwa M, Shuman AG, et al: Surveilling the potential for precision medicine-driven PD-1/PD-L1-targeted therapy in HNSCC. J Cancer. 8:332–344. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Yang H, Xu M, Chi X, Yan Q, Wang Y, Xu W, Zhuang K, Li A and Liu S: Higher PKD3 expression in hepatocellular carcinoma (HCC) tissues predicts poorer prognosis for HCC patients. Clin Res Hepatol Gastroenterol. 41:554–563. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Huck B, Duss S, Hausser A and Olayioye MA: Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem. 289:3138–3147. 2014. View Article : Google Scholar :

29 

Mimura K, The JL, Okayama H, Shiraishi K, Kua LF, Koh V, Smoot DT, Ashktorab H, Oike T, Suzuki Y, et al: PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 109:43–53. 2018. View Article : Google Scholar

30 

Vassilakopoulou M, Avgeris M, Velcheti V, Kotoula V, Rampias T, Chatzopoulos K, Perisanidis C, Kontos CK, Giotakis AI, Scorilas A, et al: Evaluation of PD-L1 expression and associated tumor-infiltrating lymphocytes in laryngeal squamous cell carcinoma. Clin Cancer Res. 22:704–713. 2016. View Article : Google Scholar

31 

Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL and Chen L: Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 4:pp. 127ra1372012, View Article : Google Scholar

32 

Jiang X, Wang J, Deng X, Xiong F, Ge J, Xiang B, Wu X, Ma J, Zhou M, Li X, et al: Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. Mol Cancer. 18:102019. View Article : Google Scholar : PubMed/NCBI

33 

LaCasse CJ, Janikashvili N, Larmonier CB, Alizadeh D, Hanke N, Kartchner J, Situ E, Centuori S, Har-Noy M, Bonnotte B, et al: Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism. J Immunol. 187:6310–6317. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Maraskovsky E, Chen W and Shortman K: IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells. J Immunol. 143:1210–1214. 1989.PubMed/NCBI

35 

Chen L, Tourvieille B, Burns GF, Bach FH, Mathieu-Mahul D, Sasportes M and Bensussan A: Interferon: A cytotoxic T lymphocyte differentiation signal. Eur J Immunol. 16:767–770. 1986. View Article : Google Scholar : PubMed/NCBI

36 

Xiao M, Wang C, Zhang J, Li Z, Zhao X and Qin Z: IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Res. 69:2010–2017. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Matsuda M, Nakamoto Y, Suzuki S, Kurata T and Kaneko SJ: Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine. Lab Invest. 85:655–663. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, et al: IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med. 203:1391–1397. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Alberts DS, Marth C, Alvarez RD, Johnson G, Bidzinski M, Kardatzke DR, Bradford WZ, Loutit J, Kirn DH, Clouser MC, et al: Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: Results from a prospectively designed analysis of progression-free survival. Gynecol Oncol. 109:174–181. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Zhang W, Zhang J, Zhang Z, Guo Y, Wu Y, Wang R, Wang L, Mao S and Yao X: Overexpression of indoleamine 2,3-dioxygenase 1 promotes epithelial-mesenchymal transition by activation of the IL-6/STAT3/PD-L1 pathway in bladder cancer. Transl Oncol. 12:485–492. 2019. View Article : Google Scholar

41 

Decker T and Kovarik P: Serine phosphorylation of STATs. Oncogene. 19:2628–2637. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Aziz MH, Manoharan HT, Church DR, Dreckschmidt NE, Zhong W, Oberley TD, Wilding G and Verma AK: Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res. 67:8828–8838. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Sakaguchi M, Oka M, Iwasaki T, Fukami Y and Nishigori C: Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells. J Invest Dermatol. 132:1877–1885. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Gough DJ, Koetz L and Levy DE: The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation. PLoS One. 8:e833952013. View Article : Google Scholar : PubMed/NCBI

45 

Decker T and Kovarik P: Transcription factor activity of STAT proteins: Structural requirements and regulation by phosphorylation and interacting proteins. Cell Mol Life Sci. 55:1535–1546. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Fang Y, Zhong L, Lin M, Zhou X, Jing H, Ying M, Luo P, Yang B and He Q: MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia. PLoS One. 8:pp. e669152013, View Article : Google Scholar : PubMed/NCBI

47 

Nitulescu II, Meyer SC, Wen QJ, Crispino JD, Lemieux ME, Levine RL, Pelish HE and Shair MD: Mediator kinase phosphorylation of STAT1 S727 promotes growth of neoplasms with JAK-STAT activation. EBioMedicine. 26:112–125. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Goren I, Pfeilschifter J and Frank S: Determination of leptin signaling pathways in human and murine keratinocytes. Biochem Bioph Res Commun. 303:1080–1085. 2003. View Article : Google Scholar

49 

Kondo K, Shaim H, Thompson PA, Burger JA, Keating M, Estrov Z, Harris D, Kim E, Ferrajoli A, Daher M, et al: Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway. Leukemia. 32:960–970. 2018. View Article : Google Scholar

50 

Zhou L, Schandené L, Mordvinov VA, Chatelain P, Pradier O, Goldman M and Stordeur P: Trapidil inhibits monocyte CD40 expression by preventing IFN-γ-induced STAT1 S727 phosphorylation. Int Immunopharmacol. 4:863–871. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cui B, Chen J, Luo M, Wang L, Chen H, Kang Y, Wang J, Zhou X, Feng Y, Zhang P, Zhang P, et al: Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling. Int J Oncol 56: 909-920, 2020.
APA
Cui, B., Chen, J., Luo, M., Wang, L., Chen, H., Kang, Y. ... Zhang, P. (2020). Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling. International Journal of Oncology, 56, 909-920. https://doi.org/10.3892/ijo.2020.4974
MLA
Cui, B., Chen, J., Luo, M., Wang, L., Chen, H., Kang, Y., Wang, J., Zhou, X., Feng, Y., Zhang, P."Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling". International Journal of Oncology 56.4 (2020): 909-920.
Chicago
Cui, B., Chen, J., Luo, M., Wang, L., Chen, H., Kang, Y., Wang, J., Zhou, X., Feng, Y., Zhang, P."Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling". International Journal of Oncology 56, no. 4 (2020): 909-920. https://doi.org/10.3892/ijo.2020.4974
Copy and paste a formatted citation
x
Spandidos Publications style
Cui B, Chen J, Luo M, Wang L, Chen H, Kang Y, Wang J, Zhou X, Feng Y, Zhang P, Zhang P, et al: Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling. Int J Oncol 56: 909-920, 2020.
APA
Cui, B., Chen, J., Luo, M., Wang, L., Chen, H., Kang, Y. ... Zhang, P. (2020). Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling. International Journal of Oncology, 56, 909-920. https://doi.org/10.3892/ijo.2020.4974
MLA
Cui, B., Chen, J., Luo, M., Wang, L., Chen, H., Kang, Y., Wang, J., Zhou, X., Feng, Y., Zhang, P."Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling". International Journal of Oncology 56.4 (2020): 909-920.
Chicago
Cui, B., Chen, J., Luo, M., Wang, L., Chen, H., Kang, Y., Wang, J., Zhou, X., Feng, Y., Zhang, P."Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling". International Journal of Oncology 56, no. 4 (2020): 909-920. https://doi.org/10.3892/ijo.2020.4974
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