|
1
|
Meyers PA and Gorlick R: Osteosarcoma.
Pediatr Clin North Am. 44:973–989. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ottaviani G and Jaffe N: The epidemiology
of osteosarcoma. Cancer Treat Res. 152:3–13. 2009. View Article : Google Scholar
|
|
3
|
Gill J, Ahluwalia MK, Geller D and Gorlick
R: New targets and approaches in osteosarcoma. Pharmacol Ther.
137:89–99. 2013. View Article : Google Scholar
|
|
4
|
Ostenfeld MS, Jeppesen DK, Laurberg JR,
Boysen AT, Bramsen JB, Primdal-Bengtson B, Hendrix A, Lamy P,
Dagnaes-Hansen F, Rasmussen MH, et al: Cellular disposal of miR23b
by RAB27-dependent exosome release is linked to acquisition of
metastatic properties. Cancer Res. 74:5758–5771. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Chou AJ, Geller DS and Gorlick R: Therapy
for osteosarcoma: Where do we go from here? Paediatr Drugs.
10:315–327. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sadikovic B, Yoshimoto M, Chilton-MacNeill
S, Thorner P, Squire JA and Zielenska M: Identification of
interactive networks of gene expression associated with
osteosarcoma oncogenesis by integrated molecular profiling. Hum Mol
Genet. 18:1962–1975. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Li Z, Dou P, Liu T and He S: Application
of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic
Targets. Cell Physiol Biochem. 42:1407–1419. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zhou J, Liu T and Wang W: Prognostic
significance of matrix metalloproteinase 9 expression in
osteosarcoma: A meta-analysis of 16 studies. Medicine (Baltimore).
97:e130512018. View Article : Google Scholar
|
|
9
|
Liu T, Yan Z, Liu Y, Choy E, Hornicek FJ,
Mankin H and Duan Z: CRISPR-Cas9-Mediated Silencing of CD44 in
Human Highly Metastatic Osteosarcoma Cells. Cell Physiol Biochem.
46:1218–1230. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Deng L, Liu T, Zhang B, Wu H, Zhao J and
Chen J: Forkhead box C1 is targeted by microRNA-133b and promotes
cell proliferation and migration in osteosarcoma. Exp Ther Med.
14:2823–2830. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Liu T, Li Z, Zhang Q, De Amorim Bernstein
K, Lozano-Calderon S, Choy E, Hornicek FJ and Duan Z: Targeting
ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the
CRISPR-Cas9 system to reverse drug resistance. Oncotarget.
7:83502–83513. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Simons M and Raposo G: Exosomes -
vesicular carriers for inter-cellular communication. Curr Opin Cell
Biol. 21:575–581. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Raposo G, Nijman HW, Stoorvogel W,
Liejendekker R, Harding CV, Melief CJ and Geuze HJ: B lymphocytes
secrete antigen-presenting vesicles. J Exp Med. 183:1161–1172.
1996. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Lee TH, D'Asti E, Magnus N, Al-Nedawi K,
Meehan B and Rak J: Microvesicles as mediators of intercellular
communication in cancer--the emerging science of cellular 'debris'.
Semin Immunopathol. 33:455–467. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kahlert C, Melo SA, Protopopov A, Tang J,
Seth S, Koch M, Zhang J, Weitz J, Chin L, Futreal A, et al:
Identification of double-stranded genomic DNA spanning all
chromosomes with mutated KRAS and p53 DNA in the serum exosomes of
patients with pancreatic cancer. J Biol Chem. 289:3869–3875. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Villarroya-Beltri C, Baixauli F,
Gutiérrez-Vázquez C, Sánchez-Madrid F and Mittelbrunn M: Sorting it
out: Regulation of exosome loading. Semin Cancer Biol. 28:3–13.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Mathivanan S, Fahner CJ, Reid GE and
Simpson RJ: ExoCarta 2012: Database of exosomal proteins, RNA and
lipids. Nucleic Acids Res. 40(D1): D1241–D1244. 2012. View Article : Google Scholar :
|
|
18
|
Mathivanan S and Simpson RJ: ExoCarta: A
compendium of exosomal proteins and RNA. Proteomics. 9:4997–5000.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Pan BT, Teng K, Wu C, Adam M and Johnstone
RM: Electron microscopic evidence for externalization of the
transferrin receptor in vesicular form in sheep reticulocytes. J
Cell Biol. 101:942–948. 1985. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Harding C, Heuser J and Stahl P:
Receptor-mediated endocytosis of transferrin and recycling of the
transferrin receptor in rat reticulocytes. J Cell Biol. 97:329–339.
1983. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Keller S, Rupp C, Stoeck A, Runz S, Fogel
M, Lugert S, Hager HD, Abdel-Bakky MS, Gutwein P and Altevogt P:
CD24 is a marker of exosomes secreted into urine and amniotic
fluid. Kidney Int. 72:1095–1102. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Taylor DD and Gercel-Taylor C: MicroRNA
signatures of tumor-derived exosomes as diagnostic biomarkers of
ovarian cancer. Gynecol Oncol. 110:13–21. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Gallo A, Tandon M, Alevizos I and Illei
GG: The majority of microRNAs detectable in serum and saliva is
concentrated in exosomes. PLoS One. 7:e306792012. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Bartel DP: MicroRNAs: Genomics,
biogenesis, mechanism, and function. Cell. 116:281–297. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Bartel DP and Chen CZ: Micromanagers of
gene expression: The potentially widespread influence of metazoan
microRNAs. Nat Rev Genet. 5:396–400. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Chen LT, Xu SD, Xu H, Zhang JF, Ning JF
and Wang SF: MicroRNA-378 is associated with non-small cell lung
cancer brain metastasis by promoting cell migration, invasion and
tumor angiogenesis. Med Oncol. 29:1673–1680. 2012. View Article : Google Scholar
|
|
27
|
Ivanovska I, Ball AS, Diaz RL, Magnus JF,
Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson
AL, et al: MicroRNAs in the miR-106b family regulate p21/CDKN1A and
promote cell cycle progression. Mol Cell Biol. 28:2167–2174. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Lu Y, Thomson JM, Wong HY, Hammond SM and
Hogan BL: Transgenic over-expression of the microRNA miR-17-92
cluster promotes proliferation and inhibits differentiation of lung
epithelial progenitor cells. Dev Biol. 310:442–453. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Takamizawa J, Konishi H, Yanagisawa K,
Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y,
et al: Reduced expression of the let-7 microRNAs in human lung
cancers in association with shortened postoperative survival.
Cancer Res. 64:3753–3756. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Wang ZX, Bian HB, Wang JR, Cheng ZX, Wang
KM and De W: Prognostic significance of serum miRNA-21 expression
in human non-small cell lung cancer. J Surg Oncol. 104:847–851.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang X, Ling C, Bai Y and Zhao J:
MicroRNA-206 is associated with invasion and metastasis of lung
cancer. Anat Rec (Hoboken). 294:88–92. 2011. View Article : Google Scholar
|
|
32
|
Ferracin M, Veronese A and Negrini M:
Micromarkers: miRNAs in cancer diagnosis and prognosis. Expert Rev
Mol Diagn. 10:297–308. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Nana-Sinkam P and Croce CM: MicroRNAs in
diagnosis and prognosis in cancer: What does the future hold?
Pharmacogenomics. 11:667–669. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Fan H, Lu S, Wang S and Zhang S:
Identification of critical genes associated with human osteosarcoma
metastasis based on integrated gene expression profiling. Mol Med
Rep. 20:915–930. 2019.PubMed/NCBI
|
|
35
|
Gulino R, Forte S, Parenti R, Memeo L and
Gulisano M: MicroRNA and pediatric tumors: Future perspectives.
Acta Histochem. 117:339–354. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Rabinowits G, Gerçel-Taylor C, Day JM,
Taylor DD and Kloecker GH: Exosomal microRNA: A diagnostic marker
for lung cancer. Clin Lung Cancer. 10:42–46. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Wang Y, Gao X, Wei F, Zhang X, Yu J, Zhao
H, Sun Q, Yan F, Yan C, Li H, et al: Diagnostic and prognostic
value of circulating miR-21 for cancer: A systematic review and
meta-analysis. Gene. 533:389–397. 2014. View Article : Google Scholar
|
|
38
|
Lagos-Quintana M, Rauhut R, Lendeckel W
and Tuschl T: Identification of novel genes coding for small
expressed RNAs. Science. 294:853–858. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Lagos-Quintana M, Rauhut R, Yalcin A,
Meyer J, Lendeckel W and Tuschl T: Identification of
tissue-specific microRNAs from mouse. Curr Biol. 12:735–739. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Landgraf P, Rusu M, Sheridan R, Sewer A,
Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M,
et al: A mammalian microRNA expression atlas based on small RNA
library sequencing. Cell. 129:1401–1414. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kumarswamy R, Volkmann I and Thum T:
Regulation and function of miRNA-21 in health and disease. RNA
Biol. 8:706–713. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Hu CH, Sui BD, Du FY, Shuai Y, Zheng CX,
Zhao P, Yu XR and Jin Y: miR-21 deficiency inhibits osteoclast
function and prevents bone loss in mice. Sci Rep. 7:431912017.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Li X, Guo L, Liu Y, Su Y, Xie Y, Du J,
Zhou J, Ding G, Wang H, Bai Y, et al: MicroRNA-21 promotes
osteogenesis of bone marrow mesenchymal stem cells via the
Smad7-Smad1/5/8-Runx2 pathway. Biochem Biophys Res Commun.
493:928–933. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Krichevsky AM and Gabriely G: miR-21: A
small multi-faceted RNA. J Cell Mol Med. 13:39–53. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Pan X, Wang ZX and Wang R: MicroRNA-21: A
novel therapeutic target in human cancer. Cancer Biol Ther.
10:1224–1232. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Asangani IA, Rasheed SA, Nikolova DA,
Leupold JH, Colburn NH, Post S and Allgayer H: MicroRNA-21 (miR-21)
post-transcriptionally downregulates tumor suppressor Pdcd4 and
stimulates invasion, intravasation and metastasis in colorectal
cancer. Oncogene. 27:2128–2136. 2008. View Article : Google Scholar
|
|
47
|
Frankel LB, Christoffersen NR, Jacobsen A,
Lindow M, Krogh A and Lund AH: Programmed cell death 4 (PDCD4) is
an important functional target of the microRNA miR-21 in breast
cancer cells. J Biol Chem. 283:1026–1033. 2008. View Article : Google Scholar
|
|
48
|
Li T, Li D, Sha J, Sun P and Huang Y:
MicroRNA-21 directly targets MARCKS and promotes apoptosis
resistance and invasion in prostate cancer cells. Biochem Biophys
Res Commun. 383:280–285. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Lu Z, Liu M, Stribinskis V, Klinge CM,
Ramos KS, Colburn NH and Li Y: MicroRNA-21 promotes cell
transformation by targeting the programmed cell death 4 gene.
Oncogene. 27:4373–4379. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Zhu S, Si ML, Wu H and Mo YY: MicroRNA-21
targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol
Chem. 282:14328–14336. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Zhu S, Wu H, Wu F, Nie D, Sheng S and Mo
YY: MicroRNA-21 targets tumor suppressor genes in invasion and
metastasis. Cell Res. 18:350–359. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Zheng J, Xue H, Wang T, Jiang Y, Liu B, Li
J, Liu Y, Wang W, Zhang B and Sun M: miR-21 downregulates the tumor
suppressor P12 CDK2AP1 and stimulates cell proliferation and
invasion. J Cell Biochem. 112:872–880. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Xu J, Wu C, Che X, Wang L, Yu D, Zhang T,
Huang L, Li H, Tan W, Wang C, et al: Circulating microRNAs, miR-21,
miR-122, and miR-223, in patients with hepatocellular carcinoma or
chronic hepatitis. Mol Carcinog. 50:136–142. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Schramedei K, Mörbt N, Pfeifer G, Läuter
J, Rosolowski M, Tomm JM, von Bergen M, Horn F and Brocke-Heidrich
K: MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4.
Oncogene. 30:2975–2985. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Gabriely G, Wurdinger T, Kesari S, Esau
CC, Burchard J, Linsley PS and Krichevsky AM: MicroRNA 21 promotes
glioma invasion by targeting matrix metalloproteinase regulators.
Mol Cell Biol. 28:5369–5380. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Meng F, Henson R, Wehbe-Janek H, Ghoshal
K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the
PTEN tumor suppressor gene in human hepatocellular cancer.
Gastroenterology. 133:647–658. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Si ML, Zhu S, Wu H, Lu Z, Wu F and Mo YY:
miR-21-mediated tumor growth. Oncogene. 26:2799–2803. 2007.
View Article : Google Scholar
|
|
58
|
Sekar D, Mani P, Biruntha M,
Sivagurunathan P and Karthigeyan M: Dissecting the functional role
of microRNA 21 in osteosarcoma. Cancer Gene Ther. 26:179–182. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Hua Y, Jin Z, Zhou F, Zhang YQ and Zhuang
Y: The expression significance of serum MiR-21 in patients with
osteosarcoma and its relationship with chemosensitivity. Eur Rev
Med Pharmacol Sci. 21:2989–2994. 2017.PubMed/NCBI
|
|
60
|
Xu B, Xia H, Cao J, Wang Z, Yang Y and Lin
Y: MicroRNA-21 Inhibits the Apoptosis of Osteosarcoma Cell Line
SAOS-2 via Targeting Caspase 8. Oncol Res. 25:1161–1168. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Ren X, Shen Y, Zheng S, Liu J and Jiang X:
miR-21 predicts poor prognosis in patients with osteosarcoma. Br J
Biomed Sci. 73:158–162. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Zhao H, Yan P, Wang J, Zhang Y, Zhang M,
Wang Z, Fu Q and Liang W: Clinical significance of tumor miR-21,
miR-221, miR-143, and miR-106a as biomarkers in patients with
osteo-sarcoma. Int J Biol Markers. 34:184–193. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Yuan J, Chen L, Chen X, Sun W and Zhou X:
Identification of serum microRNA-21 as a biomarker for
chemosensitivity and prognosis in human osteosarcoma. J Int Med
Res. 40:2090–2097. 2012. View Article : Google Scholar
|
|
64
|
Ouyang L, Liu P, Yang S, Ye S, Xu W and
Liu X: A three-plasma miRNA signature serves as novel biomarkers
for osteosarcoma. Med Oncol. 30:3402013. View Article : Google Scholar
|
|
65
|
Whiteside TL: The tumor microenvironment
and its role in promoting tumor growth. Oncogene. 27:5904–5912.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Cretu A, Brooks PC. Impact of the
non-cellular tumor micro-environment on metastasis: Potential
therapeutic and imaging opportunities. J Cell Physiol. 213:391–402.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Hartmann S, Bhola NE and Grandis JR:
HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor
Microenvironment. Clin Cancer Res. 22:4005–4013. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Gu F, Hu C, Tai Z, Yao C, Tian J, Zhang L,
Xia Q, Gong C, Gao Y and Gao S: Tumour microenvironment-responsive
lipoic acid nanoparticles for targeted delivery of docetaxel to
lung cancer. Sci Rep. 6:362812016. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Friedl P and Alexander S: Cancer invasion
and the microenvi-ronment: Plasticity and reciprocity. Cell.
147:992–1009. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Wu T, Hong Y, Jia L, Wu J, Xia J, Wang J,
Hu Q and Cheng B: Modulation of IL-1β reprogrammes the tumor
microenvironment to interrupt oral carcinogenesis. Sci Rep.
6:202082016. View Article : Google Scholar
|
|
71
|
Maia J, Caja S, Strano Moraes MC, Couto N
and Costa-Silva B: Exosome-Based Cell-Cell Communication in the
Tumor Microenvironment. Front Cell Dev Biol. 6:182018. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Hu C, Chen M, Jiang R, Guo Y, Wu M and
Zhang X: Exosome-related tumor microenvironment. J Cancer.
9:3084–3092. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Wang Z, Chen JQ, Liu JL and Tian L:
Exosomes in tumor microenvironment: Novel transporters and
biomarkers. J Transl Med. 14:2972016. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Milane L, Singh A, Mattheolabakis G,
Suresh M and Amiji MM: Exosome mediated communication within the
tumor microenvi-ronment. J Control Release. 219:278–294. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Raimondi L, De Luca A, Gallo A, Costa V,
Russelli G, Cuscino N, Manno M, Raccosta S, Carina V, Bellavia D,
et al: Osteosarcoma cell-derived exosomes affect tumor
microenvironment by specific packaging of microRNAs.
Carcinogenesis. Jul 10–2019.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Jerez S, Araya H, Hevia D, Irarrázaval CE,
Thaler R, van Wijnen AJ and Galindo M: Extracellular vesicles from
osteo-sarcoma cell lines contain miRNAs associated with cell
adhesion and apoptosis. Gene. 710:246–257. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Shen RK, Zhu X, Yi H, Wu CY, Chen F, Dai
LQ and Lin JH: Proteomic identification of osteosarcoma-derived
exosomes and their activation o f pentose phosphate pathway. Int J
Clin Exp Pathol. 9:4140–4148. 2016.
|
|
78
|
Shimbo K, Miyaki S, Ishitobi H, Kato Y,
Kubo T, Shimose S and Ochi M: Exosome-formed synthetic microRNA-143
is transferred to osteosarcoma cells and inhibits their migration.
Biochem Biophys Res Commun. 445:381–387. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Lv C, Hao Y and Tu G: MicroRNA-21 promotes
proliferation, invasion and suppresses apoptosis in human
osteosarcoma line MG63 through PTEN/Akt pathway. Tumour Biol.
37:9333–9342. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Graziano AC, Cardile V, Avola R, Vicario
N, Parenti C, Salvatorelli L, Magro G and Parenti R: Wilms' tumor
gene 1 silencing inhibits proliferation of human osteosarcoma MG-63
cell line by cell cycle arrest and apoptosis activation.
Oncotarget. 8:13917–13931. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Wang L, Tang B, Han H, Mao D, Chen J, Zeng
Y and Xiong M: miR-155 Affects Osteosarcoma MG-63 Cell Autophagy
Induced by Adriamycin Through Regulating PTEN-PI3K/AKT/mTOR
Signaling Pathway. Cancer Biother Radiopharm. 33:32–38. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Zhang J, Yu XH, Yan YG, Wang C and Wang
WJ: PI3K/Akt signaling in osteosarcoma. Clin Chim Acta.
444:182–192. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Wu YR, Qi HJ, Deng DF, Luo YY and Yang SL:
MicroRNA-21 promotes cell proliferation, migration, and resistance
to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal
cancer. Tumour Biol. 37:12061–12070. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Xue R, Lei S, Xia ZY, Wu Y, Meng Q, Zhan
L, Su W, Liu H, Xu J, Liu Z, et al: Selective inhibition of PTEN
preserves ischaemic post-conditioning cardioprotection in
STZ-induced Type 1 diabetic rats: Role of the PI3K/Akt and
JAK2/STAT3 pathways. Clin Sci (Lond). 130:377–392. 2016. View Article : Google Scholar
|
|
85
|
Li C, Xu B, Miu X, Deng Z, Liao H and Hao
L: Inhibition of miRNA-21 attenuates the proliferation and
metastasis of human osteosarcoma by upregulating PTEN. Exp Ther
Med. 15:1036–1040. 2018.PubMed/NCBI
|
|
86
|
Hu X, Li L, Lu Y, Yu X, Chen H, Yin Q and
Zhang Y: miRNA-21 inhibition inhibits osteosarcoma cell
proliferation by targeting PTEN and regulating the TGF-β1 signaling
pathway. Oncol Lett. 16:4337–4342. 2018.PubMed/NCBI
|
|
87
|
Vanas V, Haigl B, Stockhammer V and
Sutterlüty-Fall H: MicroRNA-21 Increases Proliferation and
Cisplatin Sensitivity of Osteosarcoma-Derived Cells. PLoS One.
11:e01610232016. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Heerboth S, Housman G, Leary M, Longacre
M, Byler S, Lapinska K, Willbanks A and Sarkar S: EMT and tumor
metastasis. Clin Transl Med. 4:62015. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Karlsson MC, Gonzalez SF, Welin J and Fuxe
J: Epithelial-mesenchymal transition in cancer metastasis through
the lymphatic system. Mol Oncol. 11:781–791. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Yan LX, Wu QN, Zhang Y, Li YY, Liao DZ,
Hou JH, Fu J, Zeng MS, Yun JP, Wu QL, et al: Knockdown of miR-21 in
human breast cancer cell lines inhibits proliferation, in vitro
migration and in vivo tumor growth. Breast Cancer Res. 13:R22011.
View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Zhao MY, Wang LM, Liu J, Huang X, Liu J
and Zhang YF: MiR-21 Suppresses Anoikis through Targeting PDCD4 and
PTEN in Human Esophageal Adenocarcinoma. Curr Med Sci. 38:245–251.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Liao J, Liu R, Shi YJ, Yin LH and Pu YP:
Exosome-shuttling microRNA-21 promotes cell migration and
invasion-targeting PDCD4 in esophageal cancer. Int J Oncol.
48:2567–2579. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Melnik BC: MiR-21: An environmental driver
of malignant melanoma? J Transl Med. 13:2022015. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Jiang LH, Ge MH, Hou XX, Cao J, Hu SS, Lu
XX, Han J, Wu YC, Liu X, Zhu X, et al: miR-21 regulates tumor
progression through the miR-21-PDCD4-Stat3 pathway in human
salivary adenoid cystic carcinoma. Lab Invest. 95:1398–1408. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Bera A, Das F, Ghosh-Choudhury N, Kasinath
BS, Abboud HE and Choudhury GG: microRNA-21-induced dissociation of
PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate
renal cancer cell invasion. Exp Cell Res. 328:99–117. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Zhao M, Ang L, Huang J and Wang J:
MicroRNAs regulate the epithelial-mesenchymal transition and
influence breast cancer invasion and metastasis. Tumour Biol.
39:10104283176916822017. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Han M, Wang Y, Liu M, Bi X, Bao J, Zeng N,
Zhu Z, Mo Z, Wu C and Chen X: MiR-21 regulates
epithelial-mesenchymal transition phenotype and hypoxia-inducible
factor-1α expression in third-sphere forming breast cancer stem
cell-like cells. Cancer Sci. 103:1058–1064. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
De Mattos-Arruda L, Bottai G, Nuciforo PG,
Di Tommaso L, Giovannetti E, Peg V, Losurdo A, Pérez-Garcia J,
Masci G, Corsi F, et al: MicroRNA-21 links
epithelial-to-mesenchymal transition and inflammatory signals to
confer resistance to neoadjuvant trastuzumab and chemotherapy in
HER2-positive breast cancer patients. Oncotarget. 6:37269–37280.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Liu Y, Luo F, Wang B, Li H, Xu Y, Liu X,
Shi L, Lu X, Xu W, Lu L, et al: STAT3-regulated exosomal miR-21
promotes angio-genesis and is involved in neoplastic processes of
transformed human bronchial epithelial cells. Cancer Lett.
370:125–135. 2016. View Article : Google Scholar
|
|
100
|
Mao G, Liu Y, Fang X, Liu Y, Fang L, Lin
L, Liu X and Wang N: Tumor-derived microRNA-494 promotes
angiogenesis in non-small cell lung cancer. Angiogenesis.
18:373–382. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Umezu T, Tadokoro H, Azuma K, Yoshizawa S,
Ohyashiki K and Ohyashiki JH: Exosomal miR-135b shed from hypoxic
multiple myeloma cells enhances angiogenesis by targeting
factor-inhibiting HIF-1. Blood. 124:3748–3757. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Lin XJ, Fang JH, Yang XJ, Zhang C, Yuan Y,
Zheng L and Zhuang SM: Hepatocellular Carcinoma Cell-Secreted
Exosomal MicroRNA-210 Promotes Angiogenesis In Vitro and In Vivo.
Mol Ther Nucleic Acids. 11:243–252. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Liu LZ, Li C, Chen Q, Jing Y, Carpenter R,
Jiang Y, Kung HF, Lai L and Jiang BH: MiR-21 induced angiogenesis
through AKT and ERK activation and HIF-1α expression. PLoS One.
6:e191392011. View Article : Google Scholar
|
|
104
|
Brentnall TA: Arousal of cancer-associated
stromal fibroblasts: Palladin-activated fibroblasts promote tumor
invasion. Cell Adhes Migr. 6:488–494. 2012. View Article : Google Scholar
|
|
105
|
Orimo A, Gupta PB, Sgroi DC,
Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL
and Weinberg RA: Stromal fibroblasts present in invasive human
breast carcinomas promote tumor growth and angiogenesis through
elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Camps JL, Chang SM, Hsu TC, Freeman MR,
Hong SJ, Zhau HE, von Eschenbach AC and Chung LW:
Fibroblast-mediated acceleration of human epithelial tumor growth
in vivo. Proc Natl Acad Sci USA. 87:75–79. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Gleave M, Hsieh JT, Gao CA, von Eschenbach
AC and Chung LW: Acceleration of human prostate cancer growth in
vivo by factors produced by prostate and bone fibroblasts. Cancer
Res. 51:3753–3761. 1991.PubMed/NCBI
|
|
108
|
Kanekura T, Chen X and Kanzaki T: Basigin
(CD147) is expressed on melanoma cells and induces tumor cell
invasion by stimulating production of matrix metalloproteinases by
fibroblasts. Int J Cancer. 99:520–528. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Sameshima T, Nabeshima K, Toole BP,
Yokogami K, Okada Y, Goya T and Wakisaka S: Glioma cell
extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147)
stimulates production of membrane-type matrix metalloproteinases
and activated gelatinase A in co-cultures with brain-derived
fibroblasts. Cancer Lett. 157:177–184. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Li Q, Zhang D, Wang Y, Sun P, Hou X,
Larner J, Xiong W and Mi J: MiR-21/Smad 7 signaling determines
TGF-β1-induced CAF formation. Sci Rep. 3:20382013. View Article : Google Scholar
|
|
111
|
Kunita A, Morita S, Irisa TU, Goto A, Niki
T, Takai D, Nakajima J and Fukayama M: MicroRNA-21 in
cancer-associated fibroblasts supports lung adenocarcinoma
progression. Sci Rep. 8:88382018. View Article : Google Scholar
|
|
112
|
Cheng Q, Li X and Liu J, Ye Q, Chen Y, Tan
S and Liu J: Multiple Myeloma-Derived Exosomes Regulate the
Functions of Mesenchymal Stem Cells Partially via Modulating miR-21
and miR-146a. Stem Cells Int. 2017:90121522017. View Article : Google Scholar
|
|
113
|
Mace TA, Collins AL, Wojcik SE, Croce CM,
Lesinski GB and Bloomston M: Hypoxia induces the overexpression of
microRNA-21 in pancreatic cancer cells. J Surg Res. 184:855–860.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Muller L, Mitsuhashi M, Simms P, Gooding
WE and Whiteside TL: Tumor-derived exosomes regulate expression of
immune function-related genes in human T cell subsets. Sci Rep.
6:202542016. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Greening DW, Gopal SK, Xu R, Simpson RJ
and Chen W: Exosomes and their roles in immune regulation and
cancer. Semin Cell Dev Biol. 40:72–81. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Kurywchak P, Tavormina J and Kalluri R:
The emerging roles of exosomes in the modulation of immune
responses in cancer. Genome Med. 10:232018. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Robbins PD and Morelli AE: Regulation of
immune responses by extracellular vesicles. Nat Rev Immunol.
14:195–208. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Wang L, He L, Zhang R, Liu X, Ren Y, Liu
Z, Zhang X, Cheng W and Hua ZC: Regulation of T lymphocyte
activation by microRNA-21. Mol Immunol. 59:163–171. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Carissimi C, Carucci N, Colombo T,
Piconese S, Azzalin G, Cipolletta E, Citarella F, Barnaba V, Macino
G and Fulci V: miR-21 is a negative modulator of T-cell activation.
Biochimie. 107(Pt B): 319–326. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Sheedy FJ: Turning 21: Induction of miR-21
as a Key Switch in the Inflammatory Response. Front Immunol.
6:192015. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Fabbri M, Paone A, Calore F, Galli R,
Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, et al:
MicroRNAs bind to Toll-like receptors to induce prometastatic
inflammatory response. Proc Natl Acad Sci USA. 109:E2110–E2116.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Wang Z, Brandt S, Medeiros A, Wang S, Wu
H, Dent A and Serezani CH: MicroRNA 21 is a homeostatic regulator
of macrophage polarization and prevents prostaglandin E2-mediated
M2 generation. PLoS One. 10:e01158552015. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Curtale G: MiRNAs at the Crossroads
between Innate Immunity and Cancer: Focus on Macrophages. Cells.
7:E122018. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Li L, Zhang J, Diao W, Wang D, Wei Y,
Zhang CY and Zen K: MicroRNA-155 and MicroRNA-21 promote the
expansion of functional myeloid-derived suppressor cells. J
Immunol. 192:1034–1043. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Klebanoff CA, Gattinoni L and Restifo NP:
CD8+ T-cell memory in tumor immunology and immunotherapy. Immunol
Rev. 211:214–224. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Cereghetti DM and Lee PP: Tumor-Derived
Exosomes Contain microRNAs with Immunological Function:
Implications for a Novel Immunosuppression Mechanism. MicroRNA.
2:194–204. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Miao BP, Zhang RS, Li M, Fu YT, Zhao M,
Liu ZG and Yang PC: Nasopharyngeal cancer-derived microRNA-21
promotes immune suppressive B cells. Cell Mol Immunol. 12:750–756.
2015. View Article : Google Scholar
|
|
128
|
Kosaka N, Iguchi H, Yoshioka Y, Takeshita
F, Matsuki Y and Ochiya T: Secretory mechanisms and intercellular
transfer of microRNAs in living cells. J Biol Chem.
285:17442–17452. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Melo SA, Sugimoto H, O'Connell JT, Kato N,
Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, et
al: Cancer exosomes perform cell-independent microRNA biogenesis
and promote tumorigenesis. Cancer Cell. 26:707–721. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Ohshima K, Inoue K, Fujiwara A, Hatakeyama
K, Kanto K, Watanabe Y, Muramatsu K, Fukuda Y, Ogura S, Yamaguchi
K, et al: Let-7 microRNA family is selectively secreted into the
extracellular environment via exosomes in a metastatic gastric
cancer cell line. PLoS One. 5:e132472010. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Pigati L, Yaddanapudi SC, Iyengar R, Kim
DJ, Hearn SA, Danforth D, Hastings ML and Duelli DM: Selective
release of microRNA species from normal and malignant mammary
epithelial cells. PLoS One. 5:e135152010. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Boussadia Z, Lamberti J, Mattei F, Pizzi
E, Puglisi R, Zanetti C, Pasquini L, Fratini F, Fantozzi L,
Felicetti F, et al: Acidic micro-environment plays a key role in
human melanoma progression through a sustained exosome mediated
transfer of clinically relevant metastatic molecules. J Exp Clin
Cancer Res. 37:2452018. View Article : Google Scholar
|
|
133
|
Hessvik NP and Llorente A: Current
knowledge on exosome biogenesis and release. Cell Mol Life Sci.
75:193–208. 2018. View Article : Google Scholar :
|
|
134
|
Lespagnol A, Duflaut D, Beekman C, Blanc
L, Fiucci G, Marine JC, Vidal M, Amson R and Telerman A: Exosome
secretion, including the DNA damage-induced p53-dependent secretory
pathway, is severely compromised in TSAP6/Steap3-null mice. Cell
Death Differ. 15:1723–1733. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Yu X, Harris SL and Levine AJ: The
regulation of exosome secretion: A novel function of the p53
protein. Cancer Res. 66:4795–4801. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Thompson CA, Purushothaman A, Ramani VC,
Vlodavsky I and Sanderson RD: Heparanase regulates secretion,
composition, and function of tumor cell-derived exosomes. J Biol
Chem. 288:10093–10099. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Wang K, Zhang S, Marzolf B, Troisch P,
Brightman A, Hu Z, Hood LE and Galas DJ: Circulating microRNAs,
potential biomarkers for drug-induced liver injury. Proc Natl Acad
Sci USA. 106:4402–4407. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Mitchell PS, Parkin RK, Kroh EM, Fritz BR,
Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant
KC, Allen A, et al: Circulating microRNAs as stable blood-based
markers for cancer detection. Proc Natl Acad Sci USA.
105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Greening DW, Xu R, Ji H, Tauro BJ and
Simpson RJ: A protocol for exosome isolation and characterization:
Evaluation of ultra-centrifugation, density-gradient separation,
and immunoaffinity capture methods. Methods Mol Biol. 1295:179–209.
2015. View Article : Google Scholar
|
