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Article

Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma

  • Authors:
    • Miyako Kurihara‑Shimomura
    • Tomonori Sasahira
    • Hiroyuki Shimomura
    • Anja Katrin Bosserhoff
    • Tadaaki Kirita
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Institute for Biochemistry, Friedrich‑Alexander University Erlangen‑Nürnberg, D‑91054 Erlangen, Germany
  • Pages: 1093-1100
    |
    Published online on: February 20, 2020
       https://doi.org/10.3892/ijo.2020.4996
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Abstract

Mast cells (MCs) are present in the tumor stroma, and MCs that express the mast cell‑specific proteases tryptase and chymase (MCTC) exhibit several tumor‑related functions. It was previously reported that melanoma inhibitory activity (MIA) gene family members, including MIA, MIA2, and transport and Golgi organization protein 1 (TANGO), possess oncogenic functions in oral squamous cell carcinoma (OSCC). However, the relationships between MCTC, and clinicopathological characteristics and activation of the MIA gene family in OSCC remain unknown. In the present study, the functional roles of MCTC in patients with OSCC were investigated using immunohistochemistry and reverse transcription‑quantitative PCR. In addition, the effects of extracellular chymase on oral cancer cells were examined. In patients with OSCC, MCTC density was significantly affected by tumor progression and nodal metastasis, and was correlated with vessel density. MCTC density was also correlated with MIA and MIA2 expression. In OSCC cells, extracellular chymase promoted the secretion of vascular endothelial growth factor family proteins, and the transmigration and adhesion of HSC3 cells to endothelial cells; knockdown of MIA, MIA2 and TANGO attenuated these effects. The present findings indicated that MCTC act as tumor‑progressive factors in OSCC via the activation and secretion of MIA and MIA2, and the induction of angiogenesis and lymphangiogenesis.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F and Soerjomataram I: The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 67:51–64. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Sasahira T and Kirita T: Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma. Int J Mol Sci. 19:192018. View Article : Google Scholar

5 

de Souza DA Jr, Santana AC, da Silva EZ, Oliver C and Jamur MC: The role of mast cell specific chymases and tryptases in tumor angiogenesis. BioMed Res Int. 2015:1423592015.

6 

Bauer R, Humphries M, Fässler R, Winklmeier A, Craig SE and Bosserhoff AK: Regulation of integrin activity by MIA. J Biol Chem. 281:11669–11677. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Detoraki A, Staiano RI, Granata F, Giannattasio G, Prevete N, de Paulis A, Ribatti D, Genovese A, Triggiani M and Marone G: Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol. 123:1142–1149. 11491e1–5. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Sammarco G, Varricchi G, Ferraro V, Ammendola M, De Fazio M, Altomare DF, Luposella M, Maltese L, Currò G, Marone G, et al: Mast cells, angiogenesis and lymphangiogenesis in human gastric cancer. Int J Mol Sci. 20:202019. View Article : Google Scholar

9 

Jachetti E, Cancila V, Rigoni A, Bongiovanni L, Cappetti B, Belmonte B, Enriquez C, Casalini P, Ostano P, Frossi B, et al: Cross-talk between myeloid-derived suppressor cells and mast cells mediates tumor-specific immunosuppression in prostate cancer. Cancer Immunol Res. 6:552–565. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Nagata M, Shijubo N, Walls AF, Ichimiya S, Abe S and Sato N: Chymase-positive mast cells in small sized adenocarcinoma of the lung. Virchows Arch. 443:565–573. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Ibaraki T, Muramatsu M, Takai S, Jin D, Maruyama H, Orino T, Katsumata T and Miyazaki M: The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer. Eur J Cardiothorac Surg. 28:617–621. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Carlini MJ, Dalurzo MC, Lastiri JM, Smith DE, Vasallo BC, Puricelli LI and Lauría de Cidre LS: Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance. Hum Pathol. 41:697–705. 2010. View Article : Google Scholar

13 

Shikotra A, Ohri CM, Green RH, Waller DA and Bradding P: Mast cell phenotype, TNFα expression and degranulation status in non-small cell lung cancer. Sci Rep. 6:383522016. View Article : Google Scholar

14 

Kondo K, Muramatsu M, Okamoto Y, Jin D, Takai S, Tanigawa N and Miyazaki M: Expression of chymase-positive cells in gastric cancer and its correlation with the angiogenesis. J Surg Oncol. 93:36–42; discussion 42-43. 2006. View Article : Google Scholar

15 

Siiskonen H, Poukka M, Bykachev A, Tyynelä-Korhonen K, Sironen R, Pasonen-Seppänen S and Harvima IT: Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma. Melanoma Res. 25:479–485. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Mehdawi L, Osman J, Topi G and Sjölander A: High tumor mast cell density is associated with longer survival of colon cancer patients. Acta Oncol. 55:1434–1442. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Glajcar A, Szpor J, Pacek A, Tyrak KE, Chan F, Streb J, Hodorowicz-Zaniewska D and Okoń K: The relationship between breast cancer molecular subtypes and mast cell populations in tumor microenvironment. Virchows Arch. 470:505–515. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Stieglitz D, Lamm S, Braig S, Feuerer L, Kuphal S, Dietrich P, Arndt S, Echtenacher B, Hellerbrand C, Karrer S, et al: BMP6-induced modulation of the tumor micro-milieu. Oncogene. 38:609–621. 2019. View Article : Google Scholar

19 

Bosserhoff AK: Melanoma inhibitory activity (MIA): An important molecule in melanoma development and progression. Pigment Cell Res. 18:411–416. 2005.PubMed/NCBI

20 

Kurihara M, Kirita T, Sasahira T, Ohmori H, Matsushima S, Yamamoto K, Bosserhoff AK and Kuniyasu H: Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma. Br J Cancer. 108:1460–1469. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Sasahira T, Kirita T, Kurihara M, Yamamoto K, Bhawal UK, Bosserhoff AK and Kuniyasu H: MIA-dependent angiogenesis and lymphangiogenesis are closely associated with progression, nodal metastasis and poor prognosis in tongue squamous cell carcinoma. Eur J Cancer. 46:2285–2294. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Sasahira T, Kirita T, Oue N, Bhawal UK, Yamamoto K, Fujii K, Ohmori H, Luo Y, Yasui W, Bosserhoff AK, et al: High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma. Cancer Sci. 99:1806–1812. 2008.PubMed/NCBI

23 

Sasahira T, Kirita T, Yamamoto K, Ueda N, Kurihara M, Matsushima S, Bhawal UK, Bosserhoff AK and Kuniyasu H: Transport and Golgi organisation protein 1 is a novel tumour progressive factor in oral squamous cell carcinoma. Eur J Cancer. 50:2142–2151. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Sasahira T, Nishiguchi Y, Fujiwara R, Kurihara M, Kirita T, Bosserhoff AK and Kuniyasu H: Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression. Oncotarget. 7:26751–26764. 2016. View Article : Google Scholar : PubMed/NCBI

25 

O'Sullivan B: Head and neck tumours. UICC TNM classification of malignant tumours. Brierley JD, Gospodarowicz MK and Wittekind C: 8th edition. Wiley; Chichester: pp. 17–54. 2017

26 

Sloan P, Gale N, Hunter K, Lingen M, Nylander K, Reibel J, Salo T and Zain RB: Malignant surface epithelial tumors. WHO classification of head and neck tumors. El-Naggar AK, Chan JKC, Grandis JR, et al: 4th edition. IARC Press; Lyon: pp. 17–54. 2017

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

28 

Iamaroon A, Pongsiriwet S, Jittidecharaks S, Pattanaporn K, Prapayasatok S and Wanachantararak S: Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma. J Oral Pathol Med. 32:195–199. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Mohtasham N, Babakoohi S, Salehinejad J, Montaser-Kouhsari L, Shakeri MT, Shojaee S, Sistani NS and Firooz A: Mast cell density and angiogenesis in oral dysplastic epithelium and low- and high-grade oral squamous cell carcinoma. Acta Odontol Scand. 68:300–304. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Yadav A, Desai RS, Bhuta BA, Singh JS, Mehta R and Nehete AP: Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium. PLoS One. 9:e987192014. View Article : Google Scholar : PubMed/NCBI

31 

Oliveira-Neto HH, Leite AF, Costa NL, Alencar RC, Lara VS, Silva TA, Leles CR, Mendonça FE and Batista AC: Decrease in mast cells in oral squamous cell carcinoma: Possible failure in the migration of these cells. Oral Oncol. 43:484–490. 2007. View Article : Google Scholar

32 

Sugimoto M, Furuta T, Kodaira C, Nishino M, Yamade M, Ikuma M, Sugimura H and Hishida A: Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. J Gastroenterol. 43:751–761. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Sugimoto M, Furuta T, Shirai N, Ikuma M, Sugimura H and Hishida A: Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan. Cancer Epidemiol Biomarkers Prev. 15:1929–1934. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Raica M, Cimpean AM, Popovici RA, Balica AR, Vladau M and Gaje PN: Mast cells stimulate lymphangiogenesis in the gingiva of patients with periodontal disease. In Vivo. 29:29–34. 2015.PubMed/NCBI

35 

Jiang Y, Wu Y, Hardie WJ and Zhou X: Mast cell chymase affects the proliferation and metastasis of lung carcinoma cells in vitro. Oncol Lett. 14:3193–3198. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Rolli M, Fransvea E, Pilch J, Saven A and Felding-Habermann B: Activated integrin alphavbeta3 cooperates with metallopro-teinase MMP-9 in regulating migration of metastatic breast cancer cells. Proc Natl Acad Sci USA. 100:9482–9487. 2003. View Article : Google Scholar

37 

Dyduch G, Kaczmarczyk K and Okoń K: Mast cells and cancer: Enemies or allies? Pol J Pathol. 63:1–7. 2012.PubMed/NCBI

38 

Jachimczak P, Apfel R, Bosserhoff AK, Fabel K, Hau P, Tschertner I, Wise P, Schlingensiepen KH, Schuler-Thurner B and Bogdahn U: Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques. Int J Cancer. 113:88–92. 2005. View Article : Google Scholar

39 

Pfeufer A, Osterziel KJ, Urata H, Borck G, Schuster H, Wienker T, Dietz R and Luft FC: Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy. Am J Cardiol. 78:362–364. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Shimomoto T, Ohmori H, Luo Y, Chihara Y, Denda A, Sasahira T, Tatsumoto N, Fujii K and Kuniyasu H: Diabetes-associated angiotensin activation enhances liver metastasis of colon cancer. Clin Exp Metastasis. 29:915–925. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Bowrey PF, King J, Magarey C, Schwartz P, Marr P, Bolton E and Morris DL: Histamine, mast cells and tumour cell proliferation in breast cancer: Does preoperative cimetidine administration have an effect? Br J Cancer. 82:167–170. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Yang FC, Ingram DA, Chen S, Zhu Y, Yuan J, Li X, Yang X, Knowles S, Horn W, Li Y, et al: Nf1-dependent tumors require a microenvironment containing Nf1+/−- and c-kit-dependent bone marrow. Cell. 135:437–448. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Pittoni P, Piconese S, Tripodo C and Colombo MP: Tumor-intrinsic and -extrinsic roles of c-Kit: Mast cells as the primary off-target of tyrosine kinase inhibitors. Oncogene. 30:757–769. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kurihara‑Shimomura M, Sasahira T, Shimomura H, Bosserhoff AK and Kirita T: Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. Int J Oncol 56: 1093-1100, 2020.
APA
Kurihara‑Shimomura, M., Sasahira, T., Shimomura, H., Bosserhoff, A.K., & Kirita, T. (2020). Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. International Journal of Oncology, 56, 1093-1100. https://doi.org/10.3892/ijo.2020.4996
MLA
Kurihara‑Shimomura, M., Sasahira, T., Shimomura, H., Bosserhoff, A. K., Kirita, T."Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma". International Journal of Oncology 56.5 (2020): 1093-1100.
Chicago
Kurihara‑Shimomura, M., Sasahira, T., Shimomura, H., Bosserhoff, A. K., Kirita, T."Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma". International Journal of Oncology 56, no. 5 (2020): 1093-1100. https://doi.org/10.3892/ijo.2020.4996
Copy and paste a formatted citation
x
Spandidos Publications style
Kurihara‑Shimomura M, Sasahira T, Shimomura H, Bosserhoff AK and Kirita T: Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. Int J Oncol 56: 1093-1100, 2020.
APA
Kurihara‑Shimomura, M., Sasahira, T., Shimomura, H., Bosserhoff, A.K., & Kirita, T. (2020). Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. International Journal of Oncology, 56, 1093-1100. https://doi.org/10.3892/ijo.2020.4996
MLA
Kurihara‑Shimomura, M., Sasahira, T., Shimomura, H., Bosserhoff, A. K., Kirita, T."Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma". International Journal of Oncology 56.5 (2020): 1093-1100.
Chicago
Kurihara‑Shimomura, M., Sasahira, T., Shimomura, H., Bosserhoff, A. K., Kirita, T."Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma". International Journal of Oncology 56, no. 5 (2020): 1093-1100. https://doi.org/10.3892/ijo.2020.4996
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