DJ‑1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β‑catenin signaling pathway Corrigendum in /10.3892/ijo.2022.5320

Jin,Feng; Wang,Haibo; Li,Dan; Fang,Chuanchi; Li,Wenyuan; Shi,Qingtong; Diao,Yali; Ding,Zhiyan; Dai,Xiaojun; Tao,Li; Sunagawa,Masataka; Wu,Feng; Qian,Yayun; Liu,Yanqing

doi:10.3892/ijo.2020.5005

DJ‑1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β‑catenin signaling pathway

Corrigendum in: /10.3892/ijo.2022.5320

Authors:
- Feng Jin
- Haibo Wang
- Dan Li
- Chuanchi Fang
- Wenyuan Li
- Qingtong Shi
- Yali Diao
- Zhiyan Ding
- Xiaojun Dai
- Li Tao
- Masataka Sunagawa
- Feng Wu
- Yayun Qian
- Yanqing Liu
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Affiliations: Department of Respiratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Institution of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China, Department of Thoracic Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Department of Physiology, School of Medicine, Showa University, Tokyo 142‑8555, Japan
Published online on: March 5, 2020 https://doi.org/10.3892/ijo.2020.5005
Pages: 1115-1128
Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

DJ‑1, an oncogene, has been reported to be an independent prognostic indicator of poor survival in patients with esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the role of DJ‑1 in tumor cell proliferation and invasion in ESCC and its underlying mechanisms. It was observed that the expression level of DJ‑1 was upregulated and positively associated with EMT biomarkers in 84 human ESCC tissue specimens. Overexpression and knockdown experiments demonstrated that DJ‑1 was involved in proliferation, migration, invasion and EMT in ECA‑109 cells in vitro and extensive peritoneal seeding in a peritoneal dissemination mice model. Furthermore, the present data revealed that DJ‑1 could activate the Wnt/β‑catenin signaling pathway, which mediates the EMT and metastasis in ESCC. In conclusions, DJ‑1 promoted proliferation, invasion, metastasis and the EMT in ESCC via activation of the Wnt/β‑catenin signal pathway. The present results suggested DJ‑1 could represent a promising therapeutic target for the prevention and treatment of ESCC‑related metastasis.

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