Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
June-2020 Volume 56 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2020 Volume 56 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer

  • Authors:
    • Hanna Drzewiecka
    • Donata Jarmołowska‑Jurczyszyn
    • Andrzej Kluk
    • Bartłomiej Gałęcki
    • Wojciech Dyszkiewicz
    • Paweł P. Jagodziński
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60‑781 Poznan, Poland, Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60‑355 Poznan, Poland, Department of Thoracic Surgery, Poznan University of Medical Sciences, 60‑569 Poznan, Poland
    Copyright: © Drzewiecka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1352-1372
    |
    Published online on: March 19, 2020
       https://doi.org/10.3892/ijo.2020.5014
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Numerous studies have reported that oestrogens may contribute to the development of non‑small cell lung cancer (NSCLC). Although different steroidogenic enzymes have been detected in the lung, the precise mechanism leading to an exaggerated accumulation of active oestrogens in NSCLC remains unexplained. 17‑β‑Hydroxysteroid dehydrogenase type 2 (HSD17B2) is an enzyme involved in oestrogen and androgen inactivation by converting 17‑β‑oestradiol into oestrone, and testosterone into 4‑androstenedione. Therefore, the enzyme serves an important role in regulation of the intracellular availability of active sex steroids. This study aimed to determine the expression levels of HSD17B2 in lung cancer (LC) and adjacent histopathologically unchanged tissues obtained from 161 patients with NSCLC, and to analyse the association of HSD17B2 with clinicopathological features. For that purpose, reverse transcription‑quantitative PCR, western blotting and immunohistochemistry were conducted. The results revealed that the mRNA and protein expression levels of HSD17B2 were significantly decreased in LC tissues compared with matched controls (P<10‑6). Conversely, strong cytoplasmic staining of HSD17B2 was detected in the unchanged respiratory epithelium and in glandular cells. Notably, a strong association was detected between reduced HSD17B2 expression and advanced tumour stage, grade and size. Furthermore, it was revealed that HSD17B2 may have potential prognostic significance in NSCLC. A log‑rank test revealed the benefit of high HSD17B2 protein expression for the overall survival (OS) of patients (P=0.0017), and multivariate analysis confirmed this finding (hazard ratio=0.21; 95% confidence interval=0.07‑0.63; P=0.0043). Stratified analysis in the Kaplan‑Meier Plotter database indicated that patients with higher HSD17B2 expression presented better OS and post‑progression survival. This beneficial effect was particularly evident in patients with adenocarcinoma and during the early stages of NSCLC. Decreased expression of HSD17B2 appears to be a frequent feature in NSCLC. Retrospective analysis suggests that the HSD17B2 mRNA and protein status might be independent prognostic factors in NSCLC and should be further investigated.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Dholaria B, Hammond W, Shreders A and Lou Y: Emerging therapeutic agents for lung cancer. J Hematol Oncol. 9:1382016. View Article : Google Scholar : PubMed/NCBI

3 

Alì G, Donati V, Loggini B, Servadio A, Dell'Omodarme M, Prati MC, Camacci T, Lucchi M, Melfi F, Mussi A, et al: Different estrogen receptor beta expression in distinct histologic subtypes of lung adenocarcinoma. Hum Pathol. 39:1465–1473. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Gasperino J: Gender is a risk factor for lung cancer. Med Hypotheses. 76:328–331. 2011. View Article : Google Scholar

5 

Schwartz AG, Prysak GM, Murphy V, Lonardo F, Pass H, Schwartz J and Brooks S: Nuclear estrogen receptor beta in lung cancer: Expression and survival differences by sex. Clin Cancer Res. 11:7280–7287. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wakelee HA, Chang ET, Gomez SL, Keegan TH, Feskanich D, Clarke CA, Holmberg L, Yong LC, Kolonel LN, Gould MK, et al: Lung cancer incidence in never smokers. J Clin Oncol. 25:472–478. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Papadopoulos A, Guida F, Leffondré K, Cénée S, Cyr D, Schmaus A, Radoï L, Paget Bailly S, Carton M, Menvielle G, et al: Heavy smoking and lung cancer: Are women at higher risk? Result of the ICARE study. Br J Cancer. 110:1385–1391. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ryu JS, Jeon SH, Kim JS, Lee JH, Kim SH, Hong JT, Jeong JH, Jeong JJ, Lee MD, Min SJ, et al: Gender differences in susceptibility to smoking among patients with lung cancer. Korean J Intern Med (Korean Assoc Intern Med). 26:427–431. 2011.

9 

Guo H, Huang K, Zhang X, Zhang W, Guan L, Kuang D, Deng Q, Deng H, Zhang X, He M, et al: Women are more susceptible than men to oxidative stress and chromosome damage caused by polycyclic aromatic hydrocarbons exposure. Environ Mol Mutagen. 55:472–481. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Spivack SD, Hurteau GJ, Reilly AA, Aldous KM, Ding X and Kaminsky LS: CYP1B1 expression in human lung. Drug Metab Dispos. 29:916–922. 2001.PubMed/NCBI

11 

Cavalieri E, Chakravarti D, Guttenplan J, et al: Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention. Biochim Biophys Acta. 1766:63–78. 2006.PubMed/NCBI

12 

Belous AR, Hachey DL, Dawling S, Roodi N and Parl FF: Cytochrome P450 1B1 mediated estrogen metabolism results in estrogen deoxyribonucleoside adduct formation. Cancer Res. 67:812–817. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Siegfried JM, Hershberger PA and Stabile LP: Estrogen receptor signaling in lung cancer. Semin Oncol. 36:524–531. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Lienert T, Serke M, Schönfeld N and Loddenkemper R: Lung cancer in young females. Eur Respir J. 16:986–990. 2000. View Article : Google Scholar

15 

Ross H, Oldham FB, Bandstra B, Sandalic L, Bianco J, Bonomi P and Singer JW: Serum free estradiol (E2) levels are prognostic in men with chemotherapy naive advanced non small cell lung cancer (NSCLC) and performance status (PS) 2. J Clin Oncol. (Suppl 18)25:76832007. View Article : Google Scholar

16 

Chan YX, Alfonso H, Chubb SAP, Handelsman DJ, Fegan PG, Hankey GJ, Golledge J, Flicker L and Yeap BB: Higher Dihydrotestosterone Is Associated with the Incidence of Lung Cancer in Older Men. Horm Cancer. 8:119–126. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Stabile LP, Davis AL, Gubish CT, Hopkins TM, Luketich JD, Christie N, Finkelstein S and Siegfried JM: Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res. 62:2141–2150. 2002.PubMed/NCBI

18 

Márquez-Garbán DC, Chen HW, Fishbein MC, Goodglick L and Pietras RJ: Estrogen receptor signaling pathways in human non small cell lung cancer. Steroids. 72:135–143. 2007. View Article : Google Scholar

19 

Fasco MJ, Hurteau GJ and Spivack SD: Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue. Mol Cell Endocrinol. 188:125–140. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Jala VR, Radde BN, Haribabu B and Klinge CM: Enhanced expression of G protein coupled estrogen receptor (GPER/GPR30) in lung cancer. BMC Cancer. 12:6242012. View Article : Google Scholar

21 

Liu C, Liao Y, Fan S, Tang H, Jiang Z, Zhou B, Xiong J, Zhou S, Zou M and Wang J: G protein coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17β estradiol (E2) and selective agonist G1. Med Oncol. 32:1042015. View Article : Google Scholar

22 

Słowikowski BK, Lianeri M and Jagodziński PP: Exploring estrogenic activity in lung cancer. Mol Biol Rep. 44:35–50. 2017. View Article : Google Scholar

23 

Hsu LH, Chu NM and Kao SH: Estrogen, Estrogen Receptor and Lung Cancer. Int J Mol Sci. 18:17132017. View Article : Google Scholar :

24 

Zhang G, Liu X, Farkas AM, Parwani AV, Lathrop KL, Lenzner D, Land SR and Srinivas H: Estrogen receptor beta functions through nongenomic mechanisms in lung cancer cells. Mol Endocrinol. 23:146–156. 2009. View Article : Google Scholar

25 

Hershberger PA, Stabile LP, Kanterewicz B, Rothstein ME, Gubish CT, Land S, Shuai Y, Siegfried JM and Nichols M: Estrogen receptor beta (ERbeta) subtype specific ligands increase transcription, p44/p42 mitogen activated protein kinase (MAPK) activation and growth in human non small cell lung cancer cells. J Steroid Biochem Mol Biol. 116:102–109. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Fan S, Liao Y, Liu C, Huang Q, Liang H, Ai B, Fu S and Zhou S: Estrogen promotes tumor metastasis via estrogen receptor beta mediated regulation of matrix metalloproteinase 2 in non-small cell lung cancer. Oncotarget. 8:56443–56459. 2017.PubMed/NCBI

27 

Liu C, Liao Y, Fan S, Fu X, Xiong J, Zhou S, Zou M and Wang J: G Protein Coupled Estrogen Receptor Antagonist G15 Decreases Estrogen Induced Development of Non Small Cell Lung Cancer. Oncol Res. 27:283–292. 2019. View Article : Google Scholar

28 

Luu The V: Assessment of steroidogenesis and steroidogenic enzyme functions. J Steroid Biochem Mol Biol. 137:176–182. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Labrie F: All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause. J Steroid Biochem Mol Biol. 145:133–138. 2015. View Article : Google Scholar

30 

Provost PR, Blomquist CH, Drolet R, Flamand N and Tremblay Y: Androgen inactivation in human lung fibroblasts: Variations in levels of 17 beta hydroxysteroid dehydrogenase type 2 and 5 alpha reductase activity compatible with androgen inactivation. J Clin Endocrinol Metab. 87:3883–3892. 2002.PubMed/NCBI

31 

Niikawa H, Suzuki T, Miki Y, Suzuki S, Nagasaki S, Akahira J, Honma S, Evans DB, Hayashi S, Kondo T, et al: Intratumoral estrogens and estrogen receptors in human non small cell lung carcinoma. Clin Cancer Res. 14:4417–4426. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Verma MK, Miki Y and Sasano H: Aromatase in human lung carcinoma. Steroids. 76:759–764. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Verma MK, Miki Y, Abe K, Suzuki T, Niikawa H, Suzuki S, Kondo T and Sasano H: Intratumoral localization and activity of 17β hydroxysteroid dehydrogenase type 1 in non small cell lung cancer: A potent prognostic factor. J Transl Med. 11:1672013. View Article : Google Scholar

34 

Drzewiecka H and Jagodzinski PP: Conversion of estrone to 17 beta estradiol in human non small cell lung cancer cells in vitro. Biomed Pharmacother. 66:530–534. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Drzewiecka H, Gałęcki B, Jarmołowska-Jurczyszyn D, Kluk A, Dyszkiewicz W and Jagodziński PP: Increased expression of 17 beta hydroxysteroid dehydrogenase type 1 in non small cell lung cancer. Lung Cancer. 87:107–116. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Miettinen MM, Mustonen MV, Poutanen MH, Isomaa VV and Vihko RK: Human 17 beta-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell and tissue specific expression. Biochem J. 314(Pt 3): 839–845. 1996. View Article : Google Scholar

37 

Vihko P, Isomaa V and Ghosh D: Structure and function of 17beta hydroxysteroid dehydrogenase type 1 and type 2. Mol Cell Endocrinol. 171:71–76. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, Postmus PE, Rusch V and Sobin L; International Association for the Study of Lung Cancer International Staging Committee Participating Institutions: The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol. 2:706–714. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Győrffy B, Surowiak P, Budczies J and Lánczky A: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS One. 8:e822412013. View Article : Google Scholar

40 

Tellmann G: The E Method: A highly accurate technique for gene expression analysis. Nat Methods. 3:i–ii. 2006. View Article : Google Scholar

41 

Drzewiecka H, Gałęcki B, Jarmołowska-Jurczyszyn D, Kluk A, Dyszkiewicz W and Jagodziński PPPP: Decreased expression of connective tissue growth factor in non small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. J Cancer Res Clin Oncol. 142:1927–1946. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Burns TF and Stabile LP: Targeting the estrogen pathway for the treatment and prevention of lung cancer. Lung Cancer Manag. 3:43–52. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Ivanova MM, Mazhawidza W, Dougherty SM and Klinge CM: Sex differences in estrogen receptor subcellular location and activity in lung adenocarcinoma cells. Am J Respir Cell Mol Biol. 42:320–330. 2010. View Article : Google Scholar :

44 

Hammoud Z, Tan B, Badve S and Bigsby RM: Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma. Endocr Relat Cancer. 15:475–483. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Hilborn E, Stål O, Alexeyenko A and Jansson A: The regulation of hydroxysteroid 17β dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer. Oncotarget. 8:62183–62194. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Lewis Wambi JS and Jordan VC: Estrogen regulation of apoptosis: How can one hormone stimulate and inhibit? Breast Cancer Res. 11:2062009. View Article : Google Scholar : PubMed/NCBI

47 

Speirs V, Green AR, Walton DS, Kerin MJ, Fox JN, Carleton PJ, Desai SB and Atkin SL: Short-term primary culture of epithelial cells derived from human breast tumours. Br J Cancer. 78:1421–1429. 1998. View Article : Google Scholar : PubMed/NCBI

48 

Hilborn E, Stål O and Jansson A: Estrogen and androgen converting enzymes 17β hydroxysteroid dehydrogenase and their involvement in cancer: With a special focus on 17β hydroxysteroid dehydrogenase type 1, 2, and breast cancer. Oncotarget. 8:30552–30562. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Miyoshi Y, Ando A, Shiba E, Taguchi T, Tamaki Y and Noguchi S: Involvement of up regulation of 17beta hydroxys teroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers. Int J Cancer. 94:685–689. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Zhang CYY, Chen J, Yin DCC and Lin SXX: The contri bution of 17beta hydroxysteroid dehydrogenase type 1 to the estradiol estrone ratio in estrogen sensitive breast cancer cells. PLoS One. 7:e298352012. View Article : Google Scholar

51 

Gunnarsson C, Olsson BM and Stål O; Southeast Sweden Breast Cancer Group: Abnormal expression of 17beta hydroxysteroid dehydrogenases in breast cancer predicts late recurrence. Cancer Res. 61:8448–8451. 2001.PubMed/NCBI

52 

Gunnarsson C, Hellqvist E and Stål O: 17beta Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prog nostic significance in breast cancer. Br J Cancer. 92:547–552. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Han B, Li S, Song D, Poisson Paré D, Liu G, Luu The V, Ouellet J, Li S, Labrie F and Pelletier G: Expression of 17β hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non malignant tissue: A correlation to clinicopathological parameters. J Steroid Biochem Mol Biol. 112:194–200. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Wang CT, Li CFCC, Wu WJ, Huang CN, Li CC, Li WM, Chan TC, Liang PI, Hsing CH and Liao KM: High Expression of 17β hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract. J Cancer. 7:2221–2230. 2016. View Article : Google Scholar :

55 

Frycz BA, Murawa D, Borejsza-Wysocki M, Marciniak R, Murawa P, Drews M and Jagodziński PP: Expression of 17β hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer. Biomed Pharmacother. 70:24–27. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Lee YE, He HL, Shiue YL, Lee SW, Lin LC, Wu TF, Chang IW, Lee HH and Li CF: The prognostic impact of lipid biosyn thesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy. Tumour Biol. 36:7675–7683. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Marino M: Xenoestrogens challenge 17β estradiol protective effects in colon cancer. World J Gastrointest Oncol. 6:67–73. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Cornel KMC, Krakstad C, Delvoux B, Xanthoulea S, Jori B, Bongers MY, Konings GF, Kooreman LF, Kruitwagen RF, Salvesen HB, et al ENITEC: High mRNA levels of 17β hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer. Mol Cell Endocrinol. 442:51–57. 2017. View Article : Google Scholar

59 

Jeong Y, Xie Y, Lee W, Bookout AL, Girard L, Raso G, Behrens C, Wistuba II, Gadzar AF, Minna JD, et al: Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol. 26:1443–1454. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Recchia AG, Musti AM, Lanzino M, Panno ML, Turano E, Zumpano R, Belfiore A, Andò S and Maggiolini M: A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells. Int J Biochem Cell Biol. 41:603–614. 2009. View Article : Google Scholar

61 

Harlos C, Musto G, Lambert P, Ahmed R and Pitz MW: Androgen pathway manipulation and survival in patients with lung cancer. Horm Cancer. 6:120–127. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Huuskonen P, Amezaga MR, Bellingham M, Jones LH, Storvik M, Häkkinen M, Keski-Nisula L, Heinonen S, O'Shaughnessy PJ, Fowler PA, et al: The human placental proteome is affected by maternal smoking. Reprod Toxicol. 63:22–31. 2016. View Article : Google Scholar : PubMed/NCBI

63 

Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S and Sasano H: Retinoid receptors in the human endometrium and its disorders: A possible modulator of 17 β hydroxysteroid dehydrogenase. J Clin Endocrinol Metab. 86:2721–2727. 2001.PubMed/NCBI

64 

Reed MJ, Rea D, Duncan LJ and Parker MG: Regulation of estradiol 17 beta hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells. Endocrinology. 135:4–9. 1994. View Article : Google Scholar : PubMed/NCBI

65 

Su EJ, Cheng YH, Chatterton RT, Lin ZH, Yin P, Reierstad S, Innes J and Bulun SE: Regulation of 17 beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells. Biol Reprod. 77:517–525. 2007. View Article : Google Scholar : PubMed/NCBI

66 

Li Y, Lu DG, Ma YM and Liu H: Association between Retinoic acid receptor β hypermethylation and NSCLC risk: A meta analysis and literature review. Oncotarget. 8:5814–5822. 2017.

67 

Muñiz Hernández S, Huerta Yepez S, Hernández Pedro N, Ramírez Tirado LA, Aviles Salas A, Maldonado A, Hernández Cueto D, Baay Guzmán G and Arrieta O: Association between nuclear expression of retinoic acid receptor alpha and beta and clinicopathological features and prognosis of advanced non small cell lung cancer. Int J Clin Oncol. 21:1051–1061. 2016. View Article : Google Scholar

68 

Elo JP, Härkönen P, Kyllönen AP, Lukkarinen O and Vihko P: Three independently deleted regions at chromosome arm 16q in human prostate cancer: Allelic loss at 16q24.1 q24.2 is associated with aggressive behaviour of the disease, recurrent growth, poor differentiation of the tumour and poor prognosis for the patient. Br J Cancer. 79:156–160. 1999. View Article : Google Scholar : PubMed/NCBI

69 

Jansson A: 17Beta hydroxysteroid dehydrogenase enzymes and breast cancer. J Steroid Biochem Mol Biol. 114:64–67. 2009. View Article : Google Scholar : PubMed/NCBI

70 

Sato M, Mori Y, Sakurada A, Fukushige S, Ishikawa Y, Tsuchiya E, Saito Y, Nukiwa T, Fujimura S and Horii A: Identification of a 910-kb region of common allelic loss in chromosome bands 16q24.1 q24.2 in human lung cancer. Genes Chromosomes Cancer. 22:1–8. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Drzewiecka H, Jarmołowska‑Jurczyszyn D, Kluk A, Gałęcki B, Dyszkiewicz W and Jagodziński PP: Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer. Int J Oncol 56: 1352-1372, 2020.
APA
Drzewiecka, H., Jarmołowska‑Jurczyszyn, D., Kluk, A., Gałęcki, B., Dyszkiewicz, W., & Jagodziński, P.P. (2020). Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer. International Journal of Oncology, 56, 1352-1372. https://doi.org/10.3892/ijo.2020.5014
MLA
Drzewiecka, H., Jarmołowska‑Jurczyszyn, D., Kluk, A., Gałęcki, B., Dyszkiewicz, W., Jagodziński, P. P."Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer". International Journal of Oncology 56.6 (2020): 1352-1372.
Chicago
Drzewiecka, H., Jarmołowska‑Jurczyszyn, D., Kluk, A., Gałęcki, B., Dyszkiewicz, W., Jagodziński, P. P."Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer". International Journal of Oncology 56, no. 6 (2020): 1352-1372. https://doi.org/10.3892/ijo.2020.5014
Copy and paste a formatted citation
x
Spandidos Publications style
Drzewiecka H, Jarmołowska‑Jurczyszyn D, Kluk A, Gałęcki B, Dyszkiewicz W and Jagodziński PP: Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer. Int J Oncol 56: 1352-1372, 2020.
APA
Drzewiecka, H., Jarmołowska‑Jurczyszyn, D., Kluk, A., Gałęcki, B., Dyszkiewicz, W., & Jagodziński, P.P. (2020). Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer. International Journal of Oncology, 56, 1352-1372. https://doi.org/10.3892/ijo.2020.5014
MLA
Drzewiecka, H., Jarmołowska‑Jurczyszyn, D., Kluk, A., Gałęcki, B., Dyszkiewicz, W., Jagodziński, P. P."Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer". International Journal of Oncology 56.6 (2020): 1352-1372.
Chicago
Drzewiecka, H., Jarmołowska‑Jurczyszyn, D., Kluk, A., Gałęcki, B., Dyszkiewicz, W., Jagodziński, P. P."Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer". International Journal of Oncology 56, no. 6 (2020): 1352-1372. https://doi.org/10.3892/ijo.2020.5014
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team