Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review)

  • Authors:
    • Zhiwei Sun
    • Shuo Cai
    • Catherine Zabkiewicz
    • Chang Liu
    • Lin Ye
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  • Published online on: March 26, 2020     https://doi.org/10.3892/ijo.2020.5030
  • Pages: 1335-1351
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Abstract

Bone morphogenetic proteins (BMP) are pluripotent molecules, co‑ordinating cellular functions from early embryonic and postnatal development to tissue repair, regeneration and homeostasis. They are also involved in tumourigenesis, disease progression and the metastasis of various solid tumours. Emerging evidence has indicated that BMPs are able to promote disease progression and metastasis by orchestrating communication between cancer cells and the surrounding microenvironment. The interactions occur between BMPs and epidermal growth factor receptor, hepatocyte growth factor, fibroblast growth factor, vascular endothelial growth factor and extracellular matrix components. Overall, these interactions co‑ordinate the cellular functions of tumour cells and other types of cell in the tumour to promote the growth of the primary tumour, local invasion, angiogenesis and metastasis, and the establishment and survival of cancer cells in the metastatic niche. Therefore, the present study aimed to provide an informative summary of the involvement of BMPs in the tumour microenvironment.
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June-2020
Volume 56 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sun Z, Cai S, Zabkiewicz C, Liu C and Ye L: Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review). Int J Oncol 56: 1335-1351, 2020
APA
Sun, Z., Cai, S., Zabkiewicz, C., Liu, C., & Ye, L. (2020). Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review). International Journal of Oncology, 56, 1335-1351. https://doi.org/10.3892/ijo.2020.5030
MLA
Sun, Z., Cai, S., Zabkiewicz, C., Liu, C., Ye, L."Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review)". International Journal of Oncology 56.6 (2020): 1335-1351.
Chicago
Sun, Z., Cai, S., Zabkiewicz, C., Liu, C., Ye, L."Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review)". International Journal of Oncology 56, no. 6 (2020): 1335-1351. https://doi.org/10.3892/ijo.2020.5030