Progress and prospects of biomarkers in primary liver cancer (Review)

  • Authors:
    • Yu‑Xue Gao
    • Tong‑Wang Yang
    • Ji‑Ming Yin
    • Peng‑Xiang Yang
    • Bu‑Xin Kou
    • Meng‑Yin Chai
    • Xiao‑Ni Liu
    • De‑Xi Chen
  • View Affiliations

  • Published online on: April 1, 2020     https://doi.org/10.3892/ijo.2020.5035
  • Pages: 54-66
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Tumor biomarkers are important in the early screening, diagnosis, therapeutic evaluation, recurrence and prognosis prediction of tumors. Primary liver cancer is one of the most common malignant tumors; it has high incidence and mortality rates and seriously endangers human health. The main pathological types of primary liver cancer include hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and combined HCC‑cholangiocarcinoma (cHCC‑CC). In the present review, a systematic outline of the current biomarkers of primary liver cancer is presented, from conventional blood biomarkers, histochemical biomarkers and potential biomarkers to resistance‑associated biomarkers. The important relationships are deeply elucidated between biomarkers and diagnosis, prognosis, clinicopathological features and resistance, as well as their clinical significance, in patients with the three main types of primary liver cancer. Moreover, a summary of several important biomarker signaling pathways is provided, which is helpful for studying the biological mechanism of liver cancer. The purpose of this review is to provide help for clinical or medical researchers in the early diagnosis, differential diagnosis, prognosis and treatment of HCC.

Related Articles

Journal Cover

July 2020
Volume 57 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Gao, Y., Yang, T., Yin, J., Yang, P., Kou, B., Chai, M. ... Chen, D. (2020). Progress and prospects of biomarkers in primary liver cancer (Review). International Journal of Oncology, 57, 54-66. https://doi.org/10.3892/ijo.2020.5035
MLA
Gao, Y., Yang, T., Yin, J., Yang, P., Kou, B., Chai, M., Liu, X., Chen, D."Progress and prospects of biomarkers in primary liver cancer (Review)". International Journal of Oncology 57.1 (2020): 54-66.
Chicago
Gao, Y., Yang, T., Yin, J., Yang, P., Kou, B., Chai, M., Liu, X., Chen, D."Progress and prospects of biomarkers in primary liver cancer (Review)". International Journal of Oncology 57, no. 1 (2020): 54-66. https://doi.org/10.3892/ijo.2020.5035