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Article Open Access

circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer

Erratum in: /10.3892/ijo.2020.5137
  • Authors:
    • Fang‑Wen Zou
    • Shi‑Ze Yang
    • Wen‑Ya Li
    • Chao‑Yuan Liu
    • Xu‑Hong Liu
    • Chun‑Hong Hu
    • Zheng‑Hua Liu
    • Shun Xu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, P.R. China, Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 11000, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 151-160
    |
    Published online on: April 22, 2020
       https://doi.org/10.3892/ijo.2020.5050
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Abstract

Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin‑resistant esophageal cancer. Three pairs of cisplatin‑resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis. Additionally, the effect of circRNA_001275 on cisplatin‑resistant cells was investigated. The relationship between circRNA_001275, microRNAs (miRs) and target genes were analyzed using luciferase assays, and validated via reverse transcription‑quantitative PCR (RT‑qPCR) and western blotting. The results showed that circRNA_001275 was significantly upregulated in cisplatin‑resistant esophageal cancer tissues and cells (P<0.05). Overexpression of circRNA_001275 promoted the proliferation and invasion, and decreased the apoptosis of cisplatin‑resistant cells. On the other hand, circRNA_001275 silencing inhibited cell proliferation and invasion, and promoted cell apoptosis (P<0.05). Dual‑luciferase reporter assays revealed that circRNA_001275 directly binds to miR‑370‑3p, and that Wnt family member 7A (Wnt7a) is targeted by miR‑370‑3p. RT‑qPCR and western blotting further demonstrated that circRNA_001275 serves as an miR‑370‑3p sponge to upregulate Wnt7a expression. In conclusion, the present study revealed that circRNA_001275 was upregulated in cisplatin‑resistant esophageal cancer and promoted cisplatin resistance by sponging miR‑370‑3p to upregulate Wnt7a expression. Therefore, circRNA_001275 may serve as a potential diagnostic biomarker and therapeutic target for patients with cisplatin‑resistant esophageal cancer.
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View References

1 

Hall KA, Spicer MT, Ilich JZ and Levenson CW: Nutritional care for patients with esophageal cancer. Topics Clin Nutr. 34:2–13. 2019. View Article : Google Scholar

2 

Su LL, Chang XJ, Zhou HD, Hou LB and Xue XY: Exosomes in esophageal cancer: A review on tumorigenesis, diagnosis and therapeutic potential. World J Clin Cases. 7:908–916. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Shi H, Mao Y, Ju Q, Wu Y, Bai W, Wang P, Zhang Y and Jiang M: C-terminal binding protein-2 mediates cisplatin chemoresistance in esophageal cancer cells via the inhibition of apoptosis. Int J Oncol. 53:167–176. 2018.PubMed/NCBI

4 

Huang XP, Li X, Situ MY, Huang LY, Wang JY, He TC, Yan QH, Xie XY, Zhang YJ, Gao YH, et al: Entinostat reverses cisplatin resistance in esophageal squamous cell carcinoma via down-regulation of multidrug resistance gene 1. Cancer Lett. 414:294–300. 2018. View Article : Google Scholar

5 

Sun Y, Zhai L, Ma S, Zhang C, Zhao L, Li N, Xu Y, Zhang T, Guo Z, Zhang H, et al: Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma. Cancer Lett. 418:97–108. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Meng X, Li X, Zhang P, Wang J, Zhou Y and Chen M: Circular RNA: An emerging key player in RNA world. Brief Bioinform. 18:547–557. 2017.

7 

Chen LL and Yang L: Regulation of circRNA biogenesis. RNA Biol. 12:381–388. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Huang C and Shan G: What happens at or after transcription: Insights into circRNA biogenesis and function. Transcription. 6:61–64. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Panda AC: Circular RNAs Act as miRNA sponges. Adv Exp Med Biol. 1087:67–79. 2018. View Article : Google Scholar : PubMed/NCBI

10 

World Medical Association Inc: Declaration of Helsinki. Ethical principles for medical research involving human subjects. J Indian Med Assoc. 107:403–405. 2009.PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

12 

Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ and Liang L: Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 7:26680–26691. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Zhong Z, Lv M and Chen J: Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep. 6:309192016. View Article : Google Scholar : PubMed/NCBI

14 

Li G, Xue M, Yang F, Jin Y, Fan Y and Li W: CircRBMS3 promotes gastric cancer tumorigenesis by regulating miR-153-SNAI1 axis. J Cell Physiol. 234:3020–3028. 2019. View Article : Google Scholar

15 

Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z and Li L: Screening circular RNA related to chemotherapeutic resistance in breast cancer. Epigenomics. 9:1175–1188. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Kun-Peng Z, Xiao-Long M and Chun-Lin Z: Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1. Int J Biol Sci. 14:321–330. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Dai Y, Huang Y, Huang J, Wen C, Zhou H and Wu L: Differential expression of circular RNAs in gefitinib-acquired resistant non-small cell lung cancer cells. Tumor. 37:1128–1135. 2017.

18 

Zhao K: Study on the expression profile of cyclic RNA in postmenopausal osteoporosis and screening of potential molecular markers (unpublished PhD thesis). Southern Medical University; 2018

19 

Huang X, Zhu H, Gao Z, Li J, Zhuang J, Dong Y, Shen B, Li M, Zhou H, Guo H, et al: Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p. J Biol Chem. 293:6693–6706. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Peng Z, Wu T, Li Y, Xu Z, Zhang S, Liu B, Chen Q and Tian D: MicroRNA-370-3p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting β-catenin. Brain Res. 1644:53–61. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Gao YT, Chen XB and Liu HL: Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expression. Sci Rep. 6:329722016. View Article : Google Scholar : PubMed/NCBI

22 

Anastas JN and Moon RT: WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 13:11–26. 2013. View Article : Google Scholar

23 

Tríbulo P, Jumatayeva G, Lehloenya K, Moss JI, Negrón-Pérez VM and Hansen PJ: Effects of sex on response of the bovine preimplantation embryo to insulin-like growth factor 1, activin A, and WNT7A. BMC Dev Biol. 18:162018. View Article : Google Scholar : PubMed/NCBI

24 

Wang W, Yan X, Lin Y, Ge H and Tan Q: Wnt7a promotes wound healing by regulation of angiogenesis and inflammation: Issues on diabetes and obesity. J Dermatol Sci. Feb 15–2018.Epub ahead of print. View Article : Google Scholar

25 

Liu Y, Dong Y, Zhao L, Su L and Luo J: Circular RNA-MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis. Int J Oncol. 53:1752–1762. 2018.PubMed/NCBI

26 

MacLean JA II, King ML, Okuda H and Hayashi K: WNT7A regulation by miR-15b in ovarian cancer. PLoS One. 11:e01561092016. View Article : Google Scholar : PubMed/NCBI

27 

Feng G, Fan Y, Li L, et al: MicroRNA-34a sensitizes breast cancer cells to paclitaxel treatment by targeting WNT7A. Bachu Med J. 15:6–10. 2018.In Chinese.

28 

Avasarala S, Van Scoyk M, Wang J, Sechler M, Vandervest K, Brzezinski C, Weekes C, Edwards MG, Arcaroli J, Davis RE, et al: hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression. Biol Open. 2:675–685. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zou FW, Yang SZ, Li WY, Liu CY, Liu XH, Hu CH, Liu ZH and Xu S: circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137. Int J Oncol 57: 151-160, 2020.
APA
Zou, F., Yang, S., Li, W., Liu, C., Liu, X., Hu, C. ... Xu, S. (2020). circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137. International Journal of Oncology, 57, 151-160. https://doi.org/10.3892/ijo.2020.5050
MLA
Zou, F., Yang, S., Li, W., Liu, C., Liu, X., Hu, C., Liu, Z., Xu, S."circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137". International Journal of Oncology 57.1 (2020): 151-160.
Chicago
Zou, F., Yang, S., Li, W., Liu, C., Liu, X., Hu, C., Liu, Z., Xu, S."circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137". International Journal of Oncology 57, no. 1 (2020): 151-160. https://doi.org/10.3892/ijo.2020.5050
Copy and paste a formatted citation
x
Spandidos Publications style
Zou FW, Yang SZ, Li WY, Liu CY, Liu XH, Hu CH, Liu ZH and Xu S: circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137. Int J Oncol 57: 151-160, 2020.
APA
Zou, F., Yang, S., Li, W., Liu, C., Liu, X., Hu, C. ... Xu, S. (2020). circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137. International Journal of Oncology, 57, 151-160. https://doi.org/10.3892/ijo.2020.5050
MLA
Zou, F., Yang, S., Li, W., Liu, C., Liu, X., Hu, C., Liu, Z., Xu, S."circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137". International Journal of Oncology 57.1 (2020): 151-160.
Chicago
Zou, F., Yang, S., Li, W., Liu, C., Liu, X., Hu, C., Liu, Z., Xu, S."circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer Erratum in /10.3892/ijo.2020.5137". International Journal of Oncology 57, no. 1 (2020): 151-160. https://doi.org/10.3892/ijo.2020.5050
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