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Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling

  • Authors:
    • Xiaodong Xu
    • Yingjie Xia
    • Jie Ma
    • Weijun Li
    • Nan Niu
    • Xiao Li
    • Houquan Tao
    • Ji Xu
    • Xujun He
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, Department of General Surgery, People's Hospital of Xianju, Taizhou, Zhejiang 317300, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 522-532
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    Published online on: May 26, 2020
       https://doi.org/10.3892/ijo.2020.5072
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Abstract

MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of NF‑κB signaling, remains unclear. The aim of the present study was to investigate miRNA‑301a‑3p expression in GC progression and the molecular mechanisms as regards the regulation of NF‑κB signaling. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect miRNA‑301a‑3p expression in GC and paired normal tissues. The association between the expression of miRNA‑301a‑3p and patient pathological parameters and the prognosis of GC was statistically analyzed using an in situ hybridization (ISH) assay. An MTS assay and a Transwell assay were performed to evaluate the effects of miRNA‑301a‑3p on the proliferation, invasion and migration of GC cells. RT‑qPCR and western blot analysis were used to analyze the association between miRNA‑301a‑3p and nuclear factor‑κB repressing factor (NKRF) expression and the corresponding downstream NF‑κB signaling molecules. A luciferase assay was used to verify the target effect of miRNA‑301a‑3p and NKRF. It was found that miRNA‑301a‑3p expression was significantly higher in 30 cases of primary GC compared with matched normal tissues. Additionally, the ISH assay indicated that the high expression of miRNA‑301a‑3p in GC was associated with tumor invasion depth, lymph node metastasis, lymph node invasion and tumor metastasis stage. Patients whose tumors had a higher miRNA‑301a‑3p expression level exhibited a poorer prognosis. The in vitro assay indicated that miRNA‑301a‑3p affected the proliferative and invasive ability of GC cells by targeting the expression of NKRF, which then affected NF‑κB signaling. Therefore, it was hypothesize that miRNA‑301a‑3p promotes GC progression and affects the prognosis of patients with GC by targeting NKRF, which in turn, directly influences NF‑κB activation.
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View References

1 

Voutsadakis IA: Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation. J Clin Med. 5:52016. View Article : Google Scholar

2 

Nie Y, Wu K, Yu J, Liang Q, Cai X, Shang Y, Zhou J, Pan K, Sun L, Fang J, et al: A global burden of gastric cancer: The major impact of China. Expert Rev Gastroenterol Hepatol. 11:651–661. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Strong VE, Wu AW, Selby LV, Gonen M, Hsu M, Song KY, Park CH, Coit DG, Ji JF and Brennan MF: Differences in gastric cancer survival between the U.S. and China. J Surg Oncol. 112:31–37. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Feng RM, Zong YN, Cao SM and Xu RH: Current cancer situation in China: Good or bad news from the 2018 Global Cancer Statistics? Cancer Commun (Lond). 39:222019. View Article : Google Scholar

5 

Monisha J, Roy NK, Bordoloi D, Kumar A, Golla R, Kotoky J, Padmavathi G and Kunnumakkara AB: Nuclear Factor Kappa B: A Potential Target to Persecute Head and Neck Cancer. Curr Drug Targets. 18:232–253. 2017. View Article : Google Scholar

6 

Fouani L, Kovacevic Z and Richardson DR: Targeting Oncogenic Nuclear Factor Kappa B Signaling with Redox-Active Agents for Cancer Treatment. Antioxid Redox Signal. 30:1096–1123. 2019. View Article : Google Scholar

7 

Wang Y, Ni H, Li H, Deng H, Xu LS, Xu S, Zhen Y, Shen H, Pan H and Yao M: Nuclear factor kappa B regulated monocyte chemoat-tractant protein-1/chemokine CC motif receptor-2 expressing in spinal cord contributes to the maintenance of cancer-induced bone pain in rats. Mol Pain. 14:17448069187886812018. View Article : Google Scholar

8 

Fujimura T, Kambayashi Y, Furudate S, Kakizaki A, Hidaka T and Aiba S: Possible mechanisms of the crosstalk between Langerhans cells and regulatory T cells in extramammary Paget disease by receptor activator of nuclear factor kappa B (RANK) ligand/RANK pathways. Br J Dermatol. 176:387–394. 2017. View Article : Google Scholar

9 

Cao HJ, Fang Y, Zhang X, Chen WJ, Zhou WP, Wang H, Wang LB and Wu JM: Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue. World J Gastroenterol. 11:903–907. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Tomonaga M, Hashimoto N, Tokunaga F, Onishi M, Myoui A, Yoshikawa H and Iwai K: Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells. Int J Oncol. 40:409–417. 2012.

11 

Gambhir S, Vyas D, Hollis M, Aekka A and Vyas A: Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies. World J Gastroenterol. 21:3174–3183. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Dolcet X, Llobet D, Pallares J and Matias-Guiu X: NF-kB in development and progression of human cancer. Virchows Arch. 446:475–482. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Helbig G, Christopherson KW II, Bhat-Nakshatri P, Kumar S, Kishimoto H, Miller KD, Broxmeyer HE and Nakshatri H: NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem. 278:21631–21638. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Cai Z, Tchou-Wong KM and Rom WN: NF-kappaB in lung tumorigenesis. Cancers (Basel). 3:4258–4268. 2011. View Article : Google Scholar

15 

Tong HB, Zou CL, Qin SY, Meng J, Keller ET, Zhang J and Lu Y: Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-κB signaling. J Biomed Res. 32:343–353. 2018.PubMed/NCBI

16 

Khurana N and Sikka SC: Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer. Cancers (Basel). 10:102018. View Article : Google Scholar

17 

Sokolova O and Naumann M: NF-κB Signaling in Gastric Cancer. Toxins (Basel). 9:92017. View Article : Google Scholar

18 

Jiang XJ, Lin J, Cai QH, Zhao JF and Zhang HJ: CDH17 alters MMP-2 expression via canonical NF-κB signalling in human gastric cancer. Gene. 682:92–100. 2019. View Article : Google Scholar

19 

Xu GY and Tang XJ: Troxerutin (TXN) potentiated 5-Fluorouracil (5-Fu) treatment of human gastric cancer through suppressing STAT3/NF-κB and Bcl-2 signaling pathways. Biomed Pharmacother. 92:95–107. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Huang F, Yao Y, Wu J, Liu Q, Zhang J, Pu X, Zhang Q and Xia L: Curcumin inhibits gastric cancer-derived mesenchymal stem cells mediated angiogenesis by regulating NF-κB/VEGF signaling. Am J Transl Res. 9:5538–5547. 2017.

21 

Li YS, Wu LP, Li KH, Liu YP, Xiang R, Zhang SB, Zhu LY and Zhang LY: Involvement of nuclear factor κB (NF-κB) in the downregulation of cyclooxygenase-2 (COX-2) by genistein in gastric cancer cells. J Int Med Res. 39:2141–2150. 2011. View Article : Google Scholar

22 

Chen W, Wang X, Bai L, Liang X, Zhuang J and Lin Y: Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells. J Cell Biochem. 105:554–561. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Lun M, Zhang PL, Pellitteri PK, Law A, Kennedy TL and Brown RE: Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: Pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB. Ann Clin Lab Sci. 35:251–258. 2005.PubMed/NCBI

24 

Ventura A and Jacks T: MicroRNAs and cancer: Short RNAs go a long way. Cell. 136:586–591. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Shukla GC, Singh J and Barik S: MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. Mol Cell Pharmacol. 3:83–92. 2011.PubMed/NCBI

26 

Xu X, Yang X, Xing C, Zhang S and Cao J: miRNA: The nemesis of gastric cancer (Review). Oncol Lett. 6:631–641. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Singh R, Ramasubramanian B, Kanji S, Chakraborty AR, Haque SJ and Chakravarti A: Circulating microRNAs in cancer: Hope or hype? Cancer Lett. 381:113–121. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, Leiser A, Schwartz PE, Rutherford T and Mor G: Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene. 27:4712–4723. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Taganov KD, Boldin MP, Chang KJ and Baltimore D: NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 103:12481–12486. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Lee HM, Kim TS and Jo EK: MiR-146 and miR-125 in the regulation of innate immunity and inflammation. BMB Rep. 49:311–318. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Öztemur Islakoğlu Y, Noyan S and Gür Dedeoğlu B: hsa-miR-301a- and SOX10-dependent miRNA-TF-mRNA regulatory circuits in breast cancer. Turk J Biol. 42:103–112. 2018. View Article : Google Scholar

32 

Xia X, Zhang K, Cen G, Jiang T, Cao J, Huang K, Huang C, Zhao Q and Qiu Z: MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4. Oncotarget. 6:21046–21063. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Zhou P, Jiang W, Wu L, Chang R, Wu K and Wang Z: miR-301a is a candidate oncogene that targets the homeobox gene Gax in human hepatocellular carcinoma. Dig Dis Sci. 57:1171–1180. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Wu Z, Li Y and Zhang G: Downregulation of microRNA-301a inhibited proliferation, migration and invasion of non-small cell lung cancer by directly targeting DLC1. Oncol Lett. 14:6017–6023. 2017.PubMed/NCBI

35 

Wang M, Li C, Yu B, Su L, Li J, Ju J, Yu Y, Gu Q, Zhu Z and Liu B: Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer. J Gastroenterol. 48:1023–1033. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Xu XD, He XJ, Tao HQ, Zhang W, Wang YY, Ye ZY and Zhao ZS: Abnormal expression of miR-301a in gastric cancer associated with progression and poor prognosis. J Surg Oncol. 108:197–202. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Coccia M, Rossi A, Riccio A, Trotta E and Santoro MG: Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance. Proc Natl Acad Sci USA. 114:pp. 1045–1050. 2017, View Article : Google Scholar

38 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more 'personalized' approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Washington K: 7th edition of the AJCC cancer staging manual: Stomach. Ann Surg Oncol. 7:3077–3079. 2010. View Article : Google Scholar

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Method Methods. 25:402–408. 2001. View Article : Google Scholar

41 

Zaravinos A: The Regulatory Role of MicroRNAs in EMT and Cancer. J Oncol. 2015:8658162015. View Article : Google Scholar : PubMed/NCBI

42 

Svoronos AA, Engelman DM and Slack FJ: OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer. Cancer Res. 76:3666–3670. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Ma F, Zhang J, Zhong L, Wang L, Liu Y, Wang Y, Peng L and Guo B: Upregulated microRNA-301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β-catenin signaling. Gene. 535:191–197. 2014. View Article : Google Scholar

44 

Ni Z, Shang XF, Wang YF, Sun YJ and Fu DJ: Upregulated microRNA-301a in osteosarcoma promotes tumor progression by targeting CDC14A. Genet Mol Res. 15:152016. View Article : Google Scholar

45 

Liu L, Nie J, Chen L, Dong G, Du X, Wu X, Tang Y and Han W: The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression. PLoS One. 8:e555322013. View Article : Google Scholar : PubMed/NCBI

46 

Bano N, Yadav M, Mohania D and Das BC: The role of NF-κB and miRNA in oral cancer and cancer stem cells with or without HPV16 infection. PLoS One. 13:e02055182018. View Article : Google Scholar

47 

Alderton GK: Microrna: Micro loops in NF κB signalling. Nat Rev Cancer. 11:62011. View Article : Google Scholar

48 

Qiu W, He JH, Zuo H, Niu S, Li C, Zhang S, Weng S, He J and Xu X: Identification, characterization, and function analysis of the NF-κB repressing factor (NKRF) gene from Litopenaeus vannamei. Dev Comp Immunol. 76:83–92. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Niwa H, Tsuneyama K and Takano Y: Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma. Anticancer Res. 26(5A): pp. 3579–3583. 2006, PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Xia Y, Ma J, Li W, Niu N, Li X, Tao H, Xu J and He X: Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling . Int J Oncol 57: 522-532, 2020.
APA
Xu, X., Xia, Y., Ma, J., Li, W., Niu, N., Li, X. ... He, X. (2020). Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling . International Journal of Oncology, 57, 522-532. https://doi.org/10.3892/ijo.2020.5072
MLA
Xu, X., Xia, Y., Ma, J., Li, W., Niu, N., Li, X., Tao, H., Xu, J., He, X."Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling ". International Journal of Oncology 57.2 (2020): 522-532.
Chicago
Xu, X., Xia, Y., Ma, J., Li, W., Niu, N., Li, X., Tao, H., Xu, J., He, X."Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling ". International Journal of Oncology 57, no. 2 (2020): 522-532. https://doi.org/10.3892/ijo.2020.5072
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Xia Y, Ma J, Li W, Niu N, Li X, Tao H, Xu J and He X: Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling . Int J Oncol 57: 522-532, 2020.
APA
Xu, X., Xia, Y., Ma, J., Li, W., Niu, N., Li, X. ... He, X. (2020). Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling . International Journal of Oncology, 57, 522-532. https://doi.org/10.3892/ijo.2020.5072
MLA
Xu, X., Xia, Y., Ma, J., Li, W., Niu, N., Li, X., Tao, H., Xu, J., He, X."Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling ". International Journal of Oncology 57.2 (2020): 522-532.
Chicago
Xu, X., Xia, Y., Ma, J., Li, W., Niu, N., Li, X., Tao, H., Xu, J., He, X."Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling ". International Journal of Oncology 57, no. 2 (2020): 522-532. https://doi.org/10.3892/ijo.2020.5072
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