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The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a

  • Authors:
    • Ling Chen
    • Xin Li
    • Chaojing Lu
    • Yue Zhao
    • Ji Zhu
    • Lixin Yang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Changhai Hospital, Shanghai 200433, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 466-477
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    Published online on: June 2, 2020
       https://doi.org/10.3892/ijo.2020.5076
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Abstract

Accumulating evidence has demonstrated the crucial roles of long non‑coding RNAs (lncRNAs) in various human cancers, including non‑small cell lung cancer (NSCLC). However, to the best of our knowledge, the role of the lncRNA cancer susceptibility candidate 7 (CASC7) in NSCLC has not been clearly determined. The aim of the present study was to investigate the involvement of CASC7 in NSCLC. Marked downregulation of CASC7 was observed in NSCLC tissues and cell lines, and this downregulation of CASC7 was closely associated with distant metastasis, lymph node involvement and poor overall survival in NSCLC patients. Furthermore, overexpression of CASC7 significantly suppressed the proliferation, invasion and migration of the NSCLC cells A549 and H358, and promoted cell apoptosis in vitro. In addition, CASC7 was shown to act as a competing endogenous RNA by sponging miR‑92a, which was proven to be an oncogenic miRNA in our previous study. The expression of miR‑92a was upregulated in NSCLC tissues and cell lines, and was found to be inversely associated with CASC7 expression in NSCLC tissues. It was also demonstrated that CASC7 upregulated the expression of the tumor suppressor gene phosphatase and tensin homolog (a well‑known target of miR‑92a) by sequestration of miR‑92a. Moreover, the tumor‑suppressive effects of CASC7 were partly reversed by miR‑92a overexpression in NSCLC cells. Collectively, the results of the present study indicated that CASC7 may act as a tumor‑suppressive lncRNA that inhibits NSCLC progression by sponging miR‑92a. These findings may improve our understanding of the potential mechanisms through which gain of CASC7 expression represses NSCLC progression.
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View References

1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar

2 

Chen G and Yi XH: Pathology and genetics of disease and tumours of the lung, pleura in China. Zhonghua Bing Li Xue Za Zhi. 34:490–493. 2005.In Chinese. PubMed/NCBI

3 

Ramalingam SS, Owonikoko TK and Khuri FR: Lung cancer: New biological insights and recent therapeutic advances. CA Cancer J Clin. 61:91–112. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Mostafa AA and Morris DG: Immunotherapy for lung cancer: Has it finally arrived? Front Oncol. 4:2882014. View Article : Google Scholar : PubMed/NCBI

5 

Wapinski O and Chang HY: Long noncoding RNAs and human disease. Trends Cell Biol. 21:354–361. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wang R, Ma Z, Feng L, Yang Y, Tan C, Shi Q, Lian M, He S, Ma H and Fang J: LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumori-genesis by promoting cell-cycle progression. Mol Cancer. 17:1622018. View Article : Google Scholar

7 

Zeng C, Liu S, Lu S, Yu X, Lai J, Wu Y, Chen S, Wang L, Yu Z, Luo G and Li Y: The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells. Mol Cancer. 17:1302018. View Article : Google Scholar : PubMed/NCBI

8 

Wang G, Sun J, Zhao H and Li H: Long non-coding RNA (lncRNA) growth arrest specific 5 (GAS5) suppresses esophageal squamous cell carcinoma cell proliferation and migration by inactivating phosphatidylinositol 3-kinase (PI3K)/AKT/Mammalian target of rapamycin (mTOR) signaling pathway. Med Sci Monit. 24:7689–7696. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Fan YF, Yu ZP and Cui XY: lncRNA colorectal neoplasia differentially expressed (CRNDE) promotes proliferation and inhibits apoptosis in non-small cell lung cancer cells by regulating the miR-641/CDK6 axis. Med Sci Monit. 25:2745–2755. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Song Z, Du J, Zhou L and Sun B: lncRNA AWPPH promotes proliferation and inhibits apoptosis of non-small cell lung cancer cells by activating the Wnt/β-catenin signaling pathway. Mol Med Rep. 19:4425–4432. 2019.PubMed/NCBI

11 

Zhang Y, Li Y, Han L, Zhang P and Sun S: SUMO1P3 is associated clinical progression and facilitates cell migration and invasion through regulating miR-136 in non-small cell lung cancer. Biomed Pharmacother. 113:1086862019. View Article : Google Scholar : PubMed/NCBI

12 

van Heesch S, van Iterson M, Jacobi J, Boymans S, Essers PB, de Bruijn E, Hao W, MacInnes AW, Cuppen E and Simonis M: Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes. Genome Biol. 15:R62014. View Article : Google Scholar : PubMed/NCBI

13 

Liu JH, Li C, Zhang CH and Zhang ZH: LncRNA-CASC7 enhances corticosteroid sensitivity via inhibiting the PI3K/AKT signaling pathway by targeting miR-21 in severe asthma. Pulmonology. 26:18–26. 2020. View Article : Google Scholar

14 

Liu Y, Pan L, Jiang A and Yin M: Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. Biomed Pharmacother. 98:856–862. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Gong X, Liao X and Huang M: LncRNA CASC7 inhibits the progression of glioma via regulating Wnt/β-catenin signaling pathway. Pathol Res Pract. 215:564–570. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Z, Fu C, Xu Q and Wei X: Long non-coding RNA CASC7 inhibits the proliferation and migration of colon cancer cells via inhibiting microRNA-21. Biomed Pharmacother. 95:1644–1653. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Ji D, Wang Y, Sun B, Yang J and Luo X: Long non-coding RNAMNX1-AS1 promotes hepatocellular carcinoma proliferation and invasion through targeting miR-218-5p/COMMD8 axis. Biochem Biophys Res Commun. 513:669–674. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Zhou K, Zhang C, Yao H, Zhang X, Zhou Y, Che Y and Huang Y: Knockdown of long non-coding RNA NEAT1 inhibits glioma cell migration and invasion via modulation of SOX2 targeted by miR-132. Mol Cancer. 17:1052018. View Article : Google Scholar : PubMed/NCBI

20 

Li H, Guo X, Li Q, Ran P, Xiang X, Yuan Y, Dong T, Zhu B, Wang L, Li F, et al: Long non-coding RNA1308 promotes cell invasion by regulating the miR-124/ADAM 15 axis in non-small-cell lung cancer cells. Cancer Manag Res. 10:6599–6609. 2018. View Article : Google Scholar :

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

22 

E C, Li C, Li H and Yang J: Silencing of a novel lncRNA LOC105369748 suppresses the progression of hepatocel-lular carcinoma by sponging miR-5095 from MBD2. J Cell Physiol. 234:18504–18512. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Jiang F, Qi W, Wang Y, Wang W and Fan L: lncRNA PEG10 promotes cell survival, invasion and migration by sponging miR-134 in human bladder cancer. Biomed Pharmacother. 114:1088142019. View Article : Google Scholar : PubMed/NCBI

24 

Qi H, Wen B, Wu Q, Cheng W, Lou J, Wei J, Huang J, Yao X and Weng G: Long noncoding RNA SNHG7 accelerates prostate cancer proliferation and cycle progression through cyclin D1 by sponging miR-503. Biomed Pharmacother. 102:326–332. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Yu H, Song H, Liu L, Hu S, Liao Y, Li G, Xiao X, Chen X and He S: MiR-92a modulates proliferation, apoptosis, migration and invasion of osteosarcoma cell lines by targeting Dickkopf-related protein 3. Biosci Rep. 39:BSR201904102019. View Article : Google Scholar

26 

Sun L, Jin X, Xie L, Xu G, Cui Y and Chen Z: Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression. BMC Cancer. 19:2472019. View Article : Google Scholar : PubMed/NCBI

27 

Sun B, Zhang J, Liu M and Guan L: Alkannin inhibits proliferation, migration and invasion of hepatocellular carcinoma cells via regulation of miR-92a. Biomed Pharmacother. 114:1087822019. View Article : Google Scholar : PubMed/NCBI

28 

Lu C, Shan Z, Hong J and Yang L: MicroRNA-92a promotes epithelial-mesenchymal transition through activation of PTEN/PI3K/AKT signaling pathway in non-small cell lung cancer metastasis. Int J Oncol. 51:235–244. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Fang L, Wang X, Sun Q, Papakonstantinou E, S'ng C, Tamm M, Stolz D and Roth M: IgE Downregulates PTEN through MicroRNA-21-5p and stimulates airway smooth muscle cell remodeling. Int J Mol Sci. 20:E8752019. View Article : Google Scholar : PubMed/NCBI

30 

Zhang H, Cao H, Xu D and Zhu K: MicroRNA-92a promotes metastasis of nasopharyngeal carcinoma by targeting the PTEN/AKT pathway. Onco Targets Ther. 9:3579–3588. 2016.PubMed/NCBI

31 

Ke TW, Wei PL, Yeh KT, Chen WT and Cheng YW: MiR-92a promotes cell metastasis of colorectal cancer through PTEN-Mediated PI3K/AKT pathway. Ann Surg Oncol. 22:2649–2655. 2015. View Article : Google Scholar

32 

Zhang G, Zhou H, Xiao H, Liu Z, Tian H and Zhou T: MicroRNA-92a functions as an oncogene in colorectal cancer by targeting PTEN. Dig Dis Sci. 59:98–107. 2014. View Article : Google Scholar

33 

Dong L, Li G, Li Y and Zhu Z: Upregulation of long noncoding RNA GAS5 inhibits lung cancer cell proliferation and metastasis via miR-205/PTEN axis. Med Sci Monit. 25:2311–2319. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Jin L, Jiang X, He G, Shi J, Su F and Zhu H: SNHG20 knockdown suppresses proliferation, migration and invasion, and promotes apoptosis in non-small cell lung cancer through acting as a miR-154 sponge. Biomed Pharmacother. 112:1086482019. View Article : Google Scholar

35 

Zhang MY, Zhang ZL, Cui HX, Wang RK and Fu L: Long non-coding RNA FENDRR inhibits NSCLC cell growth and aggressiveness by sponging miR-761. Eur Rev Med Pharmacol Sci. 22:8324–8332. 2018.PubMed/NCBI

36 

Shigoka M, Tsuchida A, Matsudo T, Nagakawa Y, Saito H, Suzuki Y, Aoki T, Murakami Y, Toyoda H, Kumada T, et al: Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development. Pathol Int. 60:351–357. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Liu GH, Zhou ZG, Chen R, Wang MJ, Zhou B, Li Y and Sun XF: Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer. Tumour Biol. 34:2175–2181. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Wu Q, Yang Z, Wang F, Hu S, Yang L, Shi Y and Fan D: MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells. J Cell Sci. 126:P4220–P4229. 2013. View Article : Google Scholar

39 

Zhao YB, Zhao J, Zhang LJ, Shan RG, Sun ZZ, Wang K, Chen JQ and Mu JX: MicroRNA-370 protects against myocardial isch-emia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5-dependent PPAR signaling pathway. Biomed Pharmacother. 113:1086972019. View Article : Google Scholar

40 

Ding K, Wu Z, Wang N, Wang X, Wang Y, Qian P, Meng G and Tan S: MiR-26a performs converse roles in proliferation and metastasis of different gastric cancer cells via regulating of PTEN expression. Pathol Res Pract. 213:467–475. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Perumal E, So Youn K, Sun S, Seung-Hyun J, Suji M, Jieying L and Yeun-Jun C: PTEN inactivation induces epithelial-mesenchymal transition and metastasis by intranuclear translocation of β-catenin and snail/slug in non-small cell lung carcinoma cells. Lung Cancer. 130:25–34. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Liu L, Huang L, He J, Cai S, Weng Y, Huang S and Ma S: PTEN inhibits non-small cell lung cancer cell growth by promoting G0/G1 arrest and cell apoptosis. Oncol Lett. 17:1333–1340. 2019.PubMed/NCBI

43 

Qin LB, Li ZY, Li H, Fan XQ, Liu HG, Dong XM and Jia WY: Inhibitive effects of microRNA-34a on protecting against ischemia-reperfusion injury of vital organs in hemorrhagic shock pregnant mice. Eur Rev Med Pharmacol Sci. 22:1812–1818. 2018.PubMed/NCBI

44 

Xiao J, Yu W, Hu K, Li M, Chen J and Li Z: MiR-92a promotes tumor growth of osteosarcoma by targeting PTEN/AKT signaling pathway. Oncol Rep. 37:2513–2521. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Li X, Lu C, Zhao Y, Zhu J and Yang L: The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a. Int J Oncol 57: 466-477, 2020.
APA
Chen, L., Li, X., Lu, C., Zhao, Y., Zhu, J., & Yang, L. (2020). The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a. International Journal of Oncology, 57, 466-477. https://doi.org/10.3892/ijo.2020.5076
MLA
Chen, L., Li, X., Lu, C., Zhao, Y., Zhu, J., Yang, L."The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a". International Journal of Oncology 57.2 (2020): 466-477.
Chicago
Chen, L., Li, X., Lu, C., Zhao, Y., Zhu, J., Yang, L."The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a". International Journal of Oncology 57, no. 2 (2020): 466-477. https://doi.org/10.3892/ijo.2020.5076
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Li X, Lu C, Zhao Y, Zhu J and Yang L: The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a. Int J Oncol 57: 466-477, 2020.
APA
Chen, L., Li, X., Lu, C., Zhao, Y., Zhu, J., & Yang, L. (2020). The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a. International Journal of Oncology, 57, 466-477. https://doi.org/10.3892/ijo.2020.5076
MLA
Chen, L., Li, X., Lu, C., Zhao, Y., Zhu, J., Yang, L."The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a". International Journal of Oncology 57.2 (2020): 466-477.
Chicago
Chen, L., Li, X., Lu, C., Zhao, Y., Zhu, J., Yang, L."The long non‑coding RNA CASC7 inhibits growth and invasion of non‑small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR‑92a". International Journal of Oncology 57, no. 2 (2020): 466-477. https://doi.org/10.3892/ijo.2020.5076
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